No one seems to have recognized a key person who is responsible for this moment in American history: Eric Topol.
Remember him? He was the medical researcher who saw to it that the results of the vaccine trials would not be released before the election in 2020. As Steve has argued, this very likely prevented the vote from being swung to Trump.
And now Trump has come into his second term with a powerful mandate, and what looks like a well organized plan (not exactly typical of the Trump of his first term) to take power and enforce his vision.
We should all be thankful for the unstinting efforts of Dr. Topol, who was so gloriously careless of what he wished for.
https://upload.wikimedia.org/wikipedia/commons/d/dc/Chaim_Topol%2C_1967_%28cropped%29.jpg
We should all be thankful for the unstinting efforts of Dr. Topol
What is most interesting about this entirely sensible proposal will be to see how the tech giants respond to it.
Can they really bring themselves to implement it, when they know how it exposes their ideological agenda? Yet on what grounds can they refuse to implement it?
I have a feeling we’re going to hear many excuses why it just can’t be done.
Errr, MIT never "got 14% blacks" unless that's a citation for admissions offers, where some will instead accept offers from CalTech which is stronger in science, or other such institutions, or go to much more remunerative paths at Harvard etc.
MIT boasts that it got 14% blacks with the use of the SAT, because it was able to select the best blacks. But that would be only because it was allowed to treat blacks separately. Those numbers can’t possibly stay in the same range if they can’t do so, unless they take huge hits on quality of students.
Actually, I slightly misremembered the number from the NY Times article: it was in fact 15% blacks:
“Once we brought the test requirement back, we admitted the most diverse class that we ever had in our history,” Schmill told me. “Having test scores was helpful.” In M.I.T.’s current first-year class, 15 percent of students are Black, 16 percent are Hispanic, 38 percent are white, and 40 percent are Asian American.
I have no idea where Schmill got that number, but he, as dean of admissions at M.I.T., should be in a position to know.
It is an eye-popping number, and far greater than in previous years, it seems.
What the article fails to do is to reckon with the consequences of the recent SC ruling on Affirmative Action.
Sure, it’s quite true that one can select the most capable blacks by emphasizing their SAT scores. But this only works if you can treat blacks as a separate category. The problem remains that blacks, in comparison to other groups, do most poorly on academic measures on the SAT. Blacks can do OK on grades, relatively speaking, because they compete mostly against each other in most high schools they attend.
So introducing, or retaining, the SAT as a significant factor makes them seem overall only less worthy academically than they would seem otherwise. If the ruling of the SC is at all respected, and they are not separated out for special treatment, their numbers should plummet only more dramatically with the use of the SAT as a factor than without it.
MIT boasts that it got 14% blacks with the use of the SAT, because it was able to select the best blacks. But that would be only because it was allowed to treat blacks separately. Those numbers can’t possibly stay in the same range if they can’t do so, unless they take huge hits on quality of students.
The article would have made a lot more sense and have been far more applicable before the SC ruling than afterwards.
Errr, MIT never "got 14% blacks" unless that's a citation for admissions offers, where some will instead accept offers from CalTech which is stronger in science, or other such institutions, or go to much more remunerative paths at Harvard etc.
MIT boasts that it got 14% blacks with the use of the SAT, because it was able to select the best blacks. But that would be only because it was allowed to treat blacks separately. Those numbers can’t possibly stay in the same range if they can’t do so, unless they take huge hits on quality of students.
I’m wondering, might Barack Obama take on the job of being President of Harvard?
It wouldn’t be crazy. He’d be the perfect case of a supposedly qualified DEI hire. And what is he doing now that’s so important anyhow? Who outside of the right would dare to criticize him?
And it would suit his delusions about how educated and sophisticated he is.
The thing that baffles me about the approach the “Race does not exist” crowd takes in contexts like this is that it seems to contradict the claims they make elsewhere.
If indeed including race in models does not add any power to prediction of health outcomes, how can it be that it is racism that creates worse outcomes for blacks?
You see, if adding race as a parameter does not alter the predictions, that does not tell only against relevant genetic differences between blacks and whites, it also tells against relevant environmental differences between them. And yet, according to these same authors, it is supposed to be the massive effects of racism — above and beyond all other environmental factors — that engender worse outcomes in blacks.
If these authors really believe their claims about racism, why don’t they demand that race be taken into account, lest blacks not be found to be as vulnerable as they are to health issues?
In contrast to the medical profession, economists in academia are considered quite right wing and unwoke — but their ratio of Democrats to Republicans is about 2 or 3 to 1.
One thing that puzzles me is how extremely woke is all the commentary coming out of the medical profession. It seems as woke as the worst of academia.
But the political affiliations of the medical profession hardly seem woke — indeed, it seems to be about as unwoke as it gets among the professions.
Here’s a tweet summarizing the situation as of 2016, when essentially half of all MDs have registered as Republicans — Republicans!
Surgeons are consistently among the most right-wing doctors and psychiatrists are among the most left-wing.
In line with this, here were their surveyed party registrations in 2016:
This sort of pattern also (largely, but not always) holds up when discipline-level affiliation is… pic.twitter.com/Ui2s5MZhHC— Crémieux (@cremieuxrecueil) November 15, 2023
And the more exclusive are the specialties, the more Republican they are.
How did the medical profession come to be utterly dominated by a faction that must run completely against the scientific and moral sensibilities of such a large and intellectually powerful segment of the community?
The essential question that is obvious to intelligent, numerate, and statistics-informed observers: "Is the predictive value of the algorithm (AUC) improved by adding 'race' to the other named factors (e.g. A1C and the Social Deprivation Index)?"
The new equation also has options for including a measure of blood sugar control, called hemoglobin A1C, in people with Type 2 diabetes, and for incorporating a factor called the Social Deprivation Index, which includes poverty, unemployment, education and other factors.
...The changes are “great news,” said Dr. David S. Jones, a psychiatrist and professor of the history of medicine at Harvard, who wrote a paper about the use of race in myriad medical decision-making algorithms that was published in the New England Journal of Medicine in 2020.
...“It’s been hugely gratifying to see how medical thinking has shifted about this issue over the past three to five years,” Dr. Jones said.
It’s not just that, obviously, the predictive power of the algorithm goes down if race is omitted. It’s that it is blacks who will suffer from the loss of predictive power: they, and their doctors, will be less likely to be informed of significant risk of heart disease and so less likely to take corrective measures. In short, they will die more often.
The dishonesty of the writer here is remarkable. She even brings up the case of an adjustment in how a kidney metric was calculated that originally employed race which, apparently, put blacks at greater risk of not receiving correct treatment. Clearly, she wants the reader to infer that that’s what’s going on in the case of the cardiac algorithm which includes race, when it is certainly the opposite.
Blacks might ask themselves, with allies like this, who needs hostile racists?
Hard to argue with his point that the environmental change is the first order cause of the change in obesity among the Akimel O’odham (in particular the timing), but I think he underestimates the possibility that genetics matter for current obesity prevalence. Although the thrifty gene hypothesis seems overstated (it is far from as simple as a single causal gene) I think he underestimates the role of genetics in obesity.
For champions of personalized medicine, gathering genomic information from communities of color is said to be an essential step toward combating the health crises.
...
It would be natural to applaud this well-meaning effort at making the world a more equitable place. Reflecting on an episode from the history of biomedical research, however, should leave us profoundly worried. Genetic endeavors undertaken with even the best of intentions can miss their mark and, in the process, distract from the actual causes of health disparities, with harmful consequences.
...
Sixty years after federal scientists first discovered the diabetes epidemic afflicting the Akimel O’odham, that episode offers a powerful lesson for personalized medicine ambitions of the present. Geneticists today don’t talk about a “thrifty genotype” anymore. That pseudoscientific idea has been expunged from scientific discourse. But the thought that there must be some simple, biological explanation for complex, social problems remains at the heart of personalized medicine.
That inclination distracts from the actual causes of health disparities. It reinforces the idea that health disparities aren’t something that we need to collectively fix in society; rather, they’re something that people of color need to fix in their genomes. It violates the trust of those who put their faith in a science that promised to help them. And, ultimately, it exacerbates the problem it was intended to resolve.
Tabery’s analysis is amazingly stupid.
The entire point of the “thrifty genome” is that diabetes is nowadays common in Indigenous peoples precisely because the environment for which their genome was evolved, in which energy rich food was often scarce, differs from their current environment, in which it is easily accessible. The fact that they have developed diabetes in great numbers after energy rich food became readily available doesn’t tell against the idea of a “thrifty genome”, it is exactly what that theory was intended to explain.
Talk about “pseudoscience”!
One thing I haven’t seen addressed is the potential impact of the Wilson Effect — the fact that IQs are more heritable and more reliable at ages 18+. My recollection is that in some earlier studies of the race gap, it was found that the gap had been becoming distinctly smaller at younger ages, but remained large and constant at 18+ (1.1 SD, I think).
The age of these students is 10 — which would seem subject to the Wilson Effect. One might guess that the gap would become even larger at 18.
I suspect that you’re right that in Boston, and generally on the east coast, there’s a lot more pure virtue signalling than on the west coast. I see Black Lives Matter signs everywhere in the rich suburbs of Boston, but virtually no Black lives.
Not walking the walk is a good thing.
There’s a lot to be said for hypocrisy.
I wonder how the Romans might have hit upon a mixture that was so much more durable than even modern concrete. The mixers wouldn’t be around the hundred or more years later when the difference would clearly have been noticeable. Would there be detectable differences on a much shorter timetable — say, within a career of an artisan?
Or was it just dumb luck?
I would say it was common sense, like the proprietary formula my father used. Think about it: When you mix a binding ingredient into cement, it stands to help hold it together. Asbestos is a mineral fiber perfectly suited to this, and nobody had to wait very long to realize that it would bind together the concrete structures my father manufactured. It was self-evident -- and it would continue be used today if not for the lawyer-induced-for-profit panic about asbestos.*As to what the Romans really used, I am still curious and waiting to find out...*Asbestos caused lung cancers in the factory men who breathed in fibers floating in the air. Bound into concrete it is harmless and very useful. It is a mineral fiber, for God's sake -- an extremely useful material. But no, now it is a bogeyman, something to be avoided at all costs, despite the fact that it could still be used and worked with with proper procedures... You know, kind of like nuclear energy and the internal combustion engine and a million other Evil White Man tools...Dad brought home to me actual asbestos rocks from his company's mine. He brought them home for me to play with. I picked them up with my electric, toy crane when I was five years old. I peeled away the white fibers from the greenish rocks.I'm still alive, about to turn 63, and extremely healthy and strong...
I wonder how the Romans might have hit upon a mixture that was so much more durable than even modern concrete.
Isn’t the innovation of cryptocurrency to improve upon the tulip market by removing the tulips?
That's exactly what our hyper-financialized and digitized markets do for everything. For example, there is something like 140 times the world's actual supply of physical gold that people own (or think they own). This is called "paper gold," except it's not even paper, but entries on a digital spreadsheet in the cloud somewhere.
Isn’t the innovation of cryptocurrency to improve upon the tulip market by removing the tulips?
I wonder if part of the answer might be that UK has a faster feedback mechanism than does the US. The Parliamentary government of UK might induce more rapid feedback generally.
The US system is about to get a major shock in the midterm elections. A massive rejection of the left will propagate up the hierarchy of leftist institutions, hitting first the Dem party, then the media supporting it, then (though to a lesser extent) the NGOs and academics behind the most extreme leftist policies.
But even the best insulated segments, the NGOs and academics, will likely feel obliged to pull back on their positions if they are themselves spurned as embarrassments by both the media and the Dem party.
The argument in the article is rather bizarre.
The authors emphasize that, over the last almost 20 years of aggressive Affirmative Action, blacks haven’t improved their lot.
And somehow this becomes a case for continuing Affirmative Action, rather than discontinuing it for abject failure to produce the intended effect?
And there you go again. White man's logic.
The argument in the article is rather bizarre.
The Halting problemReplies: @Rich, @Cloudbuster, @candid_observer
How so? The Turing test?
Well, the the proof of the halting problem was a fairly straightforward reworking of Godel’s proof of his first Incompleteness theorem. And Alonzo Church beat Turing to the punch on the result, though he cast it in terms of his ugly lambda calculus. Perhaps Turing’s biggest claim to fame was his articulation of the Turing machine, which was a nice encapsulation of what it means to be computable.
Turing was very important as a computer scientist, but he’s not exactly in the company of the greatest mathematicians of the last century.
I wonder how much of our ignorance of the genetic correlates of facial features comes from a poverty of phenotype data.
How many of those in the data stores for GWAS studies have pictures connected to the genotype data?
It would seem pretty easy to gather such photos, but I suspect it might not be permissible to use those photos, since they would identify the contributors. Even abstracted data, such as distance between eyes, etc., might be enough to do so.
https://en.wikipedia.org/wiki/Hard_problem_of_consciousnessThe chief point is that, say, Chalmers grants that science may come up with a full explanation of all brain states, which would imply perfect predictability (which is the so-called "easy problem"), without any explanation of subjective experiences or mental states such as qualia. Insofar as something explains the existence of qualia, it goes beyond standard science which addresses empirical matters. Chalmers assumes that standard science can, at least in principle, get all empirical matters correctly, and that there's no strange set of forces that would allow brain states to deviate from their expected paths. Put another way, qualia, and mental states, do not have causal effects that would induce alterations in the physical world as standard science understands it.The Hard Problem is that qualia seem nonetheless to exist, and demand some kind of explanation. But what is that explanation? Standard science, which predicts only things in the physical world, cannot do so. I brought up the comparison to the existence of ESP. Sean Carrol has made the point that science really doesn't seem to have any wiggle room for radically new phenomena at certain scales. It would certainly seem that the behavior of brain states are at such a scale. I think it's fair enough to say that in the end brain states are reducible to the interactions between neurons in our brains. But the behavior of individual neurons in our brains seem to be perfectly predictable based on standard chemical and electrical principles, even if we don't yet know all the details. Likewise, we certainly don't yet have all the details relevant to how these neurons interact as a network, but there seems to be no room for a deviation from how the set of individual neurons in fact would be predicted to act.I ask, where is the wiggle room in this understanding of how the brain behaves? Where's the opportunity for either a totally separate set of entities, such as qualia, or for ESP, to alter these otherwise perfectly predictable physical processes?Replies: @candid_observer
The hard problem of consciousness is the problem of explaining why and how humans have qualia[note 1] or phenomenal experiences.[2] This is in contrast to the "easy problems" of explaining the physical systems that give us and other animals the ability to discriminate, integrate information, and so forth. These problems are seen as relatively easy because all that is required for their solution is to specify the mechanisms that perform such functions.[3][4] Philosopher David Chalmers writes that even once we have solved all such problems about the brain and experience, the hard problem will still persist.[3]
I’d press the analogy to ESP a bit further.
Against ESP we have the standard science of brain states which requires, and finds, no room for ESP to act, and sets a very low prior for ESP being true. In favor of ESP, we have only very dubious experiments, typically contradicted by other experiments.
Against separate mental states we have the standard science of brain states, which finds no room for separate mental states to act, and no reason to posit their existence, and sets a very low prior for the existence of separate mental states to be true. In favor of separate mental states, we have only quite dubious metaphysical arguments and intuitions. Suffice it to say, metaphysical arguments and intuitions don’t enjoy a record of great reliability.
Why should we be far more convinced of separate mental states than of ESP?
Have you read Chalmers or McGinn?
The first is that the common understanding of the so-called Hard Problem of Consciousness is that it is Hard precisely because science will never explain it. That is, those who point to the existence of the Hard Problem assume that, from the standpoint of science, there will never be a scientific account of consciousness: mental states exist as a separate substance from brain states, but are perfectly correlated with brain states, and brain states have an entirely physical explanation.
We would? How do you know this?
The same considerations apply to the notion that consciousness might alter our brain states. If there were forces able to effect such changes, we’d presumably already know about them.
Here, from Wikipedia, is a quick and good enough summary of the Hard Problem:
The hard problem of consciousness is the problem of explaining why and how humans have qualia[note 1] or phenomenal experiences.[2] This is in contrast to the “easy problems” of explaining the physical systems that give us and other animals the ability to discriminate, integrate information, and so forth. These problems are seen as relatively easy because all that is required for their solution is to specify the mechanisms that perform such functions.[3][4] Philosopher David Chalmers writes that even once we have solved all such problems about the brain and experience, the hard problem will still persist.[3]
https://en.wikipedia.org/wiki/Hard_problem_of_consciousness
The chief point is that, say, Chalmers grants that science may come up with a full explanation of all brain states, which would imply perfect predictability (which is the so-called “easy problem”), without any explanation of subjective experiences or mental states such as qualia. Insofar as something explains the existence of qualia, it goes beyond standard science which addresses empirical matters. Chalmers assumes that standard science can, at least in principle, get all empirical matters correctly, and that there’s no strange set of forces that would allow brain states to deviate from their expected paths. Put another way, qualia, and mental states, do not have causal effects that would induce alterations in the physical world as standard science understands it.
The Hard Problem is that qualia seem nonetheless to exist, and demand some kind of explanation. But what is that explanation? Standard science, which predicts only things in the physical world, cannot do so.
I brought up the comparison to the existence of ESP. Sean Carrol has made the point that science really doesn’t seem to have any wiggle room for radically new phenomena at certain scales. It would certainly seem that the behavior of brain states are at such a scale. I think it’s fair enough to say that in the end brain states are reducible to the interactions between neurons in our brains. But the behavior of individual neurons in our brains seem to be perfectly predictable based on standard chemical and electrical principles, even if we don’t yet know all the details. Likewise, we certainly don’t yet have all the details relevant to how these neurons interact as a network, but there seems to be no room for a deviation from how the set of individual neurons in fact would be predicted to act.
I ask, where is the wiggle room in this understanding of how the brain behaves? Where’s the opportunity for either a totally separate set of entities, such as qualia, or for ESP, to alter these otherwise perfectly predictable physical processes?
Well, why not?
So are we to say that, somehow, consciousness just arose, rather magically, as a distinct substance at some point in evolution? Or that it actually co-occurs with all material objects, even though we don’t see evidence of it except with certain animals?
Isn’t either of those assertions just a little at odds with our conception of the world as science would seem to show it?
Well, "never" is a long time!
And you talk about the causal influence of consciousness. Here I’ve got a bone to pick. Are you actually claiming that consciousness influences what happens in our real world in a way in which science would never be able to account for?
Prior to the twentieth century, we had no inkling at all of the strong or weak nuclear forces, both of which, we now know, play central roles in the nature of reality.
Do you really want to say that if we think of the world as being composed of particles and physical forces, etc., we won’t be able to account for, and, at least in principle, predict everything that will take place in the world?
A couple points to make here in response.
The first is that the common understanding of the so-called Hard Problem of Consciousness is that it is Hard precisely because science will never explain it. That is, those who point to the existence of the Hard Problem assume that, from the standpoint of science, there will never be a scientific account of consciousness: mental states exist as a separate substance from brain states, but are perfectly correlated with brain states, and brain states have an entirely physical explanation. What you are suggesting instead is that there may very well be a new, scientific explanation for consciousness.
The second point is that the physics behind brain states is far more pedestrian, and better understood, than you seem to grant. The same point has been made against the existence of ESP, as in the following debate between Steve Pinker and the physicist Josephson. Sure, physics still has important unresolved issues — but not at the scale that would affect the workings of brain states that would allow for ESP:
But should we go meta, and adjust the priors to acknowledge the possibility that our understanding of physics is incomplete and yet-to-be-discovered laws might explain how psychic powers are possible? Though many phenomena at extreme scales of space and energy—near the Big Bang or a black hole, at the size of a photon or of a galaxy—are incompletely understood, this cannot be said about the physics of everyday life. As Sean Carroll shows in The Big Picture, on these scales, from nanotech to moon rockets, the laws of physics are completely understood. We aren’t in need of strange new forces or fields to explain how a bicycle works, or why eclipses happen. Carroll takes the argument a step further: our understanding is so complete that if there were as-yet unidentified fields in addition to those underlying gravity, electromagnetism and so on, we would be able to detect them, and we don’t.
https://www.skeptic.com/reading_room/debate-is-belief-in-esp-irrational/
The same considerations apply to the notion that consciousness might alter our brain states. If there were forces able to effect such changes, we’d presumably already know about them.
Have you read Chalmers or McGinn?
The first is that the common understanding of the so-called Hard Problem of Consciousness is that it is Hard precisely because science will never explain it. That is, those who point to the existence of the Hard Problem assume that, from the standpoint of science, there will never be a scientific account of consciousness: mental states exist as a separate substance from brain states, but are perfectly correlated with brain states, and brain states have an entirely physical explanation.
We would? How do you know this?
The same considerations apply to the notion that consciousness might alter our brain states. If there were forces able to effect such changes, we’d presumably already know about them.
Just to continue the final point I was making:
Do you think that consciousness can somehow alter the path that physical entities and forces are taking in the brain? Can it make an electron swerve that otherwise wouldn’t? Can it change the quantum probabilities? How does it do its causal business in our physical world?
And if it can’t change a damn thing, what is it doing for us?
So are we to say that, somehow, consciousness just arose, rather magically, as a distinct substance at some point in evolution? Or that it actually co-occurs with all material objects, even though we don’t see evidence of it except with certain animals?
Isn’t either of those assertions just a little at odds with our conception of the world as science would seem to show it?
And you talk about the causal influence of consciousness. Here I’ve got a bone to pick. Are you actually claiming that consciousness influences what happens in our real world in a way in which science would never be able to account for? Do you really want to say that if we think of the world as being composed of particles and physical forces, etc., we won’t be able to account for, and, at least in principle, predict everything that will take place in the world? (Yes, quantum phenomena make this a little messier, but essentially never at a level that affects thoughts or emotions.) If physical phenomena determine basically all cognitive activity, what’s left for the causal influence of consciousness?
The big problem with consciousness as a separate substance is that it adds zero to our understanding of the real world, which is entirely determined by physical phenomena. We need it like we need God.
Well, why not?
So are we to say that, somehow, consciousness just arose, rather magically, as a distinct substance at some point in evolution? Or that it actually co-occurs with all material objects, even though we don’t see evidence of it except with certain animals?
Isn’t either of those assertions just a little at odds with our conception of the world as science would seem to show it?
Well, "never" is a long time!
And you talk about the causal influence of consciousness. Here I’ve got a bone to pick. Are you actually claiming that consciousness influences what happens in our real world in a way in which science would never be able to account for?
Prior to the twentieth century, we had no inkling at all of the strong or weak nuclear forces, both of which, we now know, play central roles in the nature of reality.
Do you really want to say that if we think of the world as being composed of particles and physical forces, etc., we won’t be able to account for, and, at least in principle, predict everything that will take place in the world?
Well, I should have been more precise about how Kripke thought about dualism: he did indeed put up a defense of dualism (or at least a set of strong arguments for dualism) — very similar indeed to that which Chalmers and others produced — but that he was nonetheless unconvinced of it, because of countervailing considerations. As he says at the very end of the note you refer to:
I regard the mind-body problem as wide open and extremely confusing.
But, again, the arguments he produces in favor of dualism are essentially those of Chalmers, and certainly predate him.
Kripke’s larger argument is found in this excerpt from Naming and Necessity:
The thing about dualism and the Hard Problem of Consciousness is that the so-called Hardness quickly becomes an embarrassment.
If there’s just no scientific accounting of Consciousness, when and where and how did it first come about? Did it pop into existence at some point in the evolution of life? Or does it inherently co-occur with all material things, and only becomes evident in certain organisms? Doesn’t any answer to these questions seem little short of invoking magic?
The Harder the Problem is, the more it seems like a reductio ad absurdum of dualism. The rational response to it should be, let’s get rid of this consciousness-as-a-separate-substance stuff. The arguments for dualism might seem to make sense, as metaphysical arguments often do, but they can’t possibly hold up in our very real world.
Kripke famously put up a defense of dualism in Naming and Necessity. Kripke is perhaps the most highly regarded philosopher of the 30-40 years.
When I first heard of Chalmers, my first reaction was, what did he add to Kripke’s argument? To this day, I’m not sure what fundamental improvement Chalmers has made upon Kripke.
Chalmers was rather clever in his nomenclature. The “Hard Problem of Consciousness” has stuck pretty well over the years.
I recently became quite aware of just how much legal language can be like computer programming.
The definition of inheritance by representation, as stated in certain state laws, actually involves recursion. It took me a serious thinking to assure myself I understood it right — and there was a lot of money at stake.
And this is an issue a pretty standard local lawyer might have to deal with in handling an estate.
Imagine what would happen if the SC decided to reject Affirmative Action.
I’d think that if they can bring themselves to retract Roe v Wade, they should be able to forbid Affirmative Action in federally funded institutions.
I hope that they haven’t squandered whatever courage they may have on rescinding Roe v Wade, which, in my view, may have been bad jurisprudence, but reasonable policy.
The Ukrainian military has a very simple and effective strategy for opposing the Russian advance: retreat to cities, and, in effect, use the civilian population as a human shield. In today’s world, this works very well because no advanced nation wants to be held responsible for high civilian deaths.
I wonder if the Ukrainian military has already been reduced to this tactic. I see no evidence that they’ve ever been able to prevail in open countryside, where it is military vs military.
Too bad Russia isn't an advanced nation. There are tens of thousands of dead in Mariupol alone and the entire city has been bombed to rubble. Putin has no qualms against killing civilians. He has no qualms about getting his own people killed either.
n today’s world, this works very well because no advanced nation wants to be held responsible for high civilian deaths.
Replies: @candid_observer
From an operational point of view, the Russian offensive was an example of its kind: in six days, the Russians seized a territory as large as the United Kingdom, with a speed of advance greater than what the Wehrmacht had achieved in 1940. The bulk of the Ukrainian army was deployed in the south of the country in preparation for a major operation against the Donbass. This is why Russian forces were able to encircle it from the beginning of March in the “cauldron” between Slavyansk, Kramatorsk and Severodonetsk, with a thrust from the East through Kharkov and another from the South from Crimea. Troops from the Donetsk (DPR) and Lugansk (LPR) Republics are complementing the Russian forces with a push from the East. At this stage, Russian forces are slowly tightening the noose, but are no longer under time pressure. Their demilitarization goal is all but achieved and the remaining Ukrainian forces no longer have an operational and strategic command structure. The “slowdown” that our “experts” attribute to poor logistics is only the consequence of having achieved their objectives. Russia does not seem to want to engage in an occupation of the entire Ukrainian territory. In fact, it seems that Russia is trying to limit its advance to the linguistic border of the country.https://www.thepostil.com/the-military-situation-in-the-ukraine/
This analysis is interesting, but it is from April 1.
What I never seem to run into is any credible account of how the Ukrainian military is faring today, and what its prospects are.
Russia supposedly was cutting off supplies, etc. to the bulk of the Ukrainian military in the south and east — but did this really happen?
What’s left of the Ukrainian military at this point? If the supplies can’t get to most of it, of what account is the Western initiative to supply them with weapons?
Everybody’s talking about the Russian military — but we know little to nothing about the Ukrainian military.
Is Ukraine going to be reduced to fighting a guerilla war? That would be ugly and likely pointless from a Ukrainian point of view. What would they be fighting for? Possible NATO membership? Really?
I think you underestimate the power of network effects.
That's it. Social media is nothing but network effect -- the platform either has a critical mass or it doesn't. The users supply the content.
I think you underestimate the power of network effects.
Human population was about 1-15 million at the advent of agriculture. It’s now about 8 billion.
That’s a lot of reproductive success to work with. One would think that those who were better at agriculture and agricultural societies might be strongly favored by selection.
Meow!
One would think that those who were better at agriculture and agricultural societies might be strongly favored by selection.
Actually, almost all the selection for cognitive ability works on standing variation, not new mutations. The effects of common SNPs are exceedingly small. New mutations, if they impact cognitive ability, and are of sizable effect, are almost certainly deleterious, and are, as quick as possible, rooted out.
Agriculture very likely does bring about selection for cognitive ability. But it does so because it directly favors reproductive success, not because it has better variants to work with.
The absurd use of “dark skinned” shows how the Times own stylistic policy bites back at it.
The point of “Black” is to bring attention to the race of blacks, and to serve as an honorific.
But what happens if the black newsmaker does something horrible? “Black” then becomes a great embarrassment, doing the opposite from what it was intended to do, and looking ridiculous in the process.
Did it ever occur to these Times people that blacks might, in fact, feature in a number of horrible stories — in fact, in well more than their share? How did they ever think they would handle such cases?
Based upon the changes in the story during the day, there was an edit war inside the news room. In the old days you would never see these because only one version appeared in print but nowadays the edit wars occur on the web in real time.The news room (like the Democrat Party) is now divided between the old guard who are Pelosi/Biden liberals (though not as old) and the new woke AOC/Nikole Hannah-Jones generation who are radical "anti-racists" who oversaw the promotion of blacks to Blacks, thus sowing the seeds of the current conundrum - "Blacks" are by definition a good thing, so there can be no bad Blacks. So version 1.o of the story called the shooter "Black" in accordance with the description released by the police and quoted by most other news sources.Version 2.0 - the Woke brigade retaliates and he becomes "a man in a green vest" .In version 3.0, a compromise is reached and the Woke and the merely liberal agree on "dark skinned". There can be no bad Blacks but dark skinned men can do bad things. I think that "dark skinned man" is rather awkward and suggest that from now on we just called them "darkies". I think that's a cute, up to date name like "furries". Also, like Latinx, darkie is not gendered. Black would remain reserved for people who are Supreme Court Justices, and darkie would be for people who commit crimes. "Yesterday a darkie pushed an elderly Asian woman onto the subway tracks." "A darkie stole the expensive watch of a diner at a sidewalk cafe" Etc. Whaddaya say, Gen Z folks, doesn't that sound good to you?Replies: @hhsiii, @Prester John
The absurd use of “dark skinned” shows how the Times own stylistic policy bites back at it.
Shouldn’t they have something like speed golf, like speed chess?
I really think we have to investigate a good deal more carefully before we can conclude that Russian forces committed all, or most, of these atrocities.
Both sides have pushed a lot of propaganda already.
And generally, the Azov element, where ever it is involved, is brutal, barbaric, and deceptive beyond belief.
Hate hoaxes aren’t just for BLM.
Truth is the first casualty of war.
Hate hoaxes aren’t just for BLM.
Standardized testing puts supporters of Affirmative Action between a rock and a hard place.
On the one hand, using a standardized test puts on record the gross differences between white/Asian males and their favored groups. On the other hand, if they are to select the members of those groups least likely to fail, standardized tests are the best measure. Indeed, those tests are likely well more critical in making the correct decisions for their favored groups than for white/Asian males.
MIT probably saw too many minorities/women fail out (especially minorities), undermining their desire to do aggressive Affirmative Action. So they bit the bullet and went back to standardized testing.
The civilian casualties in this war have been (apparently) quite low — less than 1,000, I have read.
This must be a deliberate choice made by Putin — if he had in mind to win the war by killing civilians, I don’t see how the decisions to launch various kinds of artillery attacks, or bombing sorties, or missile could be resisted by his military commanders.
If anything, it would seem that part of what is holding Russia back from quick dominance (given its numbers) is a policy of avoiding civilian deaths, and minimizing damage to civilian infrastructure.
Putin may be a thug and a bully, but he clearly imposes limits on his tendencies.
FIghting wars in the 21st century by a largely civilized country is as much constrained by what is acceptable methods as it is by military prowess.
According to the UN it was over 1,000 confirmed deaths on March 23 but they say the actual number is much higher:
The civilian casualties in this war have been (apparently) quite low — less than 1,000, I have read.
This is false. Cuba was once a full fledged Soviet satellite. We made a deal with the Soviets for them not to station nukes in Cuba (in exchange for which we removed our nukes from Turkey) but short of that, the Soviets had massive military installations in Cuba.Defense is just the pretext that Putin uses (along with imaginary "genocide" of Russians in Ukraine). Ukraine and NATO have no desire to invade Russia. Ukraine had no capability to invade. The real reason is that he cannot tolerate that Ukraine got rid of his corrupt puppet and was beginning to form a Western oriented liberal democracy. If this is possible in Ukraine, then it is possible in Russia too and that is literally a mortal threat to him personally. He cannot allow such an example to exist.Doesn't Putin ALREADY have hostile powers on his border - e.g. Estonia, Latvia? Look at the map. It's less than 400 miles from the Latvian border to Moscow. According to this logic, Putin shouldn't have to tolerate them either (and in fact if they were not part of NATO, he probably would be pulling the same shtick in those countries). Latvia in particular has a large Russian minority planted there as colonists by the Soviets. And again is making him look bad by being democratic. He would love to get rid of them too. Is that OK also?Replies: @candid_observer, @Mr. Anon, @Paperback Writer, @Mike Tre
We would never tolerate a country bordering us — or even in the same hemisphere — which was both hostile and heavily armed.
We managed to resolve the Cuban Missile crisis by imposing a military blockade, intercepting Russian ships which carried missiles to Cuba. We came as close as we ever have to full scale nuclear war in this crisis — far, far closer than Russia has pushed its current war. Yes, we didn’t need to invade Cuba under those circumstances — but no one could reasonably assert that we were not being militarily aggressive, given the real threat of nuclear war. We didn’t need to launch a full scale invasion of Cuba because we managed to get what we sought by means of these threats.
There is no reason to believe that Russia would achieve its self interested goals for security short of an invasion. Would anyone be reassured if, instead, it threatened, in effect, to bring the world to the brink of nuclear war if it didn’t achieve its goals? I don’t think so. An invasion is the far more tolerable means of doing so.
As for Estonia and Latvia, I would expect that they simply present far less of a threat to Russia than does Ukraine.
This war, as is true in any war, tests our ability to hold many seemingly contradictory thoughts and attitudes at the same time.
On the one hand, what Putin declares himself to be seeking, namely neutrality in Ukraine and disarmament, seems reasonable. We would never tolerate a country bordering us — or even in the same hemisphere — which was both hostile and heavily armed.
On the other hand, the bar for actual use of military force is, especially in these times, very high. It’s hard to accept that Putin has achieved that sort of justification.
But would we not have employed military force if a hostile and heavily armed nation were neighboring us?
I know it’s the time for 5 minute hate sessions over Putin, and he is indeed generally a thug. But, from his point of view, why isn’t he behaving, if not rationally or justly, then at least as expected, given the circumstances and the self interest of Russia?
This is an excellent question--and history tells us the answer is "yes".
But would we not have employed military force if a hostile and heavily armed nation were neighboring us?
This is false. Cuba was once a full fledged Soviet satellite. We made a deal with the Soviets for them not to station nukes in Cuba (in exchange for which we removed our nukes from Turkey) but short of that, the Soviets had massive military installations in Cuba.Defense is just the pretext that Putin uses (along with imaginary "genocide" of Russians in Ukraine). Ukraine and NATO have no desire to invade Russia. Ukraine had no capability to invade. The real reason is that he cannot tolerate that Ukraine got rid of his corrupt puppet and was beginning to form a Western oriented liberal democracy. If this is possible in Ukraine, then it is possible in Russia too and that is literally a mortal threat to him personally. He cannot allow such an example to exist.Doesn't Putin ALREADY have hostile powers on his border - e.g. Estonia, Latvia? Look at the map. It's less than 400 miles from the Latvian border to Moscow. According to this logic, Putin shouldn't have to tolerate them either (and in fact if they were not part of NATO, he probably would be pulling the same shtick in those countries). Latvia in particular has a large Russian minority planted there as colonists by the Soviets. And again is making him look bad by being democratic. He would love to get rid of them too. Is that OK also?Replies: @candid_observer, @Mr. Anon, @Paperback Writer, @Mike Tre
We would never tolerate a country bordering us — or even in the same hemisphere — which was both hostile and heavily armed.
The thing I find strange and distressing about this situation is that I have no idea which source of news I can trust to give a reasonably objective account of what’s going on.
I can’t trust the NY Times, God knows, or any of the mainstream press. Fox News is also likely to be biased and selective.
Forget about prediction–I’d like to know what’s already happened. So who can I go for basic, unselected, and comprehensive facts?
Seriously, is this a massive Russian invasion or something else? How many troops have entered, and where?
I’ve always wondered why we don’t seem to see this sort of effect for cognitive accomplishments.
You’d expect that, say, being almost 7 vs almost 6 would have a very big effect on performance in first grade, and that teachers would reward the better students with more praise, higher level instruction, segregation into more advanced reading groups, etc.. But these advantages don’t seem to propagate through the education of students, so far as I am aware.
Why not?
https://www.jstor.org/stable/40666271Major conceptual advances in applications of mathematics can take a great amount of time to come about, and, again, have little to do with mathematical sophistication per se. The history of statistics is a testament to this fact, in which such things as a clear understanding of conditional probabilities and their importance in modeling the world dragged on over centuries.Replies: @candid_observer
It is true that if you dig deeply in earlier literature you can find instances of multivariate normal densities: Robert Adrain in 1808, Laplace about 1812, French work on artillery fire in the 1820s, the crystallographer Auguste Bravais in 1846 and Erastus De Forest in the 1870s, among these. But all of these are as simple generalizations of univariate frequency functions and none examined or exploited the conditional distributions - the multivariate structure - as Galton did. Indeed, there seems to be no one before Galton who even asked what the conditional distributions were in this setting, and much less found them and commented on the deep statistical messages that they implied.
In general I would say that people give too little credit to the importance and difficulty of inventing useful models of the world, and the distinctive talents which doing so requires, and too much credit to strictly mathematical techniques and talents, which tend to be rather cheap and abundant.
The world is in the end a bunch of word problems.
Galton’s breakthrough on correlation was fundamentally driven by a major conceptual leap that had little to do directly with mathematical techniques or sophistication. In fact, formulas which captured certain aspects of correlation, based on multivariate normal distributions, had been developed before Galton, but were never applied as did Galton.
From Stephen Stigler, “Darwin, Galton and the Statistical Enlightenment”:
It is true that if you dig deeply in earlier literature you can find instances of multivariate normal densities: Robert Adrain in 1808, Laplace about 1812, French work on artillery fire in the 1820s, the crystallographer Auguste Bravais in 1846 and Erastus De Forest in the 1870s, among these. But all of these are as simple generalizations of univariate frequency functions and none examined or exploited the conditional distributions – the multivariate structure – as Galton did. Indeed, there seems to be no one before Galton who even asked what the conditional distributions were in this setting, and much less found them and commented on the deep statistical messages that they implied.
https://www.jstor.org/stable/40666271
Major conceptual advances in applications of mathematics can take a great amount of time to come about, and, again, have little to do with mathematical sophistication per se. The history of statistics is a testament to this fact, in which such things as a clear understanding of conditional probabilities and their importance in modeling the world dragged on over centuries.
From the prominent alterations in the quote, it’s obvious that the ACLU chose it not to communicate RBG’s message about abortion, but to drive home that “men” can be pregnant.
RBG has been served notice that she’s now on the wrong side of history.
What I find amusing about this incident is how fast the media got on top of it, to demonstrate the moral that Texans are awful, only to have it turn on a dime and demonstrate that Blacks are awful.
And this is a pattern, of course. If you insist on believing things that aren’t so, Reality is always Lucy with the football, and you’re flying through the air like Charlie Brown.
Right.
The deep problem is not the incorrect prognostication itself — it’s the dead certainty with which it is held, despite so many failures in the past in prognostication.
If an expert hasn’t learned that he can be wrong, what has he learned?
The thing that gets me is that every single Afghan seems to be wrong in a different way.
What are the odds?
Michael Levin once asserted that feminism was unique among philosophies in that it was wrong about everything. Leave it to the ladies!
The thing that gets me is that every single Afghan seems to be wrong in a different way.
What are the odds?
Great column, Steve, and I admire the intellectual ambition.
Trying to understand the Great Divergence is a grand exercise in pattern finding.
https://en.wikipedia.org/wiki/Great_Divergence
There are a lot of angles on this. Upthread, someone mentioned Heinrich’s recent book on the WEIRD people of Europe. Another relevant recent book is The Knowledge Machine, which attempts to locate the peculiar mindset behind modern science. In my reading so far of The Verge, it takes, I gather, a multifactorial approach.
It’s a big puzzle to solve. A first rank pattern finder unencumbered by strictly environmental approaches is likely to make real progress.
Benoit Mandelbrot's uncle taught at Rice in the 1920s. Is that common knowledge there? He brought Benoit's family to America.
I took a music class at Rice U. along with about a quarter of the football team. Due to its easy grading, it was known among the jocks as “Clapping for Credit.”
There are several in my neck of the woods, around Lexington MA, which were developed by the architecture school at Harvard.
Five Fields is a well known example:
https://en.wikipedia.org/wiki/Five_Fields
They all have a Back to the Future feel about them. Personally, I like their combined suggestion of optimistic progress and nostalgia. When I was a kid, these sort of homes seemed supercool, and now they still seem pretty cool.
Icy might be closer to the truth. Especially in Robert Frost and Leroy Anderson's New England.Would you say Philip Johnson was more than a bit exhibitionist? His own nightmare on Elm Street:
When I was a kid, these sort of homes seemed supercool, and now they still seem pretty cool.
Steve, your ability to predict cultural/political developments is remarkable.
It’s fairly easy to imagine outcomes of movements which would be “logical” steps in the current ideological direction, but most of those would be too extreme to get traction. The delicate thing is to have a good sense of what’s viable what’s not.
You seem to have an excellent balance between appreciating the craziness of the left and understanding its limits.
For all the talk of how the best students from Africa might overpower African-Americans, it would be nice to see a single such former student who actually contributed in a major way to Western civilization.
Where are the scientists, the thinkers, the writers, the entrepreneurs?
OT, well known environmentalist Eric Turkheimer proudly displays his totalitarian colors:
https://twitter.com/ent3c/status/1387070086469627909?s=20
So a journal whose very name is Journal of Controversial Ideas must publish only articles which someone on the editorial board will publicly agree with.
The man is an out-of-control control freak. He will tell you what you are allowed to think about.
Yeah that sort of overwhelming drive to control the thoughts of the goyim -- to "Shut it down!" -- is a characteristic feature of toxic semitism:"If I may address my fellow Jews for a moment, consider this."https://www.cato-unbound.org/2007/11/21/eric-turkheimer/race-iqTurkheimer believes that all narratives, facts, and hypotheses that are not officially-certified beforehand as "Good for the jews" should be ruthlessly suppressed. See also:https://www.theoccidentalobserver.net/2017/06/16/eric-turkheimer-jewish-ethnic-interests-masquerading-as-ethical-concerns/
The man is an out-of-control control freak. He will tell you what you are allowed to think about.
It’s a very good thing to see such a journal appear in philosophy, which has been fully under the thumb of identity politics.
The paradox, of course, is that philosophy historically, and by its very nature, questions basic assumptions. Any discipline that suggests that we might all be brains in a vat ought to have room to entertain the idea that some groups are, on average, genetically different from others on a social trait.
I can’t think of another academic journal that is so explicitly pitched toward controversial ideas. Quillette seems so designed for the more general intelligent public. Philosophers ought to be well trained to do some of the more intellectual and foundational work.
It’ll be interesting to see how it plays out. I wonder what kind of contributors it will attract. One hopes that pseudonymity will draw out a number of philosophers who have, to date, mostly bitten their tongues.
The admixture studies cited are of course interesting, but the overall number is impressively small.
If a scientist had an interest in the evolution of human beings, admixture studies would be the natural first method to which he (or she!) would turn. Admixture studies of ancient peoples tell us a lot about how those peoples migrated, merged, split, or supplanted. But the other side of evolution is the selection of traits, and we can’t easily recover that information from long gone people. We can rather directly assess average differences in traits by looking at existing groups, measuring their phenotypes, and comparing via admixture.
Admixture studies are by far the most direct way to do this. Other methods, such as comparing SNPs underlying traits, are limited by difficulties in assessing SNPs across groups. SNPs across groups often don’t capture the same effects. The linkage disequilibrium for a given SNP may be quite different in different groups. And a good deal of heritability is found in rare variants, typically rare variants of negative effect. These variants are not likely to be the same across groups — they are likely, instead, to be “private” to a group.
Admixture studies can estimate the full differential effect of all variants, rare or common, and across LD structures, on a trait. If you want to understand how human groups have evolved, which traits have evolved, admixture studies are the go-to method. The results can bracket what may be found by techniques examining variants.
That admixture studies aren’t already standard and extensive demonstrates how much science has already been forestalled by ideological concerns.
Ambitious scientists and intellectuals should take Watson's statement as a guiding principle, if it is lasting achievement they seek.
“My strength is not that I’m smarter, it’s that I’m more willing to offend the crowd.”
One area in genetics that seems to me to be very much underexplored because of the toxicity of belief in group differences is admixture studies.
The genetic composition of the blacks in the US creates an almost perfect setting in which to explore the differential effects of genetics on long separated human groups. Blacks in the US vary in the amount of European ancestry they carry — and the amount they do is basically cryptic to them. This should allow convincing studies as to the effects of genes vs. the environment on many important human traits — not just such things as IQ, but also the panoply of other traits, such as disease susceptibility, development, etc. which are of natural scientific and practical import. Likely, admixture studies are by far the most direct and best way to approach these issues. And of course admixture studies are a staple technique in an area of genetics which is free (so far) of toxicity: studies of ancient genetics and ancient peoples.
How much glory — after much initial scorn — awaits those who pursue such approaches?
Not really. All they need to do is look in the mirror and they can make a pretty good guess. Of course knowing and acting upon your knowledge (in the way that you might expect in a sane world) are two different things. America has never been sane about race. In the past, one drop of African blood was enough to send you to the colored section or even make you a slave (and accordingly, light skinned blacks had a big incentive to cross the color line although not that many did because this entailed many difficulties). In current day America, the incentives have flipped and being Black is Beautiful - it opens many doors, so when someone who is 7/8 European looks in the mirror, that 7/8ths part disappears and all he or she sees is a Proud Black Warrior.Replies: @Bill, @James Speaks, @Citizen of a Silly Country, @Paperback Writer
Blacks in the US vary in the amount of European ancestry they carry — and the amount they do is basically cryptic to them.
There is a great old post by Chuck about Colorism: the idea that lighter-skinned blacks receive preferential treatment because of their lighter skin. In general, various outcomes are better for lighter-skinned blacks than for darker-skinned blacks. This could be due to discrimination or to white admixture leading to higher IQ and other more white-like genetics for the lighter-skinned.
The genetic composition of the blacks in the US creates an almost perfect setting in which to explore the differential effects of genetics on long separated human groups.
“My strength is not that I’m smarter, it’s that I’m more willing to offend the crowd.”
Ambitious scientists and intellectuals should take Watson’s statement as a guiding principle, if it is lasting achievement they seek.
How much important and original science and thought lies undiscovered today because researchers refuse to entertain obvious but currently toxic hypotheses?
If one is willing to take as a premise that groups differ on average in significant ways, what new insights in genetics, political theory, moral theory, sociology, psychology, economics, and history, become possible — perhaps even easy?
... And ye shall know the truth, and the truth shall get ye fired.
If one is willing to take as a premise that groups differ on average in significant ways, what new insights in genetics, political theory, moral theory, sociology, psychology, economics, and history, become possible — perhaps even easy
I think a more accurate statement would be that young people no longer seek to defy authority.
I live in a very left leaning area, and a common bumper sticker from not so many years ago was “Question Authority”. I never see that sticker anymore.
I suspect anyone who displayed it would today be liable for cancellation.
Not sure what it means to say that young people no longer aspire to be cool.
Being non-binary is cool. Purple hair is cool — ask the female staffer who accompanied Blinken to the diplomatic meeting with China. She showed the world how cool she was, and Blinken allowed it to show the world how cool he was.
It is my observation that Jews tend to be outspoken.
You don't say? Next you'll be telling us that we have a tendency toward being loud, verbally aggressive, presumptuous and officious, and even downright obnoxious...
It is my observation that Jews tend to be outspoken.
Seriously?
Here I disagree with you.
We haven’t heard much about Creationists in a long time, at least not among the cultural powers that be. Creationists are mostly considered a long defeated enemy. It’s as dated an issue as gay marriage, or defense of gays, rather than transgenders. It hasn’t taken much time for the interests of actual gays — such as Andrew Sullivan — to be thrown under the bus. A new cultural battle is to be won.
I see Darwin as having served his purpose for the left. He is ready to be reviled.
I guess we'll find out soon enough. I agree that the Creationist Menace is obsolete, I'm just not so sure that the institutional gatekeepers have noticed. I say this because I happen to know one of them who controls a government-funded, nonprofit institution that is supposed to promote the natural sciences to the public. She really believes she is standing athwart the barricades, keeping The Creationists from infecting the minds of our impressionable young people. (Of course she is busy infecting everyone's mind with mandatory "antiracism", but that's different!)
He is ready to be reviled.
Makes you wonder if the royal family has ever done DNA tests on its members. You’d think that an enterprise based exclusively on genealogy would want to know exactly what its true genealogy might be, even if it keeps it secret from the public.
Equity, coming in fast and hard from the Democrats:
The so-called Justice in Policing Act, introduced by Rep. Karen Bass, D-Calif., is being touted by the Biden administration as necessary to solve “systemic misconduct — and systemic racism — in police departments.”
“To make our communities safer, we must begin by rebuilding trust between law enforcement and the people they are entrusted to serve and protect. We cannot rebuild that trust if we do not hold police officers accountable for abuses of power and tackle systemic misconduct — and systemic racism — in police departments,” the White House said in a statement.
Section 311 of the act identifies that officers who pull over certain identity groups, such as more black men than black women, will be defined as a “prima facie evidence” violation. If men are found to speed at higher rates than women in a given region, for example, a police department would technically be in violation of the act. The Justice in Policing Act also calls for racial quotas for “traffic stops,” “pedestrian stops,” and “interviews.” In essence, departments would be forced to deal with all people equitably, which would fundamentally contradict the notion of equal justice in a free and fair society.
What could go wrong?
I used to be quite skeptical myself of the importance of the results described in Thinking Fast and Thinking Slow. But I’ve become very much persuaded that they are indeed quite basic and of great consequence.
The point isn’t whether Kahneman is “tricking” us into coming to the wrong conclusion in cases like Linda the bank teller. It is that we seem to have an extraordinary and powerful attraction to thinking in terms of representativeness rather than of pure logic. In this sense, Kahneman’s results might be understood as demonstrating just how easy it is for people to be tricked in this particular way — how much more inclined we are on average to leap to the intuitive, but wrong, conclusion rather than the logical one. Much of his work involved finding just how far this could be pushed before we finally succumb to logic — just how explicitly the correct logical inference had to be featured before most people would concede that the logical conclusion was the right one. Some of his more extreme examples make this clear.
And it’s not trivial in cases like decisions in sports. Certainly it was initially very hard for many managers in baseball to think in terms of the actual statistical results rather than prototypes.
There's a good reason for that. Reasoning is slow, inefficient and often clumsy. If you're playing a sport and your opponent has to stop to think about something, nine times out of ten you've got him beat. The same applies in many intellectual tasks such as law. The lawyer who knows stuff will usually beat the one who has to figure it out even if their IQ is comparable.
The point isn’t whether Kahneman is “tricking” us into coming to the wrong conclusion in cases like Linda the bank teller. It is that we seem to have an extraordinary and powerful attraction to thinking in terms of representativeness rather than of pure logic. In this sense, Kahneman’s results might be understood as demonstrating just how easy it is for people to be tricked in this particular way — how much more inclined we are on average to leap to the intuitive, but wrong, conclusion rather than the logical one.
We're culturally/socially conditioned to stories, not facts. The so-called error in Linda the Teller scenario is that people "fill in the blanks" in the story/query in ways they are used to seeing. As you say...
It is that we seem to have an extraordinary and powerful attraction to thinking in terms of representativeness rather than of pure logic.
Homo economicus (rational man) is the great assumption error of classical economics and Kahneman's psychology-infused behavioral economics. I think it's a safe bet to say that some men are capable of reasoned logic, but most are social-emotional animals reacting on instinct, intuition, feelings, and personal preferences of-the-moment--not reasoning. Rationalizations (post-hoc) are what most people think of as reasoned decision-making.
how much more inclined we are on average to leap to the intuitive, but wrong, conclusion rather than the logical one.
I do wish that the SC would be handed a number of cases in which these issues are paramount.
I can’t see any reason they shouldn’t rule on how these clauses are to be interpreted.
What are they there for, if not for that?
Maybe cabalistic is the better word here.
While I’m quite the ignoramus on music theory, the description of Schenkerian analysis sounds a lot like Chomsky’s theory of generative grammar, with deep structures and surface manifestations.
But, as with Chomsky, the question seems to be, how much of the deep structure is real, and how much an ornate illusion?
For an outsider, both seem a bit, well, Talmudic.
On McNeil’s Wikipedia page, I find this sentence:
He left The New York Times in 2021 following public reports of making racist remarks, including use of the word “n****r”, during a 2019 trip to Peru with high school students.
where the so-called n-word is actually spelled out.
https://en.wikipedia.org/wiki/Donald_McNeil_Jr.
So it’s a cancelable act to quote or mention the word in conversation, but OK to write it out in a setting as public — and as woke — as Wikipedia?
Show me the man, and I’ll find you the thought-crime.
Of course, The Name That Shall Not Be Spoken in the Times continues: Steve Sailer.
One of the problems I have with Scott Alexander is his refusal to entertain at any length the possibility that there exist between group differences on socially relevant traits.
I get, of course, how much more “toxic” that topic is than those he does consider.
But, in the end, if it is truth you seek, how do avoid such a basic, consequential truth? How do you understand a world in which this fact plays such a pivotal role, and, indeed, is figuring larger and larger over time?
Our current culture is simply built upon the dogmatic belief in the opposite. If you do believe that all differences between groups are socially constructed, on what grounds, other than procedural, can you reject attempts to right disparities in outcome by blunt, even gross corrections? Isn’t something like Critical Race Theory nearly unavoidable if you believe that all groups are the same, except for environment? What, other than some great, systematic, structural oppression, could explain the deep disparities we see?
The agnostic views of Scott Alexander and company are really helpless to understand these issues, or to correct them. He and they must instead point out the downsides and limitations of, say, Affirmative Action without addressing the full force of the arguments in its favor. I don’t see this to be an effective way of opposing them in the long run, nor does it allow a deep understanding of how the world really works.
If you wish to understand the world, you need to start from true premises, and follow them to true conclusions. That’s the only way knowledge can be advanced.
If you deny that possibility, what worthwhile and forbidden “truths” can you contribute to the world today?
One of the problems I have with Scott Alexander is his refusal to entertain at any length the possibility that there exist between group differences on socially relevant traits.
I get, of course, how much more “toxic” that topic is than those he does consider.
But, in the end, if it is truth you seek, how do avoid such a basic, consequential truth? How do you understand a world in which this fact plays such a pivotal role, and, indeed, is figuring larger and larger over time?
You're asking the wrong question. On what grounds would one *accept* or *undertake* attempts to right disparities in outcome? One can't just invent moral imperatives. And how does the verb "right" fit in? Where does one get the idea that disparities are wrong? And how can differences between "groups" be socially constructed, when "socially constructed" implies that all the "groups" are equal parts of the society that is exercising agency?
Our current culture is simply built upon the dogmatic belief in the opposite. If you do believe that all differences between groups are socially constructed, on what grounds, other than procedural, can you reject attempts to right disparities in outcome by blunt, even gross corrections?
If all groups are the same, oppression is impossible and pointless. In fact, if "all groups are the same", doesn't that mean there is just one group? What could distinguish one group from another or from the whole?Replies: @415 reasons, @bomag
Isn’t something like Critical Race Theory nearly unavoidable if you believe that all groups are the same, except for environment? What, other than some great, systematic, structural oppression, could explain the deep disparities we see?
in my view you're mostly right.
If you do believe that all differences between groups are socially constructed, on what grounds, other than procedural, can you reject attempts to right disparities in outcome by blunt, even gross corrections? Isn’t something like Critical Race Theory nearly unavoidable if you believe that all groups are the same, except for environment? What, other than some great, systematic, structural oppression, could explain the deep disparities we see?
This, but notice something really important - the requirement for true premises restricts the domain to epistemic ways of looking at the world (that's fine by me, but it does not comport with a very large range of belief systems). If your premises are beliefs, and there is no guarantee that the conclusions will be true. Because there is no formal logical link between belief and truth.It is the millennia-long battle between doxa and episteme. Doxa has always been viewed as a more primitive and less reliable way of approaching deduction.WokeBorgers believe in things. They are encouraged to believe that believing [in] a thing is the same as it being true. They don't understand the difference between doxastic and epistemic premises, and their deductions can be untrue while being logically consistent.Let's say that one of my premises is that race is a social construct. That premise can not be a fact - because it flies in the face of evidence - but it can still be a belief.The Stanford Library of Philosophy is a terrific resource - its page on Epistemic Logic is really informative. Once you look at the modal consequences of belief, it all makes sense: in epistemic logic[s], there is axiomatic veridicality . Knowledge is veridical: only true propositions can be known.Notationally: • K[a]φ→φ- i.e., if a thing φ is Known [by agent a], then it is true.This is not the case for beliefs, which is why doxastic logic[s] are much less useful (although just as rigorous). • B[a]φ↛φIf a thing φ is Believed [by agent a], then there is no requirement that it is true.There is no requirement that doxastic premises are true: there is no inconsistency with maintaining a belief in a thing that is known to be false.
If you wish to understand the world, you need to start from true premises, and follow them to true conclusions. That’s the only way knowledge can be advanced.
I found this tweet illuminating of the difference between Brady and Mahomes:
Here are the path's that Patrick Mahomes (top) and Tom Brady (bottom) took before pass attempts in shotgun during tonight's #SuperBowl
Red: complete
White: incomplete pic.twitter.com/TLFEOxzwhr— Michael Lopez (@StatsbyLopez) February 8, 2021
How hard would it be to cheat on the Wonderlic, if so inclined? Aren’t there answers one could memorize?
I could see players in certain positions wanting a higher score, and agents or insiders happy to oblige them.
And I could see some players wanting to game it so that it doesn’t come out too high or too low.
I think it’s probably going to be pretty hard to make a convincing case as to the efficacy of the vaccine by subtle arguments as to relative rates of infections, hospitalizations, or deaths across segments of the population. It would require careful controls not possible to impose.
But in the end the numbers must come out in the large statistical wash at the end of the vaccinations. Fortunately, Israel will almost completely vaccinate its over 60 population within a few weeks, and, within a few weeks after that, the downstream effects should show up.
If the efficacy of the vaccines is anything like what the trials found, the results should be obvious and incontestable. The numbers should be something like an order of magnitude lower, and should stay there pretty much for the duration.
I counsel patience. We will get some clarity soon.
Moderna has greater side effects, but I wonder if that doesn’t come with greater benefits, which have yet to show up in the statistics.
They did have a more challenging set of volunteers, with representative sets of over 60s and minorities, than did Pfizer. So equal point estimates of efficacy might indicate better efficacy for Moderna. Also, as I recollect, among those vaccinated, Pfizer had 1 serious case among 11 cases, whereas Moderna had 0 serious cases among 30.
The really important numbers for serious cases and deaths were, within the trials, too small to support strong conclusions in the comparison.
But we may see a measurable payoff in the large numbers of the real world. And it’s also possible that the higher dosage in Moderna may have a payoff in fighting mutations.
Time, and only time, will tell.
I’m sure I’ll regret this, but I’m curious about which of the numbers in this tweet you seriously dispute:
For those of you keeping score at home
26 million Americans are known to have had COVID
420K of them died from COVID29 million Americans have gotten COVID vaccines
0 have died from COVID vaccinesWhen it comes to generating immunity
vaccine > infection
Easier, way way safer
— Ashish K. Jha, MD, MPH (@ashishkjha) January 30, 2021
Even if these numbers are pretty far off — say, the exact number of deaths due to covid, or the exact number of infected — doesn’t the point remain?
One thing odd about the numbers being reported by JJ is the relative efficacy between US cohorts and those in SA, 72% and 57%. That’s a dropoff, of course, but far less dramatic than the dropoff reported in the Novavax vaccine, 89% to 60%, between UK and SA cohorts.
Now I assume that UK has mostly been similar to the US in the tractability of the virus — the UK version has shown no greater resistance to vaccines than has the original version, from what I’ve gathered.
But the ratio between, say, 11% infection rate and 40% is obviously dramatically different from the ratio between 28% and 43%. If one applies the ratios to the 5-6% of infected from the mRNA vaccines, one gets vastly different numbers — one quite troubling (app 20%), the other (app. 8-9%) not.
You may be setting up the problem incorrectly. Suppose there's a ~60% efficacy* floor for existing reasonably effective current "classic COVID-19" vaccines presented with B.1.351, the South African variant, whereas there isn't as strong a ceiling.
One thing odd about the numbers being reported by JJ is the relative efficacy between US cohorts and those in SA, 72% and 57%. That’s a dropoff, of course, but far less dramatic than the dropoff reported in the Novavax vaccine, 89% to 60%, between UK and SA cohorts.
That’s an original, deep, and persuasive book.
Anonymous[166] is correct, after enough people get vaccinated which will take some time, except in Israel. Viruses, even the coronaviruses with their unique among RNA viruses proofreading mechanism noted by Didier Raoult, mutate all the time and most of those are detrimental. But the primary circulating variants can change, it's an ecological thing. "Strain" I and the virologists I've read are reserved for something that changes enough that for example current vaccines don't work. Or like what might be seen in South Africa (will look at that tomorrow, the number of subjects aren't high so I'm curious about how big the error bars are in the efficacy calculation)) .It works the other way around.
Are we also concerned that these mutliple vaccines are pushing mutations to happen more quickly?
It seems to me that there’s another point to add to your analysis, namely, the likely effect of a slow vaccine rollout, especially as considered globally.
If, say, all mRNA vaccines were administered very quickly, the likelihood of a new strain able to escape them would be much lower, under the assumption that it would require a number of mutations in order to escape the vaccine.
If the vaccinations were to occur very quickly, then, under the pressure of selection against the vaccine, each of the required mutations might evolve separately among the 100s of millions of vaccinated people. But they would not have a chance to combine, because they would run out of potential targets. Yet if the vaccine is rolled out slowly, then each mutation might spread to a large number of people, who can then incubate another required mutation, until, at some point, all of them are present, and the virus strain can escape the vaccines entirely.
Anyway, this is a possibility I’ve been worrying about lately.
I would change the wording of your analysis from "combine," which implies something like the hybridization possible with flu due to its genome being split into multiple segments (TL;DR don't sneeze on pigs or let them sneeze on you (seriously)), to "accumulate."
If the vaccinations were to occur very quickly, then, under the pressure of selection against the vaccine, each of the required mutations might evolve separately among the 100s of millions of vaccinated people. But they would not have a chance to combine, because they would run out of potential targets. Yet if the vaccine is rolled out slowly, then each mutation might spread to a large number of people, who can then incubate another required mutation, until, at some point, all of them are present, and the virus strain can escape the vaccines entirely.
Here’s some further data for Israel, which may or may not be compatible with what’s reported above:
In this article, Maccabi reports that 66 (of 248,000) got Covid a week or later after their second dose. I suppose that the increase of numbers may reflect a greater length of average time after the second dose for the group.
It’s a little hard to make out in the graph, and the data are quite limited, but the number of hospitalizations overall seem to have taken a greater dip — it peaks at 2.3%, following the rise in the number of cases, but goes down to 0.3% on the final day reported.
I wonder if we see this because the most vulnerable — perhaps the oldest — patients were given the vaccine first, and are much overrepresented among the 60,000 vaccinated, and now much less frequently need hospitalization.
In these last 4 years, it seemed like almost half the New Yorker cartoons were about Trump. Did you know he was Bad?
I hope they will now find other subjects to be unfunny about.
What King’s scores demonstrate is the surprisingly large size of the gap between verbal fluency and verbal IQ.
In the real world, verbal fluency is a big deal, and not to be despised.
I suspect, though, that in most whites, there’s a tighter correlation between verbal fluency and verbal IQ. Or, perhaps more precisely, among blacks and whites there’s a decent correlation between the two, but only when restricted to their own race. That is, King may have had a high verbal IQ for blacks, but only for blacks, and this correlates with his high verbal fluency — high for both blacks and whites.
It’s g, but only g, which blacks seem to lack on average. In some larger sense, it’s probably whites who are the freaks of nature when it comes to g.
You forgot pigeons!
Kill all pigeons!
They threaten democracy to the core! Plus, the poop…
Almost all obituaries of famous people are pre-written. Or do you think that those long ones you see in the newspaper are written with such detail and style so quickly?Replies: @candid_observer, @Reg Cæsar
I have a hunch the obituary was pre-written. Isn’t that cheating?
Still, I’m surprised that Kathy didn’t wait until after she died to write it.
I have a hunch the obituary was pre-written. Isn’t that cheating?
Still, it’s refreshing to see some authentic biting wit.
RIP, Kathy. Wish you a real improvement in your afterlife.
Almost all obituaries of famous people are pre-written. Or do you think that those long ones you see in the newspaper are written with such detail and style so quickly?Replies: @candid_observer, @Reg Cæsar
I have a hunch the obituary was pre-written. Isn’t that cheating?
One idea I wanted to run past you is whether the best early, empirical sign that vaccines remain effective against new mutations is if those who have been infected by the original virus and have recovered are never, or rarely, reinfected by the mutation.
By now, there must be 30-60M who have been infected and recovered in the US, and several times that world wide. I haven’t heard of any large number of people becoming reinfected recently. I have to guess that that would imply the new mutations are effectively handled by the vaccines.
Yes, with the caveat that natural immunity has also been shown to include action against the nucleocapsid protein, which I've read in passing that for reasons not mentioned is not considered to be a good target for vaccines. It certainly isn't out there like the spike protein, which produces in electron microscopes the infamous corona, and is hidden behind the lipid envelope stolen from the host cell it budded off, and a tremendous amount of SARS and MERS research into spike proteins was part of how everyone could quickly develop vaccines for COVID-19.
One idea I wanted to run past you is whether the best early, empirical sign that vaccines remain effective against new mutations is if those who have been infected by the original virus and have recovered are never, or rarely, reinfected by the mutation.
As with just about everything else about this pandemic, it seems impossible to get a straight answer about a phenomenon of major importance. Why is there such an enormous lag in the numbers of vaccinated, compared to the number of doses distributed?
Reporting lag? Reluctance to take the vaccine? Improper allocation of doses? General bureaucratic incompetence at the state level in allocating vaccines?
2020 is perhaps the year in which we fully realized there are no adults in any room. You can’t trust the bureaucrats, you can’t trust political leaders, you can’t trust the journalists, you can’t trust the scientists, you can’t trust the experts, there are no institutions worthy of your respect. It’s facades behind facades.
You’ve got your own brain and your own judgment, and that’s all you’ve got. We are alone on this earth.
"Experts" these days are defined as somebody on some big institution/corporation's payroll who have an agenda to f&^% you over....
you can’t trust the experts
Also errors by the CDC, I copied the Wednesday the 30th numbers that day not all that long after the update, and note today on the massively upgraded page a total of 205,463 additional 1st doses administered were added. So a New, Improved number of 667,000 1st doses were reported from Monday to Wednesday. Before that, or maybe including some of the additional doses, 1.2 million were administered from the 24th to 28th.
As with just about everything else about this pandemic, it seems impossible to get a straight answer about a phenomenon of major importance. Why is there such an enormous lag in the numbers of vaccinated, compared to the number of doses distributed?
Reporting lag?
This page has information about the reporting systems which are mentioned in the fine print.Replies: @anon
Doses distributed and people initiating vaccination (1st dose received) ... reflect current data available as of 9:00am ET on the day of reporting. Data will be regularly updated on Monday, Wednesday and Friday. Updates will occur the following day when reporting coincides with a federal holiday.
Healthcare providers report doses to federal, state, territorial, and local agencies up to 72 hours after administration. There may be additional lag for data to be transmitted from the federal, state, territorial, or local agency to CDC. A large difference between the number of doses distributed and the number of people initiating vaccination is expected at this point in the COVID vaccination program due to several factors, including delays in reporting of administered doses and management of available vaccine stocks by jurisdictions and federal pharmacy partners.
Numbers reported on CDC’s website are validated through a submission process with each jurisdiction....
This [Long-term care facility (LTCF)] data does not include doses distributed and administered to LTCF residents and staff outside the Federal Pharmacy Partnership Program....
Today I posted similar evidence and the same conclusion as yours in a different thread. The only solace is having a wife or close friend who is also rational.
You’ve got your own brain and your own judgment, and that’s all you’ve got. We are alone on this earth.
The NY Times recently held a discussion among “ethicists” regarding vaccination priorities:
https://www.nytimes.com/2020/12/24/magazine/who-should-get-the-covid-vaccine-next.html
Peter Singer seemed to be the one fairly rational voice, which he sometimes can be. As an utilitarian, he seems genuinely to believe that All Lives Matter. He also thinks it’s critical to consider years of quality life. He’s pretty harshly critical of how the CDC handled the question. On the other hand, he’s a globalist, worrying about the Global South.
In the discussion, Emily Bazelon and participants pretend that the CDC hadn’t really had in mind to favor black lives over white ones. That’s just a vicious canard, of course.
One takeaway from the research covered in the book is that great apes keep up pretty well with early human development when it comes to solving problems about things, but can’t perform seemingly elementary tasks involving some sort of social cognition. Others just aren’t a big deal among the great apes.
Michael Tomasello has devoted most of his career to exploring and delineating the differences between the great apes and human beings in cognitive and social development.
The basic idea is that human beings have evolved a far more robust theory of mind, enabling joint intentionality between us. Joint intentionality in turn enables cultural accumulation.
Tomasello wrote a good book on this, published in 2019, Becoming Human.
A lot of very interesting research is summarized in the book, demonstrating a number of odd and surprising ways in which great apes are unable to perform certain seemingly elementary tasks.
One of the great things about being alive today is to see all the research that’s been done to investigate so many issues. The inventiveness of much this research is always a pleasure to see.
The thing I don’t get about the CDC is how it apparently refused to consider the fine grained approach to reducing deaths. I simply can’t believe that it did not occur to any among them that this was an important angle to work through. Such an oversight would, I think, represent a gross incompetence not possible even in a government agency. Certainly in the UK and in the EU, which adopted their very different plans, it was considered — would it not be communicated among epidemiologists? Does globalism not induce even this positive effect?
Obviously, the CDC epidemiologists should have put together a model like the UK plan, and pitted it against the extreme coarse categories that the CDC in fact entertained. Instead, they stuck with their coarse categories and, supposedly, found little difference in reduction of death rates between scenarios in which those above 65 and all those who were essential workers were vaccinated first.
Now, I have to say I frankly don’t entirely believe that the results even for the coarse categories are being fairly represented by the CDC. I wonder how many checks they have on the reporting of the results. So far as I know, the CDC has not released the software that they use to do the simulations. I simply don’t trust the results given that the person who claims to have been responsible for generating them is a radical “non-binary” SJW.
At this point, my trust in the CDC has plummeted to a new low. There’s not even the ghost of an excuse for their failure to do their job here, given the stakes in tens of thousands of human lives.
And epidemiologists, as a profession, have much to answer for here as well. It was left entirely to outsiders to point out the obvious defects in the CDC analysis. Can no mistake, however consequential, impel them to criticize, even gently, their colleagues? How worthless are they?
Looking at the situation, it’s hard not to wonder if the whole point of the CDC’s otherwise incompetent modeling was to justify what they wanted to do in the first place: make sure they could favor minorities at the expense of whites — the Summum Bonum for our elites.
Someone needs to do some serious FOIA on the processes of the CDC to get to the bottom of this. And we need to get the CDC to be open about how it does things like simulations, by releasing software.
The behavior of the CDC here, by any reckoning, is a disgrace. It must be exposed and corrected if we are to have any reasonable trust in them going forward.
Exactly. Maybe I should shout this time: THE US PUBLIC HEALTH COMMUNITY DOES NOT CARE ABOUT INFECTIOUS DISEASE CONTROL!!!Thus the CDC's long running gross incompetence in the subject, see their Ebola response which was directly responsible for those two nurses getting it due to not even African state of the art recommended healthcare isolation procedures, and fast forward to COVID-19. While a lot of the latter seems to be incompetence, for example only getting 4,000 people tested for COVID-19 through February, this is simply their doing what they really want to do, it's not in the least incompetence.Let me use a favorite example to try to pound this in, "No, Mr. Bond, I expect you to die." You and the CDC are working off different scripts!!! These people come from the same group our ruling trash does, and if you're white, they literally want you dead.I know this is hard to believe, let alone accept, but the sooner people do it, the fewer will die from their machinations.
Looking at the situation, it’s hard not to wonder if the whole point of the CDC’s otherwise incompetent modeling was to justify what they wanted to do in the first place: make sure they could favor minorities at the expense of whites — the Summum Bonum for our elites.
Yep, you don't get it. The CDC is working exactly as our ruling trash wants it to, first helping to get rid of the BAD ORANGE MAN, now working to get rid of as many whites as possible.Replies: @kpkinsunnyphiladelphia, @Seneca44, @Buzz Mohawk, @AnotherDad, @Corvinus
The behavior of the CDC here, by any reckoning, is a disgrace. It must be exposed and corrected if we are to have any reasonable trust in them going forward.
This is a little bit contradictory but I think what he is saying is that the vaccine is good for now, but in the long run they are going to have to tweak it and possibly require new shots every year for this year's Covid strains. I know that is not going to warm the hearts of the anti-vaxxers, who don't want to take the shot even once let alone every year but for everyone else it's not a big deal. Instead of getting just a flu shot every year you'll get a flu shot and a covid shot. I assume most of the kvetchers here don't get annual flu shots either so instead of NOT getting their annual flu shot they'll NOT get both shots.Replies: @candid_observer
Scientists routinely monitor mutations in flu viruses in order to update vaccines, and should do the same for the coronavirus, said Trevor Bedford, an evolutionary biologist at the Fred Hutchinson Cancer Research Center in Seattle.“You can imagine a process like exists for the flu vaccine, where you’re swapping in these variants and everyone’s getting their yearly Covid shot,” he said. “I think that’s what generally will be necessary.”The good news is that the technology used in the Pfizer-BioNTech and Moderna vaccines is much easier to adjust and update than conventional vaccines. The new vaccines also generate a massive immune response, so the coronavirus may need many mutations over years before the vaccines must be tweaked, Dr. Bedford said.
I’d guess, from the description in the article, that it may become necessary at some point for the vaccines to target any number of variants of the spike protein. We can certainly expect the spike protein to fork. I’d also guess that, possibly, at some point the number of variants might be so large that a single vaccine shot might not be able to activate enough of the antibodies for a given variant to be able to overwhelm it.
The one thing that may prevent this situation is if there are features of the spike protein that are necessary to its function AND which are targeted by antibodies.
But, even if this isn’t true, at least it would seem we’ll have some years to prepare for an army of variants. And I’d expect that any number of scientists will be working to find out how robust the antibodies might be.
So long as they don’t work for the CDC, and they, them.
Exactly; our hope here in the long term is that there is at least one set of antibodies that targets a "conserved" part of the spike protein, exactly what you describe. We know this is possible with lots of RNA virus for which we have "eternal" vaccines, we know this doesn't happen with the flu, natural infections or vaccines, and as of yet no one has found something in it that is conserved and that they can prod the body to make antibodies against (a big part of the Wikipedia resume of the woman not at all dedicated to science who leads Oxford's COVID-19 vaccine effort is that she was "involved with the development and testing of the universal flu vaccine," which is wording for an effort that failed).
The one thing that may prevent this situation is if there are features of the spike protein that are necessary to its function AND which are targeted by antibodies.
An article in the NY Times is informative:
The British announcement also prompted concern that the virus might evolve to become resistant to the vaccines just now rolling out. The worries are focused on a pair of alterations in the viral genetic code that may make it less vulnerable to certain antibodies.
But several experts urged caution, saying it would take years — not months — for the virus to evolve enough to render the current vaccines impotent.
“No one should worry that there is going to be a single catastrophic mutation that suddenly renders all immunity and antibodies useless,” Dr. Bloom said.
https://www.nytimes.com/2020/12/20/health/coronavirus-britain-variant.html
So the argument is that, in response to the vaccine, the body generates a large array of antibodies against the current spike protein, and if some of them are rendered obsolete by a mutation, many others will remain effective. The argument seems to make sense. One hopes it is sound.
This is a little bit contradictory but I think what he is saying is that the vaccine is good for now, but in the long run they are going to have to tweak it and possibly require new shots every year for this year's Covid strains. I know that is not going to warm the hearts of the anti-vaxxers, who don't want to take the shot even once let alone every year but for everyone else it's not a big deal. Instead of getting just a flu shot every year you'll get a flu shot and a covid shot. I assume most of the kvetchers here don't get annual flu shots either so instead of NOT getting their annual flu shot they'll NOT get both shots.Replies: @candid_observer
Scientists routinely monitor mutations in flu viruses in order to update vaccines, and should do the same for the coronavirus, said Trevor Bedford, an evolutionary biologist at the Fred Hutchinson Cancer Research Center in Seattle.“You can imagine a process like exists for the flu vaccine, where you’re swapping in these variants and everyone’s getting their yearly Covid shot,” he said. “I think that’s what generally will be necessary.”The good news is that the technology used in the Pfizer-BioNTech and Moderna vaccines is much easier to adjust and update than conventional vaccines. The new vaccines also generate a massive immune response, so the coronavirus may need many mutations over years before the vaccines must be tweaked, Dr. Bedford said.
BTW, today we are allowed to comment at the CDC site on the recommendations.
I’d also like to know: why didn’t the CDC itself model a granular approach like the UK, and test that against their coarse model?
We’re the US — we couldn’t afford to make that happen anywhere in our vast federal agencies?
Even if the mixture of Indio genes varies across Hispanic groups, the average (or median) is quite different from most whites in the US. That difference should result in measurable effects.
And in fact it offers an opportunity to demonstrate a genetic effect: see if life expectancy varies with degree of Indio mixture.
Wikipedia covers the various explanations, and studies.
https://en.wikipedia.org/wiki/Hispanic_paradox
Of course, being Wikipedia, short shrift is given to any idea that Hispanics have a genetic advantage.
But in general the various studies assuming some selection factor or environmental explanation never seem to have an account that produces, convincingly, the full effect.
Turns out Hispanics were just lucky to be living in an atypically hygienic and successful country with a liberal healthcare system, which they frequently abuse. Now that that country is finished they are sliding back to their natural mortality rates.Replies: @HA, @danand
Our findings indicate that as a result of the pandemic, the time-tested Latino paradox has rapidly diminished due to higher COVID-19 mortality among older Latino adults compared to non-Latino Whites. Future research should continue to monitor the impact of COVID-19 to assess the disparate impact of the pandemic on older non-Latino Black, Latino, and non-Latino White adults as additional data become available
Why doesn’t the CDC make the software it uses to do its modeling available to the public, as do many other researchers today?
Shouldn’t this be standard practice for such controversial issues?
If, say, Nate Silver is dead wrong in his criticisms, and the UK approach is really little better than is that of the CDC, wouldn’t releasing the software demonstrate to him and others just how wrong he is?
Unbelievably, here’s the person who claims on Twitter to be responsible for the projections of the CDC:
https://twitter.com/jo_walker_atl?lang=en
If this is true, does anyone trust that those projections have been done without twisting to push ideological goals?
Again, at least we will have UK as a counterexample. This person is essentially predicting that there’s going to be little difference.