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UA99701C2 - Человеческое моноклональное антитело, которое специфически связывается с лигандом-1 запрограммированной гибели клеток (pd-l1) - Google Patents

Человеческое моноклональное антитело, которое специфически связывается с лигандом-1 запрограммированной гибели клеток (pd-l1)

Info

Publication number
UA99701C2
UA99701C2 UAA200801212A UAA200801212A UA99701C2 UA 99701 C2 UA99701 C2 UA 99701C2 UA A200801212 A UAA200801212 A UA A200801212A UA A200801212 A UAA200801212 A UA A200801212A UA 99701 C2 UA99701 C2 UA 99701C2
Authority
UA
Ukraine
Prior art keywords
antibodies
relates
human monoclonal
ligand
monoclonal antibody
Prior art date
Application number
UAA200801212A
Other languages
English (en)
Ukrainian (uk)
Inventor
Алан Дж. Корман
Марк Дж. Селби
Чангиу Ванг
Мохан Сринивасан
Дэвид Б. Пассмор
Хайчунь Хуан
Хайбинь Чень
Original Assignee
Медарекс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37496548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA99701(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Медарекс, Инк. filed Critical Медарекс, Инк.
Publication of UA99701C2 publication Critical patent/UA99701C2/ru

Links

Classifications

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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Abstract

Данное изобретение относится к выделенным моноклональным антителам, в частности к человеческим моноклональным антителам, которые специфически связываются с PD-L1 с высокой аффинностью. Данное изобретение относится также к молекулам нуклеиновой кислоты, кодирующим антитела согласно изобретению, к экспрессирующим векторам, к клеткам-хозяевам и к способам экспрессии антител согласно изобретению. Данное изобретение относится также к иммуноконъюгатам, к биспецифическим молекулам и фармацевтическим композициям, содержащим антитела согласно изобретению. Данное изобретение относится также к способам детектирования PD-L1, а также к способам лечения различных заболеваний, включая злокачественные и инфекционные заболевания, с использованием анти-PD-L1-антител.
UAA200801212A 2005-07-01 2006-06-30 Человеческое моноклональное антитело, которое специфически связывается с лигандом-1 запрограммированной гибели клеток (pd-l1) UA99701C2 (ru)

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