AR105654A1 - Anticuerpos pd-l1 (ligando 1 de muerte celular programada) - Google Patents
Anticuerpos pd-l1 (ligando 1 de muerte celular programada)Info
- Publication number
- AR105654A1 AR105654A1 ARP160102439A ARP160102439A AR105654A1 AR 105654 A1 AR105654 A1 AR 105654A1 AR P160102439 A ARP160102439 A AR P160102439A AR P160102439 A ARP160102439 A AR P160102439A AR 105654 A1 AR105654 A1 AR 105654A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- cancer
- amino acid
- antibody
- heavy chain
- Prior art date
Links
- 102000008096 B7-H1 Antigen Human genes 0.000 title 1
- 108010074708 B7-H1 Antigen Proteins 0.000 title 1
- 238000003782 apoptosis assay Methods 0.000 title 1
- 230000005522 programmed cell death Effects 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 210000004962 mammalian cell Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000053602 DNA Human genes 0.000 abstract 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 abstract 1
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 abstract 1
- 208000008839 Kidney Neoplasms Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 206010038389 Renal cancer Diseases 0.000 abstract 1
- 206010039491 Sarcoma Diseases 0.000 abstract 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 201000004101 esophageal cancer Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 201000010536 head and neck cancer Diseases 0.000 abstract 1
- 208000014829 head and neck neoplasm Diseases 0.000 abstract 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 abstract 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 abstract 1
- 102000048776 human CD274 Human genes 0.000 abstract 1
- 201000010982 kidney cancer Diseases 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Un anticuerpo que se une a PD-L1 humano (SEQ ID Nº 1), caracterizado porque comprende una cadena ligera (LC) y una cadena pesada (HC), en donde la cadena ligera comprende una región variable de cadena ligera (LCVR) y la cadena pesada comprende una región variable de cadena pesada (HCVR), y en donde la LCVR comprende regiones determinantes de complementariedad de cadena ligera LCDR1, LCDR2, y LCDR3 que consisten de las secuencias de aminoácido SGSSSNIGSNTVN (SEQ ID Nº 5), YGNSNRPS (SEQ ID Nº 6), y QSYDSSLSGSV (SEQ ID Nº 7), respectivamente, y en donde la HCVR comprende regiones determinantes de complementariedad de cadena pesada HCDR1, HCDR2, y HCDR3 que consisten de las secuencias de aminoácido KASGGTFSSYAIS (SEQ ID Nº 2), GIIPIFGTANYAQKFQG (SEQ ID Nº 3), y ARSPDYSPYYYYGMDV (SEQ ID Nº 4), respectivamente. Reivindicación 7: Una célula de mamífero caracterizado porque comprende una molécula de ADN que comprende una secuencia de polinucleótido que codifica un polipéptido que tiene una secuencia de aminoácido de la SEQ ID Nº 11 y una secuencia de polinucleótido que codifica un polipéptido que tiene una secuencia de aminoácido de la SEQ ID Nº 10, en donde la célula es capaz de expresar un anticuerpo que comprende una cadena ligera que tiene una secuencia de aminoácido de la SEQ ID Nº11 y una cadena pesada que tiene una secuencia de aminoácido de la SEQ ID Nº 10. Reivindicación 8: Un proceso para producir un anticuerpo, caracterizado porque comprende una cadena ligera que tiene una secuencia de aminoácido de la SEQ ID Nº 11 y una cadena pesada que tiene una secuencia de aminoácido de la SEQ ID Nº 10, que comprende cultivar la célula de mamífero de conformidad con la reivindicación 7 bajo condiciones de manera que el anticuerpo es expresado, y recuperar el anticuerpo expresado. Reivindicación 10: Una composición farmacéutica, caracterizada porque comprende el anticuerpo de conformidad con cualquiera de las reivindicaciones 1 - 6 ó 9, y un portador, diluyente, o excipiente farmacéuticamente aceptable. Reivindicación 12: El método de conformidad con la reivindicación 11, caracterizado porque el cáncer es melanoma, cáncer de pulmón, cáncer de cabeza y cuello, cáncer colorrectal, cáncer pancreático, cáncer gástrico, cáncer renal, cáncer de vejiga, cáncer de próstata, cáncer de mama, cáncer de ovario, cáncer esofageal, sarcoma de tejido blando, o carcinoma hepatocelular.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562209056P | 2015-08-24 | 2015-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR105654A1 true AR105654A1 (es) | 2017-10-25 |
Family
ID=56801855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102439A AR105654A1 (es) | 2015-08-24 | 2016-08-09 | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10214586B2 (es) |
| EP (1) | EP3341020B1 (es) |
| JP (1) | JP6518005B2 (es) |
| KR (1) | KR20180030899A (es) |
| CN (1) | CN107921131A (es) |
| AR (1) | AR105654A1 (es) |
| AU (1) | AU2016313404B2 (es) |
| BR (1) | BR112018001506A2 (es) |
| CA (1) | CA2994425C (es) |
| CL (1) | CL2018000454A1 (es) |
| CO (1) | CO2018002009A2 (es) |
| CR (1) | CR20180048A (es) |
| DO (1) | DOP2018000045A (es) |
| EA (1) | EA201890278A1 (es) |
| EC (1) | ECSP18013690A (es) |
| ES (1) | ES2777603T3 (es) |
| HK (1) | HK1249023A1 (es) |
| IL (1) | IL256922A (es) |
| MX (1) | MX2018002170A (es) |
| PE (1) | PE20180604A1 (es) |
| PH (1) | PH12018500394A1 (es) |
| SV (1) | SV2018005640A (es) |
| TN (1) | TN2018000044A1 (es) |
| TW (1) | TW201718650A (es) |
| WO (1) | WO2017034916A1 (es) |
Families Citing this family (170)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2625292B1 (en) | 2010-10-07 | 2018-12-05 | The General Hospital Corporation | Biomarkers of cancer |
| WO2015048312A1 (en) | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| LT3116909T (lt) | 2014-03-14 | 2020-02-10 | Novartis Ag | Antikūno molekulės prieš lag-3 ir jų panaudojimas |
| WO2015200697A1 (en) | 2014-06-25 | 2015-12-30 | The General Hospital Corporation | Targeting human satellite ii (hsatii) |
| CA2960824A1 (en) | 2014-09-13 | 2016-03-17 | Novartis Ag | Combination therapies of alk inhibitors |
| JP6877339B2 (ja) | 2014-10-14 | 2021-05-26 | ノバルティス アーゲー | Ｐｄ−ｌ１に対する抗体分子およびその使用 |
| SG11201707383PA (en) | 2015-03-13 | 2017-10-30 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| JP2018531278A (ja) * | 2015-11-24 | 2018-10-25 | イーライ リリー アンド カンパニー | 癌のための併用療法 |
| WO2017201432A2 (en) | 2016-05-19 | 2017-11-23 | Jounaidi Youssef | Tethered interleukin-2 to its receptor il-2rbeta, a platform to enhance natural killer and regulatory t cell activity |
| MX2018015584A (es) | 2016-06-13 | 2019-09-18 | I Mab | Anticuerpos anti-pd-l1 y usos de los mismos. |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| WO2018029474A2 (en) | 2016-08-09 | 2018-02-15 | Kymab Limited | Anti-icos antibodies |
| SG11201810509PA (en) | 2016-06-20 | 2018-12-28 | Kymab Ltd | Anti-pd-l1 antibodies |
| RU2764548C2 (ru) | 2016-08-09 | 2022-01-18 | Кимаб Лимитед | Анти-icos антитела |
| KR20240019398A (ko) | 2016-10-28 | 2024-02-14 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체를 사용하여 요로상피 암종을 치료하는 방법 |
| US11117968B2 (en) | 2016-11-03 | 2021-09-14 | Bristol-Myers Squibb Company | Activatable anti-CTLA-4 antibodies and uses thereof |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| WO2018089688A1 (en) | 2016-11-09 | 2018-05-17 | Jinjun Shi | Restoration of tumor suppression using mrna-based delivery system |
| US20190358262A1 (en) | 2016-12-03 | 2019-11-28 | Juno Therapeutics, Inc. | Methods for modulation of car-t cells |
| TWI674261B (zh) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 調節劑 |
| CA3058175A1 (en) | 2017-03-31 | 2018-10-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
| WO2018187227A1 (en) | 2017-04-03 | 2018-10-11 | Concologie, Inc. | Methods for treating cancer using ps-targeting antibodies with immuno-oncology agents |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| JOP20190222A1 (ar) | 2017-04-11 | 2019-09-24 | Zymeworks Inc | الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 |
| MX2019012038A (es) | 2017-05-30 | 2019-11-18 | Bristol Myers Squibb Co | Composiciones que comprenden una combinacion de un anticuerpo anti gen 3 de activacion del linfocito (lag-3), un inhibidor de la trayectoria del receptor de muerte programada 1 (pd-1), y un agente inmunoterapeutico. |
| IL322104A (en) | 2017-05-30 | 2025-09-01 | Bristol Myers Squibb Co | Treatment of lag-3 positive tumors |
| AU2018275209A1 (en) | 2017-05-30 | 2019-10-17 | Bristol-Myers Squibb Company | Compositions comprising an anti-LAG-3 antibody or an anti-LAG-3 antibody and an anti-PD-1 or anti-PD-L1 antibody |
| KR20240149982A (ko) | 2017-06-01 | 2024-10-15 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체를 사용하여 종양을 치료하는 방법 |
| US11168144B2 (en) | 2017-06-01 | 2021-11-09 | Cytomx Therapeutics, Inc. | Activatable anti-PDL1 antibodies, and methods of use thereof |
| WO2018227018A1 (en) * | 2017-06-07 | 2018-12-13 | Silverback Therapeutics, Inc. | Antibody conjugates of immune-modulatory compounds and uses thereof |
| GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
| AR112603A1 (es) | 2017-07-10 | 2019-11-20 | Lilly Co Eli | Anticuerpos biespecíficos inhibidores de punto de control |
| WO2019014402A1 (en) | 2017-07-14 | 2019-01-17 | Innate Tumor Immunity, Inc. | MODULATORS OF NLRP3 |
| AU2018311804B2 (en) | 2017-08-01 | 2021-09-02 | Eli Lilly And Company | Anti-CD137 antibodies |
| US11512134B2 (en) | 2017-08-01 | 2022-11-29 | Eli Lilly And Company | Anti-CD137 antibodies |
| US11525002B2 (en) | 2017-10-11 | 2022-12-13 | Board Of Regents, The University Of Texas System | Human PD-L1 antibodies and methods of use therefor |
| CN111247169A (zh) | 2017-10-15 | 2020-06-05 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
| AU2018351000B2 (en) | 2017-10-18 | 2023-11-30 | Alpine Immune Sciences, Inc. | Variant ICOS Ligand immunomodulatory proteins and related compositions and methods |
| US20210292415A1 (en) | 2017-11-06 | 2021-09-23 | Bristol-Myers Squibb Company | Methods of treating a tumor |
| GB201721338D0 (en) | 2017-12-19 | 2018-01-31 | Kymab Ltd | Anti-icos Antibodies |
| WO2019121906A1 (en) * | 2017-12-19 | 2019-06-27 | F-Star Beta Limited | Specific pd-l1 binding sequences inserted in a ch3 domain |
| EP3728314A1 (en) | 2017-12-19 | 2020-10-28 | Kymab Limited | Bispecific antibody for icos and pd-l1 |
| CN109970857B (zh) * | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| US20210363242A1 (en) | 2018-01-16 | 2021-11-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
| KR20200112904A (ko) | 2018-01-22 | 2020-10-05 | 브리스톨-마이어스 스큅 컴퍼니 | 암을 치료하는 조성물 및 방법 |
| WO2019144126A1 (en) | 2018-01-22 | 2019-07-25 | Pascal Biosciences Inc. | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
| CA3090652A1 (en) | 2018-02-06 | 2019-08-15 | The General Hospital Corporation | Repeat rna as biomarkers of tumor immune response |
| TWI702954B (zh) | 2018-03-01 | 2020-09-01 | 美商美國禮來大藥廠 | Cd73抑制劑 |
| EP3768711B1 (en) | 2018-03-23 | 2023-05-03 | Eli Lilly and Company | Anti-cd137 antibodies for combination with anti-pd-l1 antibodies |
| WO2019182888A1 (en) | 2018-03-23 | 2019-09-26 | Board Of Regents, The University Of Texas System | Human pd-l2 antibodies and methods of use therefor |
| US11242393B2 (en) | 2018-03-23 | 2022-02-08 | Bristol-Myers Squibb Company | Antibodies against MICA and/or MICB and uses thereof |
| WO2019191676A1 (en) | 2018-03-30 | 2019-10-03 | Bristol-Myers Squibb Company | Methods of treating tumor |
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2016
- 2016-08-09 AR ARP160102439A patent/AR105654A1/es unknown
- 2016-08-10 TW TW105125503A patent/TW201718650A/zh unknown
- 2016-08-18 TN TNP/2018/000044A patent/TN2018000044A1/en unknown
- 2016-08-18 KR KR1020187005071A patent/KR20180030899A/ko not_active Withdrawn
- 2016-08-18 CR CR20180048A patent/CR20180048A/es unknown
- 2016-08-18 PE PE2018000240A patent/PE20180604A1/es unknown
- 2016-08-18 JP JP2018509789A patent/JP6518005B2/ja not_active Expired - Fee Related
- 2016-08-18 EP EP16757470.6A patent/EP3341020B1/en active Active
- 2016-08-18 CA CA2994425A patent/CA2994425C/en not_active Expired - Fee Related
- 2016-08-18 HK HK18108695.1A patent/HK1249023A1/zh unknown
- 2016-08-18 WO PCT/US2016/047528 patent/WO2017034916A1/en not_active Ceased
- 2016-08-18 EA EA201890278A patent/EA201890278A1/ru unknown
- 2016-08-18 AU AU2016313404A patent/AU2016313404B2/en not_active Expired - Fee Related
- 2016-08-18 US US15/239,959 patent/US10214586B2/en not_active Expired - Fee Related
- 2016-08-18 ES ES16757470T patent/ES2777603T3/es active Active
- 2016-08-18 MX MX2018002170A patent/MX2018002170A/es unknown
- 2016-08-18 CN CN201680048919.5A patent/CN107921131A/zh active Pending
- 2016-08-18 BR BR112018001506A patent/BR112018001506A2/pt not_active Application Discontinuation
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2018
- 2018-01-15 IL IL256922A patent/IL256922A/en unknown
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- 2018-02-20 CL CL2018000454A patent/CL2018000454A1/es unknown
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- 2018-02-22 PH PH12018500394A patent/PH12018500394A1/en unknown
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- 2018-02-23 CO CONC2018/0002009A patent/CO2018002009A2/es unknown
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2019
- 2019-01-25 US US16/258,192 patent/US20190144544A1/en not_active Abandoned
Also Published As
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|---|---|
| PE20180604A1 (es) | 2018-04-09 |
| AU2016313404A1 (en) | 2018-02-08 |
| AU2016313404B2 (en) | 2019-04-04 |
| ES2777603T3 (es) | 2020-08-05 |
| CR20180048A (es) | 2018-03-20 |
| SV2018005640A (es) | 2018-07-23 |
| EP3341020A1 (en) | 2018-07-04 |
| CA2994425C (en) | 2020-04-28 |
| DOP2018000045A (es) | 2018-03-30 |
| TN2018000044A1 (en) | 2019-07-08 |
| US10214586B2 (en) | 2019-02-26 |
| PH12018500394A1 (en) | 2018-08-29 |
| US20170058033A1 (en) | 2017-03-02 |
| ECSP18013690A (es) | 2018-04-30 |
| HK1249023A1 (zh) | 2018-10-26 |
| US20190144544A1 (en) | 2019-05-16 |
| JP6518005B2 (ja) | 2019-05-22 |
| IL256922A (en) | 2018-03-29 |
| MX2018002170A (es) | 2018-04-24 |
| CL2018000454A1 (es) | 2018-08-03 |
| EA201890278A1 (ru) | 2018-07-31 |
| WO2017034916A1 (en) | 2017-03-02 |
| EP3341020B1 (en) | 2020-02-26 |
| JP2018531219A (ja) | 2018-10-25 |
| TW201718650A (zh) | 2017-06-01 |
| BR112018001506A2 (pt) | 2018-09-18 |
| CA2994425A1 (en) | 2017-03-02 |
| KR20180030899A (ko) | 2018-03-26 |
| CO2018002009A2 (es) | 2018-05-10 |
| CN107921131A (zh) | 2018-04-17 |
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