SK13002000A3 - Deriváty meta-azacyklickej aminobenzoovej kyseliny a ich deriváty, ktoré sú antagonisty integrínu - Google Patents

Deriváty meta-azacyklickej aminobenzoovej kyseliny a ich deriváty, ktoré sú antagonisty integrínu Download PDF

Info

Publication number: SK13002000A3
Authority: SK; Slovakia
Prior art keywords: added; solution; mol; reaction mixture; product
Prior art date: 1998-03-04

Application number

SK1300-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Thomas E. Rogers

Peter G. Ruminski

Original Assignee

G. D. Searle & Co.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-04

Filing date

1999-02-22

Publication date

2001-07-10

1999-02-22 Application filed by G. D. Searle & Co. filed Critical G. D. Searle & Co.

2001-07-10 Publication of SK13002000A3 publication Critical patent/SK13002000A3/sk

Links

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150000001875 compounds Chemical class 0.000 claims abstract description 89
150000003839 salts Chemical class 0.000 claims abstract description 15
238000000034 method Methods 0.000 claims description 55
238000011282 treatment Methods 0.000 claims description 26
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125000005843 halogen group Chemical group 0.000 claims description 8
239000008194 pharmaceutical composition Substances 0.000 claims description 8
208000001132 Osteoporosis Diseases 0.000 claims description 7
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239000003937 drug carrier Substances 0.000 claims description 7
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208000037147 Hypercalcaemia Diseases 0.000 claims description 3
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125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
230000000148 hypercalcaemia Effects 0.000 claims description 3
230000036210 malignancy Effects 0.000 claims description 3
230000001404 mediated effect Effects 0.000 claims description 3
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208000030915 hypercalcemia disease Diseases 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 9
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- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

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Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SK1300-2000A 1998-03-04 1999-02-22 Deriváty meta-azacyklickej aminobenzoovej kyseliny a ich deriváty, ktoré sú antagonisty integrínu SK13002000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3427098A	1998-03-04	1998-03-04
PCT/US1999/003281 WO1999044994A1 (en)	1998-03-04	1999-02-22	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists

Publications (1)

Publication Number	Publication Date
SK13002000A3 true SK13002000A3 (sk)	2001-07-10

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ID=21875345

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Application Number	Title	Priority Date	Filing Date
SK1300-2000A SK13002000A3 (sk)	1998-03-04	1999-02-22	Deriváty meta-azacyklickej aminobenzoovej kyseliny a ich deriváty, ktoré sú antagonisty integrínu

Country Status (29)

Country	Link
EP (1)	EP1060164A1 (is)
JP (1)	JP2002505323A (is)
KR (1)	KR20010041584A (is)
CN (1)	CN1214011C (is)
AP (1)	AP1244A (is)
AR (1)	AR018139A1 (is)
AU (1)	AU753230B2 (is)
BG (1)	BG104740A (is)
BR (1)	BR9908470A (is)
CA (1)	CA2322207A1 (is)
EA (1)	EA200000804A1 (is)
EE (1)	EE200000506A (is)
GE (1)	GEP20033118B (is)
HR (1)	HRP20000574A2 (is)
HU (1)	HUP0100865A3 (is)
ID (1)	ID25591A (is)
IL (1)	IL137653A0 (is)
IS (1)	IS5582A (is)
MY (1)	MY123908A (is)
NO (1)	NO315703B1 (is)
NZ (1)	NZ506598A (is)
OA (1)	OA11530A (is)
PL (1)	PL342726A1 (is)
SK (1)	SK13002000A3 (is)
TR (1)	TR200002542T2 (is)
UA (1)	UA71906C2 (is)
WO (1)	WO1999044994A1 (is)
YU (1)	YU52000A (is)
ZA (1)	ZA994406B (is)

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GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
JP2003531141A (ja)	2000-04-17	2003-10-21	セルテックアールアンドディリミテッド	エナミン誘導体
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6921767B2 (en) *	2000-06-15	2005-07-26	Pharmacia Corporation	Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
JP2004505110A (ja)	2000-08-02	2004-02-19	セルテック　アール　アンド　ディ　リミテッド	３位置換イソキノリン−１−イル誘導体
AU2003299600A1 (en) *	2002-12-20	2004-07-29	Pharmacia Corpration	The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
BRPI0611814A2 (pt) *	2005-06-10	2008-12-09	Bipar Sciences Inc	moduladores parp e tratamento de cÂnceres
CN101687040A (zh)	2007-03-01	2010-03-31	马林克罗特公司	整合光活性的小分子及其用途
JP4792124B1 (ja) *	2010-11-15	2011-10-12	エフイートレード株式会社	車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
IN2015DN00099A (is)	2012-07-18	2015-05-29	Univ Saint Louis
WO2015181676A1 (en)	2014-05-30	2015-12-03	Pfizer Inc.	Carbonitrile derivatives as selective androgen receptor modulators
WO2015187774A1 (en) *	2014-06-04	2015-12-10	Monsanto Technology Llc	3,6-dichlorosalicylic acid compounds and related synthetic processes
CN108779077A (zh)	2015-12-30	2018-11-09	圣路易斯大学	作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物
CA3182964A1 (en)	2020-05-14	2021-11-18	Ube Corporation	1,4,5,6-tetrahydropyrimidin-2-amine derivative
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators
JPWO2023085396A1 (is)	2021-11-12	2023-05-19

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CZ293323B6 (cs) *	1995-08-30	2004-04-14	G. D. Searle & Co.	Meta-guanidinové, močovinové, thiomočovinové nebo azacyklické deriváty aminobenzoové kyseliny jako antagonisty integrinů

1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/xx unknown
- 1999-02-22 YU YU52000A patent/YU52000A/sh unknown
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/xx unknown
- 1999-02-22 EP EP99937927A patent/EP1060164A1/en active Pending
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/pt not_active Application Discontinuation
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/hu unknown
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/ja active Pending
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/sk unknown
- 1999-02-22 CA CA002322207A patent/CA2322207A1/en not_active Abandoned
- 1999-02-22 EA EA200000804A patent/EA200000804A1/ru unknown
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
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- 1999-02-22 UA UA2000095148A patent/UA71906C2/uk unknown
- 1999-02-22 CN CNB998035815A patent/CN1214011C/zh not_active Expired - Fee Related
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- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/en not_active Ceased
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/ko not_active Ceased
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Publication number	Publication date
EA200000804A1 (ru)	2001-04-23
CN1214011C (zh)	2005-08-10
YU52000A (sh)	2003-02-28
AR018139A1 (es)	2001-10-31
MY123908A (en)	2006-06-30
HRP20000574A2 (en)	2001-08-31
CN1291978A (zh)	2001-04-18
NZ506598A (en)	2003-07-25
NO20004316L (no)	2000-11-06
CA2322207A1 (en)	1999-09-10
GEP20033118B (en)	2003-11-25
IL137653A0 (en)	2001-10-31
TR200002542T2 (tr)	2001-05-21
OA11530A (en)	2004-05-17
JP2002505323A (ja)	2002-02-19
AP1244A (en)	2004-02-04
NO315703B1 (no)	2003-10-13
IS5582A (is)	2000-08-04
AU3294799A (en)	1999-09-20
ID25591A (id)	2000-10-19
EE200000506A (et)	2002-04-15
NO20004316D0 (no)	2000-08-30
AU753230B2 (en)	2002-10-10
HUP0100865A3 (en)	2001-11-28
PL342726A1 (en)	2001-07-02
UA71906C2 (en)	2005-01-17
KR20010041584A (ko)	2001-05-25
WO1999044994A1 (en)	1999-09-10
ZA994406B (en)	2000-02-11
HUP0100865A2 (hu)	2001-08-28
EP1060164A1 (en)	2000-12-20
BG104740A (en)	2001-02-28
BR9908470A (pt)	2000-12-05
AP2000001893A0 (en)	2000-09-30

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