CN1214011C - 作为整联蛋白拮抗剂的间－氮杂环氨基苯甲酸化合物及其衍生物 - Google Patents

作为整联蛋白拮抗剂的间－氮杂环氨基苯甲酸化合物及其衍生物 Download PDF

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Publication number: CN1214011C
Authority: CN; China
Prior art keywords: compound; solution; add; preparation; product
Prior art date: 1998-03-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CNB998035815A

Other languages

English (en)

Chinese (zh)

Other versions

CN1291978A (zh

Inventor

T·E·罗格斯

P·G·鲁敏斯基

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GD Searle LLC

Original Assignee

GD Searle LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-04

Filing date

1999-02-22

Publication date

2005-08-10

1999-02-22 Application filed by GD Searle LLC filed Critical GD Searle LLC

2001-04-18 Publication of CN1291978A publication Critical patent/CN1291978A/zh

2005-08-10 Application granted granted Critical

2005-08-10 Publication of CN1214011C publication Critical patent/CN1214011C/zh

2019-02-22 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CNB998035815A 1998-03-04 1999-02-22 作为整联蛋白拮抗剂的间－氮杂环氨基苯甲酸化合物及其衍生物 Expired - Fee Related CN1214011C (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3427098A	1998-03-04	1998-03-04
US09/034,270		1998-03-04

Publications (2)

Publication Number	Publication Date
CN1291978A CN1291978A (zh)	2001-04-18
CN1214011C true CN1214011C (zh)	2005-08-10

Family

ID=21875345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CNB998035815A Expired - Fee Related CN1214011C (zh)	1998-03-04	1999-02-22	作为整联蛋白拮抗剂的间－氮杂环氨基苯甲酸化合物及其衍生物

Country Status (29)

Country	Link
EP (1)	EP1060164A1 (is)
JP (1)	JP2002505323A (is)
KR (1)	KR20010041584A (is)
CN (1)	CN1214011C (is)
AP (1)	AP1244A (is)
AR (1)	AR018139A1 (is)
AU (1)	AU753230B2 (is)
BG (1)	BG104740A (is)
BR (1)	BR9908470A (is)
CA (1)	CA2322207A1 (is)
EA (1)	EA200000804A1 (is)
EE (1)	EE200000506A (is)
GE (1)	GEP20033118B (is)
HR (1)	HRP20000574A2 (is)
HU (1)	HUP0100865A3 (is)
ID (1)	ID25591A (is)
IL (1)	IL137653A0 (is)
IS (1)	IS5582A (is)
MY (1)	MY123908A (is)
NO (1)	NO315703B1 (is)
NZ (1)	NZ506598A (is)
OA (1)	OA11530A (is)
PL (1)	PL342726A1 (is)
SK (1)	SK13002000A3 (is)
TR (1)	TR200002542T2 (is)
UA (1)	UA71906C2 (is)
WO (1)	WO1999044994A1 (is)
YU (1)	YU52000A (is)
ZA (1)	ZA994406B (is)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
JP2003531141A (ja)	2000-04-17	2003-10-21	セルテックアールアンドディリミテッド	エナミン誘導体
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6921767B2 (en) *	2000-06-15	2005-07-26	Pharmacia Corporation	Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
JP2004505110A (ja)	2000-08-02	2004-02-19	セルテック　アール　アンド　ディ　リミテッド	３位置換イソキノリン−１−イル誘導体
AU2003299600A1 (en) *	2002-12-20	2004-07-29	Pharmacia Corpration	The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
BRPI0611814A2 (pt) *	2005-06-10	2008-12-09	Bipar Sciences Inc	moduladores parp e tratamento de cÂnceres
CN101687040A (zh)	2007-03-01	2010-03-31	马林克罗特公司	整合光活性的小分子及其用途
JP4792124B1 (ja) *	2010-11-15	2011-10-12	エフイートレード株式会社	車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
IN2015DN00099A (is)	2012-07-18	2015-05-29	Univ Saint Louis
WO2015181676A1 (en)	2014-05-30	2015-12-03	Pfizer Inc.	Carbonitrile derivatives as selective androgen receptor modulators
WO2015187774A1 (en) *	2014-06-04	2015-12-10	Monsanto Technology Llc	3,6-dichlorosalicylic acid compounds and related synthetic processes
CN108779077A (zh)	2015-12-30	2018-11-09	圣路易斯大学	作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物
CA3182964A1 (en)	2020-05-14	2021-11-18	Ube Corporation	1,4,5,6-tetrahydropyrimidin-2-amine derivative
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators
JPWO2023085396A1 (is)	2021-11-12	2023-05-19

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ293323B6 (cs) *	1995-08-30	2004-04-14	G. D. Searle & Co.	Meta-guanidinové, močovinové, thiomočovinové nebo azacyklické deriváty aminobenzoové kyseliny jako antagonisty integrinů

1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/xx unknown
- 1999-02-22 YU YU52000A patent/YU52000A/sh unknown
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/xx unknown
- 1999-02-22 EP EP99937927A patent/EP1060164A1/en active Pending
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/pt not_active Application Discontinuation
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/hu unknown
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/ja active Pending
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/sk unknown
- 1999-02-22 CA CA002322207A patent/CA2322207A1/en not_active Abandoned
- 1999-02-22 EA EA200000804A patent/EA200000804A1/ru unknown
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
- 1999-02-22 EE EEP200000506A patent/EE200000506A/xx unknown
- 1999-02-22 IL IL13765399A patent/IL137653A0/xx unknown
- 1999-02-22 PL PL99342726A patent/PL342726A1/xx unknown
- 1999-02-22 UA UA2000095148A patent/UA71906C2/uk unknown
- 1999-02-22 CN CNB998035815A patent/CN1214011C/zh not_active Expired - Fee Related
- 1999-02-22 AP APAP/P/2000/001893A patent/AP1244A/en active
- 1999-02-22 NZ NZ506598A patent/NZ506598A/en unknown
- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/en not_active Ceased
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/ko not_active Ceased
- 1999-02-22 HR HR20000574A patent/HRP20000574A2/hr not_active Application Discontinuation
- 1999-02-22 ID IDW20001695A patent/ID25591A/id unknown
- 1999-03-02 AR ARP990100880A patent/AR018139A1/es unknown
- 1999-03-03 MY MYPI99000772A patent/MY123908A/en unknown
2000
- 2000-08-04 IS IS5582A patent/IS5582A/is unknown
- 2000-08-30 NO NO20004316A patent/NO315703B1/no not_active IP Right Cessation
- 2000-09-01 BG BG104740A patent/BG104740A/xx unknown

Also Published As

Publication number	Publication date
SK13002000A3 (sk)	2001-07-10
EA200000804A1 (ru)	2001-04-23
YU52000A (sh)	2003-02-28
AR018139A1 (es)	2001-10-31
MY123908A (en)	2006-06-30
HRP20000574A2 (en)	2001-08-31
CN1291978A (zh)	2001-04-18
NZ506598A (en)	2003-07-25
NO20004316L (no)	2000-11-06
CA2322207A1 (en)	1999-09-10
GEP20033118B (en)	2003-11-25
IL137653A0 (en)	2001-10-31
TR200002542T2 (tr)	2001-05-21
OA11530A (en)	2004-05-17
JP2002505323A (ja)	2002-02-19
AP1244A (en)	2004-02-04
NO315703B1 (no)	2003-10-13
IS5582A (is)	2000-08-04
AU3294799A (en)	1999-09-20
ID25591A (id)	2000-10-19
EE200000506A (et)	2002-04-15
NO20004316D0 (no)	2000-08-30
AU753230B2 (en)	2002-10-10
HUP0100865A3 (en)	2001-11-28
PL342726A1 (en)	2001-07-02
UA71906C2 (en)	2005-01-17
KR20010041584A (ko)	2001-05-25
WO1999044994A1 (en)	1999-09-10
ZA994406B (en)	2000-02-11
HUP0100865A2 (hu)	2001-08-28
EP1060164A1 (en)	2000-12-20
BG104740A (en)	2001-02-28
BR9908470A (pt)	2000-12-05
AP2000001893A0 (en)	2000-09-30

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Legal Events

Date	Code	Title
2001-04-18	C06	Publication
2001-04-18	PB01	Publication
2001-04-25	C10	Entry into substantive examination
2001-04-25	SE01	Entry into force of request for substantive examination
2005-08-10	C14	Grant of patent or utility model
2005-08-10	GR01	Patent grant
2007-04-25	C19	Lapse of patent right due to non-payment of the annual fee
2007-04-25	CF01	Termination of patent right due to non-payment of annual fee