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BG104740A - Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists - Google Patents

Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists

Info

Publication number
BG104740A
BG104740A BG104740A BG10474000A BG104740A BG 104740 A BG104740 A BG 104740A BG 104740 A BG104740 A BG 104740A BG 10474000 A BG10474000 A BG 10474000A BG 104740 A BG104740 A BG 104740A
Authority
BG
Bulgaria
Prior art keywords
meta
derivatives
benzoic acid
acid compounds
integrin antagonists
Prior art date
Application number
BG104740A
Other languages
Bulgarian (bg)
Inventor
Thomas Rogers
Peter Ruminski
Original Assignee
G.D. Searle @ Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G.D. Searle @ Co filed Critical G.D. Searle @ Co
Publication of BG104740A publication Critical patent/BG104740A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention is directed to compounds of formula and pharmaceutically acceptable salts and isomers thereof useful as alpha-nu-beta3 integrin antagonists. 15 claims
BG104740A 1998-03-04 2000-09-01 Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists BG104740A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3427098A 1998-03-04 1998-03-04
PCT/US1999/003281 WO1999044994A1 (en) 1998-03-04 1999-02-22 Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists

Publications (1)

Publication Number Publication Date
BG104740A true BG104740A (en) 2001-02-28

Family

ID=21875345

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104740A BG104740A (en) 1998-03-04 2000-09-01 Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists

Country Status (29)

Country Link
EP (1) EP1060164A1 (en)
JP (1) JP2002505323A (en)
KR (1) KR20010041584A (en)
CN (1) CN1214011C (en)
AP (1) AP1244A (en)
AR (1) AR018139A1 (en)
AU (1) AU753230B2 (en)
BG (1) BG104740A (en)
BR (1) BR9908470A (en)
CA (1) CA2322207A1 (en)
EA (1) EA200000804A1 (en)
EE (1) EE200000506A (en)
GE (1) GEP20033118B (en)
HR (1) HRP20000574A2 (en)
HU (1) HUP0100865A3 (en)
ID (1) ID25591A (en)
IL (1) IL137653A0 (en)
IS (1) IS5582A (en)
MY (1) MY123908A (en)
NO (1) NO315703B1 (en)
NZ (1) NZ506598A (en)
OA (1) OA11530A (en)
PL (1) PL342726A1 (en)
SK (1) SK13002000A3 (en)
TR (1) TR200002542T2 (en)
UA (1) UA71906C2 (en)
WO (1) WO1999044994A1 (en)
YU (1) YU52000A (en)
ZA (1) ZA994406B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9805655D0 (en) 1998-03-16 1998-05-13 Celltech Therapeutics Ltd Chemical compounds
GB9814414D0 (en) 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
AU2001248553A1 (en) 2000-04-17 2001-10-30 Celltech R And D Limited Enamine derivatives as cell adhesion molecules
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
US6921767B2 (en) * 2000-06-15 2005-07-26 Pharmacia Corporation Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
CA2417059A1 (en) 2000-08-02 2002-02-07 Celltech R&D Limited 3-substituted isoquinolin-1-yl derivatives
EP1572210A1 (en) * 2002-12-20 2005-09-14 Pharmacia Corporation The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
KR20080031266A (en) * 2005-06-10 2008-04-08 바이파 사이언스 인코포레이티드 PAP Modulators and Cancer Treatment
EP2131861A2 (en) 2007-03-01 2009-12-16 Mallinckrodt Inc. Integrated photoactive small molecules and uses thereof
JP4792124B1 (en) * 2010-11-15 2011-10-12 エフイートレード株式会社 Method for molding protective film for vehicle and method for manufacturing protective film for vehicle
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
MX2015000794A (en) 2012-07-18 2015-10-12 Univ Saint Louis Beta amino acid derivatives as integrin antagonists.
CA2950390C (en) 2014-05-30 2020-09-22 Pfizer Inc. Carbonitrile derivatives as selective androgen receptor modulators
CN112299983B (en) * 2014-06-04 2024-05-17 孟山都技术公司 3, 6-Dichloro salicylic acid compounds and related methods of synthesis
EP3738953A1 (en) 2015-12-30 2020-11-18 Saint Louis University Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists with improved pharmacokinetic properties and methods for their manufacture
CN115551846B (en) 2020-05-14 2024-03-08 Ｕｂｅ株式会社 1,4,5, 6-tetrahydropyrimidin-2-amine derivatives
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators
US20250049806A1 (en) 2021-11-12 2025-02-13 Ube Corporation Pharmaceutical composition for providing treatment for or preventing alport syndrome

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1085980C (en) * 1995-08-30 2002-06-05 G·D·瑟尔公司 Meta-guanidino, ureido, thioureido or azacyclic aminobenzoic acid derivatives as integrin antagonists

Also Published As

Publication number Publication date
IL137653A0 (en) 2001-10-31
EA200000804A1 (en) 2001-04-23
AU753230B2 (en) 2002-10-10
CA2322207A1 (en) 1999-09-10
PL342726A1 (en) 2001-07-02
WO1999044994A1 (en) 1999-09-10
OA11530A (en) 2004-05-17
HUP0100865A3 (en) 2001-11-28
AP2000001893A0 (en) 2000-09-30
NZ506598A (en) 2003-07-25
MY123908A (en) 2006-06-30
AR018139A1 (en) 2001-10-31
HRP20000574A2 (en) 2001-08-31
KR20010041584A (en) 2001-05-25
JP2002505323A (en) 2002-02-19
BR9908470A (en) 2000-12-05
IS5582A (en) 2000-08-04
HUP0100865A2 (en) 2001-08-28
NO20004316D0 (en) 2000-08-30
CN1291978A (en) 2001-04-18
SK13002000A3 (en) 2001-07-10
AU3294799A (en) 1999-09-20
NO315703B1 (en) 2003-10-13
EE200000506A (en) 2002-04-15
NO20004316L (en) 2000-11-06
EP1060164A1 (en) 2000-12-20
YU52000A (en) 2003-02-28
GEP20033118B (en) 2003-11-25
UA71906C2 (en) 2005-01-17
ZA994406B (en) 2000-02-11
ID25591A (en) 2000-10-19
TR200002542T2 (en) 2001-05-21
AP1244A (en) 2004-02-04
CN1214011C (en) 2005-08-10

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