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BRPI0611814A2 - moduladores parp e tratamento de cÂnceres - Google Patents

moduladores parp e tratamento de cÂnceres

Info

Publication number
BRPI0611814A2
BRPI0611814A2 BRPI0611814-3A BRPI0611814A BRPI0611814A2 BR PI0611814 A2 BRPI0611814 A2 BR PI0611814A2 BR PI0611814 A BRPI0611814 A BR PI0611814A BR PI0611814 A2 BRPI0611814 A2 BR PI0611814A2
Authority
BR
Brazil
Prior art keywords
parp
activity
aromatic compound
organic aromatic
mammal
Prior art date
Application number
BRPI0611814-3A
Other languages
English (en)
Inventor
Ernest Kun
Jerome Mendeleyev
Pal Bauer
Original Assignee
Bipar Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bipar Sciences Inc filed Critical Bipar Sciences Inc
Publication of BRPI0611814A2 publication Critical patent/BRPI0611814A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P39/06—Free radical scavengers or antioxidants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/10—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring unsubstituted
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

MODULADORES PARP E TRATAMENTO DE CANGERES. A invenção se refere a um método de modulação de atividade de poli(ADP-ribose)polimerase-1 (PARP-1) em um mamífero compreendendo administrar a um mamífero uma quantidade efetiva de um composto aromático orgânico tendo de 4 a cerca de 35 átomos de carbono, onde o referido composto aromático orgânico é capaz de ligar a fração de arginina-34 localizada no dedo de Zinco-1 da enzima PARP-1 e em onde o re- ferido composto aromático orgânico tem capacidades de doação de elétron tal que seu sistema de <227>-elétron interaja com a fração de guanidinio carregada positivamente (catiónico) do resíduo de arginina-34 específico do dedo de Zinco-1 de PARP-1 e não contém substituintes de benzamida ou lactam. Em particular, as benzopironas substituidas e indóis substiuidos e suas composições farmacêuticas tais compostos que modulam a atividade PARP-I, são descritos. A invenção está também voltada à composição de materiais, kits e métodos para seu uso terapêutico e/ou profilático no tratamento de doenças e distúrbios descritos aqui, administrando-se quantidades efetivas de tais compostos. Preferivelmente. As composições e métodos fornecidos aqui inibem a atividade de PARP.
BRPI0611814-3A 2005-06-10 2006-06-12 moduladores parp e tratamento de cÂnceres BRPI0611814A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68917805P 2005-06-10 2005-06-10
PCT/US2006/022907 WO2006135873A2 (en) 2005-06-10 2006-06-12 Parp modulators and treatment of cancer

Publications (1)

Publication Number Publication Date
BRPI0611814A2 true BRPI0611814A2 (pt) 2008-12-09

Family

ID=37532884

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0611814-3A BRPI0611814A2 (pt) 2005-06-10 2006-06-12 moduladores parp e tratamento de cÂnceres

Country Status (13)

Country Link
US (2) US20070015814A1 (pt)
EP (1) EP1904468A4 (pt)
JP (1) JP2008543786A (pt)
KR (1) KR20080031266A (pt)
CN (1) CN101233121A (pt)
AU (1) AU2006257815A1 (pt)
BR (1) BRPI0611814A2 (pt)
CA (1) CA2612979A1 (pt)
IL (1) IL187898A0 (pt)
MX (1) MX2007015479A (pt)
NO (1) NO20080176L (pt)
RU (1) RU2008100017A (pt)
WO (1) WO2006135873A2 (pt)

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US20070015814A1 (en) 2007-01-18
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US20090076122A1 (en) 2009-03-19
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