PL342726A1 - Metha-azacyclic compounds of aminobenzoic acid and their derivatives constituting antagonists of integrins - Google Patents

Metha-azacyclic compounds of aminobenzoic acid and their derivatives constituting antagonists of integrins

Info

Publication number: PL342726A1
Authority: PL; Poland
Prior art keywords: metha; integrins; antagonists; aminobenzoic acid; azacyclic compounds
Prior art date: 1998-03-04

Application number

PL99342726A

Other languages

English (en)

Inventor

Thomas E Rogers

Peter G Ruminski

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-04

Filing date

1999-02-22

Publication date

2001-07-02

1999-02-22 Application filed by Searle & Co filed Critical Searle & Co

2001-07-02 Publication of PL342726A1 publication Critical patent/PL342726A1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Oncology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL99342726A 1998-03-04 1999-02-22 Metha-azacyclic compounds of aminobenzoic acid and their derivatives constituting antagonists of integrins PL342726A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3427098A	1998-03-04	1998-03-04
PCT/US1999/003281 WO1999044994A1 (en)	1998-03-04	1999-02-22	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists

Publications (1)

Publication Number	Publication Date
PL342726A1 true PL342726A1 (en)	2001-07-02

Family

ID=21875345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL99342726A PL342726A1 (en)	1998-03-04	1999-02-22	Metha-azacyclic compounds of aminobenzoic acid and their derivatives constituting antagonists of integrins

Country Status (29)

Country	Link
EP (1)	EP1060164A1 (is)
JP (1)	JP2002505323A (is)
KR (1)	KR20010041584A (is)
CN (1)	CN1214011C (is)
AP (1)	AP1244A (is)
AR (1)	AR018139A1 (is)
AU (1)	AU753230B2 (is)
BG (1)	BG104740A (is)
BR (1)	BR9908470A (is)
CA (1)	CA2322207A1 (is)
EA (1)	EA200000804A1 (is)
EE (1)	EE200000506A (is)
GE (1)	GEP20033118B (is)
HR (1)	HRP20000574A2 (is)
HU (1)	HUP0100865A3 (is)
ID (1)	ID25591A (is)
IL (1)	IL137653A0 (is)
IS (1)	IS5582A (is)
MY (1)	MY123908A (is)
NO (1)	NO315703B1 (is)
NZ (1)	NZ506598A (is)
OA (1)	OA11530A (is)
PL (1)	PL342726A1 (is)
SK (1)	SK13002000A3 (is)
TR (1)	TR200002542T2 (is)
UA (1)	UA71906C2 (is)
WO (1)	WO1999044994A1 (is)
YU (1)	YU52000A (is)
ZA (1)	ZA994406B (is)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
EP1332132B1 (en)	2000-04-17	2007-10-10	UCB Pharma, S.A.	Enamine derivatives as cell adhesion molecules
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6921767B2 (en) *	2000-06-15	2005-07-26	Pharmacia Corporation	Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
JP2004505110A (ja)	2000-08-02	2004-02-19	セルテック　アール　アンド　ディ　リミテッド	３位置換イソキノリン−１−イル誘導体
JP2006514050A (ja) *	2002-12-20	2006-04-27	ファルマシア・コーポレーション	インテグリン受容体アンタゴニスト誘導体としてのβ−アミノ酸化合物のＲ異性体
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
EP1904468A4 (en) *	2005-06-10	2009-04-22	Bipar Sciences Inc	PARP MODULATORS AND TREATMENT OF CANCER
US8313729B2 (en)	2007-03-01	2012-11-20	Medibeacon, LLC	Integrated photoactive small molecules and uses thereof
JP4792124B1 (ja) *	2010-11-15	2011-10-12	エフイートレード株式会社	車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
CN104640857B (zh)	2012-07-18	2017-07-04	圣路易斯大学	作为整合素拮抗剂的β氨基酸衍生物
BR112016027778A2 (pt)	2014-05-30	2017-08-15	Pfizer	Usos de derivados de carbonitrila, sua combinação e sua composição farmacêutica
WO2015187774A1 (en) *	2014-06-04	2015-12-10	Monsanto Technology Llc	3,6-dichlorosalicylic acid compounds and related synthetic processes
RU2729518C2 (ru)	2015-12-30	2020-08-07	Сент-Луис Юниверсити	Мета-азациклические производные аминобензойной кислоты в качестве антагонистов пан-интегрина
US20230192661A1 (en)	2020-05-14	2023-06-22	Ube Corporation	1, 4, 5, 6-tetrahydropyrimidine-2-amine derivative
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators
WO2023085396A1 (ja)	2021-11-12	2023-05-19	Ｕｂｅ株式会社	アルポート症候群を治療または予防するための医薬組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9801716A (es) *	1995-08-30	1998-05-31	Searle & Co	Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.

1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/xx unknown
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/ko not_active Ceased
- 1999-02-22 EP EP99937927A patent/EP1060164A1/en active Pending
- 1999-02-22 EE EEP200000506A patent/EE200000506A/xx unknown
- 1999-02-22 CN CNB998035815A patent/CN1214011C/zh not_active Expired - Fee Related
- 1999-02-22 ID IDW20001695A patent/ID25591A/id unknown
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/sk unknown
- 1999-02-22 CA CA002322207A patent/CA2322207A1/en not_active Abandoned
- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/en not_active Ceased
- 1999-02-22 YU YU52000A patent/YU52000A/sh unknown
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/ja active Pending
- 1999-02-22 EA EA200000804A patent/EA200000804A1/ru unknown
- 1999-02-22 NZ NZ506598A patent/NZ506598A/en unknown
- 1999-02-22 AP APAP/P/2000/001893A patent/AP1244A/en active
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/xx unknown
- 1999-02-22 PL PL99342726A patent/PL342726A1/xx unknown
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/pt not_active Application Discontinuation
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/hu unknown
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 IL IL13765399A patent/IL137653A0/xx unknown
- 1999-02-22 UA UA2000095148A patent/UA71906C2/uk unknown
- 1999-02-22 HR HR20000574A patent/HRP20000574A2/hr not_active Application Discontinuation
- 1999-03-02 AR ARP990100880A patent/AR018139A1/es unknown
- 1999-03-03 MY MYPI99000772A patent/MY123908A/en unknown
2000
- 2000-08-04 IS IS5582A patent/IS5582A/is unknown
- 2000-08-30 NO NO20004316A patent/NO315703B1/no not_active IP Right Cessation
- 2000-09-01 BG BG104740A patent/BG104740A/xx unknown

Also Published As

Publication number	Publication date
MY123908A (en)	2006-06-30
EE200000506A (et)	2002-04-15
AP1244A (en)	2004-02-04
EP1060164A1 (en)	2000-12-20
IS5582A (is)	2000-08-04
NZ506598A (en)	2003-07-25
IL137653A0 (en)	2001-10-31
OA11530A (en)	2004-05-17
AU753230B2 (en)	2002-10-10
HRP20000574A2 (en)	2001-08-31
HUP0100865A2 (hu)	2001-08-28
SK13002000A3 (sk)	2001-07-10
HUP0100865A3 (en)	2001-11-28
CA2322207A1 (en)	1999-09-10
AR018139A1 (es)	2001-10-31
AU3294799A (en)	1999-09-20
WO1999044994A1 (en)	1999-09-10
TR200002542T2 (tr)	2001-05-21
NO20004316D0 (no)	2000-08-30
AP2000001893A0 (en)	2000-09-30
CN1291978A (zh)	2001-04-18
KR20010041584A (ko)	2001-05-25
BR9908470A (pt)	2000-12-05
UA71906C2 (en)	2005-01-17
NO20004316L (no)	2000-11-06
YU52000A (sh)	2003-02-28
BG104740A (en)	2001-02-28
CN1214011C (zh)	2005-08-10
ID25591A (id)	2000-10-19
JP2002505323A (ja)	2002-02-19
GEP20033118B (en)	2003-11-25
NO315703B1 (no)	2003-10-13
ZA994406B (en)	2000-02-11
EA200000804A1 (ru)	2001-04-23

Publication	Publication Date	Title
PL342726A1 (en)	2001-07-02	Metha-azacyclic compounds of aminobenzoic acid and their derivatives constituting antagonists of integrins
SI1371647T1 (en)	2005-10-31	Pyridine-3-carboxylic acid derivatives and their use as intermediates
HUP0001684A3 (en)	2001-09-28	Use of fumaric acid derivatives
PL339330A1 (en)	2000-10-09	Method of obtaining derivatives of quinazoline and novel intermediate compounds
PL337781A1 (en)	2000-09-11	Antagonists and reverse antagonists of glucogene
HUP0102094A3 (en)	2002-06-28	Bicyclic hydroxamic acid derivatives
PL356769A1 (en)	2004-07-12	Novel heterocyclic compounds and salts thereof and medicinal use of the same
PL342500A1 (en)	2001-06-04	Derivatives of pyrolydin-3-carboxylic acid and their application as endothelin antagonists
PL342817A1 (en)	2001-07-02	Novel derivatives of dihydroxyhexanic acid
HUP0100597A3 (en)	2001-12-28	Hydroxamic and carboxylic acid derivatives
PL340461A1 (en)	2001-02-12	Derivatives of isothiazocarboxylic acid
IL139884A0 (en)	2002-02-10	N-substituted derivatives of 5-oximinobarbituric acid
HUP0001772A3 (en)	2002-03-28	Feed additives containing panthoten-acid or their salts and method of manufacture
PL341221A1 (en)	2001-03-26	Derivatives of phenylaminoalkyl carboxylic acid and pharmacological compositions containing them
HUP0202283A3 (en)	2003-10-28	Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates
PL333079A1 (en)	1999-11-08	Piparazinic derivatives as antagonists of neurokinin
GB9813679D0 (en)	1998-08-26	Improved structure of toothbrush
EG22273A (en)	2002-12-31	Production of polyamides
HUP0103309A3 (en)	2002-04-29	Novel salts of n-tert-butylhydroxylamine and preparation thereof
HUP0201729A3 (en)	2005-01-28	Inhibitors of the integrin alpha v betha 6
HUP0103947A3 (en)	2002-06-28	Novel methanesulfonate salts of pyridopyrazine compound and crystals thereof and their pharmaceutical use
PL328221A1 (en)	1999-03-01	Novel derivatives of urea
HUP0100957A3 (en)	2002-03-28	5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same, their use and pharmaceutical compositions containing them
GB0014109D0 (en)	2000-08-02	Monitoring of use restricted parking areas
HUP0201610A2 (en)	2002-10-28	Derivatives of 4'-demycarosyl-8a-aza-8a-homotylosin