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PE20140146A1 - Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak - Google Patents

Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak

Info

Publication number
PE20140146A1
PE20140146A1 PE2013001220A PE2013001220A PE20140146A1 PE 20140146 A1 PE20140146 A1 PE 20140146A1 PE 2013001220 A PE2013001220 A PE 2013001220A PE 2013001220 A PE2013001220 A PE 2013001220A PE 20140146 A1 PE20140146 A1 PE 20140146A1
Authority
PE
Peru
Prior art keywords
cyclobutyl
alkyl
pyrrolopyrimidine
substituted
cyanomethyl
Prior art date
Application number
PE2013001220A
Other languages
English (en)
Inventor
James D Rodgers
Stacey Shepard
Wenyu Zhu
Lixin Shao
Joseph Glenn
Original Assignee
Incyte Corp
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Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PE20140146A1 publication Critical patent/PE20140146A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRROLOPIRIDINA Y PIRROLOPIRIMIDINA SUSTITUIDOS CON CICLOBUTILO DE FORMULA (I) DONDE X Y W SON CADA UNO CH O N; Y ES H, CN, ALQUILO(C1-C3), ENTRE OTROS; L ES O, S, C(=O), C(=O)O, ENTRE OTROS; Z ES CR4 O N; R1, R2, R3 Y R4 SON CADA UNO H, HIDROXI, HALO, ALQUILO(C1-C3), ENTRE OTROS; R5 ES HIDROXI, ALCOXI(C1-C4), F, ALQUILO(C1-C4), ENTRE OTROS; A ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C10), ARILO(C6-C10), ENTRE OTROS; m ES DE 0 A 2; n ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: 3-[(4-{3-(CIANOMETIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]CICLOBUTIL}PIPERAZIN-1-IL)METIL]-5-FLUOROBENZONITRILO; 3-[(4-{3-(CIANOMETIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]CICLOBUTIL}PIPERAZIN-1-IL)METIL]-6-(DIMETILAMINO)-2-FLUOROBENZONITRILO; 4-{3-(CIANOMETIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]CICLOBUTIL}-N-[4-FLUORO-2-(TRIFLUOROMETIL)FENIL]PIPERAZIN-1-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE JANUS QUINASAS (JAK) SIENDO UTILES EN EL TRATAMIENTO DE ESCLEROSIS MULTIPLE, ARTRITIS REUMATOIDE, CANCER, MIELOFIBROSIS
PE2013001220A 2010-11-19 2011-11-18 Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak PE20140146A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41570510P 2010-11-19 2010-11-19

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PE20140146A1 true PE20140146A1 (es) 2014-02-06

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PE2013001220A PE20140146A1 (es) 2010-11-19 2011-11-18 Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak

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US (3) US8933085B2 (es)
EP (1) EP2640723A1 (es)
JP (1) JP5917545B2 (es)
KR (1) KR20140019300A (es)
CN (1) CN103415515B (es)
AR (1) AR083933A1 (es)
AU (1) AU2011329734B2 (es)
BR (1) BR112013012502A2 (es)
CA (1) CA2818542A1 (es)
CL (1) CL2013001412A1 (es)
CO (1) CO6761386A2 (es)
CR (1) CR20130280A (es)
EA (1) EA026201B1 (es)
EC (1) ECSP13012703A (es)
IL (1) IL226407A (es)
MX (1) MX344478B (es)
NZ (1) NZ611151A (es)
PE (1) PE20140146A1 (es)
PH (1) PH12013501001A1 (es)
SG (1) SG190839A1 (es)
TW (1) TW201249845A (es)
UA (1) UA113156C2 (es)
WO (1) WO2012068450A1 (es)

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