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PE20091158A1 - 5-anilinoimidazopiridinas y metodos de uso - Google Patents

5-anilinoimidazopiridinas y metodos de uso

Info

Publication number
PE20091158A1
PE20091158A1 PE2008002130A PE2008002130A PE20091158A1 PE 20091158 A1 PE20091158 A1 PE 20091158A1 PE 2008002130 A PE2008002130 A PE 2008002130A PE 2008002130 A PE2008002130 A PE 2008002130A PE 20091158 A1 PE20091158 A1 PE 20091158A1
Authority
PE
Peru
Prior art keywords
halo
alkyl
fluor
imidazo
pyridin
Prior art date
Application number
PE2008002130A
Other languages
English (en)
Inventor
Stephen Price
Robert Heald
Wendy Lee
Mark E Zak
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20091158A1 publication Critical patent/PE20091158A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 5-ANILINOIMIDAZOPIRIDINAS DE FORMULA (I) DONDE Z1 ES CR1 O N; R1 Y R1' SON CADA UNO H, HALO, ALQUILO(C1-C3), CF3, ENTRE OTROS; Z2 ES CR2 O N; Z3 ES CR3 O N, SIEMPRE QUE SOLO UNO DE Z1, Z2 Y Z3 SEA N; R2 Y R3 SON CADA UNO H, HALO, CN, CF3, OCF3, ENTRE OTROS; R4 ES H, ALQUILO(C1-C6) O CARBOCICLILO(C3-C4); Y ES W-C(O)- O W', DONDE W ES X1-N(R5)- O R11'-O-, EN DONDE R5 ES H O ALQUILO(C1-C12); X1 ES R11' O -OR11'; R11' ES H, ALQUILO(C1-C12), ALQUENILO(C2-C8), ENTRE OTROS; W' ES UN COMPUESTO DE FORMULA (i), (ii), ENTRE OTROS, DONDE R7 ES HALO, CN, CF3, ENTRE OTROS; R8 ES ALQUILO(C1-C12), ARILO, ENTRE OTROS; Het ES HETEROARILO; X4 ES (a), EN DONDE R6 ES H, HALO, -OCF3, ENTRE OTROS; R6' ES H, HALO, NO2, ENTRE OTROS; p ES DE 0 A 3. SON COMPUESTOS PREFERIDOS: (2-HIDROXIETOXI)-AMIDA DEL ACIDO 5-(2-FLUOR-4-YODOFENILAMINO)-IMIDAZO[1,5-a]PIRIDIN-6-CARBOXILICO, ((R)-2,3-DIHIDROXI-PROPOXI)-AMIDA DEL ACIDO 5-(2-FLUOR-4-YODO-FENILAMINO)-IMIDAZO[1,5-a]PIRIDIN-6-CARBOXILICO, ((S)-2-HIDROXI-PROPOXI)-AMIDA DEL ACIDO 5-(2-FLUOR-4-YODO-FENILAMINO)-IMIDAZO[1,5-a]PIRIDIN-6-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE MEK QUINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCER AL PULMON, LEUCEMIA, ARTRITIS REUMATOIDEA
PE2008002130A 2007-12-19 2008-12-18 5-anilinoimidazopiridinas y metodos de uso PE20091158A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1512907P 2007-12-19 2007-12-19
US5401408P 2008-05-16 2008-05-16

Publications (1)

Publication Number Publication Date
PE20091158A1 true PE20091158A1 (es) 2009-08-28

Family

ID=40350172

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2013000381A PE20131210A1 (es) 2007-12-19 2008-12-18 Derivados de 5-anilinoimidazopiridina como inhibidores de mek
PE2008002130A PE20091158A1 (es) 2007-12-19 2008-12-18 5-anilinoimidazopiridinas y metodos de uso

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2013000381A PE20131210A1 (es) 2007-12-19 2008-12-18 Derivados de 5-anilinoimidazopiridina como inhibidores de mek

Country Status (27)

Country Link
US (4) US7923456B2 (es)
EP (2) EP2222675B1 (es)
JP (1) JP5421925B2 (es)
KR (1) KR101195329B1 (es)
CN (1) CN101945870B (es)
AR (1) AR069803A1 (es)
AU (1) AU2008343065B2 (es)
BR (1) BRPI0819529A2 (es)
CA (1) CA2706571C (es)
CL (1) CL2008003810A1 (es)
CY (2) CY1114663T1 (es)
DK (2) DK2222675T3 (es)
ES (2) ES2437141T3 (es)
HR (1) HRP20151002T1 (es)
HU (1) HUE025192T2 (es)
IL (1) IL205977A (es)
MX (1) MX2010006800A (es)
MY (1) MY158829A (es)
NZ (1) NZ586802A (es)
PE (2) PE20131210A1 (es)
PL (2) PL2690101T3 (es)
PT (2) PT2690101E (es)
RU (1) RU2441004C1 (es)
SI (2) SI2222675T1 (es)
TW (1) TWI441820B (es)
WO (1) WO2009085983A1 (es)
ZA (1) ZA201003625B (es)

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