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PE20140832A1 - Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak - Google Patents

Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak

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Publication number
PE20140832A1
PE20140832A1 PE2013002852A PE2013002852A PE20140832A1 PE 20140832 A1 PE20140832 A1 PE 20140832A1 PE 2013002852 A PE2013002852 A PE 2013002852A PE 2013002852 A PE2013002852 A PE 2013002852A PE 20140832 A1 PE20140832 A1 PE 20140832A1
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PE
Peru
Prior art keywords
alkyl
carboxamide
pyridyl
derivatives
jak inhibitors
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Application number
PE2013002852A
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English (en)
Inventor
Wenqing Yao
David M Burns
Jincong Zhuo
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Incyte Corp
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Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PE20140832A1 publication Critical patent/PE20140832A1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE AZETIDINIL FENIL, PIRIDIL O PIRAZINIL CARBOXAMIDA DE FORMULA (I) DONDE X ES N O CR4, EN DONDE R4 ES H, F, Cl, CN, ENTRE OTROS; W ES N O CR6, EN DONDE R6 ES H, F, ALQUILO(C1-C3), ENTRE OTROS; Y ES N O CR7, EN DONDE R7 ES H, Cl, -CH2CN, ENTRE OTROS; R1 ES ALQUILO(C1-C6), CICLOALQUILO(C3-C6), HETEROCICLOALQUILO DE 4 A 6 MIEMBROS, ENTRE OTROS; R2 ES H O ALQUILO(C1-C3); R3 ES H, F, CN, -OCF3, ENTRE OTROS; R5 ES H, ALQUILO(C1-C3), -O-ALQUILO(C1-C3), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-{3-(CIANOMETIL)-3-[4-(1H-PIRROLO[2,3-b]PIRIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-1-IL}-N-ISOPROPILBENZAMIDA; 5-{3-(CIANOMETIL)-3-[4-(1H-PIRROLO[2,3-b]PIRIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-1-IL}-N-[(1S)-1-CICLOPROPILETIL]PIRIDINA-2-CARBOXAMIDA; 4-{3-(CIANOMETIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-1-IL}-3-FLUORO-N-ISOPROPILBENZAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA CINASA JANUS (JAK) SIENDO UTILES EN EL TRATAMIENTO DE ESCLEROSIS MULTIPLE, ARTRITIS REUMATOIDE, LUPUS, DERMATITIS ATOPICA
PE2013002852A 2011-06-20 2012-06-19 Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak PE20140832A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161498942P 2011-06-20 2011-06-20
US201261591094P 2012-01-26 2012-01-26

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PE20140832A1 true PE20140832A1 (es) 2014-07-14

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US (5) US8691807B2 (es)
EP (1) EP2721028B1 (es)
JP (1) JP5876146B2 (es)
KR (1) KR20140040819A (es)
CN (1) CN103797010B (es)
AR (1) AR086983A1 (es)
AU (1) AU2012273164B2 (es)
BR (1) BR112013032720A2 (es)
CA (1) CA2839767A1 (es)
CL (1) CL2013003647A1 (es)
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EA (1) EA201490042A1 (es)
EC (1) ECSP14013148A (es)
ES (1) ES2560611T3 (es)
IL (1) IL230008A (es)
MX (1) MX344479B (es)
MY (1) MY165963A (es)
PE (1) PE20140832A1 (es)
PH (1) PH12013502612A1 (es)
TW (1) TWI577676B (es)
WO (1) WO2012177606A1 (es)

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