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PE20110387A1 - Aminotriazolo-piridinas como inhibidores de cinasa - Google Patents

Aminotriazolo-piridinas como inhibidores de cinasa

Info

Publication number
PE20110387A1
PE20110387A1 PE2011000599A PE2011000599A PE20110387A1 PE 20110387 A1 PE20110387 A1 PE 20110387A1 PE 2011000599 A PE2011000599 A PE 2011000599A PE 2011000599 A PE2011000599 A PE 2011000599A PE 20110387 A1 PE20110387 A1 PE 20110387A1
Authority
PE
Peru
Prior art keywords
pyran
tetrahydro
methyl
triazolo
pyridin
Prior art date
Application number
PE2011000599A
Other languages
English (en)
Inventor
Sogole Bahmanyar
R J Bates
Kate Blease
Thomas Oran Daniel
Jan Elsner
Paul Erdman
Bruce Fahr
Gregory Fergunson
Branden Lee
Lisa Nadolny
Garrick Packard
Patrick Papa
Jennifer Riggs
Patricia Rohane
John Sapienza
Victor Sloan
Randall Stevens
Lida Tehrani
Jayashree Tikhe
Eduardo Torres
Brandon Wade Whitefield
Jingjing Zhao
Andrew Antony Calabrese
Mercedes Delgado
Veronique Plantevin-Krenitsky
Yoshitaka Satoh
Andrew Wallace
Sabita Sankar
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41228355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110387(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of PE20110387A1 publication Critical patent/PE20110387A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE AMINOTRIAZOLOPIRIDINAS DE FORMULA (I) DONDE R1 ES ARILO(C6-C14) O HETEROCICLILO DE 3 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDOS; R2 ES ALQUILO(C1-C8), CICLOALQUILO(C3-C10), NR3R4, ENTRE OTROS, EN DONDE R3 Y R4 SON CADA UNO H, ALQUILO(C1-C8), ARILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-METIL-N3-(TETRAHIDRO-2H-PIRAN-4-IL)-N6-(5-((TETRAHIDRO-2H-PIRAN-4-IL)METIL)-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-2-IL)-1H-INDAZOL-3,6-DIAMINA; N3-(TETRAHIDRO-2H-PIRAN-4-IL)-N6-(5-((TETRAHIDRO-2H-PIRAN-4-IL)METIL)-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-2-IL)-1H-INDAZOL-3,6-DIAMINA; 1-METIL-N3-(PIPERIDIN-4-IL)-N6-(5-((TETRAHIDRO-2H-PIRAN-4-IL)-METIL)-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-2-IL)-1H-INDAZOL-3,6-DIAMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA Syk, FLT3, JAK1 O JAK2 SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, LUPUS, ESCLEROSIS MULTIPLE, CANCER
PE2011000599A 2008-09-08 2009-09-08 Aminotriazolo-piridinas como inhibidores de cinasa PE20110387A1 (es)

Applications Claiming Priority (2)

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US9521708P 2008-09-08 2008-09-08
US23047909P 2009-07-31 2009-07-31

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PE20110387A1 true PE20110387A1 (es) 2011-06-22

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PE2011000599A PE20110387A1 (es) 2008-09-08 2009-09-08 Aminotriazolo-piridinas como inhibidores de cinasa

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US (2) US8299056B2 (es)
EP (1) EP2344494B1 (es)
JP (1) JP5689060B2 (es)
KR (1) KR20110053266A (es)
CN (2) CN104910148B (es)
AU (1) AU2009288618B2 (es)
BR (1) BRPI0918854A2 (es)
CA (1) CA2735806A1 (es)
CL (1) CL2011000480A1 (es)
CO (1) CO6531502A2 (es)
CR (1) CR20110132A (es)
EC (1) ECSP11010945A (es)
ES (1) ES2581565T3 (es)
IL (1) IL211549A (es)
MX (1) MX2011002536A (es)
NI (1) NI201100048A (es)
NZ (1) NZ591551A (es)
PE (1) PE20110387A1 (es)
RU (1) RU2552642C2 (es)
TW (1) TWI453207B (es)
WO (1) WO2010027500A1 (es)
ZA (1) ZA201101586B (es)

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