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PE20040522A1 - Derivados de diarilurea dependientes de la cinasa de proteina - Google Patents

Derivados de diarilurea dependientes de la cinasa de proteina

Info

Publication number
PE20040522A1
PE20040522A1 PE2003000513A PE2003000513A PE20040522A1 PE 20040522 A1 PE20040522 A1 PE 20040522A1 PE 2003000513 A PE2003000513 A PE 2003000513A PE 2003000513 A PE2003000513 A PE 2003000513A PE 20040522 A1 PE20040522 A1 PE 20040522A1
Authority
PE
Peru
Prior art keywords
phenyl
protein kinase
dependent
pyridin
oxy
Prior art date
Application number
PE2003000513A
Other languages
English (en)
Inventor
Paul William Manley
Guido Bold
Eugen Boss
Andrea Vaupel
Vito Guagnano
Andreas Floersheimer
Pascal Furet
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0212413A external-priority patent/GB0212413D0/en
Priority claimed from GB0305684A external-priority patent/GB0305684D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20040522A1 publication Critical patent/PE20040522A1/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DERIVADO DE DIARILUREA, DONDE G NO ESTA PRESENTE O ES ALQUILENO INFERIOR, CICLOALQUILENO C3-C5, ENTE OTROS; Z ES (A), (B); A ES CH, N O NàO; A' ES N O NàO CON LA CONDICION DE QUE NO MAS DE UNO DE A Y A' PUEDE SER Nà O; n ES 1 O 2; m ES 0, 1, O 2; p ES 0, 2 O 3; r ES DE 0 A 5; X ES N, NH, CH2, ENTRE OTROS; Y1 ES O, S, CH2; Y2 ES O, S, NH; R1, R2 Y R3 SON CADA UNO H, METILO, PROPILO, ENTRE OTROS; R4 ES METILO, METOXILO, p-HIDROXIFENILAMINO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-(4-PIRIDIN-4-IL-OXI-FENIL)-N'-(4-ETIL-FENIL)-UREA; N-(4-PIRIDIN-4-IL-OXI-FENIL)-N'-(3-TRIFLUOROMETIL-FENIL)-UREA; N-(4-PIRIDIN-4-IL-OXI-FENIL)-N'-(4-(2,2,2-TRIFLUOROETOXI)-3-TRIFLUOROMETILFENIL-FENIL)-UREA. SE REFIERE TAMBIEN A UNA PREPARACION FARMACEUTICA UTIL EN EL TRATAMIENTO DE ENFERMEDADES DEPENDIENTES DE LA CINASA DE PROTEINA
PE2003000513A 2002-05-29 2003-05-27 Derivados de diarilurea dependientes de la cinasa de proteina PE20040522A1 (es)

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WO2003099771A3 (en) 2004-04-01
IL164784A0 (en) 2005-12-18
AR037647A1 (es) 2004-12-01
KR101036394B1 (ko) 2011-05-23
AU2003242591A1 (en) 2003-12-12
EP1511730B8 (en) 2009-04-08
KR20050006281A (ko) 2005-01-15
JP4608312B2 (ja) 2011-01-12
US20060128734A1 (en) 2006-06-15
BR0311313A (pt) 2005-02-15
NZ536781A (en) 2007-12-21
MXPA04011789A (es) 2005-03-31
PL372426A1 (en) 2005-07-25
WO2003099771A2 (en) 2003-12-04
CA2484288A1 (en) 2003-12-04
TW200406374A (en) 2004-05-01
CN1656073A (zh) 2005-08-17
US7652022B2 (en) 2010-01-26
ATE417037T1 (de) 2008-12-15
PT1511730E (pt) 2009-02-18
NO20045521L (no) 2004-12-17
CN1656073B (zh) 2010-05-26
EP1511730A2 (en) 2005-03-09
AU2003242591B2 (en) 2007-07-26
DE60325209D1 (de) 2009-01-22
JP2005527622A (ja) 2005-09-15
ES2318158T3 (es) 2009-05-01

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