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EA201190303A1 - ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-а]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРЕДУПРЕЖДЕНИЯ НЕВРОЛОГИЧЕСКИХ И ПСИХИАТРИЧЕСКИХ РАССТРОЙСТВ - Google Patents

ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-а]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРЕДУПРЕЖДЕНИЯ НЕВРОЛОГИЧЕСКИХ И ПСИХИАТРИЧЕСКИХ РАССТРОЙСТВ

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Publication number
EA201190303A1
EA201190303A1 EA201190303A EA201190303A EA201190303A1 EA 201190303 A1 EA201190303 A1 EA 201190303A1 EA 201190303 A EA201190303 A EA 201190303A EA 201190303 A EA201190303 A EA 201190303A EA 201190303 A1 EA201190303 A1 EA 201190303A1
Authority
EA
Eurasian Patent Office
Prior art keywords
neurological
compounds
psychiatric disorders
prevention
treatment
Prior art date
Application number
EA201190303A
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English (en)
Other versions
EA020672B1 (ru
Inventor
Хосе Мария Сид-Нуньес
Даниель Оелрик
Андрес Авелино Трабанко-Суарес
Гэри Джон Тресадерн
Хуан Антонио Вега Рамиро
Грегор Джеймс Макдональд
Original Assignee
Янссен Фармасьютикалс, Инк.
Аддекс Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Янссен Фармасьютикалс, Инк., Аддекс Фарма С.А. filed Critical Янссен Фармасьютикалс, Инк.
Publication of EA201190303A1 publication Critical patent/EA201190303A1/ru
Publication of EA020672B1 publication Critical patent/EA020672B1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Pyridine Compounds (AREA)

Abstract

Настоящее изобретение относится к новым производным триазоло[4,3-а]пиридина формулы (I)где все радикалы являются такими, как они определены в формуле изобретения. Соединения по изобретению являются положительными аллостерическими модуляторами метаботропного глутаматного рецептора подтипа 2 ("mGluR2"), которые являются полезными для лечения или предупреждения неврологических и психиатрических расстройств, ассоциированных с глутаматной дисфункцией и заболеваниями, в которые вовлечен mGluR2-подтип метаботропных рецепторов. Изобретение также относится к фармацевтическим композициям, содержащим такие соединения, к способам получения таких соединений и композиций и к применению таких соединений для предупреждения или лечения неврологических и психиатрических расстройств и заболеваний, в которые вовлечен mGluR2.
EA201190303A 2009-05-12 2010-05-11 Производные 1,2,4-триазоло[4,3-a]пиридина и их применение для лечения или предупреждения неврологических и психиатрических расстройств EA020672B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09160059 2009-05-12
PCT/EP2010/002910 WO2010130424A1 (en) 2009-05-12 2010-05-11 1,2,3-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders

Publications (2)

Publication Number Publication Date
EA201190303A1 true EA201190303A1 (ru) 2012-06-29
EA020672B1 EA020672B1 (ru) 2014-12-30

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ID=41429238

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EA201190303A EA020672B1 (ru) 2009-05-12 2010-05-11 Производные 1,2,4-триазоло[4,3-a]пиридина и их применение для лечения или предупреждения неврологических и психиатрических расстройств

Country Status (31)

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US (4) US8937060B2 (ru)
EP (1) EP2430022B1 (ru)
JP (1) JP5634506B2 (ru)
KR (1) KR101753826B1 (ru)
CN (1) CN102439008B (ru)
AR (1) AR076861A1 (ru)
AU (1) AU2010246609B2 (ru)
BR (1) BRPI1012870B8 (ru)
CA (1) CA2760741C (ru)
CL (1) CL2011002838A1 (ru)
CY (1) CY1114718T1 (ru)
DK (1) DK2430022T3 (ru)
EA (1) EA020672B1 (ru)
ES (1) ES2440001T3 (ru)
HR (1) HRP20131122T1 (ru)
IL (1) IL215912A (ru)
JO (1) JO2907B1 (ru)
ME (1) ME01573B (ru)
MX (1) MX2011011964A (ru)
MY (1) MY161325A (ru)
NZ (1) NZ596078A (ru)
PL (1) PL2430022T3 (ru)
PT (1) PT2430022E (ru)
RS (1) RS53075B (ru)
SG (2) SG176021A1 (ru)
SI (1) SI2430022T1 (ru)
SM (1) SMT201400003B (ru)
TW (1) TWI468406B (ru)
UA (1) UA108070C2 (ru)
WO (1) WO2010130424A1 (ru)
ZA (1) ZA201107834B (ru)

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RU2696135C2 (ru) * 2014-08-01 2019-07-31 Янссен Фармацевтика Нв 6,7-ДИГИДРОПИРАЗОЛО[1,5-α]ПИРАЗИН-4(5Н)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ MGLUR2

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