CN1365701A - Nano 25-component tophus medicine and its preparing process - Google Patents
Nano 25-component tophus medicine and its preparing process Download PDFInfo
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- CN1365701A CN1365701A CN 01100644 CN01100644A CN1365701A CN 1365701 A CN1365701 A CN 1365701A CN 01100644 CN01100644 CN 01100644 CN 01100644 A CN01100644 A CN 01100644A CN 1365701 A CN1365701 A CN 1365701A
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Abstract
A nanometre 25-component tophus medicine is prepared from the nanometre powders of 25 Chinese medicinal materials including tophus, pearl, coral, cinnabar, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages include high biological utilization rate and high curative effect.
Description
The art invention relates to a kind of heat-clearing and toxic substances removing, depressed liver-energy dispersing and function of gallbladder promoting, blood stasis dispelling, cures mainly stagnation of QI due to depression of the liver, blood stasis, liver poisoning, liver pain, liver cirrhosis, the nano 25-component tophus medicine of liver infiltration and various acute and chronic hepatitis and cholecystitis the invention still further relates to the method for this medication preparation.
25-component tophus ball is a kind of classical Chinese patent medicine, mainly contains effects such as heat-clearing and toxic substances removing, depressed liver-energy dispersing and function of gallbladder promoting, blood stasis dispelling, is used for stagnation of QI due to depression of the liver, blood stasis, liver poisoning, liver pain, liver cirrhosis, liver infiltration and various acute and chronic hepatitis and cholecystitis.But traditional 25-component tophus ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano 25-component tophus medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano 25-component tophus medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer tophus 35-70 part nano-pearl 6-15 part nanometer Corallium Japonicum Kishinouye 30-50 part
Nanometer Cinnabaris 10-35 part nanometer Fructus Chebulae (enucleation) 35-70 part nanometer iron filings (Fructus Chebulae's system) 60-150 part
Nanometer Fructus Phyllanthi 30-80 part nanometer Oletum Trogopterori paste 30-55 part nanometer Lignum Santali Albi 30-55 part
Nanometer Lignum Dalbergiae Odoriferae 30-55 part nanometer Radix Aucklandiae Fructus Aristolochiae 35-80 part nanometer Adhatoda vasica Nees 35-80 part
Nano bezoar 3-8 part nanometer Radix Aucklandiae (Radix Vladimiriae) 40-80 part nanometer Herba meconopsis integrifoliae 30-80 part
Nanometer Herba Aconiti bonga 30-55 part nanometer Semen Myristicae 10-35 part nano clove 15-40 part
Nanometer pectinate rockfoil 35-80 part nanometer Fructus Terminaliae Billericae (enucleation) 3-8 part nanometer Concretio Silicea Bambusae 25-50 part
Nanometer Stigma Croci 2-8 part nanometer Flos Bombacis Malabarici 25-48 part nano musk 0.2-1.5 part
Nanometer Tufa 25-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer tophus 40-60 part nano-pearl 8-12 part nanometer Corallium Japonicum Kishinouye 35-45 part
Nanometer Cinnabaris 15-25 part nanometer Fructus Chebulae (enucleation) 40-60 part nanometer iron filings (Fructus Chebulae's system) 80-120 part
3545 parts of nanometer Lignum Santali Albis of nanometer Fructus Phyllanthi 40-60 part nanometer Oletum Trogopterori paste 35-45 part
Nanometer Lignum Dalbergiae Odoriferae 35-45 part nanometer Radix Aucklandiae Fructus Aristolochiae 40-60 part nanometer Adhatoda vasica Nees 40-60 part
Nano bezoar 4-6 part nanometer Radix Aucklandiae (Radix Vladimiriae) 50-70 part nanometer Herba meconopsis integrifoliae 40-60 part
Nanometer Herba Aconiti bonga 32-48 part nanometer Semen Myristicae 15-25 part nano clove 20-35 part
Nanometer pectinate rockfoil 40-60 part nanometer Fructus Terminaliae Billericae (enucleation) 4-6 part nanometer Concretio Silicea Bambusae 30-40 part
Nanometer Stigma Croci 4-6 part nanometer Flos Bombacis Malabarici 30-40 part nano musk 0.2-0.5 part
Nanometer Tufa 30-40 part
The optimum weight proportioning of medicine of the present invention is:
40 parts on 10 parts of nanometer Corallium Japonicum Kishinouyes of 50 parts of nano-pearls of nanometer tophus
100 parts of 50 parts of nanometer iron filings of 20 parts of nanometer Fructus Chebulaes of nanometer Cinnabaris (enucleation) (Fructus Chebulae's system)
40 parts in 40 parts of nanometer Lignum Santali Albis of 50 parts of nanometer Oletum Trogopterori pastes of nanometer Fructus Phyllanthi
50 parts of 50 parts of nanometer Adhatoda vasica Neess of 40 parts of nanometer Radix Aucklandiae of nanometer Lignum Dalbergiae Odoriferae Fructus Aristolochiae
50 parts of 60 parts of nanometer Herba meconopsis integrifoliae of 5 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of nano bezoar
25 parts of 20 parts of nano cloves of 40 parts of nanometer Semen Myristicaes of nanometer Herba Aconiti bonga
35 parts of 5 parts of nanometer Concretio Silicea Bambusaes of 50 parts of Fructus Terminaliae Billericaees of nanometer pectinate rockfoil (enucleation)
0.25 part of 35 parts of nano musk of 5 parts of nanometer Flos Bombacis Malabaricis of nanometer Stigma Croci
35 parts of nanometer Tufas
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 25-component tophus nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano 25-component tophus medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common 25-component tophus pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano 25-component tophus medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for stagnation of QI due to depression of the liver, blood stasis, and liver poisoning, liver pain, liver cirrhosis, liver infiltration and treatment of conditions such as various acute and chronic hepatitis and cholecystitis, clinical efficacy significantly is better than traditional 25-component tophus ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
40 parts on 10 parts of nanometer Corallium Japonicum Kishinouyes of 50 parts of nano-pearls of nanometer tophus
100 parts of 50 parts of nanometer iron filings of 20 parts of nanometer Fructus Chebulaes of nanometer Cinnabaris (enucleation) (Fructus Chebulae's system)
40 parts in 40 parts of nanometer Lignum Santali Albis of 50 parts of nanometer Oletum Trogopterori pastes of nanometer Fructus Phyllanthi
50 parts of 50 parts of nanometer Adhatoda vasica Neess of 40 parts of nanometer Radix Aucklandiae of nanometer Lignum Dalbergiae Odoriferae Fructus Aristolochiae
50 parts of 60 parts of nanometer Herba meconopsis integrifoliae of 5 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of nano bezoar
25 parts of 20 parts of nano cloves of 40 parts of nanometer Semen Myristicaes of nanometer Herba Aconiti bonga
35 parts of 5 parts of nanometer Concretio Silicea Bambusaes of 50 parts of Fructus Terminaliae Billericaees of nanometer pectinate rockfoil (enucleation)
0.25 part of 35 parts of nano musk of 5 parts of nanometer Flos Bombacis Malabaricis of nanometer Stigma Croci
35 parts of nanometer Tufas
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
40 parts on 10 parts of nanometer Corallium Japonicum Kishinouyes of 50 parts of nano-pearls of nanometer tophus
100 parts of 50 parts of nanometer iron filings of 20 parts of nanometer Fructus Chebulaes of nanometer Cinnabaris (enucleation) (Fructus Chebulae's system)
40 parts in 40 parts of nanometer Lignum Santali Albis of 50 parts of nanometer Oletum Trogopterori pastes of nanometer Fructus Phyllanthi
50 parts of 50 parts of nanometer Adhatoda vasica Neess of 40 parts of nanometer Radix Aucklandiae of nanometer Lignum Dalbergiae Odoriferae Fructus Aristolochiae
50 parts of 60 parts of nanometer Herba meconopsis integrifoliae of 5 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of nano bezoar
25 parts of 20 parts of nano cloves of 40 parts of nanometer Semen Myristicaes of nanometer Herba Aconiti bonga
35 parts of 5 parts of nanometer Concretio Silicea Bambusaes of 50 parts of Fructus Terminaliae Billericaees of nanometer pectinate rockfoil (enucleation)
0.25 part of 35 parts of nano musk of 5 parts of nanometer Flos Bombacis Malabaricis of nanometer Stigma Croci
35 parts of nanometer Tufas
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano 25-component tophus powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
40 parts on 10 parts of nanometer Corallium Japonicum Kishinouyes of 50 parts of nano-pearls of nanometer tophus
100 parts of 50 parts of nanometer iron filings of 20 parts of nanometer Fructus Chebulaes of nanometer Cinnabaris (enucleation) (Fructus Chebulae's system)
40 parts in 40 parts of nanometer Lignum Santali Albis of 50 parts of nanometer Oletum Trogopterori pastes of nanometer Fructus Phyllanthi
50 parts of 50 parts of nanometer Adhatoda vasica Neess of 40 parts of nanometer Radix Aucklandiae of nanometer Lignum Dalbergiae Odoriferae Fructus Aristolochiae
50 parts of 60 parts of nanometer Herba meconopsis integrifoliae of 5 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of nano bezoar
25 parts of 20 parts of nano cloves of 40 parts of nanometer Semen Myristicaes of nanometer Herba Aconiti bonga
35 parts of 5 parts of nanometer Concretio Silicea Bambusaes of 50 parts of Fructus Terminaliae Billericaees of nanometer pectinate rockfoil (enucleation)
0.25 part of 35 parts of nano musk of 5 parts of nanometer Flos Bombacis Malabaricis of nanometer Stigma Croci
35 parts of nanometer Tufas
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano 25-component tophus membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano 25-component tophus medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer tophus 35-70 part nano-pearl 6-15 part nanometer Corallium Japonicum Kishinouye 30-50 part
Nanometer Cinnabaris 10-35 part nanometer Fructus Chebulae (enucleation) 35-70 part nanometer iron filings (Fructus Chebulae's system) 60-150 part
Nanometer Fructus Phyllanthi 30-80 part nanometer Oletum Trogopterori paste 30-55 part nanometer Lignum Santali Albi 30-55 part
Nanometer Lignum Dalbergiae Odoriferae 30-55 part nanometer Radix Aucklandiae Fructus Aristolochiae 35-80 part nanometer Adhatoda vasica Nees 35-80 part
Nano bezoar 3-8 part nanometer Radix Aucklandiae (Radix Vladimiriae) 40-80 part nanometer Herba meconopsis integrifoliae 30-80 part
Nanometer Herba Aconiti bonga 30-55 part nanometer Semen Myristicae 10-35 part nano clove 15-40 part
Nanometer pectinate rockfoil 35-80 part nanometer Fructus Terminaliae Billericae (enucleation) 3-8 part nanometer Concretio Silicea Bambusae 25-50 part
Nanometer Stigma Croci 2-8 part nanometer Flos Bombacis Malabarici 25-48 part nano musk 0.2-1.5 part
Nanometer Tufa 25-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano 25-component tophus medicine according to claim 1, wherein the weight proportion of each nano raw material is;
Nanometer tophus 40-60 part nano-pearl 8-12 part nanometer Corallium Japonicum Kishinouye 35-45 part
Nanometer Cinnabaris 15-25 part nanometer Fructus Chebulae (enucleation) 40-60 part nanometer iron filings (Fructus Chebulae's system) 80-120 part
Nanometer Fructus Phyllanthi 40-60 part nanometer Oletum Trogopterori paste 35-45 part nanometer Lignum Santali Albi 35-45 part
Nanometer Lignum Dalbergiae Odoriferae 35-45 part nanometer Radix Aucklandiae Fructus Aristolochiae 40-60 part nanometer Adhatoda vasica Nees 40-60 part
Nano bezoar 4-6 part nanometer Radix Aucklandiae (Radix Vladimiriae) 50-70 part nanometer Herba meconopsis integrifoliae 40-60 part
Nanometer Herba Aconiti bonga 32-48 part nanometer Semen Myristicae 15-25 part nano clove 20-35 part
Nanometer pectinate rockfoil 40-60 part nanometer Fructus Terminaliae Billericae (enucleation) 4-6 part nanometer Concretio Silicea Bambusae 30-40 part
Nanometer Stigma Croci 4-6 part nanometer Flos Bombacis Malabarici 30-40 part nano musk 0.2-0.5 part
Nanometer Tufa 30-40 part
3, nano 25-component tophus medicine according to claim 1, wherein the weight proportion of each nano raw material is:
40 parts on 10 parts of nanometer Corallium Japonicum Kishinouyes of 50 parts of nano-pearls of nanometer tophus
100 parts of 50 parts of nanometer iron filings of 20 parts of nanometer Fructus Chebulaes of nanometer Cinnabaris (enucleation) (Fructus Chebulae's system)
40 parts in 40 parts of nanometer Lignum Santali Albis of 50 parts of nanometer Oletum Trogopterori pastes of nanometer Fructus Phyllanthi
50 parts of 50 parts of nanometer Adhatoda vasica Neess of 40 parts of nanometer Radix Aucklandiae of nanometer Lignum Dalbergiae Odoriferae Fructus Aristolochiae
50 parts of 60 parts of nanometer Herba meconopsis integrifoliae of 5 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of nano bezoar
25 parts of 20 parts of nano cloves of 40 parts of nanometer Semen Myristicaes of nanometer Herba Aconiti bonga
35 parts of 5 parts of nanometer Concretio Silicea Bambusaes of 50 parts of Fructus Terminaliae Billericaees of nanometer pectinate rockfoil (enucleation)
0.25 part of 35 parts of nano musk of 5 parts of nanometer Flos Bombacis Malabaricis of nanometer Stigma Croci
35 parts of nanometer Tufas
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano 25-component tophus medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano 25-component tophus medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100644 CN1365701A (en) | 2001-01-15 | 2001-01-15 | Nano 25-component tophus medicine and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100644 CN1365701A (en) | 2001-01-15 | 2001-01-15 | Nano 25-component tophus medicine and its preparing process |
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| Publication Number | Publication Date |
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| CN1365701A true CN1365701A (en) | 2002-08-28 |
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| CN 01100644 Pending CN1365701A (en) | 2001-01-15 | 2001-01-15 | Nano 25-component tophus medicine and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225128A (en) * | 2011-06-23 | 2011-10-26 | 班登加措 | Tibetan medicine composite and application thereof in preparation of medicine for resisting heart cerebrovascular diseases and neurologic diseases |
-
2001
- 2001-01-15 CN CN 01100644 patent/CN1365701A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225128A (en) * | 2011-06-23 | 2011-10-26 | 班登加措 | Tibetan medicine composite and application thereof in preparation of medicine for resisting heart cerebrovascular diseases and neurologic diseases |
| CN102225128B (en) * | 2011-06-23 | 2012-06-13 | 班登加措 | Tibetan medicine composite and application thereof in preparation of medicine for resisting heart cerebrovascular diseases and neurologic diseases |
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