CN1365685A - Nano medicine for reating bone fracture and injury and its preparing process - Google Patents
Nano medicine for reating bone fracture and injury and its preparing process Download PDFInfo
- Publication number
- CN1365685A CN1365685A CN 01100628 CN01100628A CN1365685A CN 1365685 A CN1365685 A CN 1365685A CN 01100628 CN01100628 CN 01100628 CN 01100628 A CN01100628 A CN 01100628A CN 1365685 A CN1365685 A CN 1365685A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- parts
- nano
- chinese
- part nanometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 208000010392 Bone Fractures Diseases 0.000 title abstract 2
- 206010061363 Skeletal injury Diseases 0.000 title abstract 2
- 230000006378 damage Effects 0.000 title abstract 2
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 10
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 10
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 10
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 208000014674 injury Diseases 0.000 claims description 20
- 230000008736 traumatic injury Effects 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 19
- 210000000582 semen Anatomy 0.000 claims description 18
- 241000131329 Carabidae Species 0.000 claims description 9
- 241000903946 Clematidis Species 0.000 claims description 9
- 241000218176 Corydalis Species 0.000 claims description 9
- 241000234653 Cyperus Species 0.000 claims description 9
- 241000219061 Rheum Species 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241001237431 Anomala Species 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000010135 fructus aurantii immaturus Substances 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000080767 Areca catechu Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000202755 Areca Species 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre medicine for treating bone fracture and injury is prepared from the nanometre powders of 20 Chinese medicinal materials including rhubarb, safflower, Chinese angelica root, Chuan-xiong rhizome, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to the nanometer traumatic injury preparation medicine of a kind of circulation of qi promoting or blood, muscles and tendons relaxing to alleviate pain, the invention still further relates to the method for this medication preparation.
Traumatic injury pill is a kind of classical Chinese patent medicine, mainly contains circulation of qi promoting or effects such as blood, muscles and tendons relaxing to alleviate pain, is used for diseases such as traumatic injury.But traditional traumatic injury pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer traumatic injury preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer traumatic injury preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano rhubarb 100-250 part nanometer Herba Artemisiae Anomalae 50-120 part nano safflower 30-90 part
Nano Chinese angelica 30-90 part nano cyperus tuber 30-90 part nanometer Rhizoma Curcumae 30-90 part
Nanometer Pericarpium Citri Reticulatae Viride 30-90 part nanometer Fructus Aurantii Immaturus 30-90 part nanometer Rhizoma Chuanxiong 30-90 part
Nanometer Lignum Dalbergiae Odoriferae 25-55 part nanometer Radix Paeoniae Rubra 25-55 part nanometer Semen Arecae 25-55 part
Nanometer Pyritum 10-35 part nanometer Rhizoma Corydalis 10-30 part nanometer Radix Achyranthis Bidentatae 40-80 part
The sub-30-65 part of nanometer Semen Persicae 50-120 part nanometer Lignum Sappan 30-65 part nanometer ground beetle
Nanometer Radix Clematidis 20-60 part nanometer rhizoma sparganic 20-60 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano rhubarb 120-200 part nanometer Herba Artemisiae Anomalae 60-100 part nano safflower 40-80 part
Nano Chinese angelica 40-80 part nano cyperus tuber 40-80 part nanometer Rhizoma Curcumae 40-80 part
Nanometer Pericarpium Citri Reticulatae Viride 40-80 part nanometer Fructus Aurantii Immaturus 40-80 part nanometer Rhizoma Chuanxiong 40-80 part
Nanometer Lignum Dalbergiae Odoriferae 30-50 part nanometer Radix Paeoniae Rubra 30-50 part nanometer Semen Arecae 30-50 part
Nanometer Pyritum 15-25 part nanometer Rhizoma Corydalis 15-25 part nanometer Radix Achyranthis Bidentatae 50-70 part
The sub-35-50 part of nanometer Semen Persicae 60-100 part nanometer Lignum Sappan 35-55 part nanometer ground beetle
Nanometer Radix Clematidis 30-50 part nanometer rhizoma sparganic 30-50 part
The optimum weight proportioning of medicine of the present invention is:
60 parts of 80 parts of nano safflowers of 160 parts of nanometer Herba Artemisiae Anomalaes of nano rhubarb
40 parts of 60 parts of nanometer Rhizoma Curcumae of 60 parts of nano cyperus tubers of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Chuanxiongs of 40 parts of nanometer Fructus Aurantii Immaturuss of nanometer Pericarpium Citri Reticulatae Viride
40 parts of 40 portions of nanometer Semen Arecaes of 40 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
60 parts of 20 parts of nanometer Radix Achyranthis Bidentataes of 20 parts of nanometer Rhizoma Corydalis of nanometer Pyritum
40 parts of 40 parts of nanometer ground beetle of 80 parts of nanometer Lignum Sappans of nanometer Semen Persicae
40 parts of 40 parts of nanometer rhizoma sparganic of nanometer Radix Clematidis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100mm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get traumatic injury preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer traumatic injury preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common traumatic injury pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer traumatic injury preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as traumatic injury, and clinical efficacy significantly is better than traditional traumatic injury pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 80 parts of nano safflowers of 160 parts of nanometer Herba Artemisiae Anomalaes of nano rhubarb
40 parts of 60 parts of nanometer Rhizoma Curcumae of 60 parts of nano cyperus tubers of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Chuanxiongs of 40 parts of nanometer Fructus Aurantii Immaturuss of nanometer Pericarpium Citri Reticulatae Viride
40 parts of 40 portions of nanometer Semen Arecaes of 40 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
60 parts of 20 parts of nanometer Radix Achyranthis Bidentataes of 20 parts of nanometer Rhizoma Corydalis of nanometer Pyritum
40 parts of 40 parts of nanometer ground beetle of 80 parts of nanometer Lignum Sappans of nanometer Semen Persicae
40 parts of 40 parts of nanometer rhizoma sparganic of nanometer Radix Clematidis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
60 parts of 80 parts of nano safflowers of 160 parts of nanometer Herba Artemisiae Anomalaes of nano rhubarb
40 parts of 60 parts of nanometer Rhizoma Curcumae of 60 parts of nano cyperus tubers of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Chuanxiongs of 40 parts of nanometer Fructus Aurantii Immaturuss of nanometer Pericarpium Citri Reticulatae Viride
40 parts of 40 portions of nanometer Semen Arecaes of 40 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
60 parts of 20 parts of nanometer Radix Achyranthis Bidentataes of 20 parts of nanometer Rhizoma Corydalis of nanometer Pyritum
40 parts of 40 parts of nanometer ground beetle of 80 parts of nanometer Lignum Sappans of nanometer Semen Persicae
40 parts of 40 parts of nanometer rhizoma sparganic of nanometer Radix Clematidis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer traumatic injury powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
60 parts of 80 parts of nano safflowers of 160 parts of nanometer Herba Artemisiae Anomalaes of nano rhubarb
40 parts of 60 parts of nanometer Rhizoma Curcumae of 60 parts of nano cyperus tubers of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Chuanxiongs of 40 parts of nanometer Fructus Aurantii Immaturuss of nanometer Pericarpium Citri Reticulatae Viride
40 parts of 40 portions of nanometer Semen Arecaes of 40 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
60 parts of 20 parts of nanometer Radix Achyranthis Bidentataes of 20 parts of nanometer Rhizoma Corydalis of nanometer Pyritum
40 parts of 40 parts of nanometer ground beetle of 80 parts of nanometer Lignum Sappans of nanometer Semen Persicae
40 parts of 40 parts of nanometer rhizoma sparganic of nanometer Radix Clematidis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer traumatic injury membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nanometer traumatic injury preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano rhubarb 100-250 part nanometer Herba Artemisiae Anomalae 50-120 part nano safflower 30-90 part
Nano Chinese angelica 30-90 part nano cyperus tuber 30-90 part nanometer Rhizoma Curcumae 30-90 part
Nanometer Pericarpium Citri Reticulatae Viride 30-90 part nanometer Fructus Aurantii Immaturus 30-90 part nanometer Rhizoma Chuanxiong 30-90 part
Nanometer Lignum Dalbergiae Odoriferae 25-55 part nanometer Radix Paeoniae Rubra 25-55 part nanometer Semen Arecae 25-55 part
Nanometer Pyritum 10-35 part nanometer Rhizoma Corydalis 10-30 part nanometer Radix Achyranthis Bidentatae 40-80 part
The sub-30-65 part of nanometer Semen Persicae 50-120 part nanometer Lignum Sappan 30-65 part nanometer ground beetle
Nanometer Radix Clematidis 20-60 part nanometer rhizoma sparganic 20-60 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer traumatic injury preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano rhubarb 120-200 part nanometer Herba Artemisiae Anomalae 60-100 part nano safflower 40-80 part
Nano Chinese angelica 40-80 part nano cyperus tuber 40-80 part nanometer Rhizoma Curcumae 40--80 part
Nanometer Pericarpium Citri Reticulatae Viride 40-80 part nanometer Fructus Aurantii Immaturus 40-80 part nanometer Rhizoma Chuanxiong 40-80 part
Nanometer Lignum Dalbergiae Odoriferae 30-50 part nanometer Radix Paeoniae Rubra 30-50 part nanometer Semen Arecae 30-50 part
Nanometer Pyritum 15-25 part nanometer Rhizoma Corydalis 15-25 part nanometer Radix Achyranthis Bidentatae 50-70 part
The sub-35-50 part of nanometer Semen Persicae 60-100 part nanometer Lignum Sappan 35-55 part nanometer ground beetle
Nanometer Radix Clematidis 30-50 part nanometer rhizoma sparganic 30-50 part
3, nanometer traumatic injury preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 80 parts of nano safflowers of 160 parts of nanometer Herba Artemisiae Anomalaes of nano rhubarb
40 parts of 60 parts of nanometer Rhizoma Curcumae of 60 parts of nano cyperus tubers of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Chuanxiongs of 40 parts of nanometer Fructus Aurantii Immaturuss of nanometer Pericarpium Citri Reticulatae Viride
40 parts of 40 portions of nanometer Semen Arecaes of 40 parts of nanometer Radix Paeoniae Rubra of nanometer Lignum Dalbergiae Odoriferae
60 parts of 20 parts of nanometer Radix Achyranthis Bidentataes of 20 parts of nanometer Rhizoma Corydalis of nanometer Pyritum
40 parts of 40 parts of nanometer ground beetle of 80 parts of nanometer Lignum Sappans of nanometer Semen Persicae
40 parts of 40 parts of nanometer rhizoma sparganic of nanometer Radix Clematidis
4, according to claim 1 or 2 or 3 described nanometer traumatic injury preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer traumatic injury preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100628 CN1365685A (en) | 2001-01-15 | 2001-01-15 | Nano medicine for reating bone fracture and injury and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100628 CN1365685A (en) | 2001-01-15 | 2001-01-15 | Nano medicine for reating bone fracture and injury and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365685A true CN1365685A (en) | 2002-08-28 |
Family
ID=4651737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100628 Pending CN1365685A (en) | 2001-01-15 | 2001-01-15 | Nano medicine for reating bone fracture and injury and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1365685A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104667076A (en) * | 2015-03-24 | 2015-06-03 | 陈志建 | Tendon-relaxing and collateral-dredging medicinal wine for treating acute soft tissue injuries |
-
2001
- 2001-01-15 CN CN 01100628 patent/CN1365685A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104667076A (en) * | 2015-03-24 | 2015-06-03 | 陈志建 | Tendon-relaxing and collateral-dredging medicinal wine for treating acute soft tissue injuries |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368292A (en) | Nano medicing 'Wenzhong Zhixie' and its preparing process | |
| CN1365808A (en) | Nano medicine 'Guilu Bushen' and its preparing process | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1366915A (en) | Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method | |
| CN1368244A (en) | Nano universal gynecologic medicine and its preparing process | |
| CN1365685A (en) | Nano medicine for reating bone fracture and injury and its preparing process | |
| CN1368192A (en) | Nano medicine for treating menalgia and its preparing process | |
| CN1368318A (en) | Nano medicine 'Shugantiaoqi' and its preparing process | |
| CN1360939A (en) | Nanometer eyesight-improving and health-clearing medicine and its prepn | |
| CN1360930A (en) | Nanometer traumatic injury-treating medicine and its prepn | |
| CN1365746A (en) | Nano medicine 'Sizheng' and its preparing process | |
| CN1368061A (en) | Nano meidcine 'Xiaoshuan Tongluo' and its preparing process | |
| CN1368357A (en) | Nano medicine 'Weitongding' and its preparing process | |
| CN1368087A (en) | Nano medicine for treating cerebral thrombus and its preparing process | |
| CN1368277A (en) | Nano medicine 'Yujin Yinxie' and its preparing process | |
| CN1368099A (en) | Nano medicine 'Xiaoyin' and its preparing process | |
| CN1365811A (en) | Nano medicine 'Huixiang Juhe' and its preparing process | |
| CN1366977A (en) | Nano Guloushan dieda preparation medicine and preparation method | |
| CN1368145A (en) | Nano medicine 'Gengnianshu' and its preparing process | |
| CN1365759A (en) | Nano antalgic medicine 'Zijin' and its preparing process | |
| CN1368361A (en) | Nano medicine 'Xiaoer Jingan' and its preparing process | |
| CN1365774A (en) | Nano medicine 'Niuhuang Shangqing' and its preparing process | |
| CN1362247A (en) | Nano stomach-nourishing medicine of Aucklandiae and Amino and its preparation | |
| CN1360929A (en) | Nanometer nasosinusitis treating medicine and its prepn | |
| CN1368360A (en) | Nano medicine for treating icteroheptitis and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |