CN1364578A - Nano consciousness restoring Zaizao medicine and its preparing method - Google Patents
Nano consciousness restoring Zaizao medicine and its preparing method Download PDFInfo
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- CN1364578A CN1364578A CN 01101921 CN01101921A CN1364578A CN 1364578 A CN1364578 A CN 1364578A CN 01101921 CN01101921 CN 01101921 CN 01101921 A CN01101921 A CN 01101921A CN 1364578 A CN1364578 A CN 1364578A
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Abstract
The nano consciousness restoring Zaicao medicine is prepared with nano Astragalus membranaceus, nano epimedium, nano grassleaved sweetflag rhizoma, nano red ginseng, nano Chinese angelica and other 31 kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of refreshment of reducing phlegm, dispelling, collateral-activating, cure mainly obnubilation, aphasia, the flaccidity syndrome and arthralgia syndrome of suffering from a deficiency of the kidney, muscles and bones is ached, contracture of the limbs, the nano consciousness restoring Zaizao medicine of hemiplegia the invention still further relates to the method for this medication preparation.
Xingnao zaizao pill is a kind of classical Chinese patent medicine, mainly contains effects such as the refreshment of reducing phlegm, dispelling, collateral-activating, is used for obnubilation, aphasia, and the flaccidity syndrome and arthralgia syndrome of suffering from a deficiency of the kidney, muscles and bones is ached, contracture of the limbs, hemiplegia.But traditional xingnao zaizao pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano consciousness restoring Zaizao medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano consciousness restoring Zaizao medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano astragalus 34-86 part nanometer Herba Epimedii 20-50 part nanometer Rhizoma Acori Graminei 8-22 part
Nanometer Radix Ginseng Rubra 7-18 part nano Chinese angelica 7-18 part nanometer earthworm 6-14 part
Nanometer Radix Notoginseng 6-14 part nano safflower 6-14 part nano powder Radix Stephaniae Tetrandrae 6-14 part
Nanometer Radix Paeoniae Rubra 6-14 part nanometer Semen Persicae (stir-fry) 6-14 part nano abalone shell 6-14 part
Nano gastrodia 6-14 part nanometer Herba Agrimoniae 6-14 part nanometer Flos Sophorae (stir-fry) 6-14 part
The nanometer Rhizoma Atractylodis Macrocephalae (stir-fry) 6-14 part nanometer Arisaema Cum Bile 6-14 part nanometer Radix Puerariae 6-14 part
Nanometer Radix Scrophulariae 6-14 part nanometer coptis 6-14 part nanometer Fructus Forsythiae 6-14 part
Nanometer Rhizoma Alismatis 6-14 part nanometer Rhizoma Chuanxiong 6-14 part nanometer Fructus Lycii 6-14 part
The sub-6-14 part of nanometer Scorpio (removing hook) 1.5-3.5 part nanometer Radix Polygoni Multiflori Preparata 3-27 part nano jueming
Nanometer Lignum Aquilariae Resinatum 3-7 part nanometer Rhizoma Typhonii (system) 3-7 part nanometric Herbra Asarum 3-7 part
Nanometer Radix Aucklandiae 3-7 part nanometer Bombyx Batryticatus (stir-fry) 2.5-3.5 part nanometer Fructus Gleditsiae Abnormalis 3-7 part
Nanometer Borneolum Syntheticum 3-7 part nano-pearl (bean curd system) 4-11 part nano rhubarb 3-7 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano astragalus 48-72 part nanometer Herba Epimedii 28-42 part nanometer Rhizoma Acori Graminei 12-18 part
Nanometer Radix Ginseng Rubra 10-15 part nano Chinese angelica 10-15 part nanometer earthworm 8-12 part
Nanometer Radix Notoginseng 8-12 part nano safflower 8-12 part nano powder Radix Stephaniae Tetrandrae 8-12 part
Nanometer Radix Paeoniae Rubra 8-12 part nanometer Semen Persicae (stir-fry) 8-12 part nano abalone shell 8-12 part
Nano gastrodia 8-12 part nanometer Herba Agrimoniae 8-12 part nanometer Flos Sophorae (stir-fry) 8-12 part
The nanometer Rhizoma Atractylodis Macrocephalae (stir-fry) 8-12 part nanometer Arisaema Cum Bile 8-12 part nanometer Radix Puerariae 8-12 part
Nanometer Radix Scrophulariae 8-12 part nanometer coptis 8-12 part nanometer Fructus Forsythiae 8-12 part
Nanometer Rhizoma Alismatis 8-12 part nanometer Rhizoma Chuanxiong 8-12 part nanometer Fructus Lycii 8-12 part
The sub-8-12 part of nanometer Scorpio (removing hook) 2-3 part nanometer Radix Polygoni Multiflori Preparata 12-18 part nano jueming
Nanometer Lignum Aquilariae Resinatum 4-6 part nanometer Rhizoma Typhonii (system) 4-6 part nanometric Herbra Asarum 4-6 part
Nanometer Radix Aucklandiae 4-6 part nanometer Bombyx Batryticatus (stir-fry) 2-3 part nanometer Fructus Gleditsiae Abnormalis 4-6 part
Nanometer Borneolum Syntheticum 4-6 part nano-pearl (bean curd system) 6-9 part nano rhubarb 4-6 part
The optimum weight proportioning of medicine of the present invention is:
15 parts of 35 parts of nanometer Rhizoma Acori Graminei of 60 parts of nanometer Herba Epimedii of nano astragalus
10 parts of 12.5 parts of nanometer earthworms of 12.5 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
10 parts of 10 parts of nano powder Radix Stephaniae Tetrandrae of 10 parts of nano safflowers of nanometer Radix Notoginseng
10 parts of 10 parts of nano abalone shells of 10 parts of nanometer Semen Persicaes of nanometer Radix Paeoniae Rubra (stir-fry)
10 parts in nano gastrodia 10 parts of nanometer Flos Sophoraes of 10 parts of nanometer Herba Agrimoniaes (stir-fry)
10 parts of 10 parts of nanometer Radix Puerariaes of 10 parts of nanometer Arisaema Cum Bile of the nanometer Rhizoma Atractylodis Macrocephalae (stir-fry)
10 parts of 10 parts of nanometer Fructus Forsythiaes of 10 parts of nanometer coptis of nanometer Radix Scrophulariae
10 parts of 10 parts of nanometer Fructus Lycii of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Alismatis
10 parts of 15 parts of nano jueming of 2.5 parts of nanometer Radix Polygoni Multiflori Preparatas of nanometer Scorpio (removing hook)
5 parts of 5 parts of nanometric Herbra Asarums of 5 parts of nanometer Rhizoma Typhoniis of nanometer Lignum Aquilariae Resinatum (system)
5 parts of 2.5 parts of nanometer Fructus Gleditsiae Abnormalis of 5 parts of nanometer Bombyx Batryticatus of the nanometer Radix Aucklandiae (stir-fry)
5 parts of 7.5 parts of nano rhubarbs of 5 parts of nano-pearls of nanometer Borneolum Syntheticum (bean curd system)
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the consciousness restoring Zaizao nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano consciousness restoring Zaizao medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common xingnao zaizao pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano consciousness restoring Zaizao medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for obnubilation, aphasia, and the flaccidity syndrome and arthralgia syndrome of suffering from a deficiency of the kidney, muscles and bones is ached, contracture of the limbs, treatment of conditions such as hemiplegia, clinical efficacy significantly is better than traditional xingnao zaizao pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
15 parts of 35 parts of nanometer Rhizoma Acori Graminei of 60 parts of nanometer Herba Epimedii of nano astragalus
10 parts of 12.5 parts of nanometer earthworms of 12.5 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
10 parts of 10 parts of nano powder Radix Stephaniae Tetrandrae of 10 parts of nano safflowers of nanometer Radix Notoginseng
10 parts of 10 parts of nano abalone shells of 10 parts of nanometer Semen Persicaes of nanometer Radix Paeoniae Rubra (stir-fry)
10 parts in nano gastrodia 10 parts of nanometer Flos Sophoraes of 10 parts of nanometer Herba Agrimoniaes (stir-fry)
10 parts of 10 parts of nanometer Radix Puerariaes of 10 parts of nanometer Arisaema Cum Bile of the nanometer Rhizoma Atractylodis Macrocephalae (stir-fry)
10 parts of 10 parts of nanometer Fructus Forsythiaes of 10 parts of nanometer coptis of nanometer Radix Scrophulariae
10 parts of 10 parts of nanometer Fructus Lycii of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Alismatis
10 parts of 15 parts of nano jueming of 2.5 parts of nanometer Radix Polygoni Multiflori Preparatas of nanometer Scorpio (removing hook)
5 parts of 5 parts of nanometric Herbra Asarums of 5 parts of nanometer Rhizoma Typhoniis of nanometer Lignum Aquilariae Resinatum (system)
5 parts of 2.5 parts of nanometer Fructus Gleditsiae Abnormalis of 5 parts of nanometer Bombyx Batryticatus of the nanometer Radix Aucklandiae (stir-fry)
5 parts of 7.5 parts of nano rhubarbs of 5 parts of nano-pearls of nanometer Borneolum Syntheticum (bean curd system)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
15 parts of 35 parts of nanometer Rhizoma Acori Graminei of 60 parts of nanometer Herba Epimedii of nano astragalus
10 parts of 12.5 parts of nanometer earthworms of 12.5 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
10 parts of 10 parts of nano powder Radix Stephaniae Tetrandrae of 10 parts of nano safflowers of nanometer Radix Notoginseng
10 parts of 10 parts of nano abalone shells of 10 parts of nanometer Semen Persicaes of nanometer Radix Paeoniae Rubra (stir-fry)
10 parts in nano gastrodia 10 parts of nanometer Flos Sophoraes of 10 parts of nanometer Herba Agrimoniaes (stir-fry)
10 parts of 10 parts of nanometer Radix Puerariaes of 10 parts of nanometer Arisaema Cum Bile of the nanometer Rhizoma Atractylodis Macrocephalae (stir-fry)
10 parts of 10 parts of nanometer Fructus Forsythiaes of 10 parts of nanometer coptis of nanometer Radix Scrophulariae
10 parts of 10 parts of nanometer Fructus Lycii of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Alismatis
10 parts of 15 parts of nano jueming of 2.5 parts of nanometer Radix Polygoni Multiflori Preparatas of nanometer Scorpio (removing hook)
5 parts of 5 parts of nanometric Herbra Asarums of 5 parts of nanometer Rhizoma Typhoniis of nanometer Lignum Aquilariae Resinatum (system)
5 parts of 2.5 parts of nanometer Fructus Gleditsiae Abnormalis of 5 parts of nanometer Bombyx Batryticatus of the nanometer Radix Aucklandiae (stir-fry)
5 parts of 7.5 parts of nano rhubarbs of 5 parts of nano-pearls of nanometer Borneolum Syntheticum (bean curd system)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make that nano consciousness restoring reproduces powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
15 parts of 35 parts of nanometer Rhizoma Acori Graminei of 60 parts of nanometer Herba Epimedii of nano astragalus
10 parts of 12.5 parts of nanometer earthworms of 12.5 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
10 parts of 10 parts of nano powder Radix Stephaniae Tetrandrae of 10 parts of nano safflowers of nanometer Radix Notoginseng
10 parts of 10 parts of nano abalone shells of 10 parts of nanometer Semen Persicaes of nanometer Radix Paeoniae Rubra (stir-fry)
10 parts in nano gastrodia 10 parts of nanometer Flos Sophoraes of 10 parts of nanometer Herba Agrimoniaes (stir-fry)
10 parts of 10 parts of nanometer Radix Puerariaes of 10 parts of nanometer Arisaema Cum Bile of the nanometer Rhizoma Atractylodis Macrocephalae (stir-fry)
10 parts of 10 parts of nanometer Fructus Forsythiaes of 10 parts of nanometer coptis of nanometer Radix Scrophulariae
10 parts of 10 parts of nanometer Fructus Lycii of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Alismatis
10 parts of 15 parts of nano jueming of 2.5 parts of nanometer Radix Polygoni Multiflori Preparatas of nanometer Scorpio (removing hook)
5 parts of 5 parts of nanometric Herbra Asarums of 5 parts of nanometer Rhizoma Typhoniis of nanometer Lignum Aquilariae Resinatum (system)
5 parts of 2.5 parts of nanometer Fructus Gleditsiae Abnormalis of 5 parts of nanometer Bombyx Batryticatus of the nanometer Radix Aucklandiae (stir-fry)
5 parts of 7.5 parts of nano rhubarbs of 5 parts of nano-pearls of nanometer Borneolum Syntheticum (bean curd system)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano consciousness restoring and reproduce membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano consciousness restoring Zaizao medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano astragalus 34-86 part nanometer Herba Epimedii 20-50 part nanometer Rhizoma Acori Graminei 8-22 part
Nanometer Radix Ginseng Rubra 7-18 part nano Chinese angelica 7-18 part nanometer earthworm 6-14 part
Nanometer Radix Notoginseng 6-14 part nano safflower 6-14 part nano powder Radix Stephaniae Tetrandrae 6-14 part
Nanometer Radix Paeoniae Rubra 6-14 part nanometer Semen Persicae (stir-fry) 6-14 part nano abalone shell 6-14 part
Nano gastrodia 6-14 part nanometer Herba Agrimoniae 6-14 part nanometer Flos Sophorae (stir-fry) 6-14 part
The nanometer Rhizoma Atractylodis Macrocephalae (stir-fry) 6-14 part nanometer Arisaema Cum Bile 6-14 part nanometer Radix Puerariae 6-14 part
Nanometer Radix Scrophulariae 6-14 part nanometer coptis 6-14 part nanometer Fructus Forsythiae 6-14 part
Nanometer Rhizoma Alismatis 6-14 part nanometer Rhizoma Chuanxiong 6-14 part nanometer Fructus Lycii 6-14 part
The sub-6-14 part of nanometer Scorpio (removing hook) 1.5-3.5 part nanometer Radix Polygoni Multiflori Preparata 3-27 part nano jueming
Nanometer Lignum Aquilariae Resinatum 3-7 part nanometer Rhizoma Typhonii (system) 3-7 part nanometric Herbra Asarum 3-7 part
Nanometer Radix Aucklandiae 3-7 part nanometer Bombyx Batryticatus (stir-fry) 2.5-3.5 part nanometer Fructus Gleditsiae Abnormalis 3-7 part
Nanometer Borneolum Syntheticum 3-7 part nano-pearl (bean curd system) 4-11 part nano rhubarb 3-7 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano consciousness restoring Zaizao medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano astragalus 48-72 part nanometer Herba Epimedii 28-42 part nanometer Rhizoma Acori Graminei 12-18 part
Nanometer Radix Ginseng Rubra 10-15 part nano Chinese angelica 10-15 part nanometer earthworm 8-12 part
Nanometer Radix Notoginseng 8-12 part nano safflower 8-12 part nano powder Radix Stephaniae Tetrandrae 8-12 part
Nanometer Radix Paeoniae Rubra 8-12 part nanometer Semen Persicae (stir-fry) 8-12 part nano abalone shell 8-12 part
Nano gastrodia 8-12 part nanometer Herba Agrimoniae 8-12 part nanometer Flos Sophorae (stir-fry) 8-12 part
The nanometer Rhizoma Atractylodis Macrocephalae (stir-fry) 8-12 part nanometer Arisaema Cum Bile 8-12 part nanometer Radix Puerariae 8-12 part
Nanometer Radix Scrophulariae 8-12 part nanometer coptis 8-12 part nanometer Fructus Forsythiae 8-12 part
Nanometer Rhizoma Alismatis 8-12 part nanometer Rhizoma Chuanxiong 8-12 part nanometer Fructus Lycii 8-12 part
The sub-8-12 part of nanometer Scorpio (removing hook) 2-3 part nanometer Radix Polygoni Multiflori Preparata 12-18 part nano jueming
Nanometer Lignum Aquilariae Resinatum 4-6 part nanometer Rhizoma Typhonii (system) 4-6 part nanometric Herbra Asarum 4-6 part
Nanometer Radix Aucklandiae 4-6 part nanometer Bombyx Batryticatus (stir-fry) 2-3 part nanometer Fructus Gleditsiae Abnormalis 4-6 part
Nanometer Borneolum Syntheticum 4-6 part nano-pearl (bean curd system) 6-9 part nano rhubarb 4-6 part
3, nano consciousness restoring Zaizao medicine according to claim 1, wherein the weight proportion of each nano raw material is:
15 parts of 35 parts of nanometer Rhizoma Acori Graminei of 60 parts of nanometer Herba Epimedii of nano astragalus
10 parts of 12.5 parts of nanometer earthworms of 12.5 parts of nano Chinese angelicas of nanometer Radix Ginseng Rubra
10 parts of 10 parts of nano powder Radix Stephaniae Tetrandrae of 10 parts of nano safflowers of nanometer Radix Notoginseng
10 parts of 10 parts of nano abalone shells of 10 parts of nanometer Semen Persicaes of nanometer Radix Paeoniae Rubra (stir-fry)
10 parts in nano gastrodia 10 parts of nanometer Flos Sophoraes of 10 parts of nanometer Herba Agrimoniaes (stir-fry)
10 parts of 10 parts of nanometer Radix Puerariaes of 10 parts of nanometer Arisaema Cum Bile of the nanometer Rhizoma Atractylodis Macrocephalae (stir-fry)
10 parts of 10 parts of nanometer Fructus Forsythiaes of 10 parts of nanometer coptis of nanometer Radix Scrophulariae
10 parts of 10 parts of nanometer Fructus Lycii of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Rhizoma Alismatis
10 parts of 15 parts of nano jueming of 2.5 parts of nanometer Radix Polygoni Multiflori Preparatas of nanometer Scorpio (removing hook)
5 parts of 5 parts of nanometric Herbra Asarums of 5 parts of nanometer Rhizoma Typhoniis of nanometer Lignum Aquilariae Resinatum (system)
5 parts of 2.5 parts of nanometer Fructus Gleditsiae Abnormalis of 5 parts of nanometer Bombyx Batryticatus of the nanometer Radix Aucklandiae (stir-fry)
5 parts of 7.5 parts of nano rhubarbs of 5 parts of nano-pearls of nanometer Borneolum Syntheticum (bean curd system)
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano consciousness restoring Zaizao medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano consciousness restoring Zaizao medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| CN 01101921 CN1364578A (en) | 2001-01-16 | 2001-01-16 | Nano consciousness restoring Zaizao medicine and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251829A (en) * | 2013-05-15 | 2013-08-21 | 广州药灸堂生物科技有限公司番禺分公司 | Chinese herbal medicine formula ointment for treating hypertension and preparation method thereof |
| CN103585372A (en) * | 2013-11-29 | 2014-02-19 | 孙桂好 | Traditional Chinese medicine preparation for treating cerebral palsy |
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2001
- 2001-01-16 CN CN 01101921 patent/CN1364578A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251829A (en) * | 2013-05-15 | 2013-08-21 | 广州药灸堂生物科技有限公司番禺分公司 | Chinese herbal medicine formula ointment for treating hypertension and preparation method thereof |
| CN103251829B (en) * | 2013-05-15 | 2015-04-01 | 广州药灸堂生物科技有限公司番禺分公司 | Chinese herbal medicine formula ointment for treating hypertension and preparation method thereof |
| CN103585372A (en) * | 2013-11-29 | 2014-02-19 | 孙桂好 | Traditional Chinese medicine preparation for treating cerebral palsy |
| CN103585372B (en) * | 2013-11-29 | 2015-07-08 | 孙桂好 | Traditional Chinese medicine preparation for treating cerebral palsy |
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