CN1366916A - Nano plum blossom tongue preparation medicine and preparation method - Google Patents
Nano plum blossom tongue preparation medicine and preparation method Download PDFInfo
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- CN1366916A CN1366916A CN 01102056 CN01102056A CN1366916A CN 1366916 A CN1366916 A CN 1366916A CN 01102056 CN01102056 CN 01102056 CN 01102056 A CN01102056 A CN 01102056A CN 1366916 A CN1366916 A CN 1366916A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 13
- 206010004542 Bezoar Diseases 0.000 claims abstract description 10
- 241000402754 Erythranthe moschata Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 210000000582 semen Anatomy 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 10
- 241000717739 Boswellia sacra Species 0.000 claims description 9
- 241000269417 Bufo Species 0.000 claims description 9
- 239000004863 Frankincense Substances 0.000 claims description 9
- 241001057584 Myrrha Species 0.000 claims description 9
- 239000011049 pearl Substances 0.000 claims description 9
- 239000009286 sanguis draxonis Substances 0.000 claims description 9
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 4
- 229910021538 borax Inorganic materials 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229910052957 realgar Inorganic materials 0.000 claims description 4
- 239000004328 sodium tetraborate Substances 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010018286 Gingival pain Diseases 0.000 description 2
- 206010018291 Gingival swelling Diseases 0.000 description 2
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano plum blossom tongue preparation medicine. It is made up by using 14 Chinese medicinal materials of nano bovine bezoar, nano pearl, nano musk, nano dried toad, nano bear's gall and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to the nano plum blossom tongue preparation medicine of a kind of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the invention still further relates to the method for this medication preparation.
The plum blossom tongue ball is a kind of classical Chinese patent medicine, mainly contains effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, be used for the furuncle carbuncle from the beginning of, throat, gingival swelling and pain, aphtha of the mouth and tongue.But traditional plum blossom tongue ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano plum blossom tongue preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano plum blossom tongue preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano bezoar 40-80 part nano-pearl 60-150 part nano musk 40-80 part
Nanometer Bufo siccus 40-80 part nanometer Fel Ursi 20-45 part nanometer-size realgar 20-45 part
Nanometer Cinnabaris 40-80 part nanometer Borax 20-45 part nanometer Semen Lepidii (Semen Descurainiae) 20-45 part
Nanometer Olibanum 20-45 part nanometer Myrrha 20-45 part nanometer Sanguis Draxonis 20-45 part
Nanometer Lignum Aquilariae Resinatum 20-45 part nanometer Borneolum Syntheticum 20-45 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano bezoar 50-70 part nano-pearl 70-120 part nano musk 50-70 part
Nanometer Bufo siccus 50-70 part nanometer Fel Ursi 25-35 part nanometer-size realgar 25-35 part
Nanometer Cinnabaris 50-70 part nanometer Borax 25-35 part nanometer Semen Lepidii (Semen Descurainiae) 25-35 part
Nanometer Olibanum 25-35 part nanometer Myrrha 25-35 part nanometer Sanguis Draxonis 25-35 part
Nanometer Lignum Aquilariae Resinatum 25-35 part nanometer Borneolum Syntheticum 25-35 part
The optimum weight proportioning of medicine of the present invention is:
60 parts of 90 parts of nano musks of 60 parts of nano-pearls of nano bezoar
30 parts of 30 parts of nanometer-size realgars of 60 parts of nanometer Fel Ursis of nanometer Bufo siccus
30 parts of 30 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 60 parts of nanometer Boraxs of nanometer Cinnabaris
30 parts of 30 parts of nanometer Sanguis Draxonis of 30 parts of nanometer Myrrhas of nanometer Olibanum
30 parts of 30 parts of nanometer Borneolum Syntheticums of nanometer Lignum Aquilariae Resinatum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get plum blossom tongue preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano plum blossom tongue preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common plum blossom tongue pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano plum blossom tongue preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the furuncle carbuncle from the beginning of, throat, gingival swelling and pain, treatment of conditions such as aphtha of the mouth and tongue, clinical efficacy significantly is better than traditional plum blossom tongue ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 90 parts of nano musks of 60 parts of nano-pearls of nano bezoar
30 parts of 30 parts of nanometer-size realgars of 60 parts of nanometer Fel Ursis of nanometer Bufo siccus
30 parts of 30 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 60 parts of nanometer Boraxs of nanometer Cinnabaris
30 parts of 30 parts of nanometer Sanguis Draxonis of 30 parts of nanometer Myrrhas of nanometer Olibanum
30 parts of 30 parts of nanometer Borneolum Syntheticums of nanometer Lignum Aquilariae Resinatum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
60 parts of 90 parts of nano musks of 60 parts of nano-pearls of nano bezoar
30 parts of 30 parts of nanometer-size realgars of 60 parts of nanometer Fel Ursis of nanometer Bufo siccus
30 parts of 30 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 60 parts of nanometer Boraxs of nanometer Cinnabaris
30 parts of 30 parts of nanometer Sanguis Draxonis of 30 parts of nanometer Myrrhas of nanometer Olibanum
30 parts of 30 parts of nanometer Borneolum Syntheticums of nanometer Lignum Aquilariae Resinatum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano plum blossom tongue powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
60 parts of 90 parts of nano musks of 60 parts of nano-pearls of nano bezoar
30 parts of 30 parts of nanometer-size realgars of 60 parts of nanometer Fel Ursis of nanometer Bufo siccus
30 parts of 30 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 60 parts of nanometer Boraxs of nanometer Cinnabaris
30 parts of 30 parts of nanometer Sanguis Draxonis of 30 parts of nanometer Myrrhas of nanometer Olibanum
30 parts of 30 parts of nanometer Borneolum Syntheticums of nanometer Lignum Aquilariae Resinatum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano plum blossom tongue membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest or affected part.
Claims (6)
1, a kind of nano plum blossom tongue preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano bezoar 40-80 part nano-pearl 60-150 part nano musk 40-80 part
Nanometer Bufo siccus 40-80 part nanometer Fel Ursi 20-45 part nanometer-size realgar 20-45 part
Nanometer Cinnabaris 40-80 part nanometer Borax 20-45 part nanometer Semen Lepidii (Semen Descurainiae) 20-45 part
Nanometer Olibanum 20-45 part nanometer Myrrha 20-45 part nanometer Sanguis Draxonis 20-45 part
Nanometer Lignum Aquilariae Resinatum 20-45 part nanometer Borneolum Syntheticum 20-45 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano plum blossom tongue preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano bezoar 50-70 part nano-pearl 70-120 part nano musk 50-70 part
Nanometer Bufo siccus 50-70 part nanometer Fel Ursi 25-35 part nanometer-size realgar 25-35 part
Nanometer Cinnabaris 50-70 part nanometer Borax 25-35 part nanometer Semen Lepidii (Semen Descurainiae) 25-35 part
Nanometer Olibanum 25-35 part nanometer Myrrha 25-35 part nanometer Sanguis Draxonis 25-35 part
Nanometer Lignum Aquilariae Resinatum 25-35 part nanometer Borneolum Syntheticum 25-35 part
3, nano plum blossom tongue preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 90 parts of nano musks of 60 parts of nano-pearls of nano bezoar
30 parts of 30 parts of nanometer-size realgars of 60 parts of nanometer Fel Ursis of nanometer Bufo siccus
30 parts of 30 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 60 parts of nanometer Boraxs of nanometer Cinnabaris
30 parts of 30 parts of nanometer Sanguis Draxonis of 30 parts of nanometer Myrrhas of nanometer Olibanum
30 parts of 30 parts of nanometer Borneolum Syntheticums of nanometer Lignum Aquilariae Resinatum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano plum blossom tongue preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano plum blossom tongue preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102056 CN1366916A (en) | 2001-01-22 | 2001-01-22 | Nano plum blossom tongue preparation medicine and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102056 CN1366916A (en) | 2001-01-22 | 2001-01-22 | Nano plum blossom tongue preparation medicine and preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1366916A true CN1366916A (en) | 2002-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102056 Pending CN1366916A (en) | 2001-01-22 | 2001-01-22 | Nano plum blossom tongue preparation medicine and preparation method |
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| Country | Link |
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| CN (1) | CN1366916A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100415273C (en) * | 2005-09-29 | 2008-09-03 | 李广中 | Preparation of Zijing paste for eye vision recovery |
| CN103494984A (en) * | 2013-09-26 | 2014-01-08 | 苏福松 | Traditional Chinese medicine for treating goat oral cavity ulceration and preparation method thereof |
-
2001
- 2001-01-22 CN CN 01102056 patent/CN1366916A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100415273C (en) * | 2005-09-29 | 2008-09-03 | 李广中 | Preparation of Zijing paste for eye vision recovery |
| CN103494984A (en) * | 2013-09-26 | 2014-01-08 | 苏福松 | Traditional Chinese medicine for treating goat oral cavity ulceration and preparation method thereof |
| CN103494984B (en) * | 2013-09-26 | 2016-02-10 | 苏福松 | Traditional Chinese medicine for treating goat oral cavity ulceration and preparation method thereof |
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