CN1365695A - Nano medicine 'Xiaoer Jindan' and its preparing process - Google Patents
Nano medicine 'Xiaoer Jindan' and its preparing process Download PDFInfo
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- CN1365695A CN1365695A CN 01100638 CN01100638A CN1365695A CN 1365695 A CN1365695 A CN 1365695A CN 01100638 CN01100638 CN 01100638 CN 01100638 A CN01100638 A CN 01100638A CN 1365695 A CN1365695 A CN 1365695A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 19
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 9
- 241000489492 Arisaema Species 0.000 claims description 9
- 241000282817 Bovidae Species 0.000 claims description 9
- 241000209020 Cornus Species 0.000 claims description 9
- 241001644295 Fritillaria przewalskii Species 0.000 claims description 9
- 241000305492 Gastrodia Species 0.000 claims description 9
- 210000000941 bile Anatomy 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 241000219780 Pueraria Species 0.000 claims description 5
- 241000951473 Schizonepeta Species 0.000 claims description 5
- 241001530126 Scrophularia Species 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 235000001759 Citrus maxima Nutrition 0.000 abstract 1
- 244000276331 Citrus maxima Species 0.000 abstract 1
- 241000935235 Fritillaria meleagris Species 0.000 abstract 1
- 241000244269 Peucedanum Species 0.000 abstract 1
- 229910052956 cinnabar Inorganic materials 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 206010010904 Convulsion Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 206010020741 Hyperpyrexia Diseases 0.000 description 3
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- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
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- 229940126678 chinese medicines Drugs 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nanometre medicine "Xiaoer Jindan" is prepared from the nanometre powders of 26 Chinese medicinal materials including cinnabar, pummelo peel, tendrilled fritillary bulb, peucedanum root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of dispelling pathogenic wind and eliminating phlegm, heat-clearing and toxic substances removing, cure mainly cold anemopyretic, contain in the phlegm-fire, fever and headache, cough and asthma, laryngopharynx swelling and pain, vomiting, the nano medicine ' Xiaoer Jindan ' of hyperpyrexia and infantile convulsion the invention still further relates to the method for this medication preparation.
Children-welfare tablet is a kind of classical Chinese patent medicine, mainly contains effects such as dispelling pathogenic wind and eliminating phlegm, heat-clearing and toxic substances removing, is used for cold anemopyretic, contains fever and headache, cough and asthma, laryngopharynx swelling and pain, vomiting, hyperpyrexia and infantile convulsion in the phlegm-fire.But traditional children-welfare tablet disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Xiaoer Jindan ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Xiaoer Jindan '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The female 30-55 part of nanometer Cinnabaris 60-95 nano Juhong 30-55 part nano Sichuan fritillary bulb
Nanometer Arisaema Cum Bile 20-45 part nanometer Radix Peucedani 20-45 part nanometer Radix Scrophulariae 20-45 part
Nanometer Rhizoma Pinelliae 20-45 part nanometer Folium Isatidis 20-45 part nanometer Caulis Aristolochiae Manshuriensis 20-45 part
Nanometer Radix Platycodonis 20-45 part nanometer Herba Schizonepetae 20-45 part nanometer Rhizoma Et Radix Notopterygii 20-45 part
Nanometer Cacumen Tamaricis 20-45 part nanometer Radix Rehmanniae 20-45 part nanometer Fructus Aurantii (parched) 20-45 part
Nanometer Radix Paeoniae Rubra 20-45 part nanometer Ramulus Uncariae Cum Uncis 20-45 part nanometer Radix Puerariae 10-35 part
Nanometer Fructus Arctii 10-35 part nano gastrodia 10-35 nanometer Radix Glycyrrhizae 10-35 part
Nanometer Radix Saposhnikoviae 10-35 part nanometer Borneolum Syntheticum 6-15 part nanometer Pulvis Cornus Bubali Concentratus 6-15 part
Nano antelope horn powder 3-8 part nanometer Mentholum 0.1-2 part
The formula optimization weight proportion scope of medicine of the present invention is:
The female 35-45 part of nanometer Cinnabaris 70-90 nano Juhong 35-45 part nano Sichuan fritillary bulb
Nanometer Arisaema Cum Bile 25-35 part nanometer Radix Peucedani 25-35 part nanometer Radix Scrophulariae 25-35 part
Nanometer Rhizoma Pinelliae 25-35 part nanometer Folium Isatidis 25-35 part nanometer Caulis Aristolochiae Manshuriensis 25-35 part
Nanometer Radix Platycodonis 25-35 part nanometer Herba Schizonepetae 25-35 part nanometer Rhizoma Et Radix Notopterygii 25-35 part
Nanometer Cacumen Tamaricis 25-35 part nanometer Radix Rehmanniae 25-35 part nanometer Fructus Aurantii (parched) 25-35 part
Nanometer Radix Paeoniae Rubra 25-35 part nanometer Ramulus Uncariae Cum Uncis 25-35 part nanometer Radix Puerariae 15-25 part
Nanometer Fructus Arctii 15-25 part nano gastrodia 15-25 nanometer Radix Glycyrrhizae 15-25 part
Nanometer Radix Saposhnikoviae 15-25 part nanometer Borneolum Syntheticum 8-12 part nanometer Pulvis Cornus Bubali Concentratus 8-12 part
Nano antelope horn powder 4-6 part nanometer Mentholum 0.1-1 part
The optimum weight proportioning of medicine of the present invention is:
Female 40 parts of 40 parts of nano Sichuan fritillary bulbs of 80 parts of nano Juhongs of nanometer Cinnabaris
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Peucedanis of nanometer Arisaema Cum Bile
30 parts of 30 parts of nanometer Caulis Aristolochiae Manshuriensis of 30 parts of nanometer Folium Isatidiss of nanometer Rhizoma Pinelliae
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nanometer Herba Schizonepetaes of nanometer Radix Platycodonis
30 parts of 30 parts of nanometer Fructus Aurantii (parched) of 30 parts of nanometer Radix Rehmanniae of nanometer Cacumen Tamaricis
20 parts of 30 parts of nanometer Radix Puerariaes of 30 parts of nanometer Ramulus Uncariae Cum Uncis of nanometer Radix Paeoniae Rubra
20 parts in 20 parts of nanometer Radix Glycyrrhizaes of 20 parts of nano gastrodias of nanometer Fructus Arctii
10 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of 20 parts of nanometer Borneolum Syntheticums of nanometer Radix Saposhnikoviae
0.1 part of 5 parts of nanometer Mentholum of nano antelope horn powder
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour:
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Xiaoer Jindan ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Xiaoer Jindan ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common children-welfare tablet preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Xiaoer Jindan ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for cold anemopyretic, contains in the phlegm-fire, and fever and headache, cough and asthma, laryngopharynx swelling and pain, vomiting, treatment of conditions such as hyperpyrexia and infantile convulsion, clinical efficacy significantly is better than traditional children-welfare tablet.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
Female 40 parts of 40 parts of nano Sichuan fritillary bulbs of 80 parts of nano Juhongs of nanometer Cinnabaris
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Peucedanis of nanometer Arisaema Cum Bile
30 parts of 30 parts of nanometer Caulis Aristolochiae Manshuriensis of 30 parts of nanometer Folium Isatidiss of nanometer Rhizoma Pinelliae
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nanometer Herba Schizonepetaes of nanometer Radix Platycodonis
30 parts of 30 parts of nanometer Fructus Aurantii (parched) of 30 parts of nanometer Radix Rehmanniae of nanometer Cacumen Tamaricis
20 parts of 30 parts of nanometer Radix Puerariaes of 30 parts of nanometer Ramulus Uncariae Cum Uncis of nanometer Radix Paeoniae Rubra
20 parts in 20 parts of nanometer Radix Glycyrrhizaes of 20 parts of nano gastrodias of nanometer Fructus Arctii
10 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of 20 parts of nanometer Borneolum Syntheticums of nanometer Radix Saposhnikoviae
0.1 part of 5 parts of nanometer Mentholum of nano antelope horn powder
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
Female 40 parts of 40 parts of nano Sichuan fritillary bulbs of 80 parts of nano Juhongs of nanometer Cinnabaris
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Peucedanis of nanometer Arisaema Cum Bile
30 parts of 30 parts of nanometer Caulis Aristolochiae Manshuriensis of 30 parts of nanometer Folium Isatidiss of nanometer Rhizoma Pinelliae
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nanometer Herba Schizonepetaes of nanometer Radix Platycodonis
30 parts of 30 parts of nanometer Fructus Aurantii (parched) of 30 parts of nanometer Radix Rehmanniae of nanometer Cacumen Tamaricis
20 parts of 30 parts of nanometer Radix Puerariaes of 30 parts of nanometer Ramulus Uncariae Cum Uncis of nanometer Radix Paeoniae Rubra
20 parts in 20 parts of nanometer Radix Glycyrrhizaes of 20 parts of nano gastrodias of nanometer Fructus Arctii
10 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of 20 parts of nanometer Borneolum Syntheticums of nanometer Radix Saposhnikoviae
0.1 part of 5 parts of nanometer Mentholum of nano antelope horn powder
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano children's Jindan powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
Female 40 parts of 40 parts of nano Sichuan fritillary bulbs of 80 parts of nano Juhongs of nanometer Cinnabaris
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Peucedanis of nanometer Arisaema Cum Bile
30 parts of 30 parts of nanometer Caulis Aristolochiae Manshuriensis of 30 parts of nanometer Folium Isatidiss of nanometer Rhizoma Pinelliae
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nanometer Herba Schizonepetaes of nanometer Radix Platycodonis
30 parts of 30 parts of nanometer Fructus Aurantii (parched) of 30 parts of nanometer Radix Rehmanniae of nanometer Cacumen Tamaricis
20 parts of 30 parts of nanometer Radix Puerariaes of 30 parts of nanometer Ramulus Uncariae Cum Uncis of nanometer Radix Paeoniae Rubra
20 parts in 20 parts of nanometer Radix Glycyrrhizaes of 20 parts of nano gastrodias of nanometer Fructus Arctii
10 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of 20 parts of nanometer Borneolum Syntheticums of nanometer Radix Saposhnikoviae
0.1 part of 5 parts of nanometer Mentholum of nano antelope horn powder
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano children's Jindan membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Xiaoer Jindan ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
The female 30-55 part of nanometer Cinnabaris 60-95 nano Juhong 30-55 part nano Sichuan fritillary bulb
Nanometer Arisaema Cum Bile 20-45 part nanometer Radix Peucedani 20-45 part nanometer Radix Scrophulariae 20-45 part
Nanometer Rhizoma Pinelliae 20-45 part nanometer Folium Isatidis 20-45 part nanometer Caulis Aristolochiae Manshuriensis 20-45 part
Nanometer Radix Platycodonis 20-45 part nanometer Herba Schizonepetae 20-45 part nanometer Rhizoma Et Radix Notopterygii 20-45 part
Nanometer Cacumen Tamaricis 20-45 part nanometer Radix Rehmanniae 20-45 part nanometer Fructus Aurantii (parched) 20-45 part
Nanometer Radix Paeoniae Rubra 20-45 part nanometer Ramulus Uncariae Cum Uncis 20-45 part nanometer Radix Puerariae 10-35 part
Nanometer Fructus Arctii 10-35 part nano gastrodia 10-35 nanometer Radix Glycyrrhizae 10-35 part
Nanometer Radix Saposhnikoviae 10-35 part nanometer Borneolum Syntheticum 6-15 part nanometer Pulvis Cornus Bubali Concentratus 6-15 part
Nano antelope horn powder 3-8 part nanometer Mentholum 0.1-2 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Xiaoer Jindan ' according to claim 1, wherein the weight proportion of each nano raw material is:
The female 35-45 part of nanometer Cinnabaris 70-90 nano Juhong 35-45 part nano Sichuan fritillary bulb
Nanometer Arisaema Cum Bile 25-35 part nanometer Radix Peucedani 25-35 part nanometer Radix Scrophulariae 25-35 part
Nanometer Rhizoma Pinelliae 25-35 part nanometer Folium Isatidis 25-35 part nanometer Caulis Aristolochiae Manshuriensis 25-35 part
Nanometer Radix Platycodonis 25-35 part nanometer Herba Schizonepetae 25-35 part nanometer Rhizoma Et Radix Notopterygii 25-35 part
Nanometer Cacumen Tamaricis 25-35 part nanometer Radix Rehmanniae 25-35 part nanometer Fructus Aurantii (parched) 25-35 part
Nanometer Radix Paeoniae Rubra 25-35 part nanometer Ramulus Uncariae Cum Uncis 25-35 part nanometer Radix Puerariae 15-25 part
Nanometer Fructus Arctii 15-25 part nano gastrodia 15-25 nanometer Radix Glycyrrhizae 15-25 part
Nanometer Radix Saposhnikoviae 15-25 part nanometer Borneolum Syntheticum 8-12 part nanometer Pulvis Cornus Bubali Concentratus 8-12 part
Nano antelope horn powder 4-6 part nanometer Mentholum 0.1-1 part
3, nano medicine ' Xiaoer Jindan ' according to claim 1, wherein the weight proportion of each nano raw material is:
Female 40 parts of 40 parts of nano Sichuan fritillary bulbs of 80 parts of nano Juhongs of nanometer Cinnabaris
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Peucedanis of nanometer Arisaema Cum Bile
30 parts of 30 parts of nanometer Caulis Aristolochiae Manshuriensis of 30 parts of nanometer Folium Isatidiss of nanometer Rhizoma Pinelliae
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nanometer Herba Schizonepetaes of nanometer Radix Platycodonis
30 parts of 30 parts of nanometer Fructus Aurantii (parched) of 30 parts of nanometer Radix Rehmanniae of nanometer Cacumen Tamaricis
20 parts of 30 parts of nanometer Radix Puerariaes of 30 parts of nanometer Ramulus Uncariae Cum Uncis of nanometer Radix Paeoniae Rubra
20 parts in 20 parts of nanometer Radix Glycyrrhizaes of 20 parts of nano gastrodias of nanometer Fructus Arctii
10 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of 20 parts of nanometer Borneolum Syntheticums of nanometer Radix Saposhnikoviae
0.1 part of 5 parts of nanometer Mentholum of nano antelope horn powder
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Xiaoer Jindan 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Xiaoer Jindan 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100638 CN1365695A (en) | 2001-01-15 | 2001-01-15 | Nano medicine 'Xiaoer Jindan' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100638 CN1365695A (en) | 2001-01-15 | 2001-01-15 | Nano medicine 'Xiaoer Jindan' and its preparing process |
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| CN1365695A true CN1365695A (en) | 2002-08-28 |
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| CN 01100638 Pending CN1365695A (en) | 2001-01-15 | 2001-01-15 | Nano medicine 'Xiaoer Jindan' and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638313A (en) * | 2013-12-11 | 2014-03-19 | 马家庆 | Traditional Chinese medicine for treating fever due to yang deficiency |
| CN105079728A (en) * | 2014-05-08 | 2015-11-25 | 青州市杏林春膏贴科学研究所 | A plant Chinese herbal medicine composition for treating exogenous high fever and its preparation process |
-
2001
- 2001-01-15 CN CN 01100638 patent/CN1365695A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638313A (en) * | 2013-12-11 | 2014-03-19 | 马家庆 | Traditional Chinese medicine for treating fever due to yang deficiency |
| CN103638313B (en) * | 2013-12-11 | 2015-10-21 | 马家庆 | A kind of Chinese medicine for the treatment of fever due to yang insufficiency |
| CN105079728A (en) * | 2014-05-08 | 2015-11-25 | 青州市杏林春膏贴科学研究所 | A plant Chinese herbal medicine composition for treating exogenous high fever and its preparation process |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |