CN1365700A - Nano 25-component coral medicine and its preparing process - Google Patents
Nano 25-component coral medicine and its preparing process Download PDFInfo
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- CN1365700A CN1365700A CN 01100643 CN01100643A CN1365700A CN 1365700 A CN1365700 A CN 1365700A CN 01100643 CN01100643 CN 01100643 CN 01100643 A CN01100643 A CN 01100643A CN 1365700 A CN1365700 A CN 1365700A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 235000014653 Carica parviflora Nutrition 0.000 title claims abstract description 21
- 241000243321 Cnidaria Species 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 13
- 230000008569 process Effects 0.000 title description 2
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 claims abstract description 10
- 229910052667 lazurite Inorganic materials 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 239000011049 pearl Substances 0.000 claims description 18
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 9
- 244000020518 Carthamus tinctorius Species 0.000 claims description 9
- 241001450685 Corallium japonicum Species 0.000 claims description 9
- 240000009087 Crescentia cujete Species 0.000 claims description 9
- 235000005983 Crescentia cujete Nutrition 0.000 claims description 9
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- 241000628997 Flos Species 0.000 claims description 9
- 235000009797 Lagenaria vulgaris Nutrition 0.000 claims description 9
- 244000223014 Syzygium aromaticum Species 0.000 claims description 9
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
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- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 241000001522 Terminalia chebula Species 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
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- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
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- 239000000829 suppository Substances 0.000 claims description 3
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- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
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- 230000000694 effects Effects 0.000 abstract description 9
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- Medicinal Preparation (AREA)
Abstract
A nanometre 25-component coral medicine is prepared from the nanometre powders of 25 Chinese medicinal materials including coral, lazurite, pearl, nacre, myrobalan, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind ofly have one's ideas straightened out, collateral dredging, pain relieving, cure mainly " aortic arch syndrome ", obnubilation, health numbness, Light-headedness, brain pain, blood pressure is uncomfortable, headache, the nano 25-component coral medicine of epilepsy and various neuropathic pains the invention still further relates to the method for this medication preparation.
The 25-component coral ball is a kind of classical Chinese patent medicine, mainly contain have one's ideas straightened out, effects such as collateral dredging, pain relieving, be used for " aortic arch syndrome ", obnubilation, the health numbness, Light-headedness, brain pain, blood pressure is uncomfortable, headache, epilepsy and various neuropathic pain.But traditional 25-component coral ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano 25-component coral medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano 25-component coral medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Corallium Japonicum Kishinouye 55-94 part nano-pearl 8-25 part nanometer lazurite 10-30 part
The female 30-80 part of nano-pearl nanometer Fructus Chebulae 60-150 part nanometer Radix Aucklandiae (Radix Vladimiriae) 40-80 part
Nano safflower 60-95 part nano clove 25-45 part nanometer Lignum Aquilariae Resinatum 50-90 part
Nanometer Cinnabaris 20-50 part nanometer Os Draconis 30-55 part nanometer Calamina 15-45 part
Nanometer encephalolith 15-45 part nano magnetite 15-45 part nanometer Limonitum 15-45 part
Nanometer Semen Sesami 25-60 part nanometer calabash 20-45 part nanometer Flos Radix Asteris 30-60 part
Nanometer Herba Swertiae bimaculatae 60-95 part nanometer Rhizoma Acori Calami 30-80 part nanometer Radix Aconiti Kusnezoffii 30-60 part
Nanometer DAJIANJU 40-95 part nanometer Radix Glycyrrhizae 40-95 part nanometer Stigma Croci 15-40 part
Nano musk 1-5 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Corallium Japonicum Kishinouye 60-90 part nano-pearl 10-20 part nanometer lazurite 15-25 part
The female 40-60 part of nano-pearl nanometer Fructus Chebulae 80-120 part nanometer Radix Aucklandiae (Radix Vladimiriae) 50-70 part
Nano safflower 70-90 part nano clove 30-40 part nanometer Lignum Aquilariae Resinatum 60-80 part
Nanometer Cinnabaris 25-40 part nanometer Os Draconis 35-45 part nanometer Calamina 20-30 part
Nanometer encephalolith 20-30 part nano magnetite 20-30 part nanometer Limonitum 20-30 part
Nanometer Semen Sesami 30-50 part nanometer calabash 25-35 part nanometer Flos Radix Asteris 40-50 part
Nanometer Herba Swertiae bimaculatae 70-90 part nanometer Rhizoma Acori Calami 40-60 part nanometer Radix Aconiti Kusnezoffii 40-50 part
Nanometer DAJIANJU 60-90 part nanometer Radix Glycyrrhizae 60-85 part nanometer Stigma Croci 20-30 part
Nano musk 2-3 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 15 parts of nanometer lazurite of 75 parts of nano-pearls of nanometer Corallium Japonicum Kishinouye
60 parts of 100 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of the female 50 parts of nanometer Fructus Chebulaes of nano-pearl
70 parts of 35 parts of nanometer Lignum Aquilariae Resinatum of 80 parts of nano cloves of nano safflower
25 parts of 40 parts of nanometer Calaminas of 30 parts of nanometer Os Draconis of nanometer Cinnabaris
25 parts of 25 parts of nanometer Limonitum of 25 parts of nano magnetites of nanometer encephalolith
45 parts of 30 parts of nanometer Flos Radix Asteriss of 40 parts of nanometer calabashs of nanometer Semen Sesami
45 parts of 50 parts of nanometer Radix Aconiti Kusnezoffii of 80 parts of nanometer Rhizoma Acori Calamis of nanometer Herba Swertiae bimaculatae
25 parts of 75 parts of nanometer Stigma Crocis of 75 parts of nanometer Radix Glycyrrhizaes of nanometer DAJIANJU
2 parts of nano musks
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get 25-component coral preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano 25-component coral medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common 25-component coral pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano 25-component coral medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for " aortic arch syndrome ", obnubilation, and the health numbness, Light-headedness, brain pain, blood pressure is uncomfortable, headache, treatment of conditions such as epilepsy and various neuropathic pains, clinical efficacy significantly is better than traditional 25-component coral ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 15 parts of nanometer lazurite of 75 parts of nano-pearls of nanometer Corallium Japonicum Kishinouye
60 parts of 100 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of the female 50 parts of nanometer Fructus Chebulaes of nano-pearl
70 parts of 35 parts of nanometer Lignum Aquilariae Resinatum of 80 parts of nano cloves of nano safflower
25 parts of 40 parts of nanometer Calaminas of 30 parts of nanometer Os Draconis of nanometer Cinnabaris
25 parts of 25 parts of nanometer Limonitum of 25 parts of nano magnetites of nanometer encephalolith
45 parts of 30 parts of nanometer Flos Radix Asteriss of 40 parts of nanometer calabashs of nanometer Semen Sesami
45 parts of 50 parts of nanometer Radix Aconiti Kusnezoffii of 80 parts of nanometer Rhizoma Acori Calamis of nanometer Herba Swertiae bimaculatae
25 parts of 75 parts of nanometer Stigma Crocis of 75 parts of nanometer Radix Glycyrrhizaes of nanometer DAJIANJU
2 parts of nano musks
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 15 parts of nanometer lazurite of 75 parts of nano-pearls of nanometer Corallium Japonicum Kishinouye
60 parts of 100 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of the female 50 parts of nanometer Fructus Chebulaes of nano-pearl
70 parts of 35 parts of nanometer Lignum Aquilariae Resinatum of 80 parts of nano cloves of nano safflower
25 parts of 40 parts of nanometer Calaminas of 30 parts of nanometer Os Draconis of nanometer Cinnabaris
25 parts of 25 parts of nanometer Limonitum of 25 parts of nano magnetites of nanometer encephalolith
45 parts of 30 parts of nanometer Flos Radix Asteriss of 40 parts of nanometer calabashs of nanometer Semen Sesami
45 parts of 50 parts of nanometer Radix Aconiti Kusnezoffii of 80 parts of nanometer Rhizoma Acori Calamis of nanometer Herba Swertiae bimaculatae
25 parts of 75 parts of nanometer Stigma Crocis of 75 parts of nanometer Radix Glycyrrhizaes of nanometer DAJIANJU
2 parts of nano musks
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano 25-component coral powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
20 parts of 15 parts of nanometer lazurite of 75 parts of nano-pearls of nanometer Corallium Japonicum Kishinouye
60 parts of 100 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of the female 50 parts of nanometer Fructus Chebulaes of nano-pearl
70 parts of 35 parts of nanometer Lignum Aquilariae Resinatum of 80 parts of nano cloves of nano safflower
25 parts of 40 parts of nanometer Calaminas of 30 parts of nanometer Os Draconis of nanometer Cinnabaris
25 parts of 25 parts of nanometer Limonitum of 25 parts of nano magnetites of nanometer encephalolith
45 parts of 30 parts of nanometer Flos Radix Asteriss of 40 parts of nanometer calabashs of nanometer Semen Sesami
45 parts of 50 parts of nanometer Radix Aconiti Kusnezoffii of 80 parts of nanometer Rhizoma Acori Calamis of nanometer Herba Swertiae bimaculatae
25 parts of 75 parts of nanometer Stigma Crocis of 75 parts of nanometer Radix Glycyrrhizaes of nanometer DAJIANJU
2 parts of nano musks
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano 25-component coral membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano 25-component coral medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Corallium Japonicum Kishinouye 55-94 part nano-pearl 8-25 part nanometer lazurite 10-30 part
The female 30-80 part of nano-pearl nanometer Fructus Chebulae 60-150 part nanometer Radix Aucklandiae (Radix Vladimiriae) 40-80 part
Nano safflower 60-95 part nano clove 25-45 part nanometer Lignum Aquilariae Resinatum 50-90 part
Nanometer Cinnabaris 20-50 part nanometer Os Draconis 30-55 part nanometer Calamina 15-45 part
Nanometer encephalolith 15-45 part nano magnetite 15-45 part nanometer Limonitum 15-45 part
Nanometer Semen Sesami 25-60 part nanometer calabash 20-45 part nanometer Flos Radix Asteris 30-60 part
Nanometer Herba Swertiae bimaculatae 60-95 part nanometer Rhizoma Acori Calami 30-80 part nanometer Radix Aconiti Kusnezoffii 30-60 part
Nanometer DAJIANJU 40-95 part nanometer Radix Glycyrrhizae 40-95 part nanometer Stigma Croci 15-40 part
Nano musk 1-5 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano 25-component coral medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Corallium Japonicum Kishinouye 60-90 part nano-pearl 10-20 part nanometer lazurite 15-25 part
The female 40-60 part of nano-pearl nanometer Fructus Chebulae 80-120 part nanometer Radix Aucklandiae (Radix Vladimiriae) 50-70 part
Nano safflower 70-90 part nano clove 30-40 part nanometer Lignum Aquilariae Resinatum 60-80 part
Nanometer Cinnabaris 25-40 part nanometer Os Draconis 35-45 part nanometer Calamina 20-30 part
Nanometer encephalolith 20-30 part nano magnetite 20-30 part nanometer Limonitum 20-30 part
Nanometer Semen Sesami 30-50 part nanometer calabash 25-35 part nanometer Flos Radix Asteris 40-50 part
Nanometer Herba Swertiae bimaculatae 70-90 part nanometer Rhizoma Acori Calami 40-60 part nanometer Radix Aconiti Kusnezoffii 40-50 part
Nanometer DAJIANJU 60-90 part nanometer Radix Glycyrrhizae 60-85 part nanometer Stigma Croci 20-30 part
Nano musk 2-3 part
3, nano 25-component coral medicine according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 15 parts of nanometer lazurite of 75 parts of nano-pearls of nanometer Corallium Japonicum Kishinouye
60 parts of 100 parts of nanometer Radix Aucklandiae (Radix Vladimiriae) of the female 50 parts of nanometer Fructus Chebulaes of nano-pearl
70 parts of 35 parts of nanometer Lignum Aquilariae Resinatum of 80 parts of nano cloves of nano safflower
25 parts of 40 parts of nanometer Calaminas of 30 parts of nanometer Os Draconis of nanometer Cinnabaris
25 parts of 25 parts of nanometer Limonitum of 25 parts of nano magnetites of nanometer encephalolith
45 parts of 30 parts of nanometer Flos Radix Asteriss of 40 parts of nanometer calabashs of nanometer Semen Sesami
45 parts of 50 parts of nanometer Radix Aconiti Kusnezoffii of 80 parts of nanometer Rhizoma Acori Calamis of nanometer Herba Swertiae bimaculatae
25 parts of 75 parts of nanometer Stigma Crocis of 75 parts of nanometer Radix Glycyrrhizaes of nanometer DAJIANJU
2 parts of nano musks
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano 25-component coral medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano 25-component coral medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100643 CN1365700A (en) | 2001-01-15 | 2001-01-15 | Nano 25-component coral medicine and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100643 CN1365700A (en) | 2001-01-15 | 2001-01-15 | Nano 25-component coral medicine and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365700A true CN1365700A (en) | 2002-08-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100643 Pending CN1365700A (en) | 2001-01-15 | 2001-01-15 | Nano 25-component coral medicine and its preparing process |
Country Status (1)
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| CN (1) | CN1365700A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427065C (en) * | 2005-07-07 | 2008-10-22 | 甘肃奇正藏药有限公司 | A Tibetan medicine preparation for treating dizziness and blood pressure disorder |
-
2001
- 2001-01-15 CN CN 01100643 patent/CN1365700A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427065C (en) * | 2005-07-07 | 2008-10-22 | 甘肃奇正藏药有限公司 | A Tibetan medicine preparation for treating dizziness and blood pressure disorder |
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