CN1368151A - Nano medicine 'Hailong Gejie' and its preparing process - Google Patents
Nano medicine 'Hailong Gejie' and its preparing process Download PDFInfo
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- CN1368151A CN1368151A CN 01102386 CN01102386A CN1368151A CN 1368151 A CN1368151 A CN 1368151A CN 01102386 CN01102386 CN 01102386 CN 01102386 A CN01102386 A CN 01102386A CN 1368151 A CN1368151 A CN 1368151A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
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- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000208340 Araliaceae Species 0.000 claims abstract description 10
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 10
- 235000008434 ginseng Nutrition 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 241000283898 Ovis Species 0.000 claims description 18
- 229940079593 drug Drugs 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 18
- 210000001550 testis Anatomy 0.000 claims description 18
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 241001061264 Astragalus Species 0.000 claims description 9
- 241000005787 Cistanche Species 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- 210000003899 penis Anatomy 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
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- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000270290 Gekkota Species 0.000 claims description 5
- 241000207929 Scutellaria Species 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
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- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Hailong Gejie" is prepared from the nanometre powders of 29 Chinese medicinal materials including pipefish, gecko, ginseng, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Hailong Gejie ' of a kind of warming the kidney to invigorate YANG, enrich and benefit essence and blood, the invention still further relates to the method for this medication preparation.
Solenognathus Gecko oral liquid is a kind of classical Chinese patent medicine, mainly contains effects such as warming the kidney to invigorate YANG, enrich and benefit essence and blood, is used for that waist foot is aching and limp, pale complexion, impotence and seminal emission, infertile, the vertigo of cold womb.But traditional Solenognathus Gecko oral liquid absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Hailong Gejie ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Hailong Gejie '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Solenognathus 30-60 part nanometer Gecko 0.2-2 part nano ginseng 2-8 part
Nanometer Testis Et penis Caprae seu Ovis 2-8 part nanometer Testis Caprae seu Ovis 2-8 part nanometer Radix Scutellariae 2-8 part
Nanometer Radix Rehmanniae Preparata 2-5 part nanometer Semen Cuscutae 2-6 part nanometer Radix Polygoni Multiflori 2-6 part
Nanometer Radix Rehmanniae 2-6 part nanometer Pericarpium Citri Reticulatae 2-6 part nano Chinese angelica 1-5 part
Nano astragalus 3-8 part nanometer Actinolitum 1-5 part nanometer Stamen Nelumbinis 1-3 part
Nanometer Radix Glycyrrhizae 1-3 part nanometer Rhizoma Chuanxiong 1-3 part nanometer Rhizoma Alismatis 1-3 part
Nanometer Herba Cynomorii 1-3 part nanometer Fructus Amomi Rotundus 1-3 part nanometer Lignum Aquilariae Resinatum 1-3 part
Nano-antler 1-3 part nanometer Fructus Lycii 1-3 part nanometer Herba Cistanches 0.5-2 part
Nanometer Herba Epimedii 1-3 part nanometer Cortex Cinnamomi 1-3 part nanometer Semen Allii Tuberosi 1-3 part
Nanometer Fructus Cnidii 1-3 part nanometer Pericarpium Zanthoxyli 0.1-4 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Solenognathus 35-50 part nanometer Gecko 0.5-1 part nano ginseng 3-5 part
Nanometer Testis Et penis Caprae seu Ovis 4-6 part nanometer Testis Caprae seu Ovis 4-6 part nanometer Radix Scutellariae 4-6 part
Nanometer Radix Rehmanniae Preparata 2-4 part nanometer Semen Cuscutae 2-5 part nanometer Radix Polygoni Multiflori 2-4 part
Nanometer Radix Rehmanniae 2-4 part nanometer Pericarpium Citri Reticulatae 2-4 part nano Chinese angelica 1-3 part
Nano astragalus 3-6 part nanometer Actinolitum 1-2 part nanometer Stamen Nelumbinis 1-2 part
Nanometer Radix Glycyrrhizae 1-2 part nanometer Rhizoma Chuanxiong 1-2 part nanometer Rhizoma Alismatis 1-2 part
Nanometer Herba Cynomorii 1-2 part nanometer Fructus Amomi Rotundus 1-2 part nanometer Lignum Aquilariae Resinatum 1-2 part
Nano-antler 1-2 part nanometer Fructus Lycii 1-2 part nanometer Herba Cistanches 0.5-1 part
Nanometer Herba Epimedii 1-2 part nanometer Cortex Cinnamomi 1-2 part nanometer Semen Allii Tuberosi 1-2 part
Nanometer Fructus Cnidii 1-2 part nanometer Pericarpium Zanthoxyli 0.1-3 part
The optimum weight proportioning of medicine of the present invention is:
4.68 parts of 0.73 part of nano ginsengs of 39.1 parts of nanometer Geckos of nanometer Solenognathus
4.68 parts of 4.68 parts of nanometer Radix Scutellariaes of 4.68 parts of nanometer Testis Caprae seu Ovis of nanometer Testis Et penis Caprae seu Ovis
3.1 parts of 3.1 parts of nanometer Radix Polygoni Multiflori of 3.1 parts of nanometer Semen Cuscutae of nanometer Radix Rehmanniae Preparata
1.56 parts of 3.1 parts of nano Chinese angelicas of 3.1 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Rehmanniae
1.56 parts of 1.56 parts of nanometer Stamen Nelumbiniss of 4.68 parts of nanometer Actinolitum of nano astragalus
1.56 parts of 1.56 parts of nanometer Rhizoma Alismatis of 1.56 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Glycyrrhizae
1.56 parts of 1.56 parts of nanometer Lignum Aquilariae Resinatum of 1.56 parts of nanometer Fructus Amomi Rotunduss of nanometer Herba Cynomorii
0.78 part of 1.56 parts of nanometer Herba Cistanches of 1.56 parts of nanometer Fructus Lycii of nano-antler
1.56 parts of 1.56 parts of nanometer Semen Allii Tuberosi of 1.56 parts of nanometer Cortex Cinnamomis of nanometer Herba Epimedii
0.31 part in 1.56 portions of nanometer Pericarpium Zanthoxylies of nanometer Fructus Cnidii
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Hailong Gejie ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Hailong Gejie ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Solenognathus Gecko oral liquid formulations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nano medicine ' Hailong Gejie ' etc. had no precedent in the past.
Treatment of conditions such as pharmaceutical preparation of the present invention can be used for that waist foot is aching and limp, pale complexion, impotence and seminal emission, cold womb are infertile, the vertigo, clinical efficacy significantly is better than traditional Solenognathus Gecko oral liquid.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
4.68 parts of 0.73 part of nano ginsengs of 39.1 parts of nanometer Geckos of nanometer Solenognathus
4.68 parts of 4.68 parts of nanometer Radix Scutellariaes of 4.68 parts of nanometer Testis Caprae seu Ovis of nanometer Testis Et penis Caprae seu Ovis
3.1 parts of 3.1 parts of nanometer Radix Polygoni Multiflori of 3.1 parts of nanometer Semen Cuscutae of nanometer Radix Rehmanniae Preparata
1.56 parts of 3.1 parts of nano Chinese angelicas of 3.1 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Rehmanniae
1.56 parts of 1.56 parts of nanometer Stamen Nelumbiniss of 4.68 parts of nanometer Actinolitum of nano astragalus
1.56 parts of 1.56 parts of nanometer Rhizoma Alismatis of 1.56 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Glycyrrhizae
1.56 parts of 1.56 parts of nanometer Lignum Aquilariae Resinatum of 1.56 parts of nanometer Fructus Amomi Rotunduss of nanometer Herba Cynomorii
0.78 part of 1.56 parts of nanometer Herba Cistanches of 1.56 parts of nanometer Fructus Lycii of nano-antler
1.56 parts of 1.56 parts of nanometer Semen Allii Tuberosi of 1.56 parts of nanometer Cortex Cinnamomis of nanometer Herba Epimedii
0.31 part in 1.56 portions of nanometer Pericarpium Zanthoxylies of nanometer Fructus Cnidii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
4.68 parts of 0.73 part of nano ginsengs of 39.1 parts of nanometer Geckos of nanometer Solenognathus
4.68 parts of 4.68 parts of nanometer Radix Scutellariaes of 4.68 parts of nanometer Testis Caprae seu Ovis of nanometer Testis Et penis Caprae seu Ovis
3.1 parts of 3.1 parts of nanometer Radix Polygoni Multiflori of 3.1 parts of nanometer Semen Cuscutae of nanometer Radix Rehmanniae Preparata
1.56 parts of 3.1 parts of nano Chinese angelicas of 3.1 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Rehmanniae
1.56 parts of 1.56 parts of nanometer Stamen Nelumbiniss of 4.68 parts of nanometer Actinolitum of nano astragalus
1.56 parts of 1.56 parts of nanometer Rhizoma Alismatis of 1.56 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Glycyrrhizae
1.56 parts of 1.56 parts of nanometer Lignum Aquilariae Resinatum of 1.56 parts of nanometer Fructus Amomi Rotunduss of nanometer Herba Cynomorii
0.78 part of 1.56 parts of nanometer Herba Cistanches of 1.56 parts of nanometer Fructus Lycii of nano-antler
1.56 parts of 1.56 parts of nanometer Semen Allii Tuberosi of 1.56 parts of nanometer Cortex Cinnamomis of nanometer Herba Epimedii
0.31 part in 1.56 portions of nanometer Pericarpium Zanthoxylies of nanometer Fructus Cnidii
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer Solenognathus Gecko powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
4.68 parts of 0.73 part of nano ginsengs of 39.1 parts of nanometer Geckos of nanometer Solenognathus
4.68 parts of 4.68 parts of nanometer Radix Scutellariaes of 4.68 parts of nanometer Testis Caprae seu Ovis of nanometer Testis Et penis Caprae seu Ovis
3.1 parts of 3.1 parts of nanometer Radix Polygoni Multiflori of 3.1 parts of nanometer Semen Cuscutae of nanometer Radix Rehmanniae Preparata
1.56 parts of 3.1 parts of nano Chinese angelicas of 3.1 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Rehmanniae
1.56 parts of 1.56 parts of nanometer Stamen Nelumbiniss of 4.68 parts of nanometer Actinolitum of nano astragalus
1.56 parts of 1.56 parts of nanometer Rhizoma Alismatis of 1.56 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Glycyrrhizae
1.56 parts of 1.56 parts of nanometer Lignum Aquilariae Resinatum of 1.56 parts of nanometer Fructus Amomi Rotunduss of nanometer Herba Cynomorii
0.78 part of 1.56 parts of nanometer Herba Cistanches of 1.56 parts of nanometer Fructus Lycii of nano-antler
1.56 parts of 1.56 parts of nanometer Semen Allii Tuberosi of 1.56 parts of nanometer Cortex Cinnamomis of nanometer Herba Epimedii
0.31 part in 1.56 portions of nanometer Pericarpium Zanthoxylies of nanometer Fructus Cnidii
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Solenognathus Gecko membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Hailong Gejie ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Solenognathus 30-60 part nanometer Gecko 0.2-2 part nano ginseng 2-8 part
Nanometer Testis Et penis Caprae seu Ovis 2-8 part nanometer Testis Caprae seu Ovis 2-8 part nanometer Radix Scutellariae 2-8 part
Nanometer Radix Rehmanniae Preparata 2-5 part nanometer Semen Cuscutae 2-6 part nanometer Radix Polygoni Multiflori 2-6 part
Nanometer Radix Rehmanniae 2-6 part nanometer Pericarpium Citri Reticulatae 2-6 part nano Chinese angelica 1-5 part
Nano astragalus 3-8 part nanometer Actinolitum 1-5 part nanometer Stamen Nelumbinis 1-3 part
Nanometer Radix Glycyrrhizae 1-3 part nanometer Rhizoma Chuanxiong 1-3 part nanometer Rhizoma Alismatis 1-3 part
Nanometer Herba Cynomorii 1-3 part nanometer Fructus Amomi Rotundus 1-3 part nanometer Lignum Aquilariae Resinatum 1-3 part
Nano-antler 1-3 part nanometer Fructus Lycii 1-3 part nanometer Herba Cistanches 0.5-2 part
Nanometer Herba Epimedii 1-3 part nanometer Cortex Cinnamomi 1-3 part nanometer Semen Allii Tuberosi 1-3 part
Nanometer Fructus Cnidii 1-3 part nanometer Pericarpium Zanthoxyli 0.1-4 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Hailong Gejie ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Solenognathus 35-50 part nanometer Gecko 0.5-1 part nano ginseng 3-5 part
Nanometer Testis Et penis Caprae seu Ovis 4-6 part nanometer Testis Caprae seu Ovis 4-6 part nanometer Radix Scutellariae 4-6 part
Nanometer Radix Rehmanniae Preparata 2-4 part nanometer Semen Cuscutae 2-5 part nanometer Radix Polygoni Multiflori 2-4 part
Nanometer Radix Rehmanniae 2-4 part nanometer Pericarpium Citri Reticulatae 2-4 part nano Chinese angelica 1-3 part
Nano astragalus 3-6 part nanometer Actinolitum 1-2 part nanometer Stamen Nelumbinis 1-2 part
Nanometer Radix Glycyrrhizae 1-2 part nanometer Rhizoma Chuanxiong 1-2 part nanometer Rhizoma Alismatis 1-2 part
Nanometer Herba Cynomorii 1-2 part nanometer Fructus Amomi Rotundus 1-2 part nanometer Lignum Aquilariae Resinatum 1-2 part
Nano-antler 1-2 part nanometer Fructus Lycii 1-2 part nanometer Herba Cistanches 0.5-1 part
Nanometer Herba Epimedii 1-2 part nanometer Cortex Cinnamomi 1-2 part nanometer Semen Allii Tuberosi 1-2 part
Nanometer Fructus Cnidii 1-2 part nanometer Pericarpium Zanthoxyli 0.1-3 part
3, nano medicine ' Hailong Gejie ' according to claim 1, wherein the weight proportion of each nano raw material is:
4.68 parts of 0.73 part of nano ginsengs of 39.1 parts of nanometer Geckos of nanometer Solenognathus
4.68 parts of 4.68 parts of nanometer Radix Scutellariaes of 4.68 parts of nanometer Testis Caprae seu Ovis of nanometer Testis Et penis Caprae seu Ovis
3.1 parts of 3.1 parts of nanometer Radix Polygoni Multiflori of 3.1 parts of nanometer Semen Cuscutae of nanometer Radix Rehmanniae Preparata
1.56 parts of 3.1 parts of nano Chinese angelicas of 3.1 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Rehmanniae
1.56 parts of 1.56 parts of nanometer Stamen Nelumbiniss of 4.68 parts of nanometer Actinolitum of nano astragalus
1.56 parts of 1.56 parts of nanometer Rhizoma Alismatis of 1.56 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Glycyrrhizae
1.56 parts of 1.56 parts of nanometer Lignum Aquilariae Resinatum of 1.56 parts of nanometer Fructus Amomi Rotunduss of nanometer Herba Cynomorii
0.78 part of 1.56 parts of nanometer Herba Cistanches of 1.56 parts of nanometer Fructus Lycii of nano-antler
1.56 parts of 1.56 parts of nanometer Semen Allii Tuberosi of 1.56 parts of nanometer Cortex Cinnamomis of nanometer Herba Epimedii
0.31 part in 1.56 portions of nanometer Pericarpium Zanthoxylies of nanometer Fructus Cnidii
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Hailong Gejie 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Hailong Gejie 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102386 CN1368151A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Hailong Gejie' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102386 CN1368151A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Hailong Gejie' and its preparing process |
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| Publication Number | Publication Date |
|---|---|
| CN1368151A true CN1368151A (en) | 2002-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102386 Pending CN1368151A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Hailong Gejie' and its preparing process |
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| CN (1) | CN1368151A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2402062A (en) * | 2003-03-28 | 2004-12-01 | Nuliv Biomedicine Inc | Pharmaceutical composition for the prophylaxis or treatment of osteoporosis |
| CN102218122A (en) * | 2011-04-13 | 2011-10-19 | 济南宏济堂制药有限责任公司 | Quality control and detection method for sea dragon and gecko oral liquid |
| CN107737191A (en) * | 2017-09-22 | 2018-02-27 | 内蒙古蒙肽生物工程有限公司 | The saline cistanche composition and preparation technology of a kind of kidney-tonifying health-care |
| CN115400077A (en) * | 2022-09-22 | 2022-11-29 | 山东宏济堂制药集团股份有限公司 | Application of sea dragon and gecko oral liquid in preparation of medicine for treating allergic rhinitis |
-
2001
- 2001-02-02 CN CN 01102386 patent/CN1368151A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2402062A (en) * | 2003-03-28 | 2004-12-01 | Nuliv Biomedicine Inc | Pharmaceutical composition for the prophylaxis or treatment of osteoporosis |
| CN102218122A (en) * | 2011-04-13 | 2011-10-19 | 济南宏济堂制药有限责任公司 | Quality control and detection method for sea dragon and gecko oral liquid |
| CN107737191A (en) * | 2017-09-22 | 2018-02-27 | 内蒙古蒙肽生物工程有限公司 | The saline cistanche composition and preparation technology of a kind of kidney-tonifying health-care |
| CN115400077A (en) * | 2022-09-22 | 2022-11-29 | 山东宏济堂制药集团股份有限公司 | Application of sea dragon and gecko oral liquid in preparation of medicine for treating allergic rhinitis |
| CN115400077B (en) * | 2022-09-22 | 2024-01-26 | 山东宏济堂制药集团股份有限公司 | Application of Hailong Gecko Oral Liquid in Preparing Drugs for Treating Allergic Rhinitis |
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