CN1368277A - Nano medicine 'Yujin Yinxie' and its preparing process - Google Patents
Nano medicine 'Yujin Yinxie' and its preparing process Download PDFInfo
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- CN1368277A CN1368277A CN 01102631 CN01102631A CN1368277A CN 1368277 A CN1368277 A CN 1368277A CN 01102631 CN01102631 CN 01102631 CN 01102631 A CN01102631 A CN 01102631A CN 1368277 A CN1368277 A CN 1368277A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 10
- 241000972673 Phellodendron amurense Species 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 18
- 241000717739 Boswellia sacra Species 0.000 claims description 9
- 244000020518 Carthamus tinctorius Species 0.000 claims description 9
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 9
- 241000234653 Cyperus Species 0.000 claims description 9
- 241001489978 Eupolyphaga Species 0.000 claims description 9
- 239000004863 Frankincense Substances 0.000 claims description 9
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims description 9
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 9
- 206010047700 Vomiting Diseases 0.000 claims description 9
- 230000008673 vomiting Effects 0.000 claims description 9
- 241001062009 Indigofera Species 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 235000014375 Curcuma Nutrition 0.000 claims description 5
- 235000009815 Momordica Nutrition 0.000 claims description 5
- 241000218984 Momordica Species 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 229940097275 indigo Drugs 0.000 claims description 4
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229910052957 realgar Inorganic materials 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 244000299790 Rheum rhabarbarum Species 0.000 claims 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000163122 Curcuma domestica Species 0.000 claims 1
- 244000283207 Indigofera tinctoria Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 201000004681 Psoriasis Diseases 0.000 abstract description 2
- 241000501743 Gentiana macrophylla Species 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 241000219061 Rheum Species 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000407170 Curcuma Species 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
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- 244000045947 parasite Species 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
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- 230000000144 pharmacologic effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000001185 psoriatic effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Yijun Yinxie" for treating psoriasis is prepared from the nanometre powders of 19 Chinese medicinal materials including large-leaf gentian root, Chinese angelica root, phellodendron bark, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Yujin Yinxie ' of a kind of promoting flow of QI and blood, softening the hard mass removing food stagnancy, heat-clearing and toxic substances removing, removing dampness and killing parasites, the invention still further relates to the method for this medication preparation.
YUJIN YINXIE PIAN is a kind of classical Chinese patent medicine, mainly contains effects such as promoting flow of QI and blood, softening the hard mass removing food stagnancy, heat-clearing and toxic substances removing, removing dampness and killing parasites, is used for psoriasis.But traditional YUJIN YINXIE PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Yujin Yinxie ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Yujin Yinxie '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Gentianae Macrophyllae 20-45 part nano Chinese angelica 20-45 part nanometer Rhizoma Acori Graminei 20-40 part
Nano phellodendron bark 20-45 part nano cyperus tuber 20-45 part nanometer Radix Curcumae 20-45 part
Nanometer Rhizoma Curcumae 20-45 part nanometer-size realgar 20-45 part nano vomiting nut 20-45 part
Nanometer Spina Gleditsiae 20-45 part nanometer Semen Persicae 20-45 part nano safflower 20-45 part
The profound bright 12-25 part of nanometer Olibanum 20-45 part nanometer Sal Ammoniacus 8-18 part nanometer
Nano rhubarb 12-25 part nanometer Eupolyphaga Seu Steleophaga 25-60 part nano natural indigo 15-45 part
Nanometer Semen Momordicae 15-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Gentianae Macrophyllae 25-35 part nano Chinese angelica 25-35 part nanometer Rhizoma Acori Graminei 25-35 part
Nano phellodendron bark 25-35 part nano cyperus tuber 25-35 part nanometer Radix Curcumae 25-35 part
Nanometer Rhizoma Curcumae 25-35 part nanometer-size realgar 25-35 part nano vomiting nut 25-35 part
Nanometer Spina Gleditsiae 25-35 part nanometer Semen Persicae 25-35 part nano safflower 25-35 part
The profound bright 15-21 part of nanometer Olibanum 25-35 part nanometer Sal Ammoniacus 9-15 part nanometer
Nano rhubarb 15-21 part nanometer Eupolyphaga Seu Steleophaga 30-50 part nano natural indigo 20-30 part
Nanometer Semen Momordicae 20-30 part
The optimum weight proportioning of medicine of the present invention is:
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nano Chinese angelicas of nanometer Radix Gentianae Macrophyllae
30 parts of 30 parts of nanometer Radix Curcumaes of 30 parts of nano cyperus tubers of nano phellodendron bark
30 parts of 30 parts of nano vomiting nuts of 30 parts of nanometer-size realgars of nanometer Rhizoma Curcumae
30 parts of 30 parts of nano safflowers of 30 parts of nanometer Semen Persicaes of nanometer Spina Gleditsiae
Profound bright 18 parts of 12 parts of nanometers of 30 parts of nanometer Sal Ammoniacuss of nanometer Olibanum
24 parts of 36 parts of nano natural indigos of 18 parts of nanometer Eupolyphaga Seu Steleophagas of nano rhubarb
24 parts of nanometer Semen Momordicaes
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Yujin Yinxie ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Yujin Yinxie ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common YUJIN YINXIE PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Yujin Yinxie ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for psoriatic treatment, and clinical efficacy significantly is better than traditional YUJIN YINXIE PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nano Chinese angelicas of nanometer Radix Gentianae Macrophyllae
30 parts of 30 parts of nanometer Radix Curcumaes of 30 parts of nano cyperus tubers of nano phellodendron bark
30 parts of 30 parts of nano vomiting nuts of 30 parts of nanometer-size realgars of nanometer Rhizoma Curcumae
30 parts of 30 parts of nano safflowers of 30 parts of nanometer Semen Persicaes of nanometer Spina Gleditsiae
Profound bright 18 parts of 12 parts of nanometers of 30 parts of nanometer Sal Ammoniacuss of nanometer Olibanum
24 parts of 36 parts of nano natural indigos of 18 parts of nanometer Eupolyphaga Seu Steleophagas of nano rhubarb
24 parts of nanometer Semen Momordicaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nano Chinese angelicas of nanometer Radix Gentianae Macrophyllae
30 parts of 30 parts of nanometer Radix Curcumaes of 30 parts of nano cyperus tubers of nano phellodendron bark
30 parts of 30 parts of nano vomiting nuts of 30 parts of nanometer-size realgars of nanometer Rhizoma Curcumae
30 parts of 30 parts of nano safflowers of 30 parts of nanometer Semen Persicaes of nanometer Spina Gleditsiae
Profound bright 18 parts of 12 parts of nanometers of 30 parts of nanometer Sal Ammoniacuss of nanometer Olibanum
24 parts of 36 parts of nano natural indigos of 18 parts of nanometer Eupolyphaga Seu Steleophagas of nano rhubarb
24 parts of nanometer Semen Momordicaes
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer Radix Curcumae silver bits powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nano Chinese angelicas of nanometer Radix Gentianae Macrophyllae
30 parts of 30 parts of nanometer Radix Curcumaes of 30 parts of nano cyperus tubers of nano phellodendron bark
30 parts of 30 parts of nano vomiting nuts of 30 parts of nanometer-size realgars of nanometer Rhizoma Curcumae
30 parts of 30 parts of nano safflowers of 30 parts of nanometer Semen Persicaes of nanometer Spina Gleditsiae
Profound bright 18 parts of 12 parts of nanometers of 30 parts of nanometer Sal Ammoniacuss of nanometer Olibanum
24 parts of 36 parts of nano natural indigos of 18 parts of nanometer Eupolyphaga Seu Steleophagas of nano rhubarb
24 parts of nanometer Semen Momordicaes
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Radix Curcumae silver bits membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest or affected part.
Claims (6)
1, a kind of nano medicine ' Yujin Yinxie ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Gentianae Macrophyllae 20-45 part nano Chinese angelica 20-45 part nanometer Rhizoma Acori Graminei 20-40 part
Nano phellodendron bark 20-45 part nano cyperus tuber 20-45 part nanometer Radix Curcumae 20-45 part
Nanometer Rhizoma Curcumae 20-45 part nanometer-size realgar 20-45 part nano vomiting nut 20-45 part
Nanometer Spina Gleditsiae 20-45 part nanometer Semen Persicae 20-45 part nano safflower 20-45 part
The profound bright 12-25 part of nanometer Olibanum 20-45 part nanometer Sal Ammoniacus 8-18 part nanometer
Nano rhubarb 12-25 part nanometer Eupolyphaga Seu Steleophaga 25-60 part nano natural indigo 15-45 part
Nanometer Semen Momordicae 15-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Yujin Yinxie ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Gentianae Macrophyllae 25-35 part nano Chinese angelica 25-35 part nanometer Rhizoma Acori Graminei 25-35 part
Nano phellodendron bark 25-35 part nano cyperus tuber 25-35 part nanometer Radix Curcumae 25-35 part
Nanometer Rhizoma Curcumae 25-35 part nanometer-size realgar 25-35 part nano vomiting nut 25-35 part
Nanometer Spina Gleditsiae 25-35 part nanometer Semen Persicae 25-35 part nano safflower 25-35 part
The profound bright 15-21 part of nanometer Olibanum 25-35 part nanometer Sal Ammoniacus 9-15 part nanometer
Nano rhubarb 15-21 part nanometer Eupolyphaga Seu Steleophaga 30-50 part nano natural indigo 20-30 part
Nanometer Semen Momordicae 20-30 part
3, nano medicine ' Yujin Yinxie ' according to claim 1, wherein the weight proportion of each nano raw material is:
30 parts of 30 parts of nanometer Rhizoma Acori Graminei of 30 parts of nano Chinese angelicas of nanometer Radix Gentianae Macrophyllae
30 parts of 30 parts of nanometer Radix Curcumaes of 30 parts of nano cyperus tubers of nano phellodendron bark
30 parts of 30 parts of nano vomiting nuts of 30 parts of nanometer-size realgars of nanometer Rhizoma Curcumae
30 parts of 30 parts of nano safflowers of 30 parts of nanometer Semen Persicaes of nanometer Spina Gleditsiae
Profound bright 18 parts of 12 parts of nanometers of 30 parts of nanometer Sal Ammoniacuss of nanometer Olibanum
24 parts of 36 parts of nano natural indigos of 18 parts of nanometer Eupolyphaga Seu Steleophagas of nano rhubarb
24 parts of nanometer Semen Momordicaes
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Yujin Yinxie 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Yujin Yinxie 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30-60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102631 CN1368277A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Yujin Yinxie' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102631 CN1368277A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Yujin Yinxie' and its preparing process |
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| Publication Number | Publication Date |
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| CN1368277A true CN1368277A (en) | 2002-09-11 |
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| CN 01102631 Pending CN1368277A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Yujin Yinxie' and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670689A (en) * | 2011-03-14 | 2012-09-19 | 苏州博创园生物医药科技有限公司 | Method for preparing spray for curing psoriasis |
| CN103381227A (en) * | 2012-05-04 | 2013-11-06 | 周士新 | External liniment and internal traditional Chinese medicine preparation formula for alopecia treatment |
-
2001
- 2001-02-06 CN CN 01102631 patent/CN1368277A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670689A (en) * | 2011-03-14 | 2012-09-19 | 苏州博创园生物医药科技有限公司 | Method for preparing spray for curing psoriasis |
| CN103381227A (en) * | 2012-05-04 | 2013-11-06 | 周士新 | External liniment and internal traditional Chinese medicine preparation formula for alopecia treatment |
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