[go: up one dir, main page]

TN2014000536A1 - Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof - Google Patents

Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof

Info

Publication number
TN2014000536A1
TN2014000536A1 TN2014000536A TN2014000536A TN2014000536A1 TN 2014000536 A1 TN2014000536 A1 TN 2014000536A1 TN 2014000536 A TN2014000536 A TN 2014000536A TN 2014000536 A TN2014000536 A TN 2014000536A TN 2014000536 A1 TN2014000536 A1 TN 2014000536A1
Authority
TN
Tunisia
Prior art keywords
antibodies
lag
antibody
methods
well
Prior art date
Application number
TN2014000536A
Other languages
English (en)
Inventor
Nils Lonberg
Mohan Srinivasan
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48795938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2014000536(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of TN2014000536A1 publication Critical patent/TN2014000536A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TN2014000536A 2012-07-02 2014-12-26 Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof TN2014000536A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261667058P 2012-07-02 2012-07-02
PCT/US2013/048999 WO2014008218A1 (fr) 2012-07-02 2013-07-02 Optimisation d'anticorps se liant à la protéine lag-3 exprimée par le gène 3 d'activation des lymphocytes, et leurs utilisations

Publications (1)

Publication Number Publication Date
TN2014000536A1 true TN2014000536A1 (en) 2016-03-30

Family

ID=48795938

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2014000536A TN2014000536A1 (en) 2012-07-02 2014-12-26 Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof

Country Status (39)

Country Link
US (7) US9505839B2 (fr)
EP (4) EP3275899B1 (fr)
JP (5) JP6320376B2 (fr)
KR (6) KR20220150417A (fr)
CN (2) CN104411723B (fr)
AR (3) AR091649A1 (fr)
AU (5) AU2013286914B2 (fr)
BR (1) BR112014032999B1 (fr)
CA (2) CA2877746C (fr)
CL (1) CL2014003637A1 (fr)
CO (1) CO7170127A2 (fr)
CY (3) CY1119563T1 (fr)
DK (3) DK2867258T3 (fr)
EA (2) EA202090227A1 (fr)
ES (3) ES2638545T3 (fr)
FI (2) FI3795592T3 (fr)
FR (1) FR22C1057I2 (fr)
HR (3) HRP20241357T1 (fr)
HU (4) HUE069061T2 (fr)
IL (1) IL236517B (fr)
LT (4) LT3795592T (fr)
LU (1) LUC00286I2 (fr)
MX (2) MX365417B (fr)
MY (3) MY197322A (fr)
NL (1) NL301205I2 (fr)
NO (2) NO2023008I1 (fr)
NZ (1) NZ628528A (fr)
PE (4) PE20191324A1 (fr)
PH (2) PH12021552200A1 (fr)
PL (2) PL2867258T3 (fr)
PT (3) PT2867258T (fr)
RS (3) RS56398B1 (fr)
SG (2) SG10201610960YA (fr)
SI (3) SI3275899T1 (fr)
SM (3) SMT202000628T1 (fr)
TN (1) TN2014000536A1 (fr)
TW (8) TWI662046B (fr)
UY (1) UY34887A (fr)
WO (1) WO2014008218A1 (fr)

Families Citing this family (574)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2439273B1 (fr) * 2005-05-09 2019-02-27 Ono Pharmaceutical Co., Ltd. Anticorps monoclonaux humains pour mort programmée 1 (PD-1) et procédés de traitement du cancer à l'aide d'anticorps anti-PD-1 seuls ou combinés à d'autres formulations immunothérapeutiques
HRP20151102T1 (xx) * 2005-07-01 2015-11-20 E. R. Squibb & Sons, L.L.C. Humana monoklonska antitijela za ligand programirane smrti 1 (pd-l1)
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
BRPI1006448B1 (pt) 2009-03-25 2021-08-17 Genentech, Inc Anticorpo antagonista anti-fgfr3, anticorpo monoclonal, polinucleotídeo, vetor, micro­organismo transgênico, método para produção de um anticorpo anti-fgfr3, formulação farmacêutica e usos do anticorpo antagonista anti-fgfr3
PT3409278T (pt) 2011-07-21 2020-12-18 Sumitomo Dainippon Pharma Oncology Inc Inibidores de proteína cinase heterocíclicos
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
UA117466C2 (uk) 2012-12-13 2018-08-10 Мерк Шарп Енд Доме Корп. СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19
US10344088B2 (en) * 2013-03-15 2019-07-09 Glaxosmithkline Intellectual Property Development Limited Antigen binding proteins
CN106211758B (zh) 2013-04-09 2021-03-23 北京强新生物科技有限公司 2-乙酰基萘并[2,3-b]呋喃-4,9-二酮用于治疗癌症的用途
AU2014296887A1 (en) * 2013-08-02 2016-01-28 Aduro Biotech Holdings, Europe B.V. Combining CD27 agonists and immune checkpoint inhibition for immune stimulation
SI3508502T1 (sl) * 2013-09-20 2023-07-31 Bristol-Myers Squibb Company Kombinacija anti-lag-3 protiteles in anti-pd-1 protiteles za zdravljenje tumorjev
WO2015048312A1 (fr) 2013-09-26 2015-04-02 Costim Pharmaceuticals Inc. Méthodes de traitement de cancers hématologiques
WO2015066413A1 (fr) 2013-11-01 2015-05-07 Novartis Ag Composés d'acide oxazolidinone-hydroxamique pour le traitement d'infections bactériennes
DK3081576T3 (da) 2013-12-12 2019-10-21 Shanghai hengrui pharmaceutical co ltd Pd-1-antistof, antigenbindende fragment deraf og medicinsk anvendelse deraf
LT3087071T (lt) 2013-12-24 2018-11-12 Bristol-Myers Squibb Company Tricikliniai junginiai kaip priešvėžiniai agentai
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
ES2902369T3 (es) * 2014-01-28 2022-03-28 Bristol Myers Squibb Co Anticuerpos anti-LAG-3 para tratar neoplasias malignas hemáticas
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
US10611829B2 (en) 2014-01-31 2020-04-07 Aimm Therapeutics B.V. Means and methods for producing stable antibodies
US10519237B2 (en) 2014-03-12 2019-12-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US9394365B1 (en) 2014-03-12 2016-07-19 Yeda Research And Development Co., Ltd Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
US10618963B2 (en) 2014-03-12 2020-04-14 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
KR20230097209A (ko) 2014-03-12 2023-06-30 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소
RS59853B1 (sr) * 2014-03-14 2020-02-28 Novartis Ag Molekuli anti-lag-3 antitela i njihove upotrebe
TWI714525B (zh) 2014-03-24 2021-01-01 瑞士商諾華公司 用於治療細菌感染之單內醯胺（ｍｏｎｏｂａｃｔａｍ）有機化合物
RU2016149812A (ru) 2014-06-06 2018-07-17 Флексус Байосайенсиз, Инк. Иммунорегулирующие средства
RS59643B1 (sr) 2014-06-06 2020-01-31 Bristol Myers Squibb Co Antitela na glukokortikoidom indukovani receptor faktora nekroze tumora (gitr) i njihova primena
US10092645B2 (en) * 2014-06-17 2018-10-09 Medimmune Limited Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
JP2017523213A (ja) 2014-08-06 2017-08-17 ノバルティス アーゲー 抗菌薬としてのキノロン誘導体
JO3663B1 (ar) * 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
KR20170060042A (ko) 2014-09-13 2017-05-31 노파르티스 아게 Alk 억제제의 조합 요법
CA2963281A1 (fr) 2014-10-03 2016-04-07 Novartis Ag Polytherapies
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
TWI716362B (zh) 2014-10-14 2021-01-21 瑞士商諾華公司 針對ｐｄ－ｌ１之抗體分子及其用途
BR112017008575B1 (pt) 2014-10-29 2021-07-13 Bicyclerd Limited Ligantes de peptídeos bicíclicos específicos a mt1-mmp, conjugado de fármaco, processo para preparação de um conjugado de fármaco e composição farmacêutica
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
AR102537A1 (es) 2014-11-05 2017-03-08 Flexus Biosciences Inc Agentes inmunomoduladores
US11242319B2 (en) 2014-11-05 2022-02-08 Flexus Biosciences, Inc. Immunoregulatory agents
WO2016081748A2 (fr) 2014-11-21 2016-05-26 Bristol-Myers Squibb Company Anticorps anti-cd73 et leurs utilisations
WO2016094639A1 (fr) * 2014-12-10 2016-06-16 Wisconsin Alumni Research Foundation Vaccins d'adn de plasmide mini-introniques en combinaison avec un blocage lag3
JP6697466B2 (ja) 2014-12-16 2020-05-20 ノバルティス アーゲー ＬｐｘＣ阻害剤としてのイソオキサゾールヒドロキサム酸化合物
EP3233918A1 (fr) 2014-12-19 2017-10-25 Novartis AG Polythérapies
TW201630907A (zh) 2014-12-22 2016-09-01 必治妥美雅史谷比公司 ＴＧＦβＲ拮抗劑
SG10202006538TA (en) 2014-12-23 2020-08-28 Bristol Myers Squibb Co Antibodies to tigit
CN107427567A (zh) * 2015-01-29 2017-12-01 宾夕法尼亚大学理事会 检查点抑制剂和疫苗组合物及其用于免疫疗法的用途
HK1247861A1 (zh) 2015-01-30 2018-10-05 President And Fellows Of Harvard College 用於癌症治疗的肿瘤周围和肿瘤内部材料
MA41463A (fr) * 2015-02-03 2017-12-12 Anaptysbio Inc Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3)
WO2016127052A1 (fr) 2015-02-05 2016-08-11 Bristol-Myers Squibb Company Cxcl11 et smica comme biomarqueurs prédictifs de l'efficacité de l'immunothérapie anti-ctla-4
US20160243228A1 (en) * 2015-02-19 2016-08-25 Bioclin Therapeutics, Inc. Methods, compositions, and kits for treatment of cancer
WO2016140884A1 (fr) 2015-03-02 2016-09-09 Rigel Pharmaceuticals, Inc. Inhibiteurs de tgf-β
KR20170129802A (ko) 2015-03-10 2017-11-27 아두로 바이오테크, 인코포레이티드 ＂인터페론 유전자의 자극인자＂-의존적 신호전달을 활성화하는 조성물 및 방법
US10399933B2 (en) 2015-04-03 2019-09-03 Bristol-Myers Squibb Company Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer
CN107709365A (zh) 2015-04-13 2018-02-16 戊瑞治疗有限公司 癌症组合疗法
RS60753B1 (sr) * 2015-04-17 2020-10-30 Bristol Myers Squibb Co Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba
US10683290B2 (en) 2015-05-11 2020-06-16 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
EP3307740B1 (fr) 2015-05-12 2019-12-18 Bristol-Myers Squibb Company Composés 5h-pyrido[3,2-b]indole en tant qu'agents anticancéreux
US9725449B2 (en) 2015-05-12 2017-08-08 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
TR201911032T4 (tr) 2015-05-18 2019-08-21 Tolero Pharmaceuticals Inc Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları.
ES2889906T3 (es) 2015-05-21 2022-01-14 Harpoon Therapeutics Inc Proteínas de unión triespecíficas y usos médicos
CN107849144B (zh) 2015-05-29 2021-09-17 艾吉纳斯公司 抗-ctla-4抗体及其使用方法
PT3303396T (pt) 2015-05-29 2023-01-30 Bristol Myers Squibb Co Anticorpos contra ox40 e utilizações dos mesmos
TW201717935A (zh) 2015-06-03 2017-06-01 波士頓生醫公司 用於治療癌症的組成物和方法
EA039293B1 (ru) * 2015-06-05 2021-12-30 Мерк Шарп И Доум Корп. Антитела против lag3 и антигенсвязывающие фрагменты
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
UY36757A (es) 2015-06-29 2016-12-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Anticuerpos monoclonales murinos contra cd40 con actividad agonista mejorada
WO2017009843A2 (fr) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. Compositions, articles de fabrication et procédés pour traiter le cancer
WO2017015560A2 (fr) * 2015-07-22 2017-01-26 Sorrento Therapeutics, Inc. Anticorps thérapeutiques qui se lient à lag3
EP3328861A1 (fr) 2015-07-28 2018-06-06 Bristol-Myers Squibb Company Antagonistes des récepteurs du tgf bêta
EP3316902A1 (fr) 2015-07-29 2018-05-09 Novartis AG Polythérapies comprenant des molécules d'anticorps contre tim -3
SI3317301T1 (sl) 2015-07-29 2021-10-29 Novartis Ag Kombinirane terapije, ki obsegajo molekule protitelesa na LAG-3
EP4378957A3 (fr) 2015-07-29 2024-08-07 Novartis AG Traitements combinés comprenant des molécules d'anticorps qui se lient à pd-1
CR20200423A (es) * 2015-07-30 2021-01-20 Macrogenics Inc Moléculas de unión a pd-1 y métodos de uso de las mismas (divisional 2018-0062)
WO2017035118A1 (fr) 2015-08-25 2017-03-02 Bristol-Myers Squibb Company Antagonistes du récepteur tgf bêta
MY205096A (en) 2015-09-02 2024-10-01 Immutep Sas Anti-lag-3 antibodies
EP3350183B1 (fr) 2015-09-14 2025-04-02 Twelve Therapeutics, Inc. Formes solides de dérivés d'isoquinolinone, leur procédé de fabrication, compositions les comprenant et méthodes d'utilisation de celles-ci
JP6952028B2 (ja) * 2015-09-29 2021-10-20 シャンハイ チャンジアン バイオテクノロジー カンパニー リミテッド Ｐｄ−１抗体およびその使用
JP6622392B2 (ja) 2015-10-02 2019-12-18 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｐｄ１とｔｉｍ３に特異的な二重特異性抗体
TWI756187B (zh) * 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途
US10149887B2 (en) 2015-10-23 2018-12-11 Canbas Co., Ltd. Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment
EP3368074A2 (fr) * 2015-10-30 2018-09-05 Hoffmann-La Roche AG Anticorps et conjugués anti-facteur d
MX2018005517A (es) 2015-11-02 2018-11-09 Five Prime Therapeutics Inc Polipeptidos del dominio extracelular de cd80 y su uso en el tratamiento del cancer.
CN108350416A (zh) 2015-11-09 2018-07-31 百时美施贵宝公司 操纵在cho细胞中产生的多肽的品质属性的方法
JP6945456B2 (ja) * 2015-11-13 2021-10-06 マクロジェニクス，インコーポレーテッド Ｌａｇ‐３結合分子及びその使用方法
WO2017087589A2 (fr) 2015-11-18 2017-05-26 Merck Sharp & Dohme Corp. Liants pd1 et/ou lag3
EA201891121A1 (ru) 2015-11-19 2018-12-28 Бристол-Майерс Сквибб Компани Антитела к глюкокортикоид-индуцированному рецептору фактора некроза опухоли (gitr) и их применения
RS61866B1 (sr) 2015-11-20 2021-06-30 Regeneron Pharma Ne-humane životinje koje imaju humanizovani gen za aktivaciju limfocita 3
TWI791422B (zh) 2015-11-23 2023-02-11 美商戊瑞治療有限公司 用於癌症治療之單獨fgfr2抑制劑或與免疫刺激劑組合
BR112018011781A2 (en) 2015-12-14 2018-12-04 Macrogenics, Inc. bispecific molecule having one or more epitope binding sites capable of immunospecific binding to (one) pd-1 epitope (s) and one or more epitope binding sites capable of immunospecific binding to (one) epitope (s) -4, and pharmaceutical composition
EP3390406A1 (fr) 2015-12-15 2018-10-24 Bristol-Myers Squibb Company Antagonistes du récepteur cxcr4
US11045547B2 (en) 2015-12-16 2021-06-29 Merck Sharp & Dohme Corp. Anti-LAG3 antibodies and antigen-binding fragments
EP3389712B1 (fr) 2015-12-17 2024-04-10 Novartis AG Molécules d'anticorps anti-pd-1 et leurs utilisations
CN109069623A (zh) 2015-12-18 2018-12-21 诺华股份有限公司 靶向CD32b的抗体及其使用方法
HK1257518A1 (zh) 2016-01-11 2019-10-25 Novartis Ag 针对人白介素-2的免疫刺激性人源化单克隆抗体及其融合蛋白
AU2017219216B2 (en) 2016-02-19 2019-12-19 Novartis Ag Tetracyclic pyridone compounds as antivirals
EP4406550A3 (fr) * 2016-03-04 2024-10-16 The Rockefeller University Anticorps anti-cd40 à activité agoniste améliorée
SG11201806861SA (en) 2016-03-04 2018-09-27 Bristol Myers Squibb Co Combination therapy with anti-cd73 antibodies
PL3433257T3 (pl) 2016-03-24 2024-02-12 Novartis Ag Analogi nukleozydów alkinylu jako inhibitory ludzkiego rinowirusa
WO2017178572A1 (fr) 2016-04-13 2017-10-19 Vivia Biotech, S.L Cellules t destructrices de cellules tumorales et leurs utilisations
WO2017184619A2 (fr) 2016-04-18 2017-10-26 Celldex Therapeutics, Inc. Anticorps agonistes se liant au cd40 humain et leurs utilisations
JP2019519485A (ja) 2016-05-04 2019-07-11 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法
US10696648B2 (en) 2016-05-04 2020-06-30 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US10323004B2 (en) 2016-05-04 2019-06-18 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
CN109414421A (zh) 2016-05-04 2019-03-01 百时美施贵宝公司 吲哚胺2,3-双加氧酶的抑制剂及其使用方法
KR20190004742A (ko) 2016-05-04 2019-01-14 브리스톨-마이어스 스큅 컴퍼니 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
RS61510B1 (sr) 2016-05-18 2021-03-31 Boehringer Ingelheim Int Anti pd-1 i anti-lag3 antitela za lečenje kancera
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
US11400155B2 (en) 2016-05-20 2022-08-02 Biohaven Therapeutics Ltd. Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers
CN119060177A (zh) 2016-05-20 2024-12-03 哈普恩治疗公司 单结构域血清白蛋白结合蛋白质
US11472856B2 (en) 2016-06-13 2022-10-18 Torque Therapeutics, Inc. Methods and compositions for promoting immune cell function
PH12018502523B1 (en) 2016-06-14 2023-05-12 Novartis Ag Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent
WO2017216686A1 (fr) 2016-06-16 2017-12-21 Novartis Ag Composés de 2-oxo-6,7-dihydropyrido-isoquinoline fusionnés en 8,9 utilisés comme antiviraux
WO2017216685A1 (fr) 2016-06-16 2017-12-21 Novartis Ag Composés pyridones pentacycliques utiles en tant qu'agents antiviraux
TW201831513A (zh) 2016-06-20 2018-09-01 Ｆ星貝塔有限公司 結合物件(一)
CA3027612A1 (fr) 2016-06-20 2017-12-28 F-Star Delta Limited Molecules de liaison liant pd-l1 et lag -3
EP3471754A1 (fr) 2016-06-20 2019-04-24 Kymab Limited Anticorps anti-pd-l1
MX2018015393A (es) 2016-06-23 2019-04-29 Jiangsu Hengrui Medicine Co Anticuerpo lag-3, fragmento de union al antigeno del mismo y aplicacion farmaceutica del mismo.
MX391135B (es) 2016-06-24 2025-03-21 Infinity Pharmaceuticals Inc Terapias de combinacion.
WO2018009466A1 (fr) 2016-07-05 2018-01-11 Aduro Biotech, Inc. Composés dinucléotidiques cycliques d'acide nucléique bloqué et leurs utilisations
WO2018013818A2 (fr) 2016-07-14 2018-01-18 Bristol-Myers Squibb Company Anticorps anti-tim3 et leurs utilisations
JP2019532017A (ja) 2016-07-14 2019-11-07 フレッド ハッチンソン キャンサー リサーチ センター がんを治療するための異なるエピトープ結合を示す複数の二重特異性結合ドメイン構築物
GB201612520D0 (en) 2016-07-19 2016-08-31 F-Star Beta Ltd Binding molecules
US20190292179A1 (en) 2016-07-21 2019-09-26 Bristol-Myers Squibb Company TGF Beta RECEPTOR ANTAGONISTS
JP7054144B2 (ja) * 2016-08-15 2022-04-13 国立大学法人北海道大学 抗ｌａｇ－３抗体
WO2018039518A1 (fr) 2016-08-26 2018-03-01 Bristol-Myers Squibb Company Inhibiteurs d'indoleamine 2,3-dioxygénase et leurs méthodes d'utilisation
CN110267990B (zh) * 2016-08-30 2023-11-07 Xencor股份有限公司 结合共刺激性和检查点受体的双特异性免疫调节抗体
WO2018047109A1 (fr) 2016-09-09 2018-03-15 Novartis Ag Composés pyridones polycycliques utiles en tant qu'agents antiviraux
JP7274413B2 (ja) 2016-09-23 2023-05-16 マレンゴ・セラピューティクス，インコーポレーテッド ラムダ及びカッパ軽鎖を含む多重特異性抗体分子
JOP20190061A1 (ar) 2016-09-28 2019-03-26 Novartis Ag مثبطات بيتا-لاكتاماز
BR112019007369A2 (pt) 2016-10-11 2019-07-16 Agenus Inc anticorpos anti-lag-3 e métodos de uso dos mesmos
WO2018069500A2 (fr) * 2016-10-13 2018-04-19 Symphogen A/S Anticorps anti-lag-3 et compositions
TW201819380A (zh) 2016-10-18 2018-06-01 瑞士商諾華公司 作為抗病毒劑之稠合四環吡啶酮化合物
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
WO2018094275A1 (fr) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Promédicaments de l'alvocidib et leur utilisation en tant qu'inhibiteurs de protéines kinases
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
PT3551660T (pt) 2016-12-07 2023-11-30 Ludwig Inst For Cancer Res Ltd Anticorpos anti-ctla-4 e métodos de uso dos mesmos
WO2018132279A1 (fr) 2017-01-05 2018-07-19 Bristol-Myers Squibb Company ANTAGONISTES DU RÉCEPTEUR TGF-β
EP3570844B1 (fr) 2017-01-20 2023-09-06 Arcus Biosciences, Inc. Azolopyrimidine pour le traitement de troubles liés au cancer
IL268667B2 (en) 2017-02-10 2024-12-01 Regeneron Pharma Radiolabeled antibodies against LAG3 for immuno-PET imaging
WO2018151820A1 (fr) 2017-02-16 2018-08-23 Elstar Therapeutics, Inc. Molécules multifonctionnelles comprenant un ligand trimérique et leurs utilisations
JP6929951B2 (ja) 2017-02-22 2021-09-01 アイ−エムエービー バイオファーマ （ハンジョウ） カンパニー リミテッド 抗ｌａｇ−３抗体およびその使用
EP3601353A1 (fr) 2017-03-31 2020-02-05 Five Prime Therapeutics, Inc. Polythérapie pour le cancer à l'aide d'anticorps anti-gitr
SG10202110594UA (en) 2017-03-31 2021-11-29 Bristol Myers Squibb Co Methods of treating tumor
CN117003887A (zh) 2017-04-03 2023-11-07 豪夫迈·罗氏有限公司 抗pd-1抗体与突变体il-2或与il-15的免疫缀合物
US11285207B2 (en) 2017-04-05 2022-03-29 Hoffmann-La Roche Inc. Bispecific antibodies specifically binding to PD1 and LAG3
CR20190434A (es) 2017-04-05 2019-11-01 Hoffmann La Roche Anticuerpos anti-lag3
EP3606957A1 (fr) 2017-04-05 2020-02-12 Symphogen A/S Polythérapies ciblant pd-1, tim-3 et lag-3
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
CA3058944A1 (fr) 2017-04-19 2018-10-25 Elstar Therapeutics, Inc. Molecules multispecifiques et utilisations correspondantes
EP3612030B1 (fr) 2017-04-21 2025-12-24 Ikena Oncology, Inc. Inhibiteurs d'indole ahr et leurs utilisations
EP3615070A1 (fr) 2017-04-26 2020-03-04 Bristol-Myers Squibb Company Procédés de production d'anticorps qui réduisent au minimum la réduction de liaison disulfure
AR111419A1 (es) 2017-04-27 2019-07-10 Novartis Ag Compuestos fusionados de indazol piridona como antivirales
SG11201909395TA (en) * 2017-04-27 2019-11-28 Tesaro Inc Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
AR111651A1 (es) 2017-04-28 2019-08-07 Novartis Ag Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
MX2019012849A (es) 2017-04-28 2019-11-28 Five Prime Therapeutics Inc Metodos de tratamiento con polipeptidos del dominio extracelular del cd80.
US20200385472A1 (en) 2017-04-28 2020-12-10 Elstar Therapeutics, Inc. Multispecific molecules comprising a non-immunoglobulin heterodimerization domain and uses thereof
UY37718A (es) 2017-05-05 2018-11-30 Novartis Ag 2-quinolinonas triciclicas como agentes antibacteriales
CN110621337B (zh) * 2017-05-10 2021-11-09 浙江时迈药业有限公司 抗lag3人单克隆抗体及其用途
WO2018209049A1 (fr) 2017-05-12 2018-11-15 Bristol-Myers Squibb Company Inhibiteurs d'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
SG10202107880XA (en) 2017-05-12 2021-09-29 Harpoon Therapeutics Inc Mesothelin binding proteins
EP3634417B1 (fr) 2017-05-17 2023-07-12 Arcus Biosciences, Inc. Dérivés quinazoline-pyrazole pour le traitement de troubles liés au cancer
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル， インコーポレイテッド がんを処置するための方法
WO2018222711A2 (fr) * 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Compositions comprenant une combinaison d'un anticorps anti-lag-3, d'un inhibiteur de voie pd-1 et d'un agent immunothérapeutique
SMT202300418T1 (it) 2017-05-30 2024-01-10 Bristol Myers Squibb Co Trattamento di tumori positivi per lag-3
WO2018222722A2 (fr) * 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Compositions comprenant un anticorps anti-lag-3 ou un anticorps anti-lag-3 et un anticorps anti-pd-1 ou anti-pd-l1
JP2020522254A (ja) 2017-05-31 2020-07-30 エルスター セラピューティクス， インコーポレイテッド 骨髄増殖性白血病（ｍｐｌ）タンパク質に結合する多特異性分子およびその使用
WO2018223004A1 (fr) 2017-06-01 2018-12-06 Xencor, Inc. Anticorps bispécifiques se liant à cd20 et cd3
US20200181274A1 (en) 2017-06-01 2020-06-11 Novartis Ag Bispecific antibodies that bind cd 123 cd3
WO2018229715A1 (fr) 2017-06-16 2018-12-20 Novartis Ag Compositions comprenant des anticorps anti-cd32b et procédés d'utilisation correspondants
AU2018287519B2 (en) 2017-06-22 2021-07-22 Novartis Ag IL-1beta binding antibodies for use in treating cancer
WO2018235056A1 (fr) 2017-06-22 2018-12-27 Novartis Ag Anticorps se liant à il-1beta destinés à être utilisés dans le traitement du cancer
US20200172628A1 (en) 2017-06-22 2020-06-04 Novartis Ag Antibody molecules to cd73 and uses thereof
WO2018237157A1 (fr) 2017-06-22 2018-12-27 Novartis Ag Molécules d'anticorps se liant à cd73 et leurs utilisations
JP2020525483A (ja) 2017-06-27 2020-08-27 ノバルティス アーゲー 抗ｔｉｍ−３抗体のための投与レジメンおよびその使用
CN111093651B (zh) 2017-06-30 2023-06-06 百时美施贵宝公司 Ido抑制剂的无定形和结晶形式
EP3652212A4 (fr) * 2017-07-13 2021-04-14 Nanjing Leads Biolabs Co., Ltd. Anticorps de liaison à lag-3 et leurs utilisations
JP2020527572A (ja) 2017-07-20 2020-09-10 ノバルティス アーゲー 抗ｌａｇ−３抗体の投薬量レジメンおよびその使用
JP7186764B2 (ja) 2017-07-28 2022-12-09 ブリストル－マイヤーズ スクイブ カンパニー 抗癌剤としての環状ジヌクレオチド
US11261214B2 (en) 2017-08-04 2022-03-01 Bicycletx Limited Bicyclic peptide ligand specific for CD137
WO2019035938A1 (fr) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. Molécules multispécifiques se liant à bcma et leurs utilisations
EP3668496A4 (fr) 2017-08-17 2021-07-14 Ikena Oncology, Inc. Inhibiteurs d'ahr et leurs utilisations
TWI785098B (zh) 2017-08-18 2022-12-01 開曼群島商科賽睿生命科學公司 Tg02之多晶型
AU2018323955A1 (en) 2017-08-30 2020-03-19 Phanes Therapeutics, Inc. Anti-LAG-3 antibodies and uses thereof
CN111032672B (zh) 2017-08-31 2024-09-13 百时美施贵宝公司 作为抗癌剂的环二核苷酸
JP7209697B2 (ja) 2017-08-31 2023-01-20 ブリストル－マイヤーズ スクイブ カンパニー 抗癌剤としての環状ジヌクレオチド
ES2904317T3 (es) 2017-08-31 2022-04-04 Bristol Myers Squibb Co Dinucleótidos cíclicos como agentes anticancerosos
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
EP3684366A4 (fr) 2017-09-22 2021-09-08 Kymera Therapeutics, Inc. Ligands crbn et utilisations de ces derniers
MX2020003190A (es) 2017-09-22 2020-11-11 Kymera Therapeutics Inc Degradadores de proteinas y usos de los mismos.
WO2019070013A1 (fr) * 2017-10-05 2019-04-11 第一三共株式会社 Composition pour déplétion de lymphocytes t cytotoxiques
WO2019074824A1 (fr) 2017-10-09 2019-04-18 Bristol-Myers Squibb Company Inhibiteurs d'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
WO2019074822A1 (fr) 2017-10-09 2019-04-18 Bristol-Myers Squibb Company Inhibiteurs d'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
WO2019075090A1 (fr) 2017-10-10 2019-04-18 Tilos Therapeutics, Inc. Anticorps anti-lap et leurs utilisations
EP3694867B1 (fr) 2017-10-10 2025-12-24 Bristol-Myers Squibb Company Dinucléotides cycliques utilisés en tant qu'agents anticancéreux
BR112020007196A2 (pt) 2017-10-13 2020-12-01 Harpoon Therapeutics, Inc. proteínas triespecíficas e métodos de uso
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
CN111247169A (zh) 2017-10-15 2020-06-05 百时美施贵宝公司 治疗肿瘤的方法
US11427610B2 (en) 2017-10-16 2022-08-30 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
EP3697434A1 (fr) 2017-10-18 2020-08-26 Vivia Biotech, S.L. Cellules car-t activées par des bite
EP3700933A1 (fr) 2017-10-25 2020-09-02 Novartis AG Anticorps ciblant cd32b et leurs procédés d'utilisation
EP3704159A1 (fr) 2017-11-01 2020-09-09 Bristol-Myers Squibb Company Anticorps agonistes immunostimulateurs destinés à être utilisés dans le traitement du cancer
WO2019090198A1 (fr) 2017-11-06 2019-05-09 Bristol-Myers Squibb Company Composés d'isofuranone utiles en tant qu'inhibiteurs de hpk1
WO2019099838A1 (fr) 2017-11-16 2019-05-23 Novartis Ag Polythérapies
JP2021503458A (ja) 2017-11-17 2021-02-12 ノバルティス アーゲー 新規のジヒドロイソキサゾール化合物及びｂ型肝炎治療のためのそれらの使用
TW201925782A (zh) 2017-11-30 2019-07-01 瑞士商諾華公司 靶向bcma之嵌合抗原受體及其用途
EP3720881A1 (fr) 2017-12-08 2020-10-14 Elstar Therapeutics, Inc. Molécules multispécifiques et utilisations correspondantes
CN111741976B (zh) 2017-12-19 2024-09-17 英沃克斯制药有限公司 包括pd-l1抗原结合位点的fc结合片段
JP2021507906A (ja) 2017-12-20 2021-02-25 ノバルティス アーゲー 抗ウイルス剤としての融合三環式ピラゾロ−ジヒドロピラジニル−ピリドン化合物
BR112020011664A2 (pt) 2017-12-22 2020-11-17 Jiangsu Hengrui Medicine Co., Ltd. composição farmacêutica do anticorpo lag-3 e seu uso
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
JP7284759B2 (ja) 2017-12-27 2023-05-31 ブリストル－マイヤーズ スクイブ カンパニー 抗ｃｄ４０抗体およびその使用
WO2019129136A1 (fr) 2017-12-27 2019-07-04 信达生物制药(苏州)有限公司 Anticorps anti-pd-l1 et ses applications
CN109970856B (zh) * 2017-12-27 2022-08-23 信达生物制药(苏州)有限公司 抗lag-3抗体及其用途
WO2019129137A1 (fr) 2017-12-27 2019-07-04 信达生物制药(苏州)有限公司 Anticorps anti-lag-3 et utilisations associées
CN109970857B (zh) 2017-12-27 2022-09-30 信达生物制药(苏州)有限公司 抗pd-l1抗体及其用途
US11447449B2 (en) 2018-01-05 2022-09-20 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
CN112218651A (zh) 2018-01-08 2021-01-12 诺华公司 用于与嵌合抗原受体疗法组合的免疫增强rna
EP3737692A4 (fr) 2018-01-09 2021-09-29 Elstar Therapeutics, Inc. Constructions de liaison à la calréticuline et lymphocytes t modifiés pour le traitement de maladies
EP3737666A4 (fr) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Agents de dégradation de protéines et utilisations associées
JP7358361B2 (ja) 2018-01-12 2023-10-10 ブリストル－マイヤーズ スクイブ カンパニー Ｔｉｍ３に対する抗体およびその使用
EP3737675A4 (fr) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Ligands crbn et leurs utilisations
US11655295B2 (en) 2018-01-18 2023-05-23 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Anti-LAG-3 antibody and use thereof
US10988477B2 (en) 2018-01-29 2021-04-27 Merck Patent Gmbh GCN2 inhibitors and uses thereof
MX2020007797A (es) 2018-01-29 2020-09-18 Merck Patent Gmbh Inhibidores de la cinasa 2 de control general no desrepresible (gcn2) y usos de los mismos.
EP3746480A1 (fr) 2018-01-31 2020-12-09 F. Hoffmann-La Roche AG Anticorps bispécifiques comprenant un site de liaison à l'antigène se liant à lag3
AU2019215031B2 (en) 2018-01-31 2025-10-09 Novartis Ag Combination therapy using a chimeric antigen receptor
JP2021511782A (ja) 2018-01-31 2021-05-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 安定化された免疫グロブリンドメイン
WO2019160956A1 (fr) 2018-02-13 2019-08-22 Novartis Ag Thérapie par récepteur antigénique chimérique en combinaison avec il-15 r et il15
US10519187B2 (en) 2018-02-13 2019-12-31 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
AU2019222747B2 (en) 2018-02-16 2024-09-05 Arcus Biosciences, Inc. Dosing with an azolopyrimidine compound
CA3091775A1 (fr) 2018-02-23 2019-08-29 Bicycletx Limited Ligands peptidiques bicycliques multimeres
WO2019165315A1 (fr) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Méthode de traitement du cancer à l'aide d'antagonistes de chimiokine seuls ou en combinaison
CN115057931B (zh) * 2018-02-28 2025-08-22 广州誉衡生物科技有限公司 抗人lag-3抗体及其用途
JP2021514982A (ja) 2018-02-28 2021-06-17 ノバルティス アーゲー インドール−２−カルボニル化合物及びｂ型肝炎治療のためのそれらの使用
US11795221B2 (en) 2018-02-28 2023-10-24 WuXi Biologics Ireland Limited Monoclonal antibody against human LAG-3, method for preparing the same, and use thereof
SG11202008113RA (en) 2018-03-05 2020-09-29 Arcus Biosciences Inc Arginase inhibitors
KR20200130362A (ko) 2018-03-08 2020-11-18 브리스톨-마이어스 스큅 컴퍼니 항암제로서의 시클릭 디뉴클레오티드
EP3765516A2 (fr) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Molécules multifonctionnelles et utilisations associées
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
WO2019179365A1 (fr) * 2018-03-20 2019-09-26 WuXi Biologics Ireland Limited Nouveau polypeptide anticorps anti-lag-3
WO2019183040A1 (fr) 2018-03-21 2019-09-26 Five Prime Therapeutics, Inc. Anticorps se liant à vista à ph acide
JP7351845B2 (ja) 2018-03-23 2023-09-27 ブリストル－マイヤーズ スクイブ カンパニー Ｍｉｃａおよび／またはｍｉｃｂに対する抗体ならびにそれらの使用
JP2021519771A (ja) 2018-03-30 2021-08-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 腫瘍を処置する方法
US11840568B2 (en) 2018-04-02 2023-12-12 Mab-Venture Biopharm Co., Ltd. Lymphocyte activation gene-3 (LAG-3) binding antibody and use thereof
CN110343178B (zh) * 2018-04-03 2022-07-22 上海开拓者生物医药有限公司 抗人lag-3单克隆抗体及其应用
US20210147547A1 (en) 2018-04-13 2021-05-20 Novartis Ag Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
AU2019255196A1 (en) 2018-04-16 2020-11-12 Arrys Therapeutics, Inc. EP4 inhibitors and use thereof
CA3097625A1 (fr) 2018-04-18 2019-10-24 Xencor, Inc. Proteines de fusion fc heterodimeres il-15/il-15ra et leurs utilisations
CA3097593A1 (fr) 2018-04-18 2019-10-24 Xencor, Inc. Proteines de fusion heterodimeres ciblant pd-1 contenant des proteines de fusion fc d'il-15/il-15ra, domaines de liaison a l'antigene pd-1 et utilisations associees
WO2019213340A1 (fr) 2018-05-03 2019-11-07 Bristol-Myers Squibb Company Dérivés d'uracile en tant qu'inhibiteurs de mer-axl
UY38247A (es) 2018-05-30 2019-12-31 Novartis Ag Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
WO2019232244A2 (fr) 2018-05-31 2019-12-05 Novartis Ag Molécules d'anticorps anti-cd73 et leurs utilisations
CA3102256A1 (fr) 2018-06-01 2019-12-05 Novartis Ag Dosage d'un anticorps bispecifique qui se lie a cd123 et cd3
IL317554A (en) 2018-06-01 2025-02-01 Novartis Ag Anti-BCMA binding molecules and their uses
CN113166972A (zh) 2018-06-11 2021-07-23 耶鲁大学 新型免疫检查点抑制剂
CN110606892B (zh) * 2018-06-14 2023-09-26 华博生物医药技术（上海）有限公司 一种高亲和力高生物活性的lag-3抗体及其应用
CN110615840A (zh) * 2018-06-19 2019-12-27 信达生物制药(苏州)有限公司 全人源的抗lag-3抗体及其应用
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
FI3814348T3 (fi) 2018-06-27 2023-09-22 Bristol Myers Squibb Co Substituoituja naftyridinoniyhdisteitä, jotka ovat käyttökelpoisia t-solun aktivoijina
LT3814347T (lt) 2018-06-27 2023-07-10 Bristol-Myers Squibb Company Naftiridinono junginiai naudotini kaip t ląstelių aktyvatoriai
US11945864B2 (en) 2018-06-29 2024-04-02 Y-Biologics Inc. Monoclonal antibody specifically binding to LAG-3 and use thereof
WO2020010250A2 (fr) 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Molécules d'anticorps anti-tcr et leurs utilisations
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
US12454520B2 (en) 2018-07-06 2025-10-28 Kymera Therapeutics, Inc. Protein degraders and uses thereof
PE20211604A1 (es) 2018-07-09 2021-08-23 Five Prime Therapeutics Inc Anticuerpos de union a ilt4
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
LT3820573T (lt) 2018-07-10 2023-11-10 Novartis Ag 3-(5-hidroksi-1-oksoizoindolin-2-il)piperidin-2,6-diono dariniai ir jų naudojimas gydyti nuo ikaros šeimos cinko pirštų 2 (ikzf2) priklausomas ligas
AU2019301120A1 (en) 2018-07-11 2021-02-25 Bristol-Myers Squibb Company Antibodies binding to VISTA at acidic pH
GB201811404D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Anti-CD137 Antibodies
GB201811450D0 (en) 2018-07-12 2018-08-29 F Star Delta Ltd Mesothelin and CD137 binding molecules
GB201811408D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd CD137 Binding Molecules
GB201811415D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Anti-Mesothelin Anti bodies
TWI847989B (zh) 2018-07-12 2024-07-11 英商Ｆ—星治療有限公司 結合cd137及ox40的抗體分子
JP7360440B2 (ja) 2018-07-12 2023-10-12 エフ－スター セラピューティクス リミテッド Ｐｄ－ｌ１及びｃｄ１３７に結合する抗体分子
GB201811403D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Antibody molecules
GB201811410D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd OX40 Binding molecules
CN113015523B (zh) 2018-07-18 2024-07-16 艾库斯生物科学有限公司 偶氮嘧啶化合物的固体形式
AU2019306628B2 (en) 2018-07-20 2024-11-14 Surface Oncology, LLC Anti-CD112R compositions and methods
WO2020023355A1 (fr) 2018-07-23 2020-01-30 Bristol-Myers Squibb Company Inhibiteurs de l'indoléamine 2,3-dioxygénase et leurs procédés d'utilisation
US12145927B2 (en) 2018-07-23 2024-11-19 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
WO2020021465A1 (fr) 2018-07-25 2020-01-30 Advanced Accelerator Applications (Italy) S.R.L. Procédé de traitement de tumeurs neuroendocrines
CA3107660A1 (fr) * 2018-07-26 2020-01-30 Bristol-Myers Squibb Company Polytherapie a base de lag-3 pour le traitement du cancer
CN110172099B (zh) * 2018-08-16 2020-03-03 上海健信生物医药科技有限公司 抗lag-3人源化单克隆抗体分子，抗原结合片段及其医药用途
US10959986B2 (en) 2018-08-29 2021-03-30 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US11253525B2 (en) 2018-08-29 2022-02-22 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
JP2022500499A (ja) 2018-09-07 2022-01-04 ピク セラピューティクス， インコーポレイテッド Ｅｉｆ４ｅ阻害剤およびその使用
US11072610B2 (en) 2018-09-12 2021-07-27 Novartis Ag Antiviral pyridopyrazinedione compounds
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
WO2020057645A1 (fr) 2018-09-21 2020-03-26 信达生物制药(苏州)有限公司 Nouvelle interleukine 2 et son utilisation
AU2019343251B2 (en) 2018-09-21 2022-06-09 Innovent Biologics (Suzhou) Co., Ltd. Novel interleukin 2 and use thereof
CA3114038A1 (fr) 2018-09-25 2020-04-02 Harpoon Therapeutics, Inc. Proteines de liaison a dll3 et methodes d'utilisation
CN113164777B (zh) 2018-09-27 2024-12-13 马伦戈治疗公司 Csf1r/ccr2多特异性抗体
EP3856345A1 (fr) 2018-09-29 2021-08-04 Novartis AG Procédé de fabrication d'un composé pour inhiber l'activité de shp2
EP3861016A2 (fr) 2018-10-03 2021-08-11 Xencor, Inc. Protéines de fusion fc hétérodimères d'il -12
WO2020076969A2 (fr) 2018-10-10 2020-04-16 Tilos Therapeutics, Inc. Variants d'anticorps anti-lap et leurs utilisations
KR20210091710A (ko) 2018-10-12 2021-07-22 젠코어 인코포레이티드 PD-1 표적화 IL-15/IL-15Rα Fc 융합 단백질 및 병용요법에서의 이의 용도
HRP20241325T1 (hr) * 2018-10-19 2024-12-20 Bristol-Myers Squibb Company Kombinirana terapija za melanom
EP3873532A1 (fr) 2018-10-31 2021-09-08 Novartis AG Conjugué médicament-anticorps anti-dc-sign
WO2020102501A1 (fr) 2018-11-16 2020-05-22 Bristol-Myers Squibb Company Anticorps anti-nkg2a et leurs utilisations
UY38476A (es) 2018-11-16 2020-06-30 Arcus Biosciences Inc Inhibidores de arg1 y/o arg2
BR112021010484A2 (pt) 2018-11-30 2021-08-24 Kymera Therapeutics, Inc. Degradadores de irak e usos dos mesmos
JP2022511029A (ja) 2018-12-04 2022-01-28 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド がんの処置のための薬剤としての使用のためのｃｄｋ９インヒビターおよびその多形
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
CN113271945A (zh) 2018-12-20 2021-08-17 诺华股份有限公司 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案和药物组合
EP3670659A1 (fr) 2018-12-20 2020-06-24 Abivax Biomarqueurs et leurs utilisations dans le traitement d'infections virales, d'inflammations ou du cancer
EP3897853A1 (fr) 2018-12-20 2021-10-27 Xencor, Inc. Protéines de fusion fc hétérodimères ciblées contenant les il-15/il-15ra et des domaines de liaison à l'antigène nkg2d
WO2020128637A1 (fr) 2018-12-21 2020-06-25 Novartis Ag UTILISATION D'ANTICORPS DE LIAISON À IL-1β DANS LE TRAITEMENT D'UN CANCER MSI-H
EP3897613A1 (fr) 2018-12-21 2021-10-27 Novartis AG Utilisation d'anticorps de liaison à il-1bêta
AU2019408408A1 (en) 2018-12-21 2021-06-03 Valerio Therapeutics New conjugated nucleic acid molecules and their uses
US20200369762A1 (en) 2018-12-21 2020-11-26 Novartis Ag Use of il-1beta binding antibodies
CN113474045A (zh) 2018-12-21 2021-10-01 拜斯科技术开发有限公司 Pd-l1特异性的双环肽配体
AU2019409139A1 (en) 2018-12-21 2021-06-03 Novartis Ag Use of IL-1β binding antibodies
CA3127502A1 (fr) 2019-02-12 2020-08-20 Sumitomo Dainippon Pharma Oncology, Inc. Formulations comprenant des inhibiteurs de proteine kinase heterocycliques
MX2021009763A (es) 2019-02-15 2021-09-08 Novartis Ag Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina -2,6-diona y usos de los mismos.
MX2021009764A (es) 2019-02-15 2021-09-08 Novartis Ag Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona sustituidos y usos de los mismos.
AU2020224681A1 (en) 2019-02-21 2021-09-16 Marengo Therapeutics, Inc. Antibody molecules that bind to NKp30 and uses thereof
CN119661722A (zh) 2019-02-21 2025-03-21 马伦戈治疗公司 结合t细胞相关癌细胞的多功能分子及其用途
CN111620949A (zh) 2019-02-28 2020-09-04 三生国健药业（上海）股份有限公司 结合人lag-3的抗体、其制备方法和用途
EP3937964A4 (fr) 2019-03-12 2022-11-16 Arcus Biosciences, Inc. Traitement de cancers induits par des oncogènes
US20220152179A1 (en) 2019-03-19 2022-05-19 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Combination therapy with omomyc and an antibody binding pd-1 or ctla-4 for the treatment of cancer
JP2022525149A (ja) 2019-03-20 2022-05-11 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置
CN113747895A (zh) 2019-03-22 2021-12-03 大日本住友制药肿瘤公司 包含pkm2调节剂的组合物和用其治疗的方法
JP2022527298A (ja) 2019-03-26 2022-06-01 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン Ｓｔａｔ３の低分子分解誘導剤
WO2020205527A1 (fr) 2019-03-29 2020-10-08 Arcus Biosciences, Inc. Traitement du cancer à l'aide d'une empreinte d'adénosine identifiée
EP3947403A1 (fr) 2019-03-29 2022-02-09 The Regents Of The University Of Michigan Agents de dégradation de protéines stat3
WO2020201753A1 (fr) 2019-04-02 2020-10-08 Bicycletx Limited Conjugués de toxines bicycliques et leurs utilisations
CA3135802A1 (fr) 2019-04-05 2020-10-08 Kymera Therapeutics, Inc. Agents de degradation de stat et leurs utilisations
EP3725370A1 (fr) 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Anticorps anti-pd-l1 modifiés et procédés et utilisations pour le traitement d'une maladie neurodégénérative
CN113825527A (zh) 2019-05-13 2021-12-21 瑞泽恩制药公司 用于在治疗癌症中增强效力的pd-1抑制剂和lag-3抑制剂的组合
US20230295087A1 (en) 2019-05-13 2023-09-21 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
US12012374B2 (en) 2019-05-13 2024-06-18 Bristol-Myers Squibb Company Agonists of ROR GAMMAt
KR20220016155A (ko) 2019-05-30 2022-02-08 브리스톨-마이어스 스큅 컴퍼니 면역-종양학 (i-o) 요법에 적합한 대상체를 확인하는 방법
WO2020243563A1 (fr) 2019-05-30 2020-12-03 Bristol-Myers Squibb Company Signatures géniques multi-tumorales destinées à être adaptées à une thérapie immuno-oncologique
US20220233691A1 (en) 2019-05-30 2022-07-28 Bristol-Myers Squibb Company Cell localization signature and combination therapy
AU2020282759A1 (en) 2019-05-31 2021-12-23 Ikena Oncology, Inc. TEAD inhibitors and uses thereof
US12521438B2 (en) 2019-06-10 2026-01-13 Kymera Therapeutics, Inc. SMARCA degraders and uses thereof
US20220265590A1 (en) 2019-06-12 2022-08-25 Vanderbilt University Dibenzylamines as amino acid transport inhibitors
US20220304984A1 (en) 2019-06-12 2022-09-29 Vanderbilt University Amino acid transport inhibitors and the uses thereof
KR20220036371A (ko) * 2019-06-24 2022-03-22 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 항-lag-3 항체를 포함하는 제제, 이의 제조방법 및 용도
CN115443329A (zh) 2019-06-27 2022-12-06 乔治华盛顿大学国会特许非营利公司 Hdac6激活的巨噬细胞、其组合物及用途
JP2022539208A (ja) 2019-07-03 2022-09-07 スミトモ ファーマ オンコロジー， インコーポレイテッド チロシンキナーゼ非受容体１（ｔｎｋ１）阻害剤およびその使用
IT201900011676A1 (it) 2019-07-12 2021-01-12 St Superiore Di Sanita Anticorpo ricombinante umano contro il recettore di membrana LAG3, suoi usi medici e diagnostici.
BR112022000713A2 (pt) 2019-07-16 2022-03-22 Univ Michigan Regents Imidazopirimidinas como inibidores de eed e o uso das mesmas
WO2021024020A1 (fr) 2019-08-06 2021-02-11 Astellas Pharma Inc. Polythérapie impliquant des anticorps dirigés contre la claudine 18.2 et inhibiteurs de point de contrôle immunitaire pour le traitement du cancer
WO2021026179A1 (fr) 2019-08-06 2021-02-11 Bristol-Myers Squibb Company Agonistes de ror gammat
JP2022545735A (ja) 2019-08-27 2022-10-28 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン セレブロンｅ３リガーゼ阻害剤
AR119821A1 (es) 2019-08-28 2022-01-12 Bristol Myers Squibb Co Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
AU2020347274A1 (en) 2019-09-13 2022-03-31 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
WO2021053559A1 (fr) 2019-09-18 2021-03-25 Novartis Ag Anticorps d'entpd2, polythérapies, et procédés d'utilisation des anticorps et des polythérapies
US20220380368A1 (en) 2019-09-19 2022-12-01 The Regents Of The University Of Michigan Spirocyclic androgen receptor protein degraders
MX2022003204A (es) 2019-09-19 2022-04-18 Bristol Myers Squibb Co Anticuerpos de union al supresor de activacion de linfocitos t que contiene inmunoglobulina con dominio v (vista) a ph acido.
CA3153777A1 (fr) 2019-09-22 2021-03-25 Bristol-Myers Squibb Company Profilage spatial quantitatif pour une therapie par antagoniste de lag-3
CN120842223A (zh) 2019-09-26 2025-10-28 诺华股份有限公司 抗病毒吡唑并吡啶酮化合物
CN115916233A (zh) 2019-10-03 2023-04-04 Xencor股份有限公司 靶向IL-12异源二聚体Fc融合蛋白
KR20220088438A (ko) * 2019-10-09 2022-06-27 주식회사 에스티큐브앤컴퍼니 글리코실화된 lag3에 대해 특이적인 항체 및 이의 사용 방법
TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
BR112022007179A2 (pt) 2019-10-21 2022-08-23 Novartis Ag Inibidores de tim-3 e usos dos mesmos
IL292347A (en) 2019-10-21 2022-06-01 Novartis Ag Combination treatments with ventoclax and tim-3 inhibitors
WO2021090146A1 (fr) 2019-11-04 2021-05-14 Astrazeneca Ab Polythérapie pour le traitement du cancer
BR112022008191A2 (pt) * 2019-11-08 2022-07-12 Bristol Myers Squibb Co Terapia com antagonista de lag-3 para melanoma
US11548870B2 (en) 2019-11-19 2023-01-10 Bristol-Myers Squibb Company Compounds useful as inhibitors of helios protein
CA3159317A1 (fr) 2019-11-26 2021-06-03 Alfredo C. Castro Derives de carbazole polymorphes et leurs utilisations
US12527783B2 (en) 2019-11-26 2026-01-20 Bristol-Myers Squibb Company Salts/cocrystals of (R)-N-(4-chlorophenyl-2-((1S,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide
CN115052627A (zh) 2019-12-17 2022-09-13 凯麦拉医疗公司 Irak降解剂和其用途
WO2021127283A2 (fr) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Agents de dégradation d'irak et leurs utilisations
JP2023507190A (ja) 2019-12-20 2023-02-21 ノバルティス アーゲー 増殖性疾患を治療するための抗ＴＧＦβ抗体及びチェックポイント阻害薬の使用
AR120823A1 (es) 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t
EP4081308A4 (fr) 2019-12-23 2024-01-24 Kymera Therapeutics, Inc. Agents de dégradation de smarca et leurs utilisations
EP4081516B1 (fr) 2019-12-23 2025-07-30 Bristol-Myers Squibb Company Composés quinazolinyle substitués utiles en tant qu'activateurs de lymphocytes t
WO2021133748A1 (fr) 2019-12-23 2021-07-01 Bristol-Myers Squibb Company Composés de quinolinonyle pipérazine substitués utiles en tant qu'activateurs de lymphocytes t
CN114846015B (zh) 2019-12-23 2024-07-30 百时美施贵宝公司 用作t细胞激活剂的经取代的杂芳基化合物
AU2020412698A1 (en) 2019-12-23 2022-08-18 Bristol-Myers Squibb Company Substituted piperazine derivatives useful as T cell activators
WO2021138407A2 (fr) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Molécules multifonctionnelles se liant à cd33 et utilisations associées
WO2021138474A2 (fr) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Molécules d'anticorps anti-tcr et leurs utilisations
US20230045791A1 (en) 2020-01-06 2023-02-16 Hifibio (Hk) Limited Anti-tnfr2 antibody and uses thereof
AU2021205143A1 (en) 2020-01-07 2022-07-28 Hifibio, Inc. Anti-Galectin-9 antibody and uses thereof
US11534441B2 (en) 2020-01-15 2022-12-27 Blueprint Medicines Corporation MAP4K1 inhibitors
WO2021144657A1 (fr) 2020-01-17 2021-07-22 Novartis Ag Polythérapies comprenant un inhibiteur tim-3 et un agent d'hypométhylation à utiliser dans le traitement du syndrome myélodysplasique ou de la leucémie myélomonocytaire chronique
CN111205371B (zh) * 2020-01-22 2022-03-29 北京吉尔麦迪生物医药科技有限公司 一种抗淋巴细胞激活基因3的抗体及应用
TW202146452A (zh) 2020-02-28 2021-12-16 瑞士商諾華公司 結合ｃｄ１２３和ｃｄ３之雙特異性抗體的給藥
MX2022010944A (es) 2020-03-03 2022-11-09 Pic Therapeutics Inc Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos.
KR20220151189A (ko) 2020-03-09 2022-11-14 브리스톨-마이어스 스큅 컴퍼니 증진된 효능제 활성을 갖는 cd40에 대한 항체
JP7474861B2 (ja) 2020-03-19 2024-04-25 アーカス バイオサイエンシーズ，インコーポレーテッド Ｈｉｆ－２アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物
CA3171258A1 (fr) 2020-03-19 2021-09-23 Nan JI Agents de degradation de mdm2 et leurs utilisations
TW202140441A (zh) 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 經取代之側氧基異吲哚啉化合物
WO2021195481A1 (fr) 2020-03-26 2021-09-30 The Regents Of The University Of Michigan Agents de dégradation de protéine stat à petites molécules
AU2021245931A1 (en) * 2020-04-03 2022-11-03 Yuhan Corporation Engineered antibodies that bind LAG3
WO2021207449A1 (fr) 2020-04-09 2021-10-14 Merck Sharp & Dohme Corp. Anticorps anti-lap à maturation d'affinité et leurs utilisations
WO2021231732A1 (fr) 2020-05-15 2021-11-18 Bristol-Myers Squibb Company Anticorps anti-garp
JP7776448B2 (ja) 2020-06-02 2025-11-26 アーカス バイオサイエンシズ インコーポレイティド Ｔｉｇｉｔに対する抗体
US20230250110A1 (en) 2020-06-03 2023-08-10 Kymera Therapeutics, Inc. Deuterated irak degraders and uses thereof
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
WO2021258010A1 (fr) 2020-06-19 2021-12-23 Gossamer Bio Services, Inc. Composés oxime utiles comme activateurs de lymphocytes t
AR122644A1 (es) 2020-06-19 2022-09-28 Onxeo Nuevas moléculas de ácido nucleico conjugado y sus usos
EP4168007A1 (fr) 2020-06-23 2023-04-26 Novartis AG Schéma posologique comprenant des dérivés de 3-(1-oxoisoindoline-2-yl) pipéridine-2,6-dione
EP4171752A1 (fr) * 2020-06-30 2023-05-03 Arxx Therapeutics AS Anticorps anti-s100a4 pour le traitement de la sclérose systémique
AU2021306613A1 (en) 2020-07-07 2023-02-02 BioNTech SE Therapeutic RNA for HPV-positive cancer
WO2022011205A1 (fr) 2020-07-10 2022-01-13 The Regents Of The University Of Michigan Agents de dégradation de protéine de récepteur des androgènes
WO2022011204A1 (fr) 2020-07-10 2022-01-13 The Regents Of The University Of Michigan Agents de dégradation des protéines du récepteur des androgènes à petites molécules
CA3187255A1 (fr) 2020-07-30 2022-02-03 Duncan Walker Procedes de traitement de lymphomes mutants
EP4188549A1 (fr) 2020-08-03 2023-06-07 Novartis AG Dérivés de 3-(1-oxoisoindolin-2-yl)pipéridine-2,6-dione substitués par hétéroaryle et leurs utilisations
CA3188996A1 (fr) 2020-08-10 2022-02-17 Tengfei XIAO Compositions et methodes pour traiter des maladies auto-immunes et des cancers par ciblage de l'igsf8
CN116194480A (zh) 2020-08-13 2023-05-30 百时美施贵宝公司 将il-2重定向到目的靶细胞的方法
KR20230074721A (ko) 2020-08-17 2023-05-31 바이사이클티엑스 리미티드 Nectin-4에 특이적인 이환 콘쥬게이트 및 이의 용도
KR20230074487A (ko) 2020-08-26 2023-05-30 마렝고 테라퓨틱스, 인크. Trbc1 또는 trbc2를 검출하는 방법
KR20230058442A (ko) 2020-08-28 2023-05-03 브리스톨-마이어스 스큅 컴퍼니 간세포성 암종에 대한 lag-3 길항제 요법
US20230321285A1 (en) 2020-08-31 2023-10-12 Advanced Accelerator Applications International Sa Method of treating psma-expressing cancers
EP4204453A1 (fr) 2020-08-31 2023-07-05 Bristol-Myers Squibb Company Signature de localisation cellulaire et immunothérapie
WO2022043558A1 (fr) 2020-08-31 2022-03-03 Advanced Accelerator Applications International Sa Méthode de traitement de cancers exprimant le psma
EP4221842A4 (fr) 2020-10-02 2024-11-20 Dracen Pharmaceuticals, Inc. Composition lyophilisée comprenant du (s)-isopropyl 2-((s)-2-acétamido-3-(1h-indol-3-yl) propanamido)-6-diazo-5-oxohexanoate pour une administration sous-cutanée et son utilisation
US20230416382A1 (en) 2020-10-14 2023-12-28 Five Prime Therapeutics, Inc. Anti-c-c chemokine receptor 8 (ccr8) antibodies and methods of use thereof
IL301907A (en) 2020-10-23 2023-06-01 Bristol Myers Squibb Co Lag-3 antagonist therapy for lung cancer
AU2021373366A1 (en) 2020-11-06 2023-06-01 Novartis Ag Cd19 binding molecules and uses thereof
WO2022120353A1 (fr) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations
EP4255929A2 (fr) 2020-12-02 2023-10-11 Vib Vzw Agoniste de ltbr utilisé pour la polythérapie contre le cancer
AU2021392040A1 (en) 2020-12-02 2023-06-29 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2022120179A1 (fr) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Signatures géniques multi-tumorales et leurs utilisations
US20240050432A1 (en) 2020-12-08 2024-02-15 Infinity Pharmaceuticals, Inc. Eganelisib for use in the treatment of pd-l1 negative cancer
TW202237119A (zh) 2020-12-10 2022-10-01 美商住友製藥腫瘤公司 Ａｌｋ﹘５抑制劑和彼之用途
CN114621344B (zh) * 2020-12-10 2022-08-30 北京东方百泰生物科技股份有限公司 一种抗lag-3单克隆抗体的纯化方法
CA3202330A1 (fr) 2020-12-16 2022-06-23 Anthony Casarez Composes utiles en tant qu'activateurs de lymphocytes t
WO2022135667A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Arn thérapeutique pour le traitement du cancer
WO2022135666A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Programme de traitement faisant intervenir des protéines cytokines
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性ｒｎａ
US20220233693A1 (en) 2020-12-28 2022-07-28 Bristol-Myers Squibb Company Antibody Compositions and Methods of Use Thereof
US20220233689A1 (en) 2020-12-28 2022-07-28 Bristol-Myers Squibb Company Methods of treating tumors
CN116867758A (zh) 2020-12-30 2023-10-10 凯麦拉医疗公司 Irak降解剂和其用途
US20250186539A2 (en) 2021-01-11 2025-06-12 Bicycletx Limited Methods for treating cancer
CA3206549A1 (fr) 2021-01-29 2022-08-04 Frederick G. Vogt Procedes de fabrication de lymphocytes infiltrant les tumeurs modifies et leur utilisation dans la therapie cellulaire adoptive
CA3210196A1 (fr) 2021-01-29 2022-08-04 Board Of Regents, The University Of Texas System Methodes de traitement du cancer a l'aide d'inhibiteurs de kinase
MX2023009060A (es) 2021-02-02 2023-09-29 Liminal Biosciences Ltd Antagonistas de gpr84 y usos de estos.
AU2022215844A1 (en) 2021-02-02 2023-09-14 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
US20240109899A1 (en) 2021-02-04 2024-04-04 Bristol-Myers Squibb Company Benzofuran compounds as sting agonists
EP4291558A1 (fr) 2021-02-12 2023-12-20 F. Hoffmann-La Roche AG Dérivés bicycliques de tétrahydroazépine pour le traitement du cancer
JP2024506909A (ja) 2021-02-12 2024-02-15 ニンバス サターン， インコーポレイテッド Ｈｐｋ１アンタゴニスト及びその使用
CA3207380A1 (fr) 2021-02-15 2022-08-18 Haojing RONG Agents de degradation d'irak4 et leurs utilisations
AU2022220043A1 (en) 2021-02-15 2023-08-31 Kymera Therapeutics, Inc. Irak4 degraders and uses thereof
WO2022187423A1 (fr) 2021-03-03 2022-09-09 The Regents Of The University Of Michigan Ligands de céréblon
US20240190874A1 (en) 2021-03-03 2024-06-13 The Regents Of The University Of Michigan Small molecule degraders of androgen receptor
US11926625B2 (en) 2021-03-05 2024-03-12 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
EP4305041A1 (fr) 2021-03-08 2024-01-17 Blueprint Medicines Corporation Inhibiteurs de map4k1
US11918582B2 (en) 2021-03-15 2024-03-05 Rapt Therapeutics, Inc. Pyrazole pyrimidine compounds and uses thereof
EP4313127A1 (fr) 2021-03-29 2024-02-07 Juno Therapeutics, Inc. Méthodes de dosage et de traitement au moyen d'une combinaison d'une thérapie par inhibiteur de point de contrôle et d'une thérapie par lymphocytes car t
WO2022213062A1 (fr) 2021-03-29 2022-10-06 Nimbus Saturn, Inc. Antagonistes de hpk1 et leurs utilisations
JP2024514530A (ja) 2021-04-02 2024-04-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 切断型ｃｄｃｐ１に対する抗体およびその使用
JP2024515545A (ja) 2021-04-05 2024-04-10 ブリストル－マイヤーズ スクイブ カンパニー がん治療のためのピリジニル置換オキソイソインドリン化合物
PE20231941A1 (es) 2021-04-06 2023-12-05 Bristol Myers Squibb Co Compuestos de oxoisoindolina sustituidos con piridinilo
TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
GB2623199A (en) 2021-04-08 2024-04-10 Marengo Therapeutics Inc Multifunctional molecules binding to TCR and uses thereof
AU2022253474A1 (en) 2021-04-08 2023-11-16 Board Of Regents, The University Of Texas System Compounds and methods for theranostic targeting of parp activity
BR112023020781A2 (pt) 2021-04-09 2023-12-19 Nimbus Clio Inc Moduladores de cbl-b e usos dos mesmos
MX2023012060A (es) 2021-04-13 2024-01-22 Nuvalent Inc Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr.
IL307673A (en) 2021-04-16 2023-12-01 Ikena Oncology Inc MEK inhibitors and their use
IL308314A (en) 2021-05-07 2024-01-01 Kymera Therapeutics Inc CDK2 compounds and their uses
US20240285740A1 (en) 2021-05-12 2024-08-29 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating cancer
AR125874A1 (es) 2021-05-18 2023-08-23 Novartis Ag Terapias de combinación
WO2022246177A1 (fr) 2021-05-21 2022-11-24 Arcus Biosciences, Inc. Composés axl
JP2024521712A (ja) 2021-05-21 2024-06-04 アーカス バイオサイエンシーズ，インコーポレーテッド Ａｘｌ阻害化合物
EP4370552A1 (fr) 2021-07-13 2024-05-22 BioNTech SE Agents de liaison multispécifiques contre cd40 et cd137 en polythérapie du cancer
TW202321237A (zh) 2021-07-14 2023-06-01 美商纜圖藥品公司 Ｍａｐ４ｋ１抑制劑
WO2023288264A1 (fr) 2021-07-15 2023-01-19 Blueprint Medicines Corporation Inhibiteurs de map4k1
CN118019739A (zh) 2021-08-25 2024-05-10 皮克医疗公司 Eif4e抑制剂及其用途
WO2023028235A1 (fr) 2021-08-25 2023-03-02 PIC Therapeutics, Inc. Inhibiteurs d'eif4e et leurs utilisations
US20240376100A1 (en) 2021-09-08 2024-11-14 Redona Therapeutics, Inc. Papd5 and/or papd7 inhibiting 4-oxo-1, 4-dihydroquinoline-3-carboxylic acid derivatives
KR20240083095A (ko) * 2021-09-29 2024-06-11 아케소 바이오파마, 인크. 항-lag3 항체, 약학 조성물 및 용도
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
IL312348A (en) 2021-10-29 2024-06-01 Arcus Biosciences Inc HIF-2ALPHA inhibitors and methods of using it
WO2023076556A1 (fr) 2021-10-29 2023-05-04 Kymera Therapeutics, Inc. Agents de dégradation d'irak4 et leur synthèse
IL309227A (en) 2021-10-29 2024-02-01 Bristol Myers Squibb Co LAG-3 antagonist therapy for hematological cancer
CN118660964A (zh) 2021-12-16 2024-09-17 瓦莱里奥治疗公司 新型缀合核酸分子及其用途
WO2023114984A1 (fr) 2021-12-17 2023-06-22 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations
WO2023122772A1 (fr) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Dérivés d'oxime utiles comme activateurs de lymphocytes t
WO2023122777A1 (fr) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Dérivés d'oxime utiles en tant qu'activateurs de lymphocytes t
WO2023122778A1 (fr) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Dérivés de pyridazinone utiles en tant qu'activateurs de lymphocytes t
US20250215076A1 (en) 2022-01-26 2025-07-03 Bristol-Myers Squibb Company Combination therapy for hepatocellular carcinoma
WO2023147488A1 (fr) 2022-01-28 2023-08-03 Iovance Biotherapeutics, Inc. Compositions et procédés de lymphocytes infiltrant les tumeurs associés à la cytokine
WO2023147594A2 (fr) 2022-01-31 2023-08-03 Kymera Therapeutics, Inc. Agents de dégradation d'irak et leurs utilisations
EP4472963A1 (fr) 2022-02-01 2024-12-11 Arvinas Operations, Inc. Composés de ciblage de dgk et utilisations associées
TWI864587B (zh) 2022-02-14 2024-12-01 美商基利科學股份有限公司 抗病毒吡唑并吡啶酮化合物
MX2024010310A (es) 2022-02-25 2024-08-28 Bristol Myers Squibb Co Terapia de combinacion para carcinoma colorrectal.
WO2023173057A1 (fr) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Inhibiteurs de mek et leurs utilisations
WO2023173053A1 (fr) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Inhibiteurs de mek et leurs utilisations
IL314346A (en) 2022-03-15 2024-09-01 Compugen Ltd Antibodies antagonistic to IL-18BP and their use in monotherapy and combination therapy in cancer treatment
KR20240159621A (ko) 2022-03-18 2024-11-05 브리스톨-마이어스 스큅 컴퍼니 폴리펩티드를 단리하는 방법
WO2023211889A1 (fr) 2022-04-25 2023-11-02 Ikena Oncology, Inc. Composés polymorphes et leurs utilisations
WO2023214325A1 (fr) 2022-05-05 2023-11-09 Novartis Ag Dérivés de pyrazolopyrimidine et leurs utilisations en tant qu'inhibiteurs de tet2
CN114874324B (zh) * 2022-05-13 2023-02-03 苏州旭光科星抗体生物科技有限公司 一种检测可溶性lag-3蛋白含量的酶联免疫检测试剂盒及应用
KR20250040894A (ko) 2022-05-25 2025-03-25 이케나 온콜로지, 인코포레이티드 Mek 억제제 및 이의 용도
JP2025518785A (ja) 2022-06-02 2025-06-19 ブリストル－マイヤーズ スクイブ カンパニー 抗体組成物及びその使用方法
AU2023308064A1 (en) 2022-07-11 2025-02-27 Genuv Inc. Cytokine fusion protein
EP4554680A1 (fr) 2022-07-15 2025-05-21 Arcus Biosciences, Inc. Inhibiteurs de hpk1 et leurs méthodes d'utilisation
US20260028336A1 (en) 2022-07-20 2026-01-29 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024028364A1 (fr) 2022-08-02 2024-02-08 Liminal Biosciences Limited Aryl-triazolyle et antagonistes de gpr84 apparentés et leurs utilisations
EP4565568A1 (fr) 2022-08-02 2025-06-11 Liminal Biosciences Limited Hétéroaryl-carboxamide et antagonistes de gpr84 associés et leurs utilisations
AU2023317742A1 (en) 2022-08-02 2025-03-20 Liminal Biosciences Limited Substituted pyridone gpr84 antagonists and uses thereof
CN119654312A (zh) 2022-08-08 2025-03-18 百时美施贵宝公司 用作t细胞活化剂的取代的四唑基化合物
WO2024036101A1 (fr) 2022-08-09 2024-02-15 Bristol-Myers Squibb Company Composés bicycliques substitués par amine tertiaire utiles comme activateurs de lymphocytes t
TW202417001A (zh) 2022-08-11 2024-05-01 瑞士商赫孚孟拉羅股份公司 雙環四氫吖呯衍生物
WO2024033389A1 (fr) 2022-08-11 2024-02-15 F. Hoffmann-La Roche Ag Dérivés bicycliques de tétrahydrothiazépine
EP4568958A1 (fr) 2022-08-11 2025-06-18 F. Hoffmann-La Roche AG Dérivés bicycliques de tétrahydrothiazépine
TW202417439A (zh) 2022-08-11 2024-05-01 瑞士商赫孚孟拉羅股份公司 雙環四氫噻吖呯衍生物
AU2023341373A1 (en) 2022-09-14 2025-03-06 Arcus Biosciences, Inc. Dispersions of etrumadenant
WO2024081385A1 (fr) 2022-10-14 2024-04-18 Arcus Biosciences, Inc. Inhibiteurs de hpk1 et leurs procédés d'utilisation
KR20250080902A (ko) 2022-10-20 2025-06-05 아르커스 바이오사이언시즈 인코포레이티드 Cd73 화합물의 동결건조된 제형
WO2024089417A1 (fr) 2022-10-24 2024-05-02 Memorial Sloan-Kettering Cancer Center Stratification de tumeurs pour déterminer la sensibilité à un inhibiteur de point de contrôle immunitaire
EP4608390A1 (fr) 2022-10-24 2025-09-03 Cancer Research Technology Limited Sensibilisation tumorale à des inhibiteurs de points de contrôle avec modificateur d'état redox
TW202430148A (zh) 2022-11-22 2024-08-01 美商皮克醫療公司 ｅＩＦ４Ｅ抑制劑及其用途
CN120418289A (zh) 2022-12-14 2025-08-01 安斯泰来制药欧洲有限公司 结合cldn18.2和cd3的双特异性结合剂与免疫检查点抑制剂的联合疗法
KR20250123912A (ko) 2022-12-21 2025-08-18 브리스톨-마이어스 스큅 컴퍼니 폐암에 대한 병용 요법
WO2024137865A1 (fr) 2022-12-22 2024-06-27 Gossamer Bio Services, Inc. Composés utiles en tant qu'activateurs de lymphocytes t
CN115819595B (zh) * 2023-01-03 2023-05-16 上海百英生物科技股份有限公司 一种抗lag3纳米抗体及其制备方法与应用
EP4649173A1 (fr) 2023-01-13 2025-11-19 Akrivia Biomedics Limited Procédé de profilage de maladies
WO2024163477A1 (fr) 2023-01-31 2024-08-08 University Of Rochester Thérapie de blocage de point de contrôle immunitaire pour le traitement d'infections par staphylococcus aureus
CN121127264A (zh) 2023-03-13 2025-12-12 瑞泽恩制药公司 用于在治疗黑素瘤中增强疗效的pd-1抑制剂和lag-3抑制剂组合
WO2024196952A1 (fr) 2023-03-20 2024-09-26 Bristol-Myers Squibb Company Évaluation de sous-type de tumeur pour une thérapie anticancéreuse
WO2024211551A1 (fr) 2023-04-06 2024-10-10 Glaxosmithkline Intellectual Property (No.4) Limited Méthodes de traitement et de surveillance du cancer
US20240425497A1 (en) 2023-05-05 2024-12-26 Arcus Biosciences, Inc. Cbl-b Inhibitors and Methods of Use Thereof
TW202500139A (zh) 2023-05-08 2025-01-01 美商必治妥美雅史谷比公司 經取代之苯基㗁唑酮化合物
TW202509014A (zh) 2023-05-10 2025-03-01 美商纜圖藥品公司 ＧＳＫ３α抑制劑及其使用方法
WO2024233853A2 (fr) * 2023-05-11 2024-11-14 Elixiron Immunotherapeutics (hong Kong) Limited Combinaison comprenant fraction de ciblage lag-3 et interleukine-10
WO2024243502A1 (fr) 2023-05-25 2024-11-28 Arcus Biosciences, Inc. Inhibiteurs de cbl-b et leurs procédés d'utilisation
WO2024249540A1 (fr) 2023-05-31 2024-12-05 Bristol-Myers Squibb Company Composé d'oxazolone substitué pour diminuer les taux de protéines ikzf 1-4
AU2024281414A1 (en) 2023-06-02 2025-12-11 Arcus Biosciences, Inc. Biomarkers for predicting cancer treatment efficacy
AU2024285766A1 (en) 2023-06-07 2026-01-08 Bristol-Myers Squibb Company Spirocyclic substituted oxoisoindolinyl piperidine-2,6-dione compound
IL321489A (en) 2023-06-23 2025-08-01 Kymera Therapeutics Inc IRAQ joints and their uses
WO2024263853A1 (fr) 2023-06-23 2024-12-26 Bristol-Myers Squibb Company Composé oxoisoindolinyl pipéridine -2,6-dione substitué utilisé comme agent anticancéreux
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途
WO2025030002A2 (fr) 2023-08-02 2025-02-06 Arvinas Operations, Inc. Composés ciblant dgk et leurs utilisations
WO2025038763A1 (fr) 2023-08-15 2025-02-20 Bristol-Myers Squibb Company Procédé de chromatographie en flux continu d'hydroxyapatite céramique
WO2025038857A1 (fr) 2023-08-16 2025-02-20 Arcus Biosciences, Inc. TÉTRALINES CIBLANT HIF-2α MUTANT
AR133696A1 (es) 2023-09-02 2025-10-22 Bristol Myers Squibb Co Compuestos de fenil oxooxazolil piperidinadiona sustituida
WO2025064197A1 (fr) 2023-09-02 2025-03-27 Bristol-Myers Squibb Company Composés d'azétidinyl oxoisoindolinyl pipéridine-2,6-dione substitués
WO2025054339A1 (fr) 2023-09-08 2025-03-13 Arcus Biosciences, Inc. Composés triazolopyridine utilisés en tant qu'inhibiteurs de kit
JP7808733B2 (ja) 2023-09-13 2026-01-29 ブリストル－マイヤーズ スクイブ カンパニー 置換オキソイソインドリニルピペリジン－２，６－ジオン化合物
WO2025072330A1 (fr) 2023-09-26 2025-04-03 Arcus Biosciences, Inc. Composés inhibiteurs de kit et leurs procédés d'utilisation
WO2025068452A1 (fr) 2023-09-29 2025-04-03 Negio Therapeutics Dérivés du guanfacine et leur utilisation dans le traitement du cancer
WO2025068461A1 (fr) 2023-09-29 2025-04-03 Negio Therapeutics Dérivés de guanfacine et leur utilisation dans le traitement du cancer
TW202517260A (zh) 2023-10-06 2025-05-01 美商阿克思生物科學有限公司 Ｃｂｌ—ｂ抑制劑及其使用方法
WO2025096505A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés de type protéase 1 spécifique de l'ubiquitine (usp1)
WO2025096490A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés de type protéase 1 spécifique de l'ubiquitine (usp1)
US20250145590A1 (en) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Ubiquitin specific processing protease 1 (usp1) compounds
WO2025096487A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés de type protéase 1 spécifique de l'ubiquitine (usp1)
WO2025096488A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés relatifs à la protéase 1 spécifique de l'ubiquitine (usp1)
WO2025096494A1 (fr) 2023-10-31 2025-05-08 Bristol-Myers Squibb Company Composés de protéase 1 de traitement spécifique de l'ubiquitine (usp1)
US12384773B2 (en) 2023-11-02 2025-08-12 Arcus Biosciences, Inc. Thiazole compounds and methods of use thereof
WO2025106736A2 (fr) 2023-11-15 2025-05-22 Regeneron Pharmaceuticals, Inc. Combinaison d'inhibiteurs de pd-1 et d'inhibiteurs de lag-3 pour une efficacité améliorée dans le traitement du cancer du poumon
WO2025121445A1 (fr) 2023-12-08 2025-06-12 Astellas Pharma Inc. Polythérapie impliquant des agents de liaison bispécifiques se liant à cldn18.2 et cd3 et agents stabilisant ou augmentant l'expression de cldn18.2
WO2025120866A1 (fr) 2023-12-08 2025-06-12 Astellas Pharma Inc. Polythérapie impliquant des agents de liaison bispécifiques se liant à cldn18.2 et cd3 et agents stabilisant ou augmentant l'expression de cldn18.2
WO2025120867A1 (fr) 2023-12-08 2025-06-12 Astellas Pharma Inc. Polythérapie impliquant des agents de liaison bispécifiques se liant à cldn18.2 et cd3 et anticorps anti-vegfr2
WO2025132831A1 (fr) 2023-12-19 2025-06-26 Universite D'aix-Marseille Dérivés de n-hétéroaryle et leurs utilisations pour le traitement du cancer
US20250230173A1 (en) 2023-12-20 2025-07-17 Arcus Biosciences, Inc. Salt forms of an axl inhibitor
US20250215087A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg depleting agent
WO2025151487A2 (fr) 2024-01-08 2025-07-17 Regents Of The University Of Michigan Inhibiteurs d'adar1 à petites molécules
WO2025184208A1 (fr) 2024-02-27 2025-09-04 Bristol-Myers Squibb Company Anticorps anti-ceacam5 et leurs utilisations
EP4658320A1 (fr) 2024-02-27 2025-12-10 Bristol-Myers Squibb Company Conjugués anticorps anti-ceacam5-médicament
WO2025193574A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193583A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193569A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193572A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193573A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193571A1 (fr) 2024-03-11 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques utiles comme immunomodulateurs
WO2025193759A1 (fr) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Formes solides d'un composé azolopyrimidine
WO2025193770A1 (fr) 2024-03-13 2025-09-18 Bristol-Myers Squibb Company Peptides macrocycliques
WO2025226767A1 (fr) 2024-04-24 2025-10-30 Bristol-Myers Squibb Company Composés de 3-(5-(6-aminopyridin-2-yl)-4-fluoro-1-oxoisoindolin-2-yl)pipéridine-2,6-dione substitués destinés à être utilisés dans le traitement du cancer
WO2025245489A1 (fr) 2024-05-24 2025-11-27 Bristol-Myers Squibb Company Traitement de tumeurs chez des sujets dont les échantillons sont positifs à fgl-1
NL2037811B1 (en) 2024-05-29 2025-12-12 Univ Oslo Treatment for Cancer
GB202408360D0 (en) 2024-06-11 2024-07-24 Cancer Research Tech Ltd Tumour sensitisation
WO2025262250A1 (fr) 2024-06-20 2025-12-26 Negio Therapeutics Dérivés de guanfacine et leurs utilisations
WO2026006759A1 (fr) 2024-06-28 2026-01-02 Arcus Biosciences, Inc. Compositions pharmaceutiques, formes galéniques, leurs procédés de production et leurs méthodes d'utilisation

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1081681A (en) 1910-08-31 1913-12-16 Otis Elevator Co Alternating-current-motor control.
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4475196A (en) 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
EP0154316B1 (fr) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Lymphokine chimiquement modifiée et son procédé de préparation
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (es) 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
DE3883899T3 (de) 1987-03-18 1999-04-22 Sb2, Inc., Danville, Calif. Geänderte antikörper.
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US5476996A (en) 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
DE68925966T2 (de) 1988-12-22 1996-08-29 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
FR2656800B1 (fr) 1990-01-08 1992-05-15 Roussy Inst Gustave Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
US5976877A (en) 1990-01-08 1999-11-02 Institut National De La Sante Et De La Recherche Medicale (Inserm) Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
ATE139258T1 (de) 1990-01-12 1996-06-15 Cell Genesys Inc Erzeugung xenogener antikörper
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DK0814159T3 (da) 1990-08-29 2005-10-24 Genpharm Int Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
GB9108652D0 (en) 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds
US5885793A (en) 1991-12-02 1999-03-23 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
EP0746609A4 (fr) 1991-12-17 1997-12-17 Genpharm Int Animaux transgeniques non humains capables de produire des anticorps heterologues
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
WO1993022332A2 (fr) 1992-04-24 1993-11-11 Board Of Regents, The University Of Texas System Production recombinante de domaines semblables a l'immunoglobuline dans des cellules procaryotes
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
AU686113B2 (en) 1992-09-16 1998-02-05 Scripps Research Institute, The Human neutralizing monoclonal antibodies to respiratory syncytial virus
JP3919830B2 (ja) 1992-11-28 2007-05-30 財団法人化学及血清療法研究所 抗ネコヘルペスウイルス−１組換え抗体および該抗体をコードする遺伝子断片
CA2161351C (fr) 1993-04-26 2010-12-21 Nils Lonberg Animaux transgeniques, pouvant produire des anticorps heterologues
CA2163345A1 (fr) 1993-06-16 1994-12-22 Susan Adrienne Morgan Anticorps
WO1995018634A1 (fr) 1994-01-04 1995-07-13 The Scripps Research Institute Anticorps humains monoclonaux du virus de l'herpes simplex et methodes associees
CA2189657C (fr) 1994-05-06 2002-03-12 Florence Faure Fractions polypeptidiques solubles de la proteine lag-3; procede de production; composition therapeutique; anticorps anti-idiotype
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
DK0843557T3 (da) 1995-07-21 2003-03-10 Inst Nat Sante Rech Med Fremgangsmåder til detektion, identifikation, isolation og selektiv mærkning og målsøgning af Th1-lymfocytter ved hjælp af LAG-3 protein
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
KR19990087557A (ko) 1996-03-07 1999-12-27 그윈넬 해리 제이 근적외선 형광 비밀정보의 열전사 인쇄 및 표시용 리본
US5922845A (en) 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
AU728911B2 (en) 1996-11-28 2001-01-18 Institut Gustave Roussy Mutants of the LAG-3 proteins, products for the expression of these mutants and use
PT941329E (pt) 1996-11-29 2004-11-30 Applied Research Systems Metodo para prevenir a rejeicao de enxertos em transplantacao e para produzir uma celula-hospedeiro para terapia genetica universal utilizando activacao de linfocitos (lag-3)
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
JP2001523958A (ja) 1997-03-21 2001-11-27 ブライハム アンド ウィミンズ ホスピタル，インコーポレイテッド 免疫療法のｃｔｌａ−４結合ペプチド
EP0983303B1 (fr) 1997-05-21 2006-03-08 Biovation Limited Procede de production de proteines non immunogenes
EP0900841A1 (fr) 1997-06-18 1999-03-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Variantes d'épissure de LAG-3
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6602684B1 (en) 1998-04-20 2003-08-05 Glycart Biotechnology Ag Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
GB9814383D0 (en) 1998-07-02 1998-09-02 Cambridge Antibody Tech Improvements relating to antibodies
US6951646B1 (en) 1998-07-21 2005-10-04 Genmab A/S Anti hepatitis C virus antibody and uses thereof
PL210435B1 (pl) 1998-12-23 2012-01-31 Amgen Fremont Inc Ludzkie przeciwciała monoklonalne wiążące się z CTLA-4
ES2694002T3 (es) 1999-01-15 2018-12-17 Genentech, Inc. Polipéptido que comprende una región Fc de IgG1 humana variante
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
EP2270150B2 (fr) 1999-04-09 2019-08-07 Kyowa Hakko Kirin Co., Ltd. Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle
GB9911569D0 (en) 1999-05-18 1999-07-21 Oxford Biomedica Ltd Antibodies
US6808710B1 (en) 1999-08-23 2004-10-26 Genetics Institute, Inc. Downmodulating an immune response with multivalent antibodies to PD-1
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
KR20020047132A (ko) 1999-08-24 2002-06-21 메다렉스, 인코포레이티드 인간 씨티엘에이-4 항체 및 그의 용도
US6794132B2 (en) 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
KR20120053525A (ko) 2000-06-16 2012-05-25 캠브리지 안티바디 테크놀로지 리미티드 면역특이적으로 ＢＬｙＳ에 결합하는 항체
US6818216B2 (en) 2000-11-28 2004-11-16 Medimmune, Inc. Anti-RSV antibodies
ES2295228T3 (es) 2000-11-30 2008-04-16 Medarex, Inc. Roedores transcromosomicos transgenicos para la preparacion de anticuerpos humanos.
US7538206B2 (en) 2001-02-22 2009-05-26 Institut Pasteur Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses
US20020146753A1 (en) 2001-04-06 2002-10-10 Henrik Ditzel Autoantibodies to glucose-6-phosphate isomerase and their participation in autoimmune disease
CA2446968C (fr) 2001-05-11 2012-07-03 Kirin Beer Kabushiki Kaisha Chromosome humain artificiel contenant le gene a chaine legere de l'anticorps humain .lambda. et espece non-humaine contenant le chromosome artificiel humain pouvant se transmettre genetiquement
MXPA03011094A (es) 2001-05-31 2004-12-06 Medarex Inc Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello.
PT1436404E (pt) 2001-09-19 2009-12-16 Alexion Pharma Inc Moldes manipulados e sua utilização em amplificação com iniciador único
EP1295895B1 (fr) 2001-09-19 2011-08-10 Institut Gustave Roussy Peptides et proteines se liant aux motifs glu-pro, compositions thérapeutiques les comprenant et leurs applications
ATE430580T1 (de) 2001-10-25 2009-05-15 Genentech Inc Glycoprotein-zusammensetzungen
EP2388265A1 (fr) 2002-02-22 2011-11-23 Genentech, Inc. Compositions et procédés pour le traitement de maladies liées au système immunitaire
CN1930288B (zh) 2002-04-09 2012-08-08 协和发酵麒麟株式会社 基因组被修饰的细胞
NZ535925A (en) 2002-04-16 2008-06-30 Genentech Inc An isolated antibody that binds to a particular polypeptide
WO2004004771A1 (fr) 2002-07-03 2004-01-15 Ono Pharmaceutical Co., Ltd. Compositions immunostimulantes
EP1576137A4 (fr) 2002-10-29 2010-06-30 Genentech Inc Compositions et methodes de traitement de maladies liees au systeme immunitaire
US20050009136A1 (en) 2003-02-19 2005-01-13 Dyax Corporation PAPP-A ligands
WO2004078928A2 (fr) 2003-02-28 2004-09-16 The Johns Hopkins University Regulation par lymphocytes t
JP2007510622A (ja) 2003-10-08 2007-04-26 ザ・フェインスタイン・インスティチュート・フォー・メディカル・リサーチ Ｂ細胞慢性リンパ性白血病の診断及び治療のための方法及び組成物
US7741449B2 (en) * 2003-12-10 2010-06-22 Medarex, Inc. Anti-interferon alpha antibodies
HRP20130440T1 (en) 2004-04-13 2013-06-30 F. Hoffmann - La Roche Ag Anti-p-selectin antibodies
US7850962B2 (en) 2004-04-20 2010-12-14 Genmab A/S Human monoclonal antibodies against CD20
RU2402548C2 (ru) 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
CA2564076C (fr) 2004-05-19 2014-02-18 Medarex, Inc. Bras de liaison chimiques et conjugues associes
MX2007000644A (es) 2004-07-20 2007-03-28 Symphogen As Anticuerpo policlonal recombinante anti-rhesus d y metodos de fabricacion.
JP2008515774A (ja) 2004-08-03 2008-05-15 ダイアックス コーポレイション ｈＫ１結合タンパク質
WO2006029219A2 (fr) 2004-09-08 2006-03-16 Ohio State University Research Foundation Anticorps monoclonaux humains anti-ctla4 dans le traitement du cancer
EP1802345A2 (fr) 2004-10-01 2007-07-04 Medarex, Inc. Procede pour traiter des lymphomes positifs cd30
ES2671893T3 (es) 2004-10-06 2018-06-11 Mayo Foundation For Medical Education And Research B7-H1 y PD-1 en el tratamiento del carcinoma de células renales
CN101160324B (zh) 2005-02-18 2013-04-24 米德列斯公司 缺乏岩藻糖残基的抗前列腺特异性膜抗原(psma)单克隆抗体
BRPI0609427A2 (pt) 2005-03-23 2010-04-06 Pfizer Prod Inc composição farmacêutica para o tratamento de cáncer de próstata e uso de um agente de terapia hormonal e de um anticorpo, ou uma porção de ligação a antìgeno do mesmo
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
EP2439273B1 (fr) 2005-05-09 2019-02-27 Ono Pharmaceutical Co., Ltd. Anticorps monoclonaux humains pour mort programmée 1 (PD-1) et procédés de traitement du cancer à l'aide d'anticorps anti-PD-1 seuls ou combinés à d'autres formulations immunothérapeutiques
HRP20151102T1 (xx) 2005-07-01 2015-11-20 E. R. Squibb & Sons, L.L.C. Humana monoklonska antitijela za ligand programirane smrti 1 (pd-l1)
EP1940470B1 (fr) 2005-09-26 2013-04-17 Medarex, Inc. Conjugués anticorps-medicament et leur utilisation
WO2007051081A1 (fr) 2005-10-26 2007-05-03 Medarex, Inc. Procede et composes pour la preparation d'analogues de cc-1065
WO2007056441A2 (fr) 2005-11-07 2007-05-18 Genentech, Inc. Polypeptides de liaison comprenant des sequences diversifiees et des sequences consensus hypervariables vh/vl
WO2007059404A2 (fr) 2005-11-10 2007-05-24 Medarex, Inc. Composes et conjugues cytotoxiques
US7850965B2 (en) 2005-12-05 2010-12-14 Symphogen A/S Anti-orthopoxvirus recombinant polyclonal antibody
JP5382692B2 (ja) 2006-07-10 2014-01-08 学校法人藤田学園 抗体の分類法、抗原の同定法、抗体又は抗体セットの取得法、抗体パネルの作成法、並びに抗体又は抗体セット及びその用途
WO2008073160A2 (fr) 2006-08-17 2008-06-19 The Trustees Of Columbia University In The City Of New York Procédés de conversion ou d'induction d'une immunité protectrice
HRP20140081T1 (hr) 2006-08-18 2014-03-28 Novartis Ag Prlr-specifiäśna antitijela i njihova uporaba
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
WO2008103693A2 (fr) 2007-02-21 2008-08-28 Medarex, Inc. Liants chimiques avec acides aminés uniques et conjugués de ceux-ci
WO2008121615A2 (fr) 2007-03-30 2008-10-09 Medimmune, Inc. Formulation d'anticorps
EP1987839A1 (fr) * 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Anticorps monoclonal cytotoxique anti-LAG-3 et son utilisation pour le traitement ou la prévention d'un rejet de greffe d'organe et de maladies auto-immunes
PT2170959E (pt) 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
WO2009014708A2 (fr) 2007-07-23 2009-01-29 Cell Genesys, Inc. Anticorps pd-1 en combinaison avec une cellule sécrétant de la cytokine et leurs procédés d'utilisation
WO2009034172A1 (fr) 2007-09-14 2009-03-19 Vrije Universiteit Brussel Augmentation de l'action stimulante des lymphocytes t de cellules humaines présentant un antigène et leur utilisation pour une vaccination
BRPI0816014A8 (pt) 2007-10-01 2018-06-19 Bristol Myers Squibb Co anticorpo humano monoclonal isolado, composição, conjugado anticorpo-molécula parceiro, mólecula isolada de ácido nucléico, vetor de expressão, célula hospedeira, método para preparar um anticorpo anti-mesotelina, método de inibição do crescimento de uma célula tumoral expressando a mesotelina, método de tratamento do câncer em um indivíduo, anticorpo anti-mesotelina isolado, e método de inibir o crescimento de uma célula expressando a mesotelina
US20110085970A1 (en) 2007-11-30 2011-04-14 Terrett Jonathan A Anti-b7h4 monoclonal antibody-drug conjugate and methods of use
CL2008003527A1 (es) 2007-11-30 2009-10-09 Medarex Inc Conjugado de anticuerpo o porcion de union de antigeno del mismo, que se une a la proteina tirosina quinasa 7 (ptk-7/cck4); composicion que lo comprende; acido nulceico cidificante del anticuerpo; vector y celula huesped; uso del conjugado para tratar o prevenir una enfermedad de celulas tumorales que expresan ptk7
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
EA201170375A1 (ru) 2008-08-25 2012-03-30 Эмплиммьюн, Инк. Антагонисты pd-1 и способы их применения
AU2009288730B2 (en) 2008-08-25 2013-06-20 Amplimmune, Inc. Compositions of PD-1 antagonists and methods of use
SMT202500126T1 (it) 2008-12-09 2025-05-12 Hoffmann La Roche Anticorpi anti-pd-l1 e loro uso per potenziare la funzione dei linfociti t
TWI502068B (zh) * 2009-07-15 2015-10-01 Aimm Therapiutics B V 革蘭氏陽性菌特異性結合的化合物
HRP20171653T1 (hr) 2009-11-24 2017-12-15 Medimmune Limited Vezna sredstva koja služe ciljano protiv b7-h1
MX338640B (es) * 2010-07-14 2016-04-25 Merck Sharp & Dohme Anticuerpo monoclonal anti-ligando difundible derivado de amiloide beta y usos de los mismos.
WO2012054438A1 (fr) * 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
EA037351B8 (ru) 2012-05-15 2021-04-29 Бристол-Майерс Сквибб Компани Способ лечения злокачественных опухолей с использованием комбинации антител против pd-1 и ctla-4
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
US10344088B2 (en) 2013-03-15 2019-07-09 Glaxosmithkline Intellectual Property Development Limited Antigen binding proteins
AU2014296887A1 (en) 2013-08-02 2016-01-28 Aduro Biotech Holdings, Europe B.V. Combining CD27 agonists and immune checkpoint inhibition for immune stimulation
SI3508502T1 (sl) 2013-09-20 2023-07-31 Bristol-Myers Squibb Company Kombinacija anti-lag-3 protiteles in anti-pd-1 protiteles za zdravljenje tumorjev
ES2902369T3 (es) 2014-01-28 2022-03-28 Bristol Myers Squibb Co Anticuerpos anti-LAG-3 para tratar neoplasias malignas hemáticas
RS60753B1 (sr) 2015-04-17 2020-10-30 Bristol Myers Squibb Co Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途

Also Published As

Publication number Publication date
MX2019006411A (es) 2019-08-14
KR20240168469A (ko) 2024-11-29
MY197544A (en) 2023-06-22
PH12014502854B1 (en) 2015-02-23
AU2019204803C1 (en) 2023-06-29
AU2013286914B2 (en) 2017-06-29
SMT201700449T1 (it) 2017-11-15
JP2020103301A (ja) 2020-07-09
LTC2867258I2 (fr) 2025-06-10
KR102126596B1 (ko) 2020-06-24
PH12021552200A1 (en) 2022-05-02
PL2867258T3 (pl) 2017-11-30
EP4553086A2 (fr) 2025-05-14
UY34887A (es) 2013-12-31
CO7170127A2 (es) 2015-01-28
TW201938198A (zh) 2019-10-01
FI3795592T3 (fi) 2024-10-01
NO2023008I1 (no) 2023-02-07
RS61084B1 (sr) 2020-12-31
HK1249535A1 (en) 2018-11-02
BR112014032999B1 (pt) 2022-10-18
TW202432599A (zh) 2024-08-16
HUE052406T2 (hu) 2021-04-28
ES2831406T3 (es) 2021-06-08
PL3795592T3 (pl) 2024-10-07
KR20200075891A (ko) 2020-06-26
US10377824B2 (en) 2019-08-13
KR102461102B1 (ko) 2022-10-31
US20170137514A1 (en) 2017-05-18
KR20150023909A (ko) 2015-03-05
CA2877746C (fr) 2022-07-19
SG11201408780XA (en) 2015-01-29
HK1207386A1 (en) 2016-01-29
PE20241623A1 (es) 2024-08-07
US20150307609A1 (en) 2015-10-29
AU2017221874A1 (en) 2017-09-21
US10266591B2 (en) 2019-04-23
NO2023020I1 (no) 2023-05-03
NL301205I2 (nl) 2023-05-24
JP2022064901A (ja) 2022-04-26
ES2638545T3 (es) 2017-10-23
TWI617581B (zh) 2018-03-11
CY2022035I1 (el) 2023-01-05
EA202090227A1 (ru) 2020-05-31
HUS2300002I1 (hu) 2023-01-28
PE20191759A1 (es) 2019-12-12
CL2014003637A1 (es) 2015-03-27
EA035013B1 (ru) 2020-04-17
SI3275899T1 (sl) 2020-11-30
CN108101991A (zh) 2018-06-01
SMT202000628T1 (it) 2021-01-05
KR20230159625A (ko) 2023-11-21
FR22C1057I1 (fr) 2023-01-06
LUC00286I2 (fr) 2025-05-12
TW201831515A (zh) 2018-09-01
CY1119563T1 (el) 2018-03-07
AR125268A2 (es) 2023-06-28
US9505839B2 (en) 2016-11-29
HRP20201852T1 (hr) 2021-01-08
IL236517A0 (en) 2015-02-26
US11345752B2 (en) 2022-05-31
DK3275899T3 (da) 2020-11-30
EP3275899B1 (fr) 2020-08-26
JP2015527880A (ja) 2015-09-24
AU2013286914A1 (en) 2015-01-29
CA3161329A1 (fr) 2014-01-09
CN104411723B (zh) 2018-01-30
DK3795592T3 (da) 2024-10-14
PT3275899T (pt) 2020-11-17
EP2867258B1 (fr) 2017-06-28
JP7009531B2 (ja) 2022-02-10
PE20191324A1 (es) 2019-09-24
TWI576355B (zh) 2017-04-01
TWI701045B (zh) 2020-08-11
MY169383A (en) 2019-03-26
HUE069061T2 (hu) 2025-02-28
PH12014502854A1 (en) 2015-02-23
JP2018126149A (ja) 2018-08-16
NZ628528A (en) 2016-07-29
HRP20171315T1 (hr) 2017-10-20
AR129651A2 (es) 2024-09-18
SI3795592T1 (sl) 2024-10-30
TW202313688A (zh) 2023-04-01
TWI771721B (zh) 2022-07-21
KR20210102485A (ko) 2021-08-19
WO2014008218A1 (fr) 2014-01-09
MX365417B (es) 2019-06-03
EP3795592B1 (fr) 2024-07-24
US20230077348A1 (en) 2023-03-16
MY197322A (en) 2023-06-13
AU2017221874B2 (en) 2019-05-02
AU2019204803B2 (en) 2021-06-10
TW202118789A (zh) 2021-05-16
CY2022035I2 (el) 2023-01-27
JP2024041966A (ja) 2024-03-27
TW201406784A (zh) 2014-02-16
FIC20230009I1 (fi) 2023-02-09
JP6320376B2 (ja) 2018-05-09
CN108101991B (zh) 2022-02-11
LT3275899T (lt) 2020-12-10
LT2867258T (lt) 2017-09-11
US20190256594A1 (en) 2019-08-22
KR20220150417A (ko) 2022-11-10
HUE034553T2 (en) 2018-02-28
SI2867258T1 (sl) 2017-10-30
US20180371087A1 (en) 2018-12-27
LTPA2022015I1 (fr) 2022-12-12
RS56398B1 (sr) 2017-12-29
PE20150221A1 (es) 2015-02-19
TW202540190A (zh) 2025-10-16
HRP20241357T1 (hr) 2024-12-20
IL236517B (en) 2018-06-28
EA201590138A1 (ru) 2015-07-30
SMT202400395T1 (it) 2024-11-15
US20250136684A1 (en) 2025-05-01
PT3795592T (pt) 2024-09-17
MX2015000116A (es) 2015-04-14
DK2867258T3 (en) 2017-10-02
SG10201610960YA (en) 2017-02-27
BR112014032999A2 (pt) 2017-08-01
CN104411723A (zh) 2015-03-11
EP2867258A1 (fr) 2015-05-06
EP3275899A1 (fr) 2018-01-31
HRP20201852T8 (hr) 2021-06-25
ES2987734T3 (es) 2024-11-18
EP3795592A1 (fr) 2021-03-24
PT2867258T (pt) 2017-08-31
CA2877746A1 (fr) 2014-01-09
TWI662046B (zh) 2019-06-11
TW201726743A (zh) 2017-08-01
AU2019204803A1 (en) 2019-07-25
KR102290633B1 (ko) 2021-08-19
CY1123609T1 (el) 2022-03-24
US20140093511A1 (en) 2014-04-03
AU2025200257A1 (en) 2025-02-20
LT3795592T (lt) 2024-09-25
JP6668405B2 (ja) 2020-03-18
RS65997B1 (sr) 2024-10-31
FR22C1057I2 (fr) 2023-12-15
AR091649A1 (es) 2015-02-18
AU2021225177A1 (en) 2021-09-30
NL301205I1 (fr) 2023-04-19

Similar Documents

Publication Publication Date Title
TN2014000536A1 (en) Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
WO2010019570A3 (fr) Anticorps humains qui se lient au gène 3 d'activation des lymphocytes (lag-3), et leurs utilisations
PH12019501241A1 (en) Novel t cell receptors and immune therapy using the same
WO2018170338A3 (fr) Tcr spécifiques de mage-a1 à haute affinité et leurs utilisations
NZ754730A (en) Anti-icos agonist antibodies and uses thereof
MX2009005189A (es) Anticuerpos humanos monoclonales para btla y metodos de uso.
MX341076B (es) Formulaciones estables de anticuerpos para el receptor humano pd-1 de meurte programada y tratamientos relacionados.
EA036814B9 (ru) Антитело против pd-l1 (варианты), композиция, содержащая это антитело, и их применение
MY189836A (en) Antibodies against cd73 and uses thereof
MY177065A (en) 4-1bb binding molecules
WO2007067730A3 (fr) Anticorps monoclonaux humains contre la proteine tyrosine kinase 7 (ptk7) et procedes pour utiliser des anticorps anti-ptk7
WO2007067992A3 (fr) Anticorps monoclonaux humains se liant au fucosyl-gm1, et procedes d'utilisation de l'anti-fucosyl-gm1
MX2010005830A (es) Conjugado de anticuerpo monoclonal anti-b7h4 - farmaco y metodos de uso del mismo.
PH12019500571A1 (en) Anti-pd-1 antibodies
EA201892548A1 (ru) Антитела к альфа-синуклеину и их применение
MX2015014198A (es) Anticuerpos cuyo objetivo es m-csf.