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EA036814B9 - Антитело против pd-l1 (варианты), композиция, содержащая это антитело, и их применение - Google Patents

Антитело против pd-l1 (варианты), композиция, содержащая это антитело, и их применение

Info

Publication number
EA036814B9
EA036814B9 EA201400625A EA201400625A EA036814B9 EA 036814 B9 EA036814 B9 EA 036814B9 EA 201400625 A EA201400625 A EA 201400625A EA 201400625 A EA201400625 A EA 201400625A EA 036814 B9 EA036814 B9 EA 036814B9
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
cell
antibodies
treatment
antigen binding
Prior art date
Application number
EA201400625A
Other languages
English (en)
Other versions
EA036814B1 (ru
EA201400625A1 (ru
Inventor
Орасио Г. Настри
Кристел Иффленд
Оливье Лежер
Ци Ань
Марк Картрайт
Шон Д. МакКенна
Ванита Д. Суд
Ган Хао
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47221305&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA036814(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201400625A1 publication Critical patent/EA201400625A1/ru
Publication of EA036814B1 publication Critical patent/EA036814B1/ru
Publication of EA036814B9 publication Critical patent/EA036814B9/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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Abstract

Изобретение касается антител против PD-L1 или их антигенсвязывающих фрагментов, композиций, содержащих эти антитела и их антигенсвязывающие фрагменты, и их применения для усиления функции Т-клеток для повышающей регуляции клеточно-опосредованных иммунных реакций и для лечения связанных с дисфункцией Т-клеток нарушений, таких как резистентность опухоли к атаке иммунной системы, для лечения рака.
EA201400625A 2011-11-28 2012-11-21 Антитело против pd-l1 (варианты), композиция, содержащая это антитело, и их применение EA036814B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161563903P 2011-11-28 2011-11-28
PCT/EP2012/004822 WO2013079174A1 (en) 2011-11-28 2012-11-21 Anti-pd-l1 antibodies and uses thereof

Publications (3)

Publication Number Publication Date
EA201400625A1 EA201400625A1 (ru) 2014-11-28
EA036814B1 EA036814B1 (ru) 2020-12-23
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KR101764096B1 (ko) 2017-08-02
JP2015500207A (ja) 2015-01-05
AU2012344260B2 (en) 2017-09-07
KR20140104982A (ko) 2014-08-29
SI2785375T1 (sl) 2020-11-30
MX2014006316A (es) 2014-09-04
AR089010A1 (es) 2014-07-23
MX349096B (es) 2017-07-11
EP3763741A1 (en) 2021-01-13
IL232778B (en) 2020-09-30

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