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PE20190907A1 - Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas - Google Patents

Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas

Info

Publication number
PE20190907A1
PE20190907A1 PE2019000665A PE2019000665A PE20190907A1 PE 20190907 A1 PE20190907 A1 PE 20190907A1 PE 2019000665 A PE2019000665 A PE 2019000665A PE 2019000665 A PE2019000665 A PE 2019000665A PE 20190907 A1 PE20190907 A1 PE 20190907A1
Authority
PE
Peru
Prior art keywords
degeneration
antibody
neurites
diagnosis
treatment
Prior art date
Application number
PE2019000665A
Other languages
English (en)
Inventor
Bernhard Mueller
Lili Huang
Philip D Bardwell
Yuliya Kutskova
John Memmott
Original Assignee
AbbVie Deutschland GmbH and Co KG
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AbbVie Deutschland GmbH and Co KG, Abbvie Inc filed Critical AbbVie Deutschland GmbH and Co KG
Publication of PE20190907A1 publication Critical patent/PE20190907A1/es

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
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    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
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    • A61K51/1021—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against cytokines, e.g. growth factors, VEGF, TNF, lymphokines or interferons
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Abstract

Se refiere a un anticuerpo monoclonal aislado anti-Molecula de Guia Repulsiva a (RGMa) o un fragmento de anticuerpo del mismo aislado caracterizado porque son humanos y pueden unirse a la molecula de Guia Repulsiva a (RGMa), en donde el anticuerpo comprende un dominio o una region del dominio variable de la cadena pesada que comprende una secuencia de aminoacidos SEQ ID N°9, una region del dominio variable de la cadena liviana que comprende una secuencia de aminoacidos SEQ ID N°13, entre otros. Tambien se refiere a una composicion farmaceutica. Dicho anticuerpo es util para tratar y diagnosticar las enfermedades y los trastornos asociados a la degeneracion de las neuritas, tales como la esclerosis multiple.
PE2019000665A 2012-01-27 2013-01-25 Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas PE20190907A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261591324P 2012-01-27 2012-01-27
PCT/US2013/023277 WO2013112922A1 (en) 2012-01-27 2013-01-25 Composition and method for diagnosis and treatment of diseases associated with neurite degeneration

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PE20190907A1 true PE20190907A1 (es) 2019-06-26

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PE2014001182A PE20142168A1 (es) 2012-01-27 2013-01-25 Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas
PE2019000665A PE20190907A1 (es) 2012-01-27 2013-01-25 Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas

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US (6) US20130330347A1 (es)
EP (3) EP3653647A1 (es)
JP (4) JP6271441B2 (es)
KR (1) KR102129234B1 (es)
CN (2) CN104487455A (es)
AU (4) AU2013211939C1 (es)
BR (1) BR112014018592B1 (es)
CA (1) CA2857967C (es)
CL (1) CL2014001963A1 (es)
CO (1) CO7020876A2 (es)
CR (1) CR20140360A (es)
CY (1) CY1120390T1 (es)
DK (1) DK2807192T3 (es)
DO (1) DOP2014000174A (es)
EC (1) ECSP14010817A (es)
ES (1) ES2676725T3 (es)
GT (1) GT201400162A (es)
HR (1) HRP20181087T1 (es)
HU (1) HUE039611T2 (es)
IL (7) IL305223A (es)
LT (1) LT2807192T (es)
MX (3) MX352772B (es)
MY (2) MY194587A (es)
NZ (2) NZ714482A (es)
PE (2) PE20142168A1 (es)
PH (1) PH12014501682B1 (es)
PL (1) PL2807192T3 (es)
PT (1) PT2807192T (es)
RS (1) RS57603B1 (es)
RU (2) RU2644337C2 (es)
SG (3) SG10201600316SA (es)
SI (1) SI2807192T1 (es)
TR (1) TR201809967T4 (es)
UA (1) UA118083C2 (es)
WO (1) WO2013112922A1 (es)

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