AR128047A2 - Moléculas de anticuerpos que se unen a il-17a e il-17f - Google Patents
Moléculas de anticuerpos que se unen a il-17a e il-17fInfo
- Publication number
- AR128047A2 AR128047A2 ARP220103527A ARP220103527A AR128047A2 AR 128047 A2 AR128047 A2 AR 128047A2 AR P220103527 A ARP220103527 A AR P220103527A AR P220103527 A ARP220103527 A AR P220103527A AR 128047 A2 AR128047 A2 AR 128047A2
- Authority
- AR
- Argentina
- Prior art keywords
- antibody molecules
- antibody
- bind
- light chain
- human
- Prior art date
Links
- 102000013691 Interleukin-17 Human genes 0.000 title abstract 7
- 108050003558 Interleukin-17 Proteins 0.000 title abstract 7
- 101000998146 Homo sapiens Interleukin-17A Proteins 0.000 abstract 1
- 101000998151 Homo sapiens Interleukin-17F Proteins 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 102000053162 human IL17A Human genes 0.000 abstract 1
- 102000056946 human IL17F Human genes 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Surgery (AREA)
- Virology (AREA)
Abstract
La invención se refiere a moléculas de anticuerpos que tienen especificidad por determinantes antigénicos de ambos IL-17A e IL-17F, usos terapéuticos de las moléculas de anticuerpos y métodos para producir dichas moléculas de anticuerpos. Reivindicación 1: Un anticuerpo de neutralización que se une a IL-17A humano y IL-17F humano caracterizado porque tiene una cadena liviana en donde el dominio variable de la cadena liviana comprende la secuencia dada en la SEC ID Nº 7. Reivindicación 19: El uso de un anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 hasta 8 o una composición farmacéutica de acuerdo con la reivindicación 15 o la reivindicación 16 en la fabricación de un medicamento para el tratamiento o la profilaxis de un trastorno patológico que está mediado por IL-17A y/o IL-17F o que está asociado con un aumento en el nivel de IL-17A y/o IL-17F.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161432814P | 2011-01-14 | 2011-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR128047A2 true AR128047A2 (es) | 2024-03-20 |
Family
ID=45496193
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100115A AR084845A1 (es) | 2011-01-14 | 2012-01-12 | Moleculas de anticuerpos que se unen a il-17a e il-17f |
| ARP220103527A AR128047A2 (es) | 2011-01-14 | 2022-12-21 | Moléculas de anticuerpos que se unen a il-17a e il-17f |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100115A AR084845A1 (es) | 2011-01-14 | 2012-01-12 | Moleculas de anticuerpos que se unen a il-17a e il-17f |
Country Status (39)
| Country | Link |
|---|---|
| US (6) | US8580265B2 (es) |
| EP (2) | EP3219728A1 (es) |
| JP (2) | JP6028737B2 (es) |
| KR (1) | KR101950306B1 (es) |
| CN (1) | CN103384682B (es) |
| AR (2) | AR084845A1 (es) |
| AU (1) | AU2012206431B2 (es) |
| BR (1) | BR112013017951B1 (es) |
| CA (1) | CA2823812C (es) |
| CL (1) | CL2013002044A1 (es) |
| CO (1) | CO6781516A2 (es) |
| CY (2) | CY1119055T1 (es) |
| DK (1) | DK2663577T3 (es) |
| EA (1) | EA037071B1 (es) |
| ES (1) | ES2632583T3 (es) |
| FI (1) | FIC20220002I1 (es) |
| FR (1) | FR22C1000I2 (es) |
| HR (1) | HRP20171034T1 (es) |
| HU (1) | HUS2200001I1 (es) |
| IL (1) | IL227347B (es) |
| LT (2) | LT2663577T (es) |
| LU (1) | LUC00246I2 (es) |
| MA (1) | MA34907B1 (es) |
| ME (1) | ME02734B (es) |
| MX (1) | MX341489B (es) |
| MY (1) | MY162790A (es) |
| NL (1) | NL301159I2 (es) |
| NO (1) | NO2021053I1 (es) |
| PH (1) | PH12013501435B1 (es) |
| PL (1) | PL2663577T3 (es) |
| PT (1) | PT2663577T (es) |
| RS (1) | RS56298B1 (es) |
| SG (2) | SG10201510762YA (es) |
| SI (1) | SI2663577T1 (es) |
| TN (1) | TN2013000292A1 (es) |
| TW (1) | TWI511978B (es) |
| UA (1) | UA110358C2 (es) |
| WO (1) | WO2012095662A1 (es) |
| ZA (1) | ZA201306080B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0620729D0 (en) * | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
| GB0807413D0 (en) * | 2008-04-23 | 2008-05-28 | Ucb Pharma Sa | Biological products |
| AU2011254557B2 (en) | 2010-05-20 | 2015-09-03 | Ablynx Nv | Biological materials related to HER3 |
| PL2663577T3 (pl) | 2011-01-14 | 2017-09-29 | Ucb Biopharma Sprl | Przeciwciało wiążące IL-17A i IL-17F |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| KR102023401B1 (ko) | 2012-05-10 | 2019-11-04 | 바이오아트라, 엘엘씨 | 다중-특이적 모노클로날 항체 |
| GB201310544D0 (en) | 2013-06-13 | 2013-07-31 | Ucb Pharma Sa | Obtaining an improved therapeutic ligand |
| SI3072905T1 (sl) * | 2013-11-18 | 2020-12-31 | Shanghai Hengrui Pharmaceutical Co., Ltd. | IL-17A-vezavno sredstvo in uporabe le-tega |
| WO2015127405A2 (en) | 2014-02-21 | 2015-08-27 | Genentech, Inc. | Anti-il-13/il-17 bispecific antibodies and uses thereof |
| AU2015258859B2 (en) | 2014-05-15 | 2020-07-23 | Rani Therapeutics, Llc | Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins |
| TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| EP3250927B1 (en) | 2015-01-28 | 2020-02-19 | H. Hoffnabb-La Roche Ag | Gene expression markers and treatment of multiple sclerosis |
| MY196489A (en) * | 2015-10-27 | 2023-04-17 | UCB Biopharma SRL | Methods of Treatment Using Anti-IL-17A/F Antibodies |
| RU2680011C2 (ru) | 2016-04-29 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы |
| AU2017328310B2 (en) | 2016-09-14 | 2020-10-15 | Beijing Hanmi Pharm. Co., Ltd. | Antibody specifically binding to IL-17A and functional fragment thereof |
| EP3558363A1 (en) | 2016-12-21 | 2019-10-30 | Amgen Inc. | Anti-tnf alpha antibody formulations |
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