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MX2012002927A - Anticuerpos humanos de alta afinidad con el receptor activado por proteasa humana-2. - Google Patents

Anticuerpos humanos de alta afinidad con el receptor activado por proteasa humana-2.

Info

Publication number
MX2012002927A
MX2012002927A MX2012002927A MX2012002927A MX2012002927A MX 2012002927 A MX2012002927 A MX 2012002927A MX 2012002927 A MX2012002927 A MX 2012002927A MX 2012002927 A MX2012002927 A MX 2012002927A MX 2012002927 A MX2012002927 A MX 2012002927A
Authority
MX
Mexico
Prior art keywords
human
antibodies
proteasa
high affinity
par
Prior art date
Application number
MX2012002927A
Other languages
English (en)
Inventor
Lynn Macdonald
Andrew J Murphy
Nicholas J Papadopulos
Marc R Morra
Robert R Salzler
Michael L Laccroix-Fralish
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2012002927A publication Critical patent/MX2012002927A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención proporciona anticuerpos que unen al receptor- 2 activado por proteasa (PAR-2) y métodos para usar los mismos. De acuerdo a ciertas modalidades de la invención, los anticuerpos son anticuerpos completamente humanos que unen al humano PAR-2. Los anticuerpos de la invención son útiles, entre otras cosas, para el tratamiento de enfermedades o desórdenes asociados con una o mas actividades biológicas de PAR-2, incluyendo el tratamiento de condiciones de dolor, condiciones inflamatorias y condiciones gastrointestinales.
MX2012002927A 2009-09-09 2010-09-08 Anticuerpos humanos de alta afinidad con el receptor activado por proteasa humana-2. MX2012002927A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24078309P 2009-09-09 2009-09-09
US24282109P 2009-09-16 2009-09-16
US31783910P 2010-03-26 2010-03-26
PCT/US2010/048034 WO2011031695A1 (en) 2009-09-09 2010-09-08 High affinity human antibodies to human protease-activated receptor-2

Publications (1)

Publication Number Publication Date
MX2012002927A true MX2012002927A (es) 2012-08-03

Family

ID=43063654

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012002927A MX2012002927A (es) 2009-09-09 2010-09-08 Anticuerpos humanos de alta afinidad con el receptor activado por proteasa humana-2.

Country Status (29)

Country Link
US (3) US8101724B2 (es)
EP (1) EP2475684B1 (es)
JP (2) JP5832435B2 (es)
KR (1) KR101766701B1 (es)
CN (1) CN102574923B (es)
AR (1) AR078346A1 (es)
AU (1) AU2010292342C1 (es)
BR (1) BR112012005338A2 (es)
CA (1) CA2773541A1 (es)
CY (1) CY1118714T1 (es)
DK (1) DK2475684T3 (es)
ES (1) ES2609780T3 (es)
HR (1) HRP20170324T1 (es)
HU (1) HUE031725T2 (es)
IL (1) IL218501A (es)
JO (1) JO3246B1 (es)
LT (1) LT2475684T (es)
MX (1) MX2012002927A (es)
MY (1) MY159551A (es)
NZ (1) NZ599204A (es)
PL (1) PL2475684T3 (es)
PT (1) PT2475684T (es)
SG (1) SG178976A1 (es)
SI (1) SI2475684T1 (es)
SM (2) SMT201700102T1 (es)
TW (1) TWI492757B (es)
UY (1) UY32883A (es)
WO (1) WO2011031695A1 (es)
ZA (1) ZA201201730B (es)

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JO3246B1 (ar) * 2009-09-09 2018-03-08 Regeneron Pharma اجسام مضادة بشرية ذات ألفة تفاعل عالية مع مستقبل 2 المفعل بالبروتين البشري
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US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
CA2821515A1 (en) 2010-12-01 2012-06-07 Alder Biopharmaceuticals, Inc. Anti-ngf compositions and use thereof
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
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AU2016354478B2 (en) * 2015-11-13 2021-07-22 Oasis Pharmaceuticals, LLC Protease-activated receptor-2 modulators
CN118480125A (zh) 2016-11-08 2024-08-13 齐鲁皮吉特湾生物治疗有限公司 抗pd1和抗ctla4抗体
CR20190417A (es) * 2017-03-16 2019-12-06 Medimmune Ltd Anticuerpos anti-par2 y usos de los mismos referencia cruzada a solicitudes relacionadas
EP3911677A1 (en) * 2019-01-18 2021-11-24 Janssen Biotech, Inc. Gprc5d chimeric antigen receptors and cells expressing the same
AU2020250933A1 (en) 2019-04-05 2021-10-28 Centre Hospitalier Régional Et Universitaire De Brest Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning
KR102758039B1 (ko) * 2019-05-30 2025-01-22 샨동 보안 바이오테크놀로지 컴퍼니, 리미티드 클라우딘(Claudin) 18.2를 표적화하는 항체 또는 키메라 항원 수용체
CN114599351A (zh) * 2019-11-01 2022-06-07 株式会社资生堂 以皮肤中的活性型par-2为指标的皮肤状态评价方法、par-2激活促进剂或抑制剂的筛选方法和par-2激活抑制剂
WO2021202770A2 (en) * 2020-03-31 2021-10-07 Fred Hutchinson Cancer Research Center Human anti-cd33 antibodies and uses thereof
EP4200018B1 (en) 2020-08-18 2025-01-01 Cephalon LLC Anti-par-2 antibodies and methods of use thereof
JP2024535740A (ja) * 2021-09-02 2024-10-02 メモリアル スローン ケタリング キャンサー センター Ｃｄ３３を標的とする抗原認識受容体及びその使用
EP4396235A4 (en) * 2021-09-02 2025-07-02 Memorial Sloan Kettering Cancer Center ANTI-CD33 ANTIBODIES AND THEIR USES
CN114181311B (zh) * 2021-12-20 2023-06-20 华东师范大学 一种全人源抗DLL3 scFv及其在CART细胞治疗中的应用
GB202204159D0 (en) * 2022-03-24 2022-05-11 Heptares Therapeutics Ltd Antibodies
WO2024059336A1 (en) * 2022-09-18 2024-03-21 Memorial Sloan Kettering Cancer Center Inhibition of protease-activated receptor 2 (par2) pathway for treatment and prevention of lymphedema

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KR101338681B1 (ko) 2009-06-18 2013-12-09 (주)아모레퍼시픽 밤껍질 추출물을 포함하는 건강 식품 또는 약학 조성물
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Also Published As

Publication number Publication date
AR078346A1 (es) 2011-11-02
CN102574923A (zh) 2012-07-11
EP2475684B1 (en) 2016-11-30
CN102574923B (zh) 2016-12-07
HK1166509A1 (en) 2012-11-02
AU2010292342B2 (en) 2015-04-30
JP2015227381A (ja) 2015-12-17
EP2475684A1 (en) 2012-07-18
US20120093824A1 (en) 2012-04-19
AU2010292342C1 (en) 2015-08-27
HRP20170324T1 (hr) 2017-04-21
JO3246B1 (ar) 2018-03-08
WO2011031695A1 (en) 2011-03-17
CA2773541A1 (en) 2011-03-17
AU2010292342A1 (en) 2012-05-03
UY32883A (es) 2011-03-31
BR112012005338A2 (pt) 2016-11-22
MY159551A (en) 2017-01-13
SMT201700102T1 (it) 2017-03-08
US8101724B2 (en) 2012-01-24
SI2475684T1 (sl) 2017-03-31
HUE031725T2 (en) 2017-08-28
CY1118714T1 (el) 2017-07-12
JP6055055B2 (ja) 2016-12-27
IL218501A0 (en) 2012-07-31
DK2475684T3 (en) 2017-03-06
US9028819B2 (en) 2015-05-12
PL2475684T3 (pl) 2017-04-28
SG178976A1 (en) 2012-04-27
IL218501A (en) 2017-03-30
ZA201201730B (en) 2012-11-28
US20110059095A1 (en) 2011-03-10
JP5832435B2 (ja) 2015-12-16
US20140179903A1 (en) 2014-06-26
KR20120059611A (ko) 2012-06-08
LT2475684T (lt) 2017-01-25
NZ599204A (en) 2014-05-30
US8425907B2 (en) 2013-04-23
PT2475684T (pt) 2017-02-10
JP2013504577A (ja) 2013-02-07
TW201121565A (en) 2011-07-01
TWI492757B (zh) 2015-07-21
KR101766701B1 (ko) 2017-08-09
SMT201700102B (it) 2017-03-08
ES2609780T3 (es) 2017-04-24

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