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PE20091340A1 - Anticuerpos bivalentes biespecificos - Google Patents

Anticuerpos bivalentes biespecificos

Info

Publication number
PE20091340A1
PE20091340A1 PE2008002107A PE2008002107A PE20091340A1 PE 20091340 A1 PE20091340 A1 PE 20091340A1 PE 2008002107 A PE2008002107 A PE 2008002107A PE 2008002107 A PE2008002107 A PE 2008002107A PE 20091340 A1 PE20091340 A1 PE 20091340A1
Authority
PE
Peru
Prior art keywords
antibody
long chain
interface
bispecific bivalent
domains
Prior art date
Application number
PE2008002107A
Other languages
English (en)
Inventor
Christian Klein
Wolfgang Schaefer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39687068&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091340(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20091340A1 publication Critical patent/PE20091340A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA A UN ANTICUERPO BIVALENTE BIESPECIFICO QUE CONSTA DE: a) LA CADENA CORTA Y LARGA DE UN ANTICUERPO QUE SE UNE ESPECIFICAMENTE A UN PRIMER ANTIGENO Y b) LA CADENA CORTA Y LARGA DE UN ANTICUERPO QUE SE UNE ESPECIFICAMENTE A UN SEGUNDO ANTIGENO EN LAS QUE LOS DOMINIOS VARIABLES VL Y VH SE REEMPLAZAN ENTRE SI Y LOS DOMINIOS CONSTANTES CL Y CH1 SE REEMPLAZAN ENTRE SI, DONDE EL DOMINIO CH3 DE UNA CADENA LARGA Y EL DOMINIO CH3 DE LA OTRA CADENA LARGA ENTRAN EN CONTACTO ENTRE SI EN LA INTERFASE QUE COMPRENDE UNA INTERFASE ORIGINAL ENTRE LOS DOMINIOS CH3 DEL ANTICUERPO; DICHA INTERFASE SE ALTERA PARA FOMENTAR LA FORMACION DEL ANTICUERPO BIVALENTE, BIESPECIFICO. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION, UNA COMPOSICION FARMACEUTICA Y UNA CELULA HUESPED
PE2008002107A 2007-12-21 2008-12-17 Anticuerpos bivalentes biespecificos PE20091340A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07024867 2007-12-21

Publications (1)

Publication Number Publication Date
PE20091340A1 true PE20091340A1 (es) 2009-09-03

Family

ID=39687068

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002107A PE20091340A1 (es) 2007-12-21 2008-12-17 Anticuerpos bivalentes biespecificos

Country Status (17)

Country Link
US (1) US9266967B2 (es)
EP (1) EP2231709B1 (es)
JP (1) JP5281096B2 (es)
KR (1) KR101265912B1 (es)
CN (1) CN101896504B (es)
AR (1) AR069776A1 (es)
AU (1) AU2008340692A1 (es)
BR (1) BRPI0821375B8 (es)
CA (1) CA2709345C (es)
CL (1) CL2008003779A1 (es)
ES (1) ES2468265T3 (es)
IL (1) IL205285A0 (es)
MX (1) MX2010005888A (es)
PE (1) PE20091340A1 (es)
RU (1) RU2547615C2 (es)
TW (1) TW200927171A (es)
WO (1) WO2009080251A1 (es)

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