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PE20091520A1 - Anticuerpos bivalentes biespecificos - Google Patents

Anticuerpos bivalentes biespecificos

Info

Publication number
PE20091520A1
PE20091520A1 PE2008002109A PE2008002109A PE20091520A1 PE 20091520 A1 PE20091520 A1 PE 20091520A1 PE 2008002109 A PE2008002109 A PE 2008002109A PE 2008002109 A PE2008002109 A PE 2008002109A PE 20091520 A1 PE20091520 A1 PE 20091520A1
Authority
PE
Peru
Prior art keywords
heavy chain
antibody
chain
antigen
replaced
Prior art date
Application number
PE2008002109A
Other languages
English (en)
Inventor
Christian Klein
Wolfgang Schaefer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20091520A1 publication Critical patent/PE20091520A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN ANTICUERPO BIVALENTE BIESPECIFICO, QUE COMPRENDE: A) CADENA LIGERA Y CADENA PESADA QUE SE UNE ESPECIFICAMENTE A UN PRIMER ANTIGENO, DONDE EL DOMINIO CH3 DE LA CADENA PESADA SE REEMPLAZA POR UN DOMINIO CONSTANTE CH1 DE LA CADENA PESADA; Y B) CADENA LIGERA Y CADENA PESADA QUE SE UNE ESPECIFICAMENTE A UN SEGUNDO ANTIGENO, DONDE EL DOMINIO CONSTANTE CH3 DE LA CADENA PESADA SE REEMPLAZA POR UN DOMINIO CONSTANTE CL DE LA CADENA LIGERA; CARACTERIZADO PORQUE LA CADENA LIGERA Y PESADA DE DICHO PRIMER ANTICUERPO SE UNE ESPECIFICAMENTE A UN PRIMER ANTIGENO O DICHO SEGUNDO ANTICUERPO QUE SE UNE ESPECIFICAMENTE A UN SEGUNDO ANTIGENO ESTAN ALTERADAS PORQUE LOS DOMINIOS VARIABLES VL Y VH ESTAN REEMPLAZADOS EL UNO POR EL OTRO; Y/O PORQUE LOS DOMINIOS VARIABLES CL Y CH1 ESTAN REEMPLAZADOS EL UNO POR EL OTRO. TAMBIEN REFIERE A UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE. DICHO ANTICUERPO ES DE UTILIDAD PARA EL TRATAMIENTO DE TUMORES Y TRASTORNOS AUTOINMUNES
PE2008002109A 2007-12-21 2008-12-17 Anticuerpos bivalentes biespecificos PE20091520A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07024866 2007-12-21

Publications (1)

Publication Number Publication Date
PE20091520A1 true PE20091520A1 (es) 2009-09-25

Family

ID=39684152

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002109A PE20091520A1 (es) 2007-12-21 2008-12-17 Anticuerpos bivalentes biespecificos

Country Status (15)

Country Link
US (1) US8227577B2 (es)
EP (1) EP2238173A1 (es)
JP (1) JP2011507489A (es)
KR (1) KR101266659B1 (es)
CN (1) CN101903405A (es)
AR (1) AR069797A1 (es)
AU (1) AU2008340695A1 (es)
BR (1) BRPI0821405A2 (es)
CA (1) CA2709347A1 (es)
CL (1) CL2008003782A1 (es)
IL (1) IL205750A0 (es)
MX (1) MX2010005682A (es)
PE (1) PE20091520A1 (es)
TW (1) TW200932270A (es)
WO (1) WO2009080254A1 (es)

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