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AR055137A1 - Moleculas de union al antigeno modificadas con actividad de senalizacion celular alterada - Google Patents

Moleculas de union al antigeno modificadas con actividad de senalizacion celular alterada

Info

Publication number
AR055137A1
AR055137A1 ARP060103708A ARP060103708A AR055137A1 AR 055137 A1 AR055137 A1 AR 055137A1 AR P060103708 A ARP060103708 A AR P060103708A AR P060103708 A ARP060103708 A AR P060103708A AR 055137 A1 AR055137 A1 AR 055137A1
Authority
AR
Argentina
Prior art keywords
modified
refers
cell signaling
signaling activity
abms
Prior art date
Application number
ARP060103708A
Other languages
English (en)
Original Assignee
Glycart Biotechnology Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37865318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR055137(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glycart Biotechnology Ag filed Critical Glycart Biotechnology Ag
Publication of AR055137A1 publication Critical patent/AR055137A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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Abstract

La presente se refiere a moléculas de union al antígeno modificadas (sigla en inglés, ABM). En realizaciones particulares, la presente se refiere a anticuerpos o fragmentos monoclonales recombinantes, que incluyen anticuerpos o fragmentos quiméricos, primatizados o humanizados, que tienen alterada la capacidad de mediar la actividad de senalizacion celular por un antígeno blanco y/o alterada la capacidad de mediar el entrecruzamiento de uno o más antígenos blanco. Además, la presente se refiere a moléculas de ácido nucleico que codifican tales ABM modificadas y vectores y células hospedantes que comprenden tales moléculas de ácido nucleico. La presente se refiere además a métodos para producir las ABM modificadas de la presente y a métodos de uso de estas ABM modificadas para el tratamiento de la enfermedad. Además, la presente se refiere a ABM modificadas con glicosilacion modificada que tienen propiedades terapéuticas mejoradas, que incluyen a anticuerpos con union aumentada a receptores Fc y funcion efectora aumentada.
ARP060103708A 2005-08-26 2006-08-25 Moleculas de union al antigeno modificadas con actividad de senalizacion celular alterada AR055137A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71145405P 2005-08-26 2005-08-26

Publications (1)

Publication Number Publication Date
AR055137A1 true AR055137A1 (es) 2007-08-08

Family

ID=37865318

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103708A AR055137A1 (es) 2005-08-26 2006-08-25 Moleculas de union al antigeno modificadas con actividad de senalizacion celular alterada

Country Status (18)

Country Link
US (2) US20070071745A1 (es)
EP (3) EP2395024B1 (es)
JP (3) JP5373396B2 (es)
KR (2) KR101460932B1 (es)
CN (2) CN101291954B (es)
AR (1) AR055137A1 (es)
AU (1) AU2006290433B2 (es)
BR (2) BRPI0615397B1 (es)
CA (1) CA2619298C (es)
CL (2) CL2010000823A1 (es)
IL (1) IL189756A (es)
NO (2) NO345919B1 (es)
PH (1) PH12012502376B1 (es)
RU (2) RU2547931C2 (es)
SG (1) SG192479A1 (es)
TW (2) TWI615407B (es)
WO (1) WO2007031875A2 (es)
ZA (1) ZA200802500B (es)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
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MXPA04001072A (es) 2001-08-03 2005-02-17 Glycart Biotechnology Ag Variantes de glicosilacion de anticuerpos que tienen citotoxicidad celulares dependiente de anticuerpos incrementada.
ES2527871T3 (es) 2003-05-01 2015-02-02 Imclone Llc Anticuerpos completamente humanos dirigidos contra el receptor del factor de crecimiento 1 similar a la insulina humana
KR101364902B1 (ko) 2003-11-05 2014-02-21 로슈 글리카트 아게 증가된 ｆｃ 수용체 결합 친화성 및 효과기 기능을 가진 ｃｄ20 항체
PT1871805T (pt) 2005-02-07 2019-12-02 Roche Glycart Ag Moléculas de ligação a antigénios que se ligam ao rfce, vetores que as codificam e as suas utilizações
EP2100618B1 (en) 2005-06-17 2014-02-12 ImClone LLC An anti-PDGFRalpha antibody for use in the treatment of metastatic bone cancer
JP5373396B2 (ja) * 2005-08-26 2013-12-18 ロシュ グリクアート アクチェンゲゼルシャフト 改変された細胞シグナル活性有する改変抗原結合分子
CN101484587B (zh) 2006-02-03 2014-02-12 英克隆有限责任公司 Igf-ir拮抗剂作为辅药用于前列腺癌的治疗
AR062223A1 (es) 2006-08-09 2008-10-22 Glycart Biotechnology Ag Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
RU2540150C2 (ru) 2007-06-25 2015-02-10 Эсбатек, Эн Элкон Биомедикал Рисёрч Юнит Ллк Способы модификации антител и модифицированные антитела с улучшенными функциональными свойствами
KR101234436B1 (ko) * 2007-09-05 2013-02-18 로슈 글리카트 아게 유형 ⅰ 및 유형 ⅱ 항-ｃｄ２０ 항체를 사용하는 병용 치료요법
US20090098118A1 (en) 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
US20090110688A1 (en) * 2007-10-24 2009-04-30 Georg Fertig Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
BRPI0819593A2 (pt) * 2007-12-21 2015-05-05 Genentech Inc "método para tratamento de um paciente com artrite reumatóide (ra)"
RU2540013C2 (ru) * 2008-03-13 2015-01-27 Биотест Аг Средство для лечения заболевания
KR20100135257A (ko) * 2008-03-13 2010-12-24 바이오테스트 아게 질병 치료제
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