CN1365791A - Nano medicine 'Shenrong Baotai' and its preparing process - Google Patents
Nano medicine 'Shenrong Baotai' and its preparing process Download PDFInfo
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Abstract
A nanometre medicine "Shenrong Baotai" is prepared from the nanometre powders of 23 Chinese medicinal materials including pilose asiabell root, longan aril, dodder seed, cyperus tuber, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of nourishing the liver and kidney, enriching blood to prevent miscarriage, cure mainly that deficiency of the liver and kindey, deficiency of nutrient QI and blood, physical weakness, waist and leg ache, few abdomen weigh down and expand, the nano medicine ' Shenrong Baotai ' of gestation hemorrhage, frequent fetal movement, the invention still further relates to the method for this medication preparation.
The ginseng and pilose antler pill for protecting fetus is a kind of classical Chinese patent medicine, mainly contain and promote hemopoietic function, regulate effects such as uterus function, enhance immunity, analgesia, antiinflammatory, be used for that deficiency of the liver and kindey, deficiency of nutrient QI and blood, physical weakness, waist and leg ache, few abdomen weigh down and expand, gestation hemorrhage, frequent fetal movement.But traditional ginseng and pilose antler pill for protecting fetus disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Shenrong Baotai ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Shenrong Baotai '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Codonopsis 40-90 part nanometer Arillus Longan 10-30 part nanometer Semen Cuscutae 20-50 part
Nano cyperus tuber 30-60 part nano Poria 40-80 part nanometer Rhizoma Dioscoreae 30-80 part
Nanometer Folium Artemisiae Argyi 30-65 part nanometer Rhizoma Atractylodis Macrocephalae 30-80 part nanometer Radix Scutellariae 40-90 part
Nanometer Radix Rehmanniae Preparata 30-65 part nanometer Radix Paeoniae Alba 30-65 part nano ass hide glue 30-65 part
Nanometer Radix Glycyrrhizae Preparata 15-50 part nano Chinese angelica 30-80 part nanometer Herba Taxilli 30-65 part
Nanometer Rhizoma Chuanxiong 25-60 part nanometer Rhizoma Et Radix Notopterygii 10-35 part nanometer Radix Dipsaci 25-60 part
The female 10-35 part of nano-antler 10-35 part nanometer Cortex Eucommiae 40-80 part nano Sichuan fritillary bulb
The tangerine 25-60 part of nanometer Fructus Amomi 20-50 part nanorize
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Codonopsis 50-80 part nanometer Arillus Longan 15-25 part nanometer Semen Cuscutae 25-40 part
Nano cyperus tuber 35-50 part nano Poria 50-70 part nanometer Rhizoma Dioscoreae 40-60 part
Nanometer Folium Artemisiae Argyi 35-55 part nanometer Rhizoma Atractylodis Macrocephalae 40-60 part nanometer Radix Scutellariae 50-80 part
Nanometer Radix Rehmanniae Preparata 35-55 part nanometer Radix Paeoniae Alba 35-55 part nano ass hide glue 35-55 part
Nanometer Radix Glycyrrhizae Preparata 20-40 part nano Chinese angelica 40-60 part nanometer Herba Taxilli 35-55 part
Nanometer Rhizoma Chuanxiong 30-50 part nanometer Rhizoma Et Radix Notopterygii 15-25 part nanometer Radix Dipsaci 30-50 part
The female 15-25 part of nano-antler 15-25 part nanometer Cortex Eucommiae 50-70 part nano Sichuan fritillary bulb
The tangerine 30-50 part of nanometer Fructus Amomi 25-40 part nanorize
The optimum weight proportioning of medicine of the present invention is:
33 parts of 20 parts of nanometer Semen Cuscutae of 66 portions of nanometer Arillus Longans of nanometer Radix Codonopsis
50 parts of 58 parts of nanometer Rhizoma Dioscoreaes of 41 parts of nano Porias of nano cyperus tuber
66 parts of 50 parts of nanometer Radix Scutellariaes of 41 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Folium Artemisiae Argyi
41 parts of 41 parts of nano ass hide glues of 41 parts of nanometer Radix Paeoniae Albas of nanometer Radix Rehmanniae Preparata
41 parts of 50 parts of nanometer Herba Taxillis of 28 parts of nano Chinese angelicas of nanometer Radix Glycyrrhizae Preparata
41 parts of 20 parts of nanometer Radix Dipsacis of 41 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Rhizoma Chuanxiong
Female 20 parts of 58 parts of nano Sichuan fritillary bulbs of 20 parts of nanometer Cortexs Eucommiae of nano-antler
Tangerine 41 parts of 33 parts of nanorize of nanometer Fructus Amomi
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Shenrong Baotai ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Shenrong Baotai ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common ginseng and pilose antler pill for protecting fetus preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Shenrong Baotai ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for frequent fetal movement, vaginal bleeding during pregnancy, lumbago during pregnancy, stomachache and treatment of conditions such as infertile, and clinical efficacy significantly is better than traditional ginseng and pilose antler pill for protecting fetus.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
33 parts of 20 parts of nanometer Semen Cuscutae of 66 portions of nanometer Arillus Longans of nanometer Radix Codonopsis
50 parts of 58 parts of nanometer Rhizoma Dioscoreaes of 41 parts of nano Porias of nano cyperus tuber
66 parts of 50 parts of nanometer Radix Scutellariaes of 41 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Folium Artemisiae Argyi
41 parts of 41 parts of nano ass hide glues of 41 parts of nanometer Radix Paeoniae Albas of nanometer Radix Rehmanniae Preparata
41 parts of 50 parts of nanometer Herba Taxillis of 28 parts of nano Chinese angelicas of nanometer Radix Glycyrrhizae Preparata
41 parts of 20 parts of nanometer Radix Dipsacis of 41 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Rhizoma Chuanxiong
Female 20 parts of 58 parts of nano Sichuan fritillary bulbs of 20 parts of nanometer Cortexs Eucommiae of nano-antler
Tangerine 41 parts of 33 parts of nanorize of nanometer Fructus Amomi
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
33 parts of 20 parts of nanometer Semen Cuscutae of 66 portions of nanometer Arillus Longans of nanometer Radix Codonopsis
50 parts of 58 parts of nanometer Rhizoma Dioscoreaes of 41 parts of nano Porias of nano cyperus tuber
66 parts of 50 parts of nanometer Radix Scutellariaes of 41 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Folium Artemisiae Argyi
41 parts of 41 parts of nano ass hide glues of 41 parts of nanometer Radix Paeoniae Albas of nanometer Radix Rehmanniae Preparata
41 parts of 50 parts of nanometer Herba Taxillis of 28 parts of nano Chinese angelicas of nanometer Radix Glycyrrhizae Preparata
41 parts of 20 parts of nanometer Radix Dipsacis of 41 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Rhizoma Chuanxiong
Female 20 parts of 58 parts of nano Sichuan fritillary bulbs of 20 parts of nanometer Cortexs Eucommiae of nano-antler
Tangerine 41 parts of 33 parts of nanorize of nanometer Fructus Amomi
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, making prevent miscarriage powder needle injection, every injection content of nanometer ginseng and pilose antler is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
33 parts of 20 parts of nanometer Semen Cuscutae of 66 portions of nanometer Arillus Longans of nanometer Radix Codonopsis
50 parts of 58 parts of nanometer Rhizoma Dioscoreaes of 41 parts of nano Porias of nano cyperus tuber
66 parts of 50 parts of nanometer Radix Scutellariaes of 41 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Folium Artemisiae Argyi
41 parts of 41 parts of nano ass hide glues of 41 parts of nanometer Radix Paeoniae Albas of nanometer Radix Rehmanniae Preparata
41 parts of 50 parts of nanometer Herba Taxillis of 28 parts of nano Chinese angelicas of nanometer Radix Glycyrrhizae Preparata
41 parts of 20 parts of nanometer Radix Dipsacis of 41 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Rhizoma Chuanxiong
Female 20 parts of 58 parts of nano Sichuan fritillary bulbs of 20 parts of nanometer Cortexs Eucommiae of nano-antler
Tangerine 41 parts of 33 parts of nanorize of nanometer Fructus Amomi
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer ginseng and pilose antler membrane of preventing miscarriage, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Shenrong Baotai ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Codonopsis 40-90 part nanometer Arillus Longan 10-30 part nanometer Semen Cuscutae 20-50 part
Nano cyperus tuber 30-60 part nano Poria 40-80 part nanometer Rhizoma Dioscoreae 30-80 part
Nanometer Folium Artemisiae Argyi 30-65 part nanometer Rhizoma Atractylodis Macrocephalae 30-80 part nanometer Radix Scutellariae 40-90 part
Nanometer Radix Rehmanniae Preparata 30-65 part nanometer Radix Paeoniae Alba 30-65 part nano ass hide glue 30-65 part
Nanometer Radix Glycyrrhizae Preparata 15-50 part nano Chinese angelica 30-80 part nanometer Herba Taxilli 30-65 part
Nanometer Rhizoma Chuanxiong 25-60 part nanometer Rhizoma Et Radix Notopterygii 10-35 part nanometer Radix Dipsaci 25-60 part
The female 10-35 part of nano-antler 10-35 part nanometer Cortex Eucommiae 40-80 part nano Sichuan fritillary bulb
The tangerine 25-60 part of nanometer Fructus Amomi 20-50 part nanorize
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Shenrong Baotai ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Codonopsis 50-80 part nanometer Arillus Longan 15-25 part nanometer Semen Cuscutae 25-40 part
Nano cyperus tuber 35-50 part nano Poria 50-70 part nanometer Rhizoma Dioscoreae 40-60 part
Nanometer Folium Artemisiae Argyi 35-55 part nanometer Rhizoma Atractylodis Macrocephalae 40-60 part nanometer Radix Scutellariae 50-80 part
Nanometer Radix Rehmanniae Preparata 35-55 part nanometer Radix Paeoniae Alba 35-55 part nano ass hide glue 35-55 part
Nanometer Radix Glycyrrhizae Preparata 20-40 part nano Chinese angelica 40-60 part nanometer Herba Taxilli 35-55 part
Nanometer Rhizoma Chuanxiong 30-50 part nanometer Rhizoma Et Radix Notopterygii 15-25 part nanometer Radix Dipsaci 30-50 part
The female 15-25 part of nano-antler 15-25 part nanometer Cortex Eucommiae 50-70 part nano Sichuan fritillary bulb
The tangerine 30-50 part of nanometer Fructus Amomi 25-40 part nanorize
3, nano medicine ' Shenrong Baotai ' according to claim 1, wherein the weight proportion of each nano raw material is:
33 parts of 20 parts of nanometer Semen Cuscutae of 66 portions of nanometer Arillus Longans of nanometer Radix Codonopsis
50 parts of 58 parts of nanometer Rhizoma Dioscoreaes of 41 parts of nano Porias of nano cyperus tuber
66 parts of 50 parts of nanometer Radix Scutellariaes of 41 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Folium Artemisiae Argyi
41 parts of 41 parts of nano ass hide glues of 41 parts of nanometer Radix Paeoniae Albas of nanometer Radix Rehmanniae Preparata
41 parts of 50 parts of nanometer Herba Taxillis of 28 parts of nano Chinese angelicas of nanometer Radix Glycyrrhizae Preparata
41 parts of 20 parts of nanometer Radix Dipsacis of 41 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Rhizoma Chuanxiong
Female 20 parts of 58 parts of nano Sichuan fritillary bulbs of 20 parts of nanometer Cortexs Eucommiae of nano-antler
Tangerine 41 parts of 33 parts of nanorize of nanometer Fructus Amomi
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Shenrong Baotai 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Shenrong Baotai 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01101990 CN1365791A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Shenrong Baotai' and its preparing process |
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| CN 01101990 CN1365791A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Shenrong Baotai' and its preparing process |
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| CN1365791A true CN1365791A (en) | 2002-08-28 |
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| CN 01101990 Pending CN1365791A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Shenrong Baotai' and its preparing process |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205064A (en) * | 2011-05-25 | 2011-10-05 | 王万玲 | Traditional Chinese medicine (TCM) for treating threatened abortion |
| CN102641464A (en) * | 2012-03-30 | 2012-08-22 | 王伟 | Traditional Chinese medicine composition for preventing habitual abortion |
| CN102641465A (en) * | 2012-03-30 | 2012-08-22 | 王伟 | Abortion-prevention traditional Chinese medicine composition for preventing habitual abortion |
| CN102641467A (en) * | 2012-03-30 | 2012-08-22 | 王伟 | Abortion-prevention traditional Chinese medicine composition |
| CN102641466A (en) * | 2012-03-30 | 2012-08-22 | 王伟 | Chinese medicinal composition for preventing abortion |
| CN102743551A (en) * | 2012-08-08 | 2012-10-24 | 孙丽 | Traditional Chinese medicine for treating habitual abortion |
| CN104027511A (en) * | 2014-05-23 | 2014-09-10 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine (TCM) for treating abdominal pain during pregnancy induced by deficiency-cold syndrome |
| CN104147298A (en) * | 2014-07-18 | 2014-11-19 | 甘保明 | Traditional Chinese medicine composition for fetus protection |
-
2001
- 2001-01-18 CN CN 01101990 patent/CN1365791A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205064A (en) * | 2011-05-25 | 2011-10-05 | 王万玲 | Traditional Chinese medicine (TCM) for treating threatened abortion |
| CN102205064B (en) * | 2011-05-25 | 2012-09-05 | 姜秀芹 | Traditional Chinese medicine (TCM) for treating threatened abortion |
| CN102641464A (en) * | 2012-03-30 | 2012-08-22 | 王伟 | Traditional Chinese medicine composition for preventing habitual abortion |
| CN102641465A (en) * | 2012-03-30 | 2012-08-22 | 王伟 | Abortion-prevention traditional Chinese medicine composition for preventing habitual abortion |
| CN102641467A (en) * | 2012-03-30 | 2012-08-22 | 王伟 | Abortion-prevention traditional Chinese medicine composition |
| CN102641466A (en) * | 2012-03-30 | 2012-08-22 | 王伟 | Chinese medicinal composition for preventing abortion |
| CN102743551A (en) * | 2012-08-08 | 2012-10-24 | 孙丽 | Traditional Chinese medicine for treating habitual abortion |
| CN104027511A (en) * | 2014-05-23 | 2014-09-10 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine (TCM) for treating abdominal pain during pregnancy induced by deficiency-cold syndrome |
| CN104147298A (en) * | 2014-07-18 | 2014-11-19 | 甘保明 | Traditional Chinese medicine composition for fetus protection |
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