CN1360914A - Nanometer Aifunuangong preparation medicine for warming womb and its preparing method - Google Patents
Nanometer Aifunuangong preparation medicine for warming womb and its preparing method Download PDFInfo
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- CN1360914A CN1360914A CN 00136674 CN00136674A CN1360914A CN 1360914 A CN1360914 A CN 1360914A CN 00136674 CN00136674 CN 00136674 CN 00136674 A CN00136674 A CN 00136674A CN 1360914 A CN1360914 A CN 1360914A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000010792 warming Methods 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims description 20
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 21
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 10
- 241000234653 Cyperus Species 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 241001061264 Astragalus Species 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241001078983 Tetradium ruticarpum Species 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 8
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- KBDSLGBFQAGHBE-MSGMIQHVSA-N limonin Chemical compound C=1([C@H]2[C@]3(C)CC[C@H]4[C@@]([C@@]53O[C@@H]5C(=O)O2)(C)C(=O)C[C@@H]2[C@]34COC(=O)C[C@@H]3OC2(C)C)C=COC=1 KBDSLGBFQAGHBE-MSGMIQHVSA-N 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010016326 Feeling cold Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
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- 230000002349 favourable effect Effects 0.000 description 1
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- 238000005457 optimization Methods 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The nano Aifunuangong medicine for warming womb is prepared with nano moxa leaf, nano cyperus tuber, nano evodia fruit, nano cassia, nano Chinese angelica and other five kinds of nano Chinese medicinal materials in certain proportion as material. It has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to a kind of regulate the flow of vital energy enrich blood, warm mode of ancient Chinese music warp, cure mainly the nanometer Aifunuangong preparation medicine for warming womb of menoxenia, the invention still further relates to the method for this medication preparation.
Aifu Nuangong Wan is a kind of classical Chinese patent medicine, mainly contains the adjusting uterine smooth muscle, and the is antibacterial effect of Denging is used for the uterus deficiency and coldness, menoxenia, menstrual pain, soreness of waist leukorrhagia.But traditional Aifu Nuangong Wan disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer Aifunuangong preparation medicine for warming womb of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer Aifunuangong preparation medicine for warming womb.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Folium Artemisiae Argyi 10-50 part nano cyperus tuber 40-80 part
Nanometer Fructus Evodiae 5-40 part nanometer Cortex Cinnamomi 1-20 part
Nano Chinese angelica 10-50 part nanometer Rhizoma Chuanxiong 5-40 part
Nanometer Radix Paeoniae Alba 5-40 part nanometer Radix Rehmanniae 2-30 part
Nano astragalus 5-40 part nanometer Radix Dipsaci 5-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Folium Artemisiae Argyi 20-40 part nano cyperus tuber 50-70 part
Nanometer Fructus Evodiae 10-30 part nanometer Cortex Cinnamomi 3-10 part
Nano Chinese angelica 20-40 part nanometer Rhizoma Chuanxiong 10-30 part
Nanometer Radix Paeoniae Alba 10-30 part nanometer Radix Rehmanniae 5-20 part
Nano astragalus 10-30 part nanometer Radix Dipsaci 10-20 part
The best important proportioning of medicine of the present invention is:
20 parts of 60 parts of nanometer Fructus Evodiaes of 30 parts of nano cyperus tubers of nanometer Folium Artemisiae Argyi
20 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 5 parts of nano Chinese angelicas of nanometer Cortex Cinnamomi
20 parts of 10 parts of nano astragalus of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
15 parts of nanometer Radix Dipsacis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05MPa under the pressure,, get Aifunuangong preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer Aifunuangong preparation medicine for warming womb is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common Aifu Nuangong Wan preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, syrup, oral solution of nanometer Aifunuangong preparation medicine for warming womb etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for infertility, dysmenorrhea, and stomachache, treatment of conditions such as leukorrhagia, clinical efficacy significantly is better than traditional Aifu Nuangong Wan.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 60 parts of nanometer Fructus Evodiaes of 30 parts of nano cyperus tubers of nanometer Folium Artemisiae Argyi
20 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 5 parts of nano Chinese angelicas of nanometer Cortex Cinnamomi
20 parts of 10 parts of nano astragalus of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
15 parts of nanometer Radix Dipsacis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 60 parts of nanometer Fructus Evodiaes of 30 parts of nano cyperus tubers of nanometer Folium Artemisiae Argyi
20 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 5 parts of nano Chinese angelicas of nanometer Cortex Cinnamomi
20 parts of 10 parts of nano astragalus of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
15 parts of nanometer Radix Dipsacis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the warm hydrocerussitum needle injection of nanometer Aifunuangong, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
20 parts of 60 parts of nanometer Fructus Evodiaes of 30 parts of nano cyperus tubers of nanometer Folium Artemisiae Argyi
20 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 5 parts of nano Chinese angelicas of nanometer Cortex Cinnamomi
20 parts of 10 parts of nano astragalus of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
15 parts of nanometer Radix Dipsacis
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the warm palace of nanometer Aifunuangong membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nanometer Aifunuangong preparation medicine for warming womb is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Folium Artemisiae Argyi 10-50 part nano cyperus tuber 40-80 part
Nanometer Fructus Evodiae 5-40 part nanometer Cortex Cinnamomi 1-20 part
Nano Chinese angelica 10-50 part nanometer Rhizoma Chuanxiong 5-40 part
Nanometer Radix Paeoniae Alba 5-40 part nanometer Radix Rehmanniae 2-30 part
Nano astragalus 5-40 part nanometer Radix Dipsaci 5-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer Aifunuangong preparation medicine for warming womb according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Folium Artemisiae Argyi 20-40 part nano cyperus tuber 50-70 part
Nanometer Fructus Evodiae 10-30 part nanometer Cortex Cinnamomi 3-10 part
Nano Chinese angelica 20-40 part nanometer Rhizoma Chuanxiong 10-30 part
Nanometer Radix Paeoniae Alba 10-30 part nanometer Radix Rehmanniae 5-20 part
Nano astragalus 10-30 part nanometer Radix Dipsaci 10-20 part
3, nanometer Aifunuangong preparation medicine for warming womb according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 60 parts of nanometer Fructus Evodiaes of 30 parts of nano cyperus tubers of nanometer Folium Artemisiae Argyi
20 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 5 parts of nano Chinese angelicas of nanometer Cortex Cinnamomi
20 parts of 10 parts of nano astragalus of 20 parts of nanometer Radix Rehmanniae of the nanometer Radix Paeoniae Alba
15 parts of nanometer Radix Dipsacis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nanometer Aifunuangong preparation medicine for warming womb.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer Aifunuangong preparation medicine for warming womb; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136674 CN1360914A (en) | 2000-12-29 | 2000-12-29 | Nanometer Aifunuangong preparation medicine for warming womb and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136674 CN1360914A (en) | 2000-12-29 | 2000-12-29 | Nanometer Aifunuangong preparation medicine for warming womb and its preparing method |
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| Publication Number | Publication Date |
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| CN1360914A true CN1360914A (en) | 2002-07-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 00136674 Pending CN1360914A (en) | 2000-12-29 | 2000-12-29 | Nanometer Aifunuangong preparation medicine for warming womb and its preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434767A (en) * | 2016-02-02 | 2016-03-30 | 刘云杰 | Traditional Chinese medicine for treating infertility |
| CN106860514A (en) * | 2015-12-11 | 2017-06-20 | 上海融萱生物科技有限公司 | A kind of external medicine composition, its extract, its preparation and its application |
| CN108578908A (en) * | 2018-03-15 | 2018-09-28 | 广西中医药大学 | A kind of graphene Warn uterus paste and preparation method thereof |
| CN117919329A (en) * | 2024-01-04 | 2024-04-26 | 江苏七〇七天然制药有限公司 | Preparation method and detection method of uterus warming patch |
-
2000
- 2000-12-29 CN CN 00136674 patent/CN1360914A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860514A (en) * | 2015-12-11 | 2017-06-20 | 上海融萱生物科技有限公司 | A kind of external medicine composition, its extract, its preparation and its application |
| CN106860514B (en) * | 2015-12-11 | 2020-08-21 | 上海融萱生物科技有限公司 | External traditional Chinese medicine composition, extract thereof, preparation thereof and application thereof |
| CN105434767A (en) * | 2016-02-02 | 2016-03-30 | 刘云杰 | Traditional Chinese medicine for treating infertility |
| CN108578908A (en) * | 2018-03-15 | 2018-09-28 | 广西中医药大学 | A kind of graphene Warn uterus paste and preparation method thereof |
| CN117919329A (en) * | 2024-01-04 | 2024-04-26 | 江苏七〇七天然制药有限公司 | Preparation method and detection method of uterus warming patch |
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