CN1366960A - Nano Dingkun preparation medicine and preparation method - Google Patents
Nano Dingkun preparation medicine and preparation method Download PDFInfo
- Publication number
- CN1366960A CN1366960A CN 01102156 CN01102156A CN1366960A CN 1366960 A CN1366960 A CN 1366960A CN 01102156 CN01102156 CN 01102156 CN 01102156 A CN01102156 A CN 01102156A CN 1366960 A CN1366960 A CN 1366960A
- Authority
- CN
- China
- Prior art keywords
- nano
- nanometer
- parts
- chinese
- dingkun
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 13
- 241000208340 Araliaceae Species 0.000 claims abstract description 10
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 10
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 10
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 10
- 235000008434 ginseng Nutrition 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 10
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 241000218176 Corydalis Species 0.000 claims description 9
- 241000234653 Cyperus Species 0.000 claims description 9
- 240000000260 Typha latifolia Species 0.000 claims description 9
- 235000005324 Typha latifolia Nutrition 0.000 claims description 9
- 239000003292 glue Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000124209 Crocus sativus Species 0.000 abstract 1
- 235000015655 Crocus sativus Nutrition 0.000 abstract 1
- 241000521581 Millettia Species 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 235000013974 saffron Nutrition 0.000 abstract 1
- 239000004248 saffron Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 208000034656 Contusions Diseases 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 208000007502 anemia Diseases 0.000 description 3
- 208000034526 bruise Diseases 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 208000018299 prostration Diseases 0.000 description 3
- 239000011800 void material Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 208000028659 discharge Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Dingkun preparation medicine. It is made up by using 17 Chinese medicinal materials of nano ginseng, nano velvet deerhorn, nano saffron, nano millettia, nano notoginseng and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of nourishing qi and blood, regulating menstruation Shu Yu, cure mainly that menoxenia, menalgia, metrostaxis, leucorrhea with red and white discharge, anemia are weak, bruise blood prostration, puerperal all void, osteopyrexia and fever etc. the nano Dingkun preparation medicine, the invention still further relates to the method for this medication preparation.
DINGKUNDAN is a kind of classical Chinese patent medicine, mainly contain estrogen sample diastole uterine smooth muscle, analgesia improves effects such as phagocytic function, be used for that menoxenia, menalgia, metrostaxis, leucorrhea with red and white discharge, anemia are weak, bruise blood prostration, puerperal all void, osteopyrexia and fever etc.But traditional DINGKUNDAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Dingkun preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Dingkun preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano ginseng 10-50 part nano-antler 1-10 part nanometer Stigma Croci 10-50 part
Nanometer Caulis Spatholobi 10-70 part nanometer Radix Notoginseng 8-50 part nanometer Radix Paeoniae Alba 15-70 part
Nanometer Radix Rehmanniae Preparata 10-50 part nano Chinese angelica 8-50 part nanometer Rhizoma Atractylodis Macrocephalae 10-50 part
Nanometer Fructus Lycii 10-50 part nanometer Radix Scutellariae 10-50 part nano cyperus tuber 5-50 part
The luxuriant sub-5-50 part nanometer Rhizoma Chuanxiong 5-50 part nano deerhorn frost 5-30 part of nanometer tabernaemontanus bulrush
Nano ass hide glue 5-30 part nanometer Rhizoma Corydalis 10-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano ginseng 20-40 part nano-antler 3-8 part nanometer Stigma Croci 20-40 part
Nanometer Caulis Spatholobi 20-50 part nanometer Radix Notoginseng 15-40 part nanometer Radix Paeoniae Alba 25-50 part
Nanometer Radix Rehmanniae Preparata 20-40 part nano Chinese angelica 15-40 part nanometer Rhizoma Atractylodis Macrocephalae 20-40 part
Nanometer Fructus Lycii 20-40 part nanometer Radix Scutellariae 20-40 part nano cyperus tuber 10-30 part
The luxuriant sub-15-40 part nanometer Rhizoma Chuanxiong 15-40 part nano deerhorn frost 8-15 part of nanometer tabernaemontanus bulrush
Nano ass hide glue 8-15 part nanometer Rhizoma Corydalis 20-40 part
The optimum weight proportioning of medicine of the present invention is:
28 parts of 5 parts of nanometer Stigma Crocis of 30 parts of nano-antlers of nano ginseng
35 parts of 25 parts of nanometer Radix Paeoniae Albas of 30 parts of nanometer Radix Notoginseng of nanometer Caulis Spatholobi
28 parts of 25 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 28 parts of nano Chinese angelicas of nanometer Radix Rehmanniae Preparata
20 parts of 30 parts of nano cyperus tubers of 30 parts of nanometer Radix Scutellariae of nanometer Fructus Lycii
10 parts of 26 parts of nano deerhorn frosts of the luxuriant sub 25 parts of nanometer Rhizoma Chuanxiongs of nanometer tabernaemontanus bulrush
30 parts of 10 parts of nanometer Rhizoma Corydalis of nano ass hide glue
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, must decide female preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Dingkun preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common DINGKUNDAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Dingkun preparation medicine etc. had no precedent in the past.
That pharmaceutical preparation of the present invention can be used for is weak through uncomfortable, menalgia, metrostaxis, leucorrhea with red and white discharge, anemia, bruise blood prostration, puerperal treatment of conditions such as all void, osteopyrexia and fever, clinical efficacy significantly is better than traditional DINGKUNDAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
28 parts of 5 parts of nanometer Stigma Crocis of 30 parts of nano-antlers of nano ginseng
35 parts of 25 parts of nanometer Radix Paeoniae Albas of 30 parts of nanometer Radix Notoginseng of nanometer Caulis Spatholobi
28 parts of 25 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 28 parts of nano Chinese angelicas of nanometer Radix Rehmanniae Preparata
20 parts of 30 parts of nano cyperus tubers of 30 parts of nanometer Radix Scutellariae of nanometer Fructus Lycii
10 parts of 26 parts of nano deerhorn frosts of the luxuriant sub 25 parts of nanometer Rhizoma Chuanxiongs of nanometer tabernaemontanus bulrush
30 parts of 10 parts of nanometer Rhizoma Corydalis of nano ass hide glue
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
28 parts of 5 parts of nanometer Stigma Crocis of 30 parts of nano-antlers of nano ginseng
35 parts of 25 parts of nanometer Radix Paeoniae Albas of 30 parts of nanometer Radix Notoginseng of nanometer Caulis Spatholobi
28 parts of 25 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 28 parts of nano Chinese angelicas of nanometer Radix Rehmanniae Preparata
20 parts of 30 parts of nano cyperus tubers of 30 parts of nanometer Radix Scutellariae of nanometer Fructus Lycii
10 parts of 26 parts of nano deerhorn frosts of the luxuriant sub 25 parts of nanometer Rhizoma Chuanxiongs of nanometer tabernaemontanus bulrush
30 parts of 10 parts of nanometer Rhizoma Corydalis of nano ass hide glue
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano Dingkun powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
28 parts of 5 parts of nanometer Stigma Crocis of 30 parts of nano-antlers of nano ginseng
35 parts of 25 parts of nanometer Radix Paeoniae Albas of 30 parts of nanometer Radix Notoginseng of nanometer Caulis Spatholobi
28 parts of 25 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 28 parts of nano Chinese angelicas of nanometer Radix Rehmanniae Preparata
20 parts of 30 parts of nano cyperus tubers of 30 parts of nanometer Radix Scutellariae of nanometer Fructus Lycii
10 parts of 26 parts of nano deerhorn frosts of the luxuriant sub 25 parts of nanometer Rhizoma Chuanxiongs of nanometer tabernaemontanus bulrush
30 parts of 10 parts of nanometer Rhizoma Corydalis of nano ass hide glue
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Dingkun membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano Dingkun preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano ginseng 10-50 part nano-antler 1-10 part nanometer Stigma Croci 10-50 part
Nanometer Caulis Spatholobi 10-70 part nanometer Radix Notoginseng 8-50 part nanometer Radix Paeoniae Alba 15-70 part
Nanometer Radix Rehmanniae Preparata 10-50 part nano Chinese angelica 8-50 part nanometer Rhizoma Atractylodis Macrocephalae 10-50 part
Nanometer Fructus Lycii 10-50 part nanometer Radix Scutellariae 10-50 part nano cyperus tuber 5-50 part
The luxuriant sub-5-50 part nanometer Rhizoma Chuanxiong 5-50 part nano deerhorn frost 5-30 part of nanometer tabernaemontanus bulrush
Nano ass hide glue 5-30 part nanometer Rhizoma Corydalis 10-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Dingkun preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano ginseng 20-40 part nano-antler 3-8 part nanometer Stigma Croci 20-40 part
Nanometer Caulis Spatholobi 20-50 part nanometer Radix Notoginseng 15-40 part nanometer Radix Paeoniae Alba 25-50 part
Nanometer Radix Rehmanniae Preparata 20-40 part nano Chinese angelica 15-40 part nanometer Rhizoma Atractylodis Macrocephalae 20-40 part
Nanometer Fructus Lycii 20-40 part nanometer Radix Scutellariae 20-40 part nano cyperus tuber 10-30 part
The luxuriant sub-15-40 part nanometer Rhizoma Chuanxiong 15-40 part nano deerhorn frost 8-15 part of nanometer tabernaemontanus bulrush
Nano ass hide glue 8-15 part nanometer Rhizoma Corydalis 20-40 part
3, nano Dingkun preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
28 parts of 5 parts of nanometer Stigma Crocis of 30 parts of nano-antlers of nano ginseng
35 parts of 25 parts of nanometer Radix Paeoniae Albas of 30 parts of nanometer Radix Notoginseng of nanometer Caulis Spatholobi
28 parts of 25 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 28 parts of nano Chinese angelicas of nanometer Radix Rehmanniae Preparata
20 parts of 30 parts of nano cyperus tubers of 30 parts of nanometer Radix Scutellariae of nanometer Fructus Lycii
10 parts of 26 parts of nano deerhorn frosts of the luxuriant sub 25 parts of nanometer Rhizoma Chuanxiongs of nanometer tabernaemontanus bulrush
30 parts of 10 parts of nanometer Rhizoma Corydalis of nano ass hide glue
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Dingkun preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Dingkun preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102156 CN1366960A (en) | 2001-01-20 | 2001-01-20 | Nano Dingkun preparation medicine and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102156 CN1366960A (en) | 2001-01-20 | 2001-01-20 | Nano Dingkun preparation medicine and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1366960A true CN1366960A (en) | 2002-09-04 |
Family
ID=4652519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102156 Pending CN1366960A (en) | 2001-01-20 | 2001-01-20 | Nano Dingkun preparation medicine and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1366960A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784915A (en) * | 2013-06-03 | 2014-05-14 | 吕汉 | Female qi-blood regulating prescription |
-
2001
- 2001-01-20 CN CN 01102156 patent/CN1366960A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784915A (en) * | 2013-06-03 | 2014-05-14 | 吕汉 | Female qi-blood regulating prescription |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1365791A (en) | Nano medicine 'Shenrong Baotai' and its preparing process | |
| CN1365808A (en) | Nano medicine 'Guilu Bushen' and its preparing process | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1368239A (en) | Nano medicine 'Anshenyangxin' and its preparing process | |
| CN1366960A (en) | Nano Dingkun preparation medicine and preparation method | |
| CN1365697A (en) | Nano medicine 'Naoling' and its preparing process | |
| CN1368201A (en) | Nano medicine 'Fukangbao' and its preparing process | |
| CN1368318A (en) | Nano medicine 'Shugantiaoqi' and its preparing process | |
| CN1366921A (en) | Nano Juhong preparation medicine and preparation method | |
| CN1368192A (en) | Nano medicine for treating menalgia and its preparing process | |
| CN1366895A (en) | Nano supplement both qi and blood preparation medicine and preparation method thereof | |
| CN1366959A (en) | Nano Tiaojing Cuyun preparation medicine and preparation method | |
| CN1368099A (en) | Nano medicine 'Xiaoyin' and its preparing process | |
| CN1368145A (en) | Nano medicine 'Gengnianshu' and its preparing process | |
| CN1364479A (en) | Nano gastrodia tuber and fleece-flower root medicine and its preparing method | |
| CN1368182A (en) | Nano medicine 'Shuganghewei' and its preparing process | |
| CN1368155A (en) | Nano medicine 'Huanshao' and its preparing process | |
| CN1365805A (en) | Nano medicine 'Chenxiang Huaqi' and its preparing process | |
| CN1368241A (en) | Nano medicine 'Tiaojing Zhongzi' and its preparing process | |
| CN1368360A (en) | Nano medicine for treating icteroheptitis and its preparing process | |
| CN1365801A (en) | Nano medicine 'Shenrong Guben' and its preparing process | |
| CN1368166A (en) | Nano medicine 'Shuganzhitong' and its preparing process | |
| CN1368156A (en) | Nano medicine 'Huanyuan Gujing' and its preparing process | |
| CN1368191A (en) | Nano medicine 'Qufengshujin' and its preparing process | |
| CN1364525A (en) | Nano body strengthening and brain invigorating medicine and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |