CN1368143A - Nano medicine 'Pishenshuangbu' and its preparing process - Google Patents
Nano medicine 'Pishenshuangbu' and its preparing process Download PDFInfo
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- CN1368143A CN1368143A CN 01102375 CN01102375A CN1368143A CN 1368143 A CN1368143 A CN 1368143A CN 01102375 CN01102375 CN 01102375 CN 01102375 A CN01102375 A CN 01102375A CN 1368143 A CN1368143 A CN 1368143A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 210000000582 semen Anatomy 0.000 claims description 36
- 229940079593 drug Drugs 0.000 claims description 18
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 241001061264 Astragalus Species 0.000 claims description 9
- 241000756943 Codonopsis Species 0.000 claims description 9
- 244000268590 Euryale ferox Species 0.000 claims description 9
- 235000006487 Euryale ferox Nutrition 0.000 claims description 9
- 240000008669 Hedera helix Species 0.000 claims description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 abstract description 12
- 210000000952 spleen Anatomy 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 9
- 241000736199 Paeonia Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 206010006895 Cachexia Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 206010061428 decreased appetite Diseases 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 208000026500 emaciation Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A nanometre (0.1-200 nm) medicine for nourishing spleen and kidney is prepared from the nanometre powders of 23 Chinese medicinal materials including pilose asiabell root, prepared rehmannia root, peony bark, yam, estragalus root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of spleen benefiting and stimulating the appetite, liver and kidney tonifying, cure mainly that the spleen kidney two loses, the nano medicine ' Pishenshuangbu ' of deficiency of both QI and YIN, emaciation and sallow complexion, inappetence, the invention still further relates to the method for this medication preparation.
The reinforce spleen and kidney together ball is a kind of classical Chinese patent medicine, mainly contains effects such as spleen benefiting and stimulating the appetite, liver and kidney tonifying, is used for that the spleen kidney two loses, deficiency of both QI and YIN, emaciation and sallow complexion, inappetence.But traditional reinforce spleen and kidney together ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Pishenshuangbu ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Pishenshuangbu '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Codonopsis 40-90 part nanometer Radix Rehmanniae Preparata 50-120 part nanometer Fructus Corni 40-90 part
Nanometer Rhizoma Alismatis 40-90 part nano Poria 50-120 part nanometer Cortex Moutan 40-90 part
Nanometer Rhizoma Dioscoreae 40-90 part nano astragalus 40-65 part nanometer Radix Glycyrrhizae 12-45 part
Nano Chinese angelica 25-60 part nanometer Rhizoma Chuanxiong 12-30 part nanometer Radix Paeoniae Alba 12-30 part
Nanometer Semen Nelumbinis 25-60 part nanometer Fructus Lycii 25-60 part nanometer Rhizoma Atractylodis Macrocephalae 25-60 part
Nanometer Cortex Cinnamomi 12-30 part nanometer 12-30 Radix Ophiopogonis part nanometer Semen Coicis 30-55 part
Nanometer Semen Euryales 30-65 part nanometer Radix Achyranthis Bidentatae 25-60 part nanometer Pericarpium Citri Reticulatae 25-60 part
Nanometer Semen Lablab Album 20-55 part nanometer Fructus Schisandrae Chinensis 12-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Codonopsis 50--80 part nanometer Radix Rehmanniae Preparata 60-100 part nanometer Fructus Corni 50-80 part
Nanometer Rhizoma Alismatis 50-80 part nano Poria 60-100 part nanometer Cortex Moutan 50-80 part
Nanometer Rhizoma Dioscoreae 50-80 part nano astragalus 35-55 part nanometer Radix Glycyrrhizae 15-35 part
Nano Chinese angelica 30-50 part nanometer Rhizoma Chuanxiong 15-25 part nanometer Radix Paeoniae Alba 15-25 part
Nanometer Semen Nelumbinis 30-50 part nanometer Fructus Lycii 30-50 part nanometer Rhizoma Atractylodis Macrocephalae 30-50 part
Nanometer Cortex Cinnamomi 15-25 part nanometer 15-25 Radix Ophiopogonis part nanometer Semen Coicis 35-45 part
Nanometer Semen Euryales 35-55 part nanometer Radix Achyranthis Bidentatae 30-50 part nanometer Pericarpium Citri Reticulatae 30-50 part
Nanometer Semen Lablab Album 25-35 part nanometer Fructus Schisandrae Chinensis 15-25 part
The optimum weight proportioning of medicine of the present invention is:
60 parts of 80 parts of nanometer Fructus Corni of 60 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
60 parts of 80 parts of nanometer Cortex Moutans of 60 parts of nano Porias of nanometer Rhizoma Alismatis
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 60 parts of nano astragalus of nanometer Rhizoma Dioscoreae
20 parts of 20 parts of nanometer Radix Paeoniae Albas of 40 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 40 parts of nanometer Fructus Lycii of nanometer Semen Nelumbinis
40 parts of 20 parts of nanometers of nanometer Cortex Cinnamomi, 20 parts of nanometer Semen Coiciss Radix Ophiopogonis
40 parts of 40 parts of nanometer Pericarpium Citri Reticulataes of 40 parts of nanometer Radix Achyranthis Bidentataes of nanometer Semen Euryales
20 parts of 30 parts of nanometer Fructus Schisandrae Chinensis of nanometer Semen Lablab Album
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Pishenshuangbu ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Pishenshuangbu ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common reinforce spleen and kidney together pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Pishenshuangbu ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as the spleen kidney is two thanks to, deficiency of both QI and YIN, emaciation and sallow complexion, inappetence, and clinical efficacy significantly is better than traditional reinforce spleen and kidney together ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 80 parts of nanometer Fructus Corni of 60 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
60 parts of 80 parts of nanometer Cortex Moutans of 60 parts of nano Porias of nanometer Rhizoma Alismatis
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 60 parts of nano astragalus of nanometer Rhizoma Dioscoreae
20 parts of 20 parts of nanometer Radix Paeoniae Albas of 40 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 40 parts of nanometer Fructus Lycii of nanometer Semen Nelumbinis
40 parts of 20 parts of nanometers of nanometer Cortex Cinnamomi, 20 parts of nanometer Semen Coiciss Radix Ophiopogonis
40 parts of 40 parts of nanometer Pericarpium Citri Reticulataes of 40 parts of nanometer Radix Achyranthis Bidentataes of nanometer Semen Euryales
20 parts of 30 parts of nanometer Fructus Schisandrae Chinensis of nanometer Semen Lablab Album
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
60 parts of 80 parts of nanometer Fructus Corni of 60 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
60 parts of 80 parts of nanometer Cortex Moutans of 60 parts of nano Porias of nanometer Rhizoma Alismatis
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 60 parts of nano astragalus of nanometer Rhizoma Dioscoreae
20 parts of 20 parts of nanometer Radix Paeoniae Albas of 40 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 40 parts of nanometer Fructus Lycii of nanometer Semen Nelumbinis
40 parts of 20 parts of nanometers of nanometer Cortex Cinnamomi, 20 parts of nanometer Semen Coiciss Radix Ophiopogonis
40 parts of 40 parts of nanometer Pericarpium Citri Reticulataes of 40 parts of nanometer Radix Achyranthis Bidentataes of nanometer Semen Euryales
20 parts of 30 parts of nanometer Fructus Schisandrae Chinensis of nanometer Semen Lablab Album
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer reinforce spleen and kidney together powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
60 parts of 80 parts of nanometer Fructus Corni of 60 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
60 parts of 80 parts of nanometer Cortex Moutans of 60 parts of nano Porias of nanometer Rhizoma Alismatis
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 60 parts of nano astragalus of nanometer Rhizoma Dioscoreae
20 parts of 20 parts of nanometer Radix Paeoniae Albas of 40 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 40 parts of nanometer Fructus Lycii of nanometer Semen Nelumbinis
40 parts of 20 parts of nanometers of nanometer Cortex Cinnamomi, 20 parts of nanometer Semen Coiciss Radix Ophiopogonis
40 parts of 40 parts of nanometer Pericarpium Citri Reticulataes of 40 parts of nanometer Radix Achyranthis Bidentataes of nanometer Semen Euryales
20 parts of 30 parts of nanometer Fructus Schisandrae Chinensis of nanometer Semen Lablab Album
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer reinforce spleen and kidney together membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Pishenshuangbu ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Codonopsis 40-90 part nanometer Radix Rehmanniae Preparata 50-120 part nanometer Fructus Corni 40-90 part
Nanometer Rhizoma Alismatis 40-90 part nano Poria 50-120 part nanometer Cortex Moutan 40-90 part
Nanometer Rhizoma Dioscoreae 40-90 part nano astragalus 40-65 part nanometer Radix Glycyrrhizae 12-45 part
Nano Chinese angelica 25-60 part nanometer Rhizoma Chuanxiong 12-30 part nanometer Radix Paeoniae Alba 12-30 part
Nanometer Semen Nelumbinis 25-60 part nanometer Fructus Lycii 25-60 part nanometer Rhizoma Atractylodis Macrocephalae 25-60 part
Nanometer Cortex Cinnamomi 12-30 part nanometer 12-30 Radix Ophiopogonis part nanometer Semen Coicis 30-55 part
Nanometer Semen Euryales 30-65 part nanometer Radix Achyranthis Bidentatae 25-60 part nanometer Pericarpium Citri Reticulatae 25-60 part
Nanometer Semen Lablab Album 20-55 part nanometer Fructus Schisandrae Chinensis 12-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Pishenshuangbu ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Codonopsis 50--80 part nanometer Radix Rehmanniae Preparata 60-100 part nanometer Fructus Corni 50-80 part
Nanometer Rhizoma Alismatis 50-80 part nano Poria 60-100 part nanometer Cortex Moutan 50-80 part
Nanometer Rhizoma Dioscoreae 50-80 part nano astragalus 35-55 part nanometer Radix Glycyrrhizae 15-35 part
Nano Chinese angelica 30-50 part nanometer Rhizoma Chuanxiong 15-25 part nanometer Radix Paeoniae Alba 15-25 part
Nanometer Semen Nelumbinis 30-50 part nanometer Fructus Lycii 30-50 part nanometer Rhizoma Atractylodis Macrocephalae 30-50 part
Nanometer Cortex Cinnamomi 15-25 part nanometer 15-25 Radix Ophiopogonis part nanometer Semen Coicis 35-45 part
Nanometer Semen Euryales 35-55 part nanometer Radix Achyranthis Bidentatae 30-50 part nanometer Pericarpium Citri Reticulatae 30-50 part
Nanometer Semen Lablab Album 25-35 part nanometer Fructus Schisandrae Chinensis 15-25 part
3, nano medicine ' Pishenshuangbu ' according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 80 parts of nanometer Fructus Corni of 60 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Codonopsis
60 parts of 80 parts of nanometer Cortex Moutans of 60 parts of nano Porias of nanometer Rhizoma Alismatis
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 60 parts of nano astragalus of nanometer Rhizoma Dioscoreae
20 parts of 20 parts of nanometer Radix Paeoniae Albas of 40 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
40 parts of 40 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 40 parts of nanometer Fructus Lycii of nanometer Semen Nelumbinis
40 parts of 20 parts of nanometers of nanometer Cortex Cinnamomi, 20 parts of nanometer Semen Coiciss Radix Ophiopogonis
40 parts of 40 parts of nanometer Pericarpium Citri Reticulataes of 40 parts of nanometer Radix Achyranthis Bidentataes of nanometer Semen Euryales
20 parts of 30 parts of nanometer Fructus Schisandrae Chinensis of nanometer Semen Lablab Album
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Pishenshuangbu 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Pishenshuangbu 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102375 CN1368143A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Pishenshuangbu' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102375 CN1368143A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Pishenshuangbu' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
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| CN1368143A true CN1368143A (en) | 2002-09-11 |
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| CN 01102375 Pending CN1368143A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Pishenshuangbu' and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316208A (en) * | 2013-06-17 | 2013-09-25 | 邓占峰 | Traditional Chinese medicine preparation with functions of benefiting qi and nourishing blood, resisting aging and prolonging life |
-
2001
- 2001-02-02 CN CN 01102375 patent/CN1368143A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316208A (en) * | 2013-06-17 | 2013-09-25 | 邓占峰 | Traditional Chinese medicine preparation with functions of benefiting qi and nourishing blood, resisting aging and prolonging life |
| CN103316208B (en) * | 2013-06-17 | 2014-11-12 | 邓占峰 | Traditional Chinese medicine preparation with the functions of nourishing qi and nourishing blood, anti-aging, and prolonging life |
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