CN1368355A - Nano medicine 'Suojing' and its preparing process - Google Patents
Nano medicine 'Suojing' and its preparing process Download PDFInfo
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- CN1368355A CN1368355A CN 01103645 CN01103645A CN1368355A CN 1368355 A CN1368355 A CN 1368355A CN 01103645 CN01103645 CN 01103645 CN 01103645 A CN01103645 A CN 01103645A CN 1368355 A CN1368355 A CN 1368355A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 230000008569 process Effects 0.000 title description 2
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000208340 Araliaceae Species 0.000 claims abstract description 10
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 10
- 235000008434 ginseng Nutrition 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 18
- 241001061264 Astragalus Species 0.000 claims description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 235000005903 Dioscorea Nutrition 0.000 claims description 5
- 241000234273 Dioscorea Species 0.000 claims description 5
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 5
- 241001523579 Ostrea Species 0.000 claims description 5
- 241000208966 Polygala Species 0.000 claims description 5
- 235000004879 dioscorea Nutrition 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 241000405414 Rehmannia Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
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- 230000003203 everyday effect Effects 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 230000000422 nocturnal effect Effects 0.000 description 2
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- 239000000825 pharmaceutical preparation Substances 0.000 description 2
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- 210000000952 spleen Anatomy 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
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- 229940126678 chinese medicines Drugs 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Suojing" is prepared from the nanometre powders of 15 Chinese medicinal materials including ginseng, astragalus root, rehmannia root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Suojing of a kind of tonic heart spleen, supplementing the kidney to control the nocturnal, the invention still further relates to the method for this medication preparation.
Locking smart ball is a kind of classical Chinese patent medicine, mainly contains effects such as taking a tonic or nourishing food to build up one's health heart spleen, supplementing the kidney to control the nocturnal, is used for premature ejacuation emission, spontaneous sweating, insomnia and dreamful sleep, the waist gland is aching and limp, limbs are thin and weak etc.But the smart ball disintegrate of traditional lock is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Suojing of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Suojing.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano ginseng 80-180 part nano astragalus 120-250 part nanometer Cortex Cinnamomi 80-180 part
Nanometer Fructus Corni 120-250 part nanometer Radix Rehmanniae 200-400 part nanometer Rhizoma Dioscoreae 120-300 part
Nanometer Rhizoma Alismatis 80-180 part nanometer Cortex Moutan 80-180 part nanometer Concha Ostreae 150-400 part
Nanometer Os Draconis 150-400 part nanometer Semen Platycladi 80-180 part nm acid Semen Ziziphi Spinosae 80-180 part
Nanometer Poria cum Radix Pini 80-180 part nanometer Radix Polygalae 80-180 part nanometer Fructus Schisandrae Chinensis 80-180 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano ginseng 100-150 part nano astragalus 150-200 part nanometer Cortex Cinnamomi 90-150 part
Nanometer Fructus Corni 150-200 part nanometer Radix Rehmanniae 250-350 part nanometer Rhizoma Dioscoreae 150-250 part
Nanometer Rhizoma Alismatis 90-150 part nanometer Cortex Moutan 90-150 part nanometer Concha Ostreae 200-300 part
Nanometer Os Draconis 200-300 part nanometer Semen Platycladi 90-150 part nm acid Semen Ziziphi Spinosae 90-150 part
Nanometer Poria cum Radix Pini 90-150 part nanometer Radix Polygalae 90-150 part nanometer Fructus Schisandrae Chinensis 90-150 part
The optimum weight proportioning of medicine of the present invention is:
120 parts of 180 parts of nanometer Cortex Cinnamomis of 120 parts of nano astragalus of nano ginseng
180 parts of 300 parts of nanometer Rhizoma Dioscoreaes of 180 parts of nanometer Radix Rehmanniae of nanometer Fructus Corni
240 parts of 120 parts of nanometer Concha Ostreaes of 120 parts of nanometer Cortex Moutans of nanometer Rhizoma Alismatis
120 parts of 120 parts of nm acid Semen Ziziphi Spinosaes of 240 parts of nanometer Semen Platycladi of nanometer Os Draconis
120 parts of 120 parts of nanometer Fructus Schisandrae Chinensis of 120 parts of nanometer Radix Polygalaes of nanometer Poria cum Radix Pini
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Suojing nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Suojing is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the smart pill material of common lock is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Suojing etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as premature ejacuation emission, spontaneous sweating, insomnia and dreamful sleep, soreness of the waist and knees, limbs be thin and weak, and clinical efficacy significantly is better than the smart ball of traditional lock.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
120 parts of 180 parts of nanometer Cortex Cinnamomis of 120 parts of nano astragalus of nano ginseng
180 parts of 300 parts of nanometer Rhizoma Dioscoreaes of 180 parts of nanometer Radix Rehmanniae of nanometer Fructus Corni
240 parts of 120 parts of nanometer Concha Ostreaes of 120 parts of nanometer Cortex Moutans of nanometer Rhizoma Alismatis
120 parts of 120 parts of nm acid Semen Ziziphi Spinosaes of 240 parts of nanometer Semen Platycladi of nanometer Os Draconis
120 parts of 120 parts of nanometer Fructus Schisandrae Chinensis of 120 parts of nanometer Radix Polygalaes of nanometer Poria cum Radix Pini
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
120 parts of 180 parts of nanometer Cortex Cinnamomis of 120 parts of nano astragalus of nano ginseng
180 parts of 300 parts of nanometer Rhizoma Dioscoreaes of 180 parts of nanometer Radix Rehmanniae of nanometer Fructus Corni
240 parts of 120 parts of nanometer Concha Ostreaes of 120 parts of nanometer Cortex Moutans of nanometer Rhizoma Alismatis
120 parts of 120 parts of nm acid Semen Ziziphi Spinosaes of 240 parts of nanometer Semen Platycladi of nanometer Os Draconis
120 parts of 120 parts of nanometer Fructus Schisandrae Chinensis of 120 parts of nanometer Radix Polygalaes of nanometer Poria cum Radix Pini
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make that nanometer is locked smart powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
120 parts of 180 parts of nanometer Cortex Cinnamomis of 120 parts of nano astragalus of nano ginseng
180 parts of 300 parts of nanometer Rhizoma Dioscoreaes of 180 parts of nanometer Radix Rehmanniae of nanometer Fructus Corni
240 parts of 120 parts of nanometer Concha Ostreaes of 120 parts of nanometer Cortex Moutans of nanometer Rhizoma Alismatis
120 parts of 120 parts of nm acid Semen Ziziphi Spinosaes of 240 parts of nanometer Semen Platycladi of nanometer Os Draconis
120 parts of 120 parts of nanometer Fructus Schisandrae Chinensis of 120 parts of nanometer Radix Polygalaes of nanometer Poria cum Radix Pini
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer and lock smart membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Suojing is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano ginseng 80-180 part nano astragalus 120-250 part nanometer Cortex Cinnamomi 80-180 part
Nanometer Fructus Corni 120-250 part nanometer Radix Rehmanniae 200-400 part nanometer Rhizoma Dioscoreae 120-300 part
Nanometer Rhizoma Alismatis 80-180 part nanometer Cortex Moutan 80-180 part nanometer Concha Ostreae 150-400 part
Nanometer Os Draconis 150--400 part nanometer Semen Platycladi 80-180 part nm acid Semen Ziziphi Spinosae 80-180 part
Nanometer Poria cum Radix Pini 80-180 part nanometer Radix Polygalae 80-180 part nanometer Fructus Schisandrae Chinensis 80-180 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Suojing according to claim 1, wherein the weight proportion of each nano raw material is:
Nano ginseng 100-150 part nano astragalus 150-200 part nanometer Cortex Cinnamomi 90-150 part
Nanometer Fructus Corni 150-200 part nanometer Radix Rehmanniae 250-350 part nanometer Rhizoma Dioscoreae 150-250 part
Nanometer Rhizoma Alismatis 90-150 part nanometer Cortex Moutan 90-150 part nanometer Concha Ostreae 200-300 part
Nanometer Os Draconis 200-300 part nanometer Semen Platycladi 90-150 part nm acid Semen Ziziphi Spinosae 90-150 part
Nanometer Poria cum Radix Pini 90-150 part nanometer Radix Polygalae 90-150 part nanometer Fructus Schisandrae Chinensis 90-150 part
3, nano medicine ' Suojing according to claim 1, wherein the weight proportion of each nano raw material is:
120 parts of 180 parts of nanometer Cortex Cinnamomis of 120 parts of nano astragalus of nano ginseng
180 parts of 300 parts of nanometer Rhizoma Dioscoreaes of 180 parts of nanometer Radix Rehmanniae of nanometer Fructus Corni
240 parts of 120 parts of nanometer Concha Ostreaes of 120 parts of nanometer Cortex Moutans of nanometer Rhizoma Alismatis
120 parts of 120 parts of nm acid Semen Ziziphi Spinosaes of 240 parts of nanometer Semen Platycladi of nanometer Os Draconis
120 parts of 120 parts of nanometer Fructus Schisandrae Chinensis of 120 parts of nanometer Radix Polygalaes of nanometer Poria cum Radix Pini
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Suojings.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Suojings; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103645 CN1368355A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Suojing' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01103645 CN1368355A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Suojing' and its preparing process |
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| Publication Number | Publication Date |
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| CN1368355A true CN1368355A (en) | 2002-09-11 |
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| CN 01103645 Pending CN1368355A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Suojing' and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106547A (en) * | 2015-09-27 | 2015-12-02 | 南京晶云化工有限公司 | Pharmaceutic preparation for treating neurasthenia |
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2001
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106547A (en) * | 2015-09-27 | 2015-12-02 | 南京晶云化工有限公司 | Pharmaceutic preparation for treating neurasthenia |
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