CN1368247A - Nano medicine 'Fuming' and its preparing process - Google Patents
Nano medicine 'Fuming' and its preparing process Download PDFInfo
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- CN1368247A CN1368247A CN 01102581 CN01102581A CN1368247A CN 1368247 A CN1368247 A CN 1368247A CN 01102581 CN01102581 CN 01102581 CN 01102581 A CN01102581 A CN 01102581A CN 1368247 A CN1368247 A CN 1368247A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000282817 Bovidae Species 0.000 claims abstract description 10
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 10
- 235000008434 ginseng Nutrition 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 241000628997 Flos Species 0.000 claims description 18
- 229940079593 drug Drugs 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 18
- 241000208340 Araliaceae Species 0.000 claims description 9
- 244000247747 Coptis groenlandica Species 0.000 claims description 9
- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 239000008697 jueming Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000179560 Prunella vulgaris Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- MUKYLHIZBOASDM-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid 2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound NC(=N)N(C)CC(O)=O.OCC(O)C(O)C(O)C(O)C(O)=O MUKYLHIZBOASDM-UHFFFAOYSA-N 0.000 abstract 1
- 235000007516 Chrysanthemum Nutrition 0.000 abstract 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 241000159213 Zygophyllaceae Species 0.000 abstract 1
- 230000004377 improving vision Effects 0.000 abstract 1
- 235000009165 saligot Nutrition 0.000 abstract 1
- 230000004438 eyesight Effects 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 206010034960 Photophobia Diseases 0.000 description 4
- 241001529739 Prunella <angiosperm> Species 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 208000002177 Cataract Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000010412 Glaucoma Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 208000031971 Yin Deficiency Diseases 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Fuming" for improving vision is prepared from the nanometre powders of 23 Chiense medicinal materials including Antelope's horn, caltrop, chrysanthemum flower, ginseng, etc through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Fuming ' of a kind of nourishing the liver and kidney, YIN nourishing and the production of body fluid promoting, liver heat removing and eyesight improving, the invention still further relates to the method for this medication preparation.
The sheet of recovering lost eyesight is a kind of classical Chinese patent medicine, mainly contains effects such as nourishing the liver and kidney, YIN nourishing and the production of body fluid promoting, liver heat removing and eyesight improving, is used for glaucoma, first mid-term cataract and disease such as photophobia photophobia of causing of the hepatic and renal YIN deficiency, blurred vision.But traditional sheet disintegrate of recovering lost eyesight is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Fuming ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Fuming '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano antelope horn 1-5 part nanometer Fructus Tribuli 20-65 part nanometer Herba Equiseti Hiemalis 15-40 part
Nanometer Flos Chrysanthemi 34-70 part nanometer Semen Plantaginis 15-40 part nanometer Spica Prunellae 15-40 part
The sub-25-65 part of nano jueming nano ginseng 10-25 part nanometer Fructus Corni 15-40 part
Nanometer Herba Dendrobii 30-65 part nanometer Fructus Lycii 30-65 part nanometer Semen Cuscutae 15-40 part
Nanometer Fructus Ligustri Lucidi 15-40 part nano abalone shell 25-80 part nanometer coptis 6-15 part
Nanometer Flos Eriocauli 15-40 part nanometer Caulis Aristolochiae Manshuriensis 15-40 part nanometer Radix Rehmanniae Preparata 15-40 part
Nanometer Rhizoma Dioscoreae 15-40 part nanometer Rhizoma Alismatis 6-20 part nano Poria 15-40 part
Nanometer Cortex Moutan 15-40 part nanometer Radix Rehmanniae 15-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano antelope horn 1-3 part nanometer Fructus Tribuli 25-55 part nanometer Herba Equiseti Hiemalis 20-30 part
Nanometer Flos Chrysanthemi 40-60 part nanometer Semen Plantaginis 20-30 part nanometer Spica Prunellae 20-30 part
The sub-35-55 part of nano jueming nano ginseng 12-18 part nanometer Fructus Corni 20-30 part
Nanometer Herba Dendrobii 35-55 part nanometer Fructus Lycii 35-55 part nanometer Semen Cuscutae 20-30 part
Nanometer Fructus Ligustri Lucidi 20-30 part nano abalone shell 40-60 part nanometer coptis 8-12 part
Nanometer Flos Eriocauli 20-30 part nanometer Caulis Aristolochiae Manshuriensis 20-30 part nanometer Radix Rehmanniae Preparata 20-30 part
Nanometer Rhizoma Dioscoreae 20-30 part nanometer Rhizoma Alismatis 8-12 part nano Poria 20-30 part
Nanometer Cortex Moutan 20-30 part nanometer Radix Rehmanniae 20-30 part
The optimum weight proportioning of medicine of the present invention is:
25 parts of 40 parts of nanometer Herba Equiseties Hiemalis of 1 part of nanometer Fructus Tribuli of nano antelope horn
25 parts of 25 parts of nanometer Spica Prunellaes of 50 parts of nanometer Semen Plantaginiss of nanometer Flos Chrysanthemi
25 parts of 15 parts of nanometer Fructus Corni of nano jueming 40 parts of nano ginsengs of son
25 parts of 40 parts of nanometer Semen Cuscutae of 40 parts of nanometer Fructus Lycii of nanometer Herba Dendrobii
10 parts of 50 parts of nanometer coptis of 25 parts of nano abalone shells of nanometer Fructus Ligustri Lucidi
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 25 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Flos Eriocauli
25 parts of 10 parts of nano Porias of 25 parts of nanometer Rhizoma Alismatis of nanometer Rhizoma Dioscoreae
25 parts of 25 parts of nanometer Radix Rehmanniae of nanometer Cortex Moutan
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Fuming ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Fuming ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the common tablet preparation material of recovering lost eyesight is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Fuming ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for glaucoma, just, mid-term cataract and treatment of conditions such as the photophobia photophobia that causes of the hepatic and renal YIN deficiency, blurred vision, clinical efficacy significantly is better than traditional sheet of recovering lost eyesight.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
25 parts of 40 parts of nanometer Herba Equiseties Hiemalis of 1 part of nanometer Fructus Tribuli of nano antelope horn
25 parts of 25 parts of nanometer Spica Prunellaes of 50 parts of nanometer Semen Plantaginiss of nanometer Flos Chrysanthemi
25 parts of 15 parts of nanometer Fructus Corni of nano jueming 40 parts of nano ginsengs of son
25 parts of 40 parts of nanometer Semen Cuscutae of 40 parts of nanometer Fructus Lycii of nanometer Herba Dendrobii
10 parts of 50 parts of nanometer coptis of 25 parts of nano abalone shells of nanometer Fructus Ligustri Lucidi
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 25 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Flos Eriocauli
25 parts of 10 parts of nano Porias of 25 parts of nanometer Rhizoma Alismatis of nanometer Rhizoma Dioscoreae
25 parts of 25 parts of nanometer Radix Rehmanniae of nanometer Cortex Moutan
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
25 parts of 40 parts of nanometer Herba Equiseties Hiemalis of 1 part of nanometer Fructus Tribuli of nano antelope horn
25 parts of 25 parts of nanometer Spica Prunellaes of 50 parts of nanometer Semen Plantaginiss of nanometer Flos Chrysanthemi
25 parts of 15 parts of nanometer Fructus Corni of nano jueming 40 parts of nano ginsengs of son
25 parts of 40 parts of nanometer Semen Cuscutae of 40 parts of nanometer Fructus Lycii of nanometer Herba Dendrobii
10 parts of 50 parts of nanometer coptis of 25 parts of nano abalone shells of nanometer Fructus Ligustri Lucidi
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 25 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Flos Eriocauli
25 parts of 10 parts of nano Porias of 25 parts of nanometer Rhizoma Alismatis of nanometer Rhizoma Dioscoreae
25 parts of 25 parts of nanometer Radix Rehmanniae of nanometer Cortex Moutan
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, making recover lost eyesight powder needle injection, every injection content of nanometer is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
25 parts of 40 parts of nanometer Herba Equiseties Hiemalis of 1 part of nanometer Fructus Tribuli of nano antelope horn
25 parts of 25 parts of nanometer Spica Prunellaes of 50 parts of nanometer Semen Plantaginiss of nanometer Flos Chrysanthemi
25 parts of 15 parts of nanometer Fructus Corni of nano jueming 40 parts of nano ginsengs of son
25 parts of 40 parts of nanometer Semen Cuscutae of 40 parts of nanometer Fructus Lycii of nanometer Herba Dendrobii
10 parts of 50 parts of nanometer coptis of 25 parts of nano abalone shells of nanometer Fructus Ligustri Lucidi
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 25 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Flos Eriocauli
25 parts of 10 parts of nano Porias of 25 parts of nanometer Rhizoma Alismatis of nanometer Rhizoma Dioscoreae
25 parts of 25 parts of nanometer Radix Rehmanniae of nanometer Cortex Moutan
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer membrane of recovering lost eyesight, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Fuming ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano antelope horn 1-5 part nanometer Fructus Tribuli 20-65 part nanometer Herba Equiseti Hiemalis 15-40 part
Nanometer Flos Chrysanthemi 34-70 part nanometer Semen Plantaginis 15-40 part nanometer Spica Prunellae 15-40 part
The sub-25-65 part of nano jueming nano ginseng 10-25 part nanometer Fructus Corni 15-40 part
Nanometer Herba Dendrobii 30-65 part nanometer Fructus Lycii 30-65 part nanometer Semen Cuscutae 15-40 part
Nanometer Fructus Ligustri Lucidi 15-40 part nano abalone shell 25-80 part nanometer coptis 6-15 part
Nanometer Flos Eriocauli 15-40 part nanometer Caulis Aristolochiae Manshuriensis 15-40 part nanometer Radix Rehmanniae Preparata 15-40 part
Nanometer Rhizoma Dioscoreae 15-40 part nanometer Rhizoma Alismatis 6-20 part nano Poria 15-40 part
Nanometer Cortex Moutan 15-40 part nanometer Radix Rehmanniae 15-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs: place extraction pot, solubilizer also imports microwave extracting, make it do the change in polarity motion with hundred million times/second speed of 20--30, the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Fuming ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano antelope horn 1-3 part nanometer Fructus Tribuli 25-55 part nanometer Herba Equiseti Hiemalis 20-30 part
Nanometer Flos Chrysanthemi 40-60 part nanometer Semen Plantaginis 20-30 part nanometer Spica Prunellae 20-30 part
The sub-35-55 part of nano jueming nano ginseng 12-18 part nanometer Fructus Corni 20-30 part
Nanometer Herba Dendrobii 35-55 part nanometer Fructus Lycii 35-55 part nanometer Semen Cuscutae 20-30 part
Nanometer Fructus Ligustri Lucidi 20-30 part nano abalone shell 40-60 part nanometer coptis 8-12 part
Nanometer Flos Eriocauli 20-30 part nanometer Caulis Aristolochiae Manshuriensis 20-30 part nanometer Radix Rehmanniae Preparata 20-30 part
Nanometer Rhizoma Dioscoreae 20-30 part nanometer Rhizoma Alismatis 8-12 part nano Poria 20-30 part
Nanometer Cortex Moutan 20-30 part nanometer Radix Rehmanniae 20-30 part
3, nano medicine ' Fuming ' according to claim 1, wherein the weight proportion of each nano raw material is:
25 parts of 40 parts of nanometer Herba Equiseties Hiemalis of 1 part of nanometer Fructus Tribuli of nano antelope horn
25 parts of 25 parts of nanometer Spica Prunellaes of 50 parts of nanometer Semen Plantaginiss of nanometer Flos Chrysanthemi
25 parts of 15 parts of nanometer Fructus Corni of nano jueming 40 parts of nano ginsengs of son
25 parts of 40 parts of nanometer Semen Cuscutae of 40 parts of nanometer Fructus Lycii of nanometer Herba Dendrobii
10 parts of 50 parts of nanometer coptis of 25 parts of nano abalone shells of nanometer Fructus Ligustri Lucidi
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 25 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Flos Eriocauli
25 parts of 10 parts of nano Porias of 25 parts of nanometer Rhizoma Alismatis of nanometer Rhizoma Dioscoreae
25 parts of 25 parts of nanometer Radix Rehmanniae of nanometer Cortex Moutan
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Fuming 's.
5, according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Fuming 's, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs: place extraction pot, solubilizer also imports microwave extracting, make it do the change in polarity motion with hundred million times/second speed of 20--30, the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102581 CN1368247A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Fuming' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102581 CN1368247A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Fuming' and its preparing process |
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| Publication Number | Publication Date |
|---|---|
| CN1368247A true CN1368247A (en) | 2002-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102581 Pending CN1368247A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Fuming' and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100566740C (en) * | 2006-03-15 | 2009-12-09 | 吴佳勋 | A kind of Chinese herb medicine of preventing and treating myopia |
| CN104151812A (en) * | 2014-08-18 | 2014-11-19 | 德清家意炭业有限公司 | Cassia seed-containing negative ion memory cotton and making method thereof |
-
2001
- 2001-02-01 CN CN 01102581 patent/CN1368247A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100566740C (en) * | 2006-03-15 | 2009-12-09 | 吴佳勋 | A kind of Chinese herb medicine of preventing and treating myopia |
| CN104151812A (en) * | 2014-08-18 | 2014-11-19 | 德清家意炭业有限公司 | Cassia seed-containing negative ion memory cotton and making method thereof |
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