CN1362180A - Nano spleen and stomach invigorating and vital energy benefiting medicine and its preparation - Google Patents
Nano spleen and stomach invigorating and vital energy benefiting medicine and its preparation Download PDFInfo
- Publication number
- CN1362180A CN1362180A CN 01100335 CN01100335A CN1362180A CN 1362180 A CN1362180 A CN 1362180A CN 01100335 CN01100335 CN 01100335 CN 01100335 A CN01100335 A CN 01100335A CN 1362180 A CN1362180 A CN 1362180A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- chinese
- spleen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 210000000952 spleen Anatomy 0.000 title claims description 19
- 210000002784 stomach Anatomy 0.000 title description 2
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 241001061264 Astragalus Species 0.000 claims abstract description 10
- 241000756943 Codonopsis Species 0.000 claims abstract description 10
- 235000006533 astragalus Nutrition 0.000 claims abstract description 10
- 210000004233 talus Anatomy 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 241000202807 Glycyrrhiza Species 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 241000202726 Bupleurum Species 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 241000206501 Actaea <angiosperm> Species 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000132012 Atractylodes Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000005156 Dehydration Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010018045 Gastroptosis Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Buzhong-Yiqi preparation medicine. It is made up by uisng 10 Chinese medicinal materials of nano astragalus, nano codonopsis, nano licorice, nano tangkui, nano ovate atractylodes and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in whic hmost of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of invigorating the spleen and replenishing QI, yang invigorating master and fall into, cure mainly the insufficiency of the spleen nanometer invigorating the spleen and replenishing QI preparation medicine that waits disease, the invention still further relates to the method for this medication preparation.
BUZHONG YIQI WAN is a kind of classical Chinese patent medicine, mainly contains the adjusting gastrointestinal motility, anti-gastric-ulcer and anti-gastric mucosa injury, excited uterus, regulate immunologic function, promote effects such as metabolism, be used for weakness of the spleen and stomach, sinking of QI of middle-JIAO and cause fatigue and asthenia, lack of appetite abdominal distention, chronic diarrhea, diseases such as dehydration.But traditional BUZHONG YIQI WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer invigorating the spleen and replenishing QI preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer invigorating the spleen and replenishing QI preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano astragalus 150-250 part nanometer Radix Codonopsis 40-80 part nanometer Radix Glycyrrhizae 60-140 part
Nano Chinese angelica 40-80 part nanometer Rhizoma Atractylodis Macrocephalae 40-80 part nanometer Rhizoma Cimicifugae 40-80 part
Nano bupleurum 40-80 part nanometer Pericarpium Citri Reticulatae 40-80 part nanometer Rhizoma Zingiberis Recens 10-30 part
Nanometer Fructus Jujubae 20-60 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano astragalus 160-240 part nanometer Radix Codonopsis 50-70 part nanometer Radix Glycyrrhizae 80-120 part
Nano Chinese angelica 50-70 part nanometer Rhizoma Atractylodis Macrocephalae 50-70 part nanometer Rhizoma Cimicifugae 50-70 part
Nano bupleurum 50-70 part nanometer Pericarpium Citri Reticulatae 50-70 part nanometer Rhizoma Zingiberis Recens 15-25 part
Nanometer Fructus Jujubae 30-50 part
The optimum weight proportioning of medicine of the present invention is:
100 parts in 60 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Radix Codonopsis of nano astragalus
60 parts of 60 parts of nanometer Rhizoma Cimicifugaes of 60 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nano Chinese angelica
20 parts in 60 portions of nanometer Rhizoma Zingiberis Recenss of 60 parts of nanometer Pericarpium Citri Reticulataes of nano bupleurum
40 parts in nanometer Fructus Jujubae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get invigorating the spleen and replenishing QI preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer invigorating the spleen and replenishing QI preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common BUZHONG YIQI WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nanometer invigorating the spleen and replenishing QI preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for spleen deficiency, gastroptosis, and uterine prolapse, proctoptosis, treatment of conditions such as metrorrhagia, clinical efficacy significantly is better than traditional BUZHONG YIQI WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts in 60 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Radix Codonopsis of nano astragalus
60 parts of 60 parts of nanometer Rhizoma Cimicifugaes of 60 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nano Chinese angelica
20 parts in 60 portions of nanometer Rhizoma Zingiberis Recenss of 60 parts of nanometer Pericarpium Citri Reticulataes of nano bupleurum
40 parts in nanometer Fructus Jujubae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and is every with 1-4 time.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts in 60 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Radix Codonopsis of nano astragalus
60 parts of 60 parts of nanometer Rhizoma Cimicifugaes of 60 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nano Chinese angelica
20 parts in 60 portions of nanometer Rhizoma Zingiberis Recenss of 60 parts of nanometer Pericarpium Citri Reticulataes of nano bupleurum
40 parts in nanometer Fructus Jujubae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make nanometer invigorating the spleen and replenishing QI powder needle injection, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts in 60 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Radix Codonopsis of nano astragalus
60 parts of 60 parts of nanometer Rhizoma Cimicifugaes of 60 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nano Chinese angelica
20 parts in 60 portions of nanometer Rhizoma Zingiberis Recenss of 60 parts of nanometer Pericarpium Citri Reticulataes of nano bupleurum
40 parts in nanometer Fructus Jujubae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make nanometer invigorating the spleen and replenishing QI membrane, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer invigorating the spleen and replenishing QI preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano astragalus 150-250 part nanometer Radix Codonopsis 40-80 part nanometer Radix Glycyrrhizae 60-140 part
Nano Chinese angelica 40-80 part nanometer Rhizoma Atractylodis Macrocephalae 40-80 part nanometer Rhizoma Cimicifugae 40-80 part
Nano bupleurum 40-80 part nanometer Pericarpium Citri Reticulatae 40-80 part nanometer Rhizoma Zingiberis Recens 10-30 part
Nanometer Fructus Jujubae 20-60 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer invigorating the spleen and replenishing QI preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano astragalus 160-240 part nanometer Radix Codonopsis 50-70 part nanometer Radix Glycyrrhizae 80-120 part
Nano Chinese angelica 50-70 part nanometer Rhizoma Atractylodis Macrocephalae 50-70 part nanometer Rhizoma Cimicifugae 50-70 part
Nano bupleurum 50-70 part nanometer Pericarpium Citri Reticulatae 50-70 part nanometer Rhizoma Zingiberis Recens 15-25 part
Nanometer Fructus Jujubae 30-50 part
3, nanometer invigorating the spleen and replenishing QI preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts in 60 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Radix Codonopsis of nano astragalus
60 parts of 60 parts of nanometer Rhizoma Cimicifugaes of 60 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nano Chinese angelica
20 parts in 60 portions of nanometer Rhizoma Zingiberis Recenss of 60 parts of nanometer Pericarpium Citri Reticulataes of nano bupleurum
40 parts in nanometer Fructus Jujubae
4, according to claim 1 or 2 or 3 described nanometer invigorating the spleen and replenishing QI preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer invigorating the spleen and replenishing QI preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100335 CN1362180A (en) | 2001-01-02 | 2001-01-02 | Nano spleen and stomach invigorating and vital energy benefiting medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100335 CN1362180A (en) | 2001-01-02 | 2001-01-02 | Nano spleen and stomach invigorating and vital energy benefiting medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362180A true CN1362180A (en) | 2002-08-07 |
Family
ID=4651504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100335 Pending CN1362180A (en) | 2001-01-02 | 2001-01-02 | Nano spleen and stomach invigorating and vital energy benefiting medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362180A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251856A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Traditional Chinese medicine preparation for benefiting Qi and nourishing blood and preparation method of traditional Chinese medicine preparation |
| CN105193967A (en) * | 2015-09-12 | 2015-12-30 | 南京正亮医药科技有限公司 | Method for extracting plant composition containing cimicifugae foetidae and application |
-
2001
- 2001-01-02 CN CN 01100335 patent/CN1362180A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251856A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Traditional Chinese medicine preparation for benefiting Qi and nourishing blood and preparation method of traditional Chinese medicine preparation |
| CN103251856B (en) * | 2013-05-08 | 2015-07-22 | 山西省肿瘤研究所 | Traditional Chinese medicine preparation for benefiting Qi and nourishing blood and preparation method of traditional Chinese medicine preparation |
| CN105193967A (en) * | 2015-09-12 | 2015-12-30 | 南京正亮医药科技有限公司 | Method for extracting plant composition containing cimicifugae foetidae and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368188A (en) | Nano medicine 'Weichangan' and its preparing process | |
| CN1368292A (en) | Nano medicing 'Wenzhong Zhixie' and its preparing process | |
| CN1362180A (en) | Nano spleen and stomach invigorating and vital energy benefiting medicine and its preparation | |
| CN1362160A (en) | Nano Heavn king tonic medicine for mental discomfort and its preparation | |
| CN1362173A (en) | Nano medicine prepared with six mild drugs and Aucklandiae and Amomi and its preparation | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1360914A (en) | Nanometer Aifunuangong preparation medicine for warming womb and its preparing method | |
| CN1362184A (en) | Nano tonic ginsneg medicine and its preparation | |
| CN1364564A (en) | Nano Zisheng medicine and its preparing method | |
| CN1366895A (en) | Nano supplement both qi and blood preparation medicine and preparation method thereof | |
| CN1362126A (en) | Nano wind-evil dispelling and itch stopping medicine and its preparation | |
| CN1368184A (en) | Nano medicine 'Shujin Huoluo' and its preparing process | |
| CN1362195A (en) | Nano Jinkuishenqi medicine for invigorating kidney essence and its preparation | |
| CN1363295A (en) | Nano medicine 'Yougui' and its preparing process | |
| CN1362247A (en) | Nano stomach-nourishing medicine of Aucklandiae and Amino and its preparation | |
| CN1362098A (en) | Nano antiphlogistic forsythiae medicine and its preparation | |
| CN1360929A (en) | Nanometer nasosinusitis treating medicine and its prepn | |
| CN1368234A (en) | Nano medicine 'Ganyou' and its preparing process | |
| CN1362232A (en) | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation | |
| CN1365805A (en) | Nano medicine 'Chenxiang Huaqi' and its preparing process | |
| CN1362248A (en) | Nano stomach-calming medicine of Aucklandiae and Amomi and its preparation | |
| CN1362179A (en) | Nano eight-ingredient medicine and its preparation | |
| CN1362185A (en) | Nano six-mild-ingredient medicine and its preparation | |
| CN1368078A (en) | Nano medicine 'Qingshengjianfei' and its preparing process | |
| CN1362128A (en) | Nano tranquilizing and brain nourishing medicine and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |