CN1364564A - Nano Zisheng medicine and its preparing method - Google Patents
Nano Zisheng medicine and its preparing method Download PDFInfo
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- CN1364564A CN1364564A CN 01101907 CN01101907A CN1364564A CN 1364564 A CN1364564 A CN 1364564A CN 01101907 CN01101907 CN 01101907 CN 01101907 A CN01101907 A CN 01101907A CN 1364564 A CN1364564 A CN 1364564A
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- 239000003814 drug Substances 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000756943 Codonopsis Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 210000000582 semen Anatomy 0.000 claims description 36
- 229940079593 drug Drugs 0.000 claims description 20
- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 9
- 244000247747 Coptis groenlandica Species 0.000 claims description 9
- 235000006487 Euryale ferox Nutrition 0.000 claims description 9
- 244000268590 Euryale ferox Species 0.000 claims description 9
- 240000008669 Hedera helix Species 0.000 claims description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 239000010271 massa medicata fermentata Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 7
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000001142 anti-diarrhea Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
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- 229940126678 chinese medicines Drugs 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The nano Zisheng medicine is prepared with nano Codonopsis Pilosulae, nano tuckahoe, nano licorice, nano Chinese yam, nano Atractylodis Macrocephalae and other 13 kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of spleen benefiting and stimulating the appetite, the antidiarrheal nano Zisheng medicine that helps digestion, the invention still further relates to the method for this medication preparation.
It is a kind of classical Chinese patent medicine that money is given birth to ball, mainly contains spleen benefiting and stimulating the appetite, effect such as the antidiarrheal that helps digestion, and is used for that insufficiency of the spleen discomfort, insufficiency of stomach are not received, refreshing tired power lacks, has one's mind filled with disease such as have loose bowels.It is slower that but traditional money is given birth to the ball disintegrate, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Zisheng medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Zisheng medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Codonopsis 400-800 part nano Poria 200-450 part nanometer Radix Glycyrrhizae 60-150 part
Nanometer Rhizoma Dioscoreae 200-450 part nanometer Rhizoma Atractylodis Macrocephalae 400-800 part nanometer Semen Lablab Album 100-300 part
Nanometer Semen Euryales 200-450 part nanometer Semen Nelumbinis 100-350 part nanometer Fructus Crataegi 250-600 part
Nanometer Massa Medicata Fermentata 250-600 part nanometer Fructus Hordei Germinatus 200-450 part nanometer Semen Coicis 400-800 part
Nanometer Pericarpium Citri Reticulatae 250-600 part nanometer coptis 50-90 part nanometer Rhizoma Alismatis 50-90 part
Nanometer Fructus Amomi Rotundus 50-90 part nanometer Herba Pogostemonis 60-150 part nanometer Radix Platycodonis 60-150 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Codonopsis 500-700 part nano Poria 250-350 part nanometer Radix Glycyrrhizae 80-120 part
Nanometer Rhizoma Dioscoreae 250-350 part nanometer Rhizoma Atractylodis Macrocephalae 500-700 part nanometer Semen Lablab Album 150-250 part
Nanometer Semen Euryales 250-350 part nanometer Semen Nelumbinis 150-250 part nanometer Fructus Crataegi 320-480 part
Nanometer Massa Medicata Fermentata 320-480 part nanometer Fructus Hordei Germinatus 250-350 part nanometer Semen Coicis 500-700 part
Nanometer Pericarpium Citri Reticulatae 320-480 part nanometer coptis 60-80 part nanometer Rhizoma Alismatis 60-80 part
Nanometer Fructus Amomi Rotundus 60-80 part nanometer Herba Pogostemonis 80-120 part nanometer Radix Platycodonis 80-120 part
The optimum weight proportioning of medicine of the present invention is:
100 parts in 300 parts of nanometer Radix Glycyrrhizaes of 600 parts of nano Porias of nanometer Radix Codonopsis
200 parts of 600 portions of nanometer Semen Lablab Albums of 300 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Rhizoma Dioscoreae
400 parts of 200 parts of nanometer Fructus Crataegis of 300 parts of nanometer Semen Nelumbinis of nanometer Semen Euryales
600 parts of 300 parts of nanometer Semen Coiciss of 400 parts of nanometer Fructus Hordei Germinatus of nanometer Massa Medicata Fermentata
70 parts of 70 parts of nanometer Rhizoma Alismatis of 400 parts of nanometer coptis of nanometer Pericarpium Citri Reticulatae
100 parts of 100 parts of nanometer Radix Platycodoniss of 70 parts of nanometer Herba Pogostemonis of nanometer Fructus Amomi Rotundus
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Zisheng nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Zisheng medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common money is given birth to the pill material and is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Zisheng medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for that insufficiency of the spleen discomfort, insufficiency of stomach are not received, refreshing tired power lacks, have one's mind filled with treatment of conditions such as have loose bowels, and clinical efficacy significantly is better than traditional money and gives birth to ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts in 300 parts of nanometer Radix Glycyrrhizaes of 600 parts of nano Porias of nanometer Radix Codonopsis
200 parts of 600 portions of nanometer Semen Lablab Albums of 300 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Rhizoma Dioscoreae
400 parts of 200 parts of nanometer Fructus Crataegis of 300 parts of nanometer Semen Nelumbinis of nanometer Semen Euryales
600 parts of 300 parts of nanometer Semen Coiciss of 400 parts of nanometer Fructus Hordei Germinatus of nanometer Massa Medicata Fermentata
70 parts of 70 parts of nanometer Rhizoma Alismatis of 400 parts of nanometer coptis of nanometer Pericarpium Citri Reticulatae
100 parts of 100 parts of nanometer Radix Platycodoniss of 70 parts of nanometer Herba Pogostemonis of nanometer Fructus Amomi Rotundus
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts in 300 parts of nanometer Radix Glycyrrhizaes of 600 parts of nano Porias of nanometer Radix Codonopsis
200 parts of 600 portions of nanometer Semen Lablab Albums of 300 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Rhizoma Dioscoreae
400 parts of 200 parts of nanometer Fructus Crataegis of 300 parts of nanometer Semen Nelumbinis of nanometer Semen Euryales
600 parts of 300 parts of nanometer Semen Coiciss of 400 parts of nanometer Fructus Hordei Germinatus of nanometer Massa Medicata Fermentata
70 parts of 70 parts of nanometer Rhizoma Alismatis of 400 parts of nanometer coptis of nanometer Pericarpium Citri Reticulatae
100 parts of 100 parts of nanometer Radix Platycodoniss of 70 parts of nanometer Herba Pogostemonis of nanometer Fructus Amomi Rotundus
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer money fecula needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts in 300 parts of nanometer Radix Glycyrrhizaes of 600 parts of nano Porias of nanometer Radix Codonopsis
200 parts of 600 portions of nanometer Semen Lablab Albums of 300 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Rhizoma Dioscoreae
400 parts of 200 parts of nanometer Fructus Crataegis of 300 parts of nanometer Semen Nelumbinis of nanometer Semen Euryales
600 parts of 300 parts of nanometer Semen Coiciss of 400 parts of nanometer Fructus Hordei Germinatus of nanometer Massa Medicata Fermentata
70 parts of 70 parts of nanometer Rhizoma Alismatis of 400 parts of nanometer coptis of nanometer Pericarpium Citri Reticulatae
100 parts of 100 parts of nanometer Radix Platycodoniss of 70 parts of nanometer Herba Pogostemonis of nanometer Fructus Amomi Rotundus
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer money and give birth to membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano Zisheng medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Codonopsis 400-800 part nano Poria 200-450 part nanometer Radix Glycyrrhizae 60-150 part
Nanometer Rhizoma Dioscoreae 200-450 part nanometer Rhizoma Atractylodis Macrocephalae 400-800 part nanometer Semen Lablab Album 100-300 part
Nanometer Semen Euryales 200-450 part nanometer Semen Nelumbinis 100-350 part nanometer Fructus Crataegi 250-600 part
Nanometer Massa Medicata Fermentata 250-600 part nanometer Fructus Hordei Germinatus 200-450 part nanometer Semen Coicis 400-800 part
Nanometer Pericarpium Citri Reticulatae 250-600 part nanometer coptis 50-90 part nanometer Rhizoma Alismatis 50-90 part
Nanometer Fructus Amomi Rotundus 50-90 part nanometer Herba Pogostemonis 60-150 part nanometer Radix Platycodonis 60-150 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Zisheng medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Codonopsis 500-700 part nano Poria 250-350 part nanometer Radix Glycyrrhizae 80-120 part
Nanometer Rhizoma Dioscoreae 250-350 part nanometer Rhizoma Atractylodis Macrocephalae 500-700 part nanometer Semen Lablab Album 150-250 part
Nanometer Semen Euryales 250-350 part nanometer Semen Nelumbinis 150-250 part nanometer Fructus Crataegi 320-480 part
Nanometer Massa Medicata Fermentata 320-480 part nanometer Fructus Hordei Germinatus 250-350 part nanometer Semen Coicis 500-700 part
Nanometer Pericarpium Citri Reticulatae 320-480 part nanometer coptis 60-80 part nanometer Rhizoma Alismatis 60-80 part
Nanometer Fructus Amomi Rotundus 60-80 part nanometer Herba Pogostemonis 80-120 part nanometer Radix Platycodonis 80-120 part
3, nano Zisheng medicine according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts in 300 parts of nanometer Radix Glycyrrhizaes of 600 parts of nano Porias of nanometer Radix Codonopsis
200 parts of 600 portions of nanometer Semen Lablab Albums of 300 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Rhizoma Dioscoreae
400 parts of 200 parts of nanometer Fructus Crataegis of 300 parts of nanometer Semen Nelumbinis of nanometer Semen Euryales
600 parts of 300 parts of nanometer Semen Coiciss of 400 parts of nanometer Fructus Hordei Germinatus of nanometer Massa Medicata Fermentata
70 parts of 70 parts of nanometer Rhizoma Alismatis of 400 parts of nanometer coptis of nanometer Pericarpium Citri Reticulatae
100 parts of 100 parts of nanometer Radix Platycodoniss of 70 parts of nanometer Herba Pogostemonis of nanometer Fructus Amomi Rotundus
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Zisheng medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Zisheng medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101907 CN1364564A (en) | 2001-01-16 | 2001-01-16 | Nano Zisheng medicine and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101907 CN1364564A (en) | 2001-01-16 | 2001-01-16 | Nano Zisheng medicine and its preparing method |
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| CN1364564A true CN1364564A (en) | 2002-08-21 |
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Family Applications (1)
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| CN 01101907 Pending CN1364564A (en) | 2001-01-16 | 2001-01-16 | Nano Zisheng medicine and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583898A (en) * | 2013-11-05 | 2014-02-19 | 上海交通大学 | Chinese medicinal herb-containing feed additive capable of preventing weaned pig multisystem failure syndrome and pig feed containing same |
| CN103768492A (en) * | 2014-02-21 | 2014-05-07 | 杨延庆 | Application of Buyizisheng pill in preparing drugs for treating hyperlipemia |
| CN104906454A (en) * | 2015-06-19 | 2015-09-16 | 韦木兰 | Chinese herbal medicine preparation with effects of tonifying spleens and promoting appetite and preparation method of Chinese herbal medicine preparation |
-
2001
- 2001-01-16 CN CN 01101907 patent/CN1364564A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583898A (en) * | 2013-11-05 | 2014-02-19 | 上海交通大学 | Chinese medicinal herb-containing feed additive capable of preventing weaned pig multisystem failure syndrome and pig feed containing same |
| CN103768492A (en) * | 2014-02-21 | 2014-05-07 | 杨延庆 | Application of Buyizisheng pill in preparing drugs for treating hyperlipemia |
| CN103768492B (en) * | 2014-02-21 | 2015-12-30 | 杨延庆 | The application of the raw ball of tonification money in preparation treatment hyperlipidemia |
| CN104906454A (en) * | 2015-06-19 | 2015-09-16 | 韦木兰 | Chinese herbal medicine preparation with effects of tonifying spleens and promoting appetite and preparation method of Chinese herbal medicine preparation |
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