CN1363295A - Nano medicine 'Yougui' and its preparing process - Google Patents
Nano medicine 'Yougui' and its preparing process Download PDFInfo
- Publication number
- CN1363295A CN1363295A CN 01100218 CN01100218A CN1363295A CN 1363295 A CN1363295 A CN 1363295A CN 01100218 CN01100218 CN 01100218 CN 01100218 A CN01100218 A CN 01100218A CN 1363295 A CN1363295 A CN 1363295A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- chinese
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 45
- 239000008883 yougui Substances 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 10
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 239000003292 glue Substances 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000208688 Eucommia Species 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 239000011858 nanopowder Substances 0.000 abstract description 3
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 235000008499 Canella winterana Nutrition 0.000 abstract 1
- 244000080208 Canella winterana Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 229940023019 aconite Drugs 0.000 abstract 1
- 229940017545 cinnamon bark Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010063659 Aversion Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000008765 Sciatica Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 206010003883 azoospermia Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A nano medicine "Yougui" is prepared from the nano powders of 10 Chinese-medicinal materials including prepared rehmannia root, prepared aconite root, cinnamon bark, haw, etc through proportioning microwave extracting, vacuum concentrating and supersonic-jet spray drying. Its advantages include high biologic utilization rate and high curative effect.
Description
The present invention relates to a kind of kidney warming and yang invigorating, fill essence and blood, cure mainly the nano medicine ' Yougui ' of insufficiency of kidney-YANG, the invention still further relates to the method for this medication preparation.
Yougui Wan, the kidney-Yang-Reinforcing Bolus is a kind of classical Chinese patent medicine; mainly contain and strengthen effects such as exempting from service, protect and regulate internal organs function, defying age, adjusting hormone-content, inhibition spontaneity discharge; be used for the treatment of insufficiency of kidney-YANG; or congenital granary declines; or impairment caused by overstrain is excessive; so that decline of the fire from the gate of life has aversion to cold and cold limbs, yin-cold excess disease concurrently.But traditional Yougui Wan, the kidney-Yang-Reinforcing Bolus disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Yougui ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Yougui '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Rehmanniae Preparata 10-60 part nanometer river Radix Aconiti Lateralis Preparata 10-50 part nanometer Cortex Cinnamomi 10-50 part
Nanometer Rhizoma Dioscoreae 10-50 part nanometer Fructus Corni 10-50 part nanometer Semen Cuscutae 10-50 part
Nano deerhorn glue 5-30 part nanometer Fructus Lycii 10-50 part nano Chinese angelica 10-50 part
Nanometer charred Cortex Eucommiae 10-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Rehmanniae Preparata 20-50 part nanometer river Radix Aconiti Lateralis Preparata 15-40 part nanometer Cortex Cinnamomi 20-40 part
Nanometer Rhizoma Dioscoreae 20-40 part nanometer Fructus Corni 20-40 part nanometer Semen Cuscutae 15-40 part
Nano deerhorn glue 10-20 part nanometer Fructus Lycii 15-40 part nano Chinese angelica 20-40 part
Nanometer charred Cortex Eucommiae 15-40 part
The optimum weight proportioning of medicine of the present invention is:
28 parts of 25 parts of nanometer Cortex Cinnamomis of 30 parts of nanometer rivers of nanometer Radix Rehmanniae Preparata Radix Aconiti Lateralis Preparata
25 parts of 28 parts of nanometer Semen Cuscutae of 28 parts of nanometer Fructus Corni of nanometer Rhizoma Dioscoreae
28 parts of 26 parts of nano Chinese angelicas of 15 parts of nanometer Fructus Lycii of nano deerhorn glue
25 parts of nanometer charred Cortex Eucommiaes
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Yougui ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Yougui ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Yougui Wan, the kidney-Yang-Reinforcing Bolus preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano medicine ' Yougui ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as sexual hypofunction, azoospermie, the too much disease of senile red and white leukorrhea, chronic bronchitis, sciatica, and clinical efficacy significantly is better than traditional Yougui Wan, the kidney-Yang-Reinforcing Bolus.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer Cortex Cinnamomis of 30 parts of nanometer rivers of nanometer Radix Rehmanniae Preparata Radix Aconiti Lateralis Preparata
25 parts of 28 parts of nanometer Semen Cuscutae of 28 parts of nanometer Fructus Corni of nanometer Rhizoma Dioscoreae
28 parts of 26 parts of nano Chinese angelicas of 15 parts of nanometer Fructus Lycii of nano deerhorn glue
25 parts of nanometer charred Cortex Eucommiaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer Cortex Cinnamomis of 30 parts of nanometer rivers of nanometer Radix Rehmanniae Preparata Radix Aconiti Lateralis Preparata
25 parts of 28 parts of nanometer Semen Cuscutae of 28 parts of nanometer Fructus Corni of nanometer Rhizoma Dioscoreae
28 parts of 26 parts of nano Chinese angelicas of 15 parts of nanometer Fructus Lycii of nano deerhorn glue
25 parts of nanometer charred Cortex Eucommiaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer Yougui powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer Cortex Cinnamomis of 30 parts of nanometer rivers of nanometer Radix Rehmanniae Preparata Radix Aconiti Lateralis Preparata
25 parts of 28 parts of nanometer Semen Cuscutae of 28 parts of nanometer Fructus Corni of nanometer Rhizoma Dioscoreae
28 parts of 26 parts of nano Chinese angelicas of 15 parts of nanometer Fructus Lycii of nano deerhorn glue
25 parts of nanometer charred Cortex Eucommiaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Yougui membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Yougui ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Rehmanniae Preparata 10-60 part nanometer river Radix Aconiti Lateralis Preparata 10-50 part nanometer Cortex Cinnamomi 10-50 part
Nanometer Rhizoma Dioscoreae 10-50 part nanometer Fructus Corni 10-50 part nanometer Semen Cuscutae 10-50 part
Nano deerhorn glue 5-30 part nanometer Fructus Lycii 10-50 part nano Chinese angelica 10-50 part
Nanometer charred Cortex Eucommiae 10-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Yougui ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Rehmanniae Preparata 20-50 part nanometer river Radix Aconiti Lateralis Preparata 15-40 part nanometer Cortex Cinnamomi 20-40 part
Nanometer Rhizoma Dioscoreae 20-40 part nanometer Fructus Corni 20-40 part nanometer Semen Cuscutae 15-40 part
Nano deerhorn glue 10-20 part nanometer Fructus Lycii 15-40 part nano Chinese angelica 20-40 part
Nanometer charred Cortex Eucommiae 15-40 part
3, nano medicine ' Yougui ' according to claim 1, wherein the weight proportion of each nano raw material is;
28 parts of 25 parts of nanometer Cortex Cinnamomis of 30 parts of nanometer rivers of nanometer Radix Rehmanniae Preparata Radix Aconiti Lateralis Preparata
25 parts of 28 parts of nanometer Semen Cuscutae of 28 parts of nanometer Fructus Corni of nanometer Rhizoma Dioscoreae
28 parts of 26 parts of nano Chinese angelicas of 15 parts of nanometer Fructus Lycii of nano deerhorn glue
25 parts of nanometer charred Cortex Eucommiaes
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Yougui 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Yougui 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100218 CN1363295A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Yougui' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100218 CN1363295A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Yougui' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1363295A true CN1363295A (en) | 2002-08-14 |
Family
ID=4651394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100218 Pending CN1363295A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Yougui' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1363295A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194501A (en) * | 2015-10-29 | 2015-12-30 | 宋建刚 | Traditional Chinese medicine preparation for treating kidney dispersion and preparation method of preparation |
| CN107303350A (en) * | 2016-04-18 | 2017-10-31 | 孙建业 | It is a kind of to strengthen the medicinal liquor prescription of acquired immunodeficiency syndrome herd immunity |
-
2001
- 2001-01-10 CN CN 01100218 patent/CN1363295A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194501A (en) * | 2015-10-29 | 2015-12-30 | 宋建刚 | Traditional Chinese medicine preparation for treating kidney dispersion and preparation method of preparation |
| CN107303350A (en) * | 2016-04-18 | 2017-10-31 | 孙建业 | It is a kind of to strengthen the medicinal liquor prescription of acquired immunodeficiency syndrome herd immunity |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1363295A (en) | Nano medicine 'Yougui' and its preparing process | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1362176A (en) | Nano shugan medicine for dispersing stagnated liver-energy and its preparation | |
| CN1363341A (en) | Nano medicine 'Jiuwei Qianghuo' and its preparing process | |
| CN1365697A (en) | Nano medicine 'Naoling' and its preparing process | |
| CN1362083A (en) | Nano zuogui meidcine and its preparation | |
| CN1365810A (en) | Nano medicine 'Guishao Dihuang' and its preparing process | |
| CN1362184A (en) | Nano tonic ginsneg medicine and its preparation | |
| CN1363311A (en) | Nano medicine 'Kaixiong Shunqi' and its preparing process | |
| CN1362180A (en) | Nano spleen and stomach invigorating and vital energy benefiting medicine and its preparation | |
| CN1368184A (en) | Nano medicine 'Shujin Huoluo' and its preparing process | |
| CN1362195A (en) | Nano Jinkuishenqi medicine for invigorating kidney essence and its preparation | |
| CN1362247A (en) | Nano stomach-nourishing medicine of Aucklandiae and Amino and its preparation | |
| CN1365805A (en) | Nano medicine 'Chenxiang Huaqi' and its preparing process | |
| CN1362232A (en) | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation | |
| CN1368280A (en) | Nano medicine 'Zhuangyao Jiansheng' and its preparing process | |
| CN1368356A (en) | Nano medicine 'Tianjingbushen' and its preparing process | |
| CN1365715A (en) | Nano medicine 'Jiuqi Niantong' and its preparing process | |
| CN1368259A (en) | Nano medicine 'Yangweining' and its preparing process | |
| CN1368199A (en) | Nano medicine for treating deafness and its preparing process | |
| CN1363305A (en) | Nano compound fleece flower root-rehmannia root medicine and its preparing process | |
| CN1362090A (en) | Nano energy-stagnation stomachache treating medicine and its preparation | |
| CN1363333A (en) | Nano medicine 'Chenxiang Huazhi' and its preparing process | |
| CN1368316A (en) | Nano medicine 'Shuxinjangzhi' and its preparing process | |
| CN1363335A (en) | Nano medicine 'Chuan Xiong Tea' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |