CN1362185A - Nano six-mild-ingredient medicine and its preparation - Google Patents
Nano six-mild-ingredient medicine and its preparation Download PDFInfo
- Publication number
- CN1362185A CN1362185A CN 01100340 CN01100340A CN1362185A CN 1362185 A CN1362185 A CN 1362185A CN 01100340 CN01100340 CN 01100340 CN 01100340 A CN01100340 A CN 01100340A CN 1362185 A CN1362185 A CN 1362185A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- medicine
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000004615 ingredient Substances 0.000 title 1
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 241000756943 Codonopsis Species 0.000 claims abstract description 10
- 241001522129 Pinellia Species 0.000 claims abstract description 10
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 238000009472 formulation Methods 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 239000002775 capsule Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 239000008876 liujunzi Substances 0.000 abstract description 5
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000007882 Gastritis Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Liujunzi preparation medicine. It is made up by using the Chinese medicinal materials of nano codonopsis, nano ovate atractylodes, nano poria, nano licorice, nano tangerine peel and nano pinellia as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in whic hmost of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of replenishing QI to invigorate the spleen, drying dampness to eliminate phlegm, cure mainly the nanometer Traditional Chinese medicine formulation medicine of gastritis, the invention still further relates to the method for this medication preparation.
LIUJUNZI WAN is a kind of classical Chinese patent medicine, mainly contains the adjusting gastrointestinal motility, anti-gastric-ulcer, and anti-gastric mucosa injury is regulated effects such as immunity, is used for deficiency of spleen-QI and stomach-QI, and lack of appetite god is tired, cough with copious phlegm, distension and fullness of the chest and abdomen.But traditional LIUJUNZI WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer Traditional Chinese medicine formulation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer Traditional Chinese medicine formulation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Codonopsis 140-260 part nanometer Rhizoma Atractylodis Macrocephalae 140-260 part nano Poria 140-260 part
Nanometer Radix Glycyrrhizae 60-140 part nanometer Pericarpium Citri Reticulatae 60-140 part nano pinellia 140-260 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Codonopsis 160-240 part nanometer Rhizoma Atractylodis Macrocephalae 160-240 part nano Poria 160-240 part
Nanometer Radix Glycyrrhizae 80-120 part nanometer Pericarpium Citri Reticulatae 80-120 part nano pinellia 160-240 part
The optimum weight proportioning of medicine of the present invention is:
200 parts of 200 parts of nano Porias of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Codonopsis
200 parts of 100 parts of nano pinellias of 100 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get the Traditional Chinese medicine formulation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer Traditional Chinese medicine formulation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common LIUJUNZI WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer Traditional Chinese medicine formulation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for chronic gastritis, peptic ulcer, and chronic nephritis, chronic bronchitis, treatment of conditions such as vomiting during pregnancy, clinical efficacy significantly is better than traditional LIUJUNZI WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
200 parts of 200 parts of nano Porias of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Codonopsis
200 parts of 100 parts of nano pinellias of 100 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and is every with 1-4 time.
Embodiment 2:
Prepare nano raw material by preceding method:
200 parts of 200 parts of nano Porias of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Codonopsis
200 parts of 100 parts of nano pinellias of 100 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make nanometer six gentleman's powder needle injections, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
200 parts of 200 parts of nano Porias of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Codonopsis
200 parts of 100 parts of nano pinellias of 100 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make nanometer six gentleman's membrane, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nanometer Traditional Chinese medicine formulation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Codonopsis 140-260 part nanometer Rhizoma Atractylodis Macrocephalae 140-260 part nano Poria 140-260 part
Nanometer Radix Glycyrrhizae 60-140 part nanometer Pericarpium Citri Reticulatae 60-140 part nano pinellia 140-260 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer Traditional Chinese medicine formulation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Codonopsis 160-240 part nanometer Rhizoma Atractylodis Macrocephalae 160-240 part nano Poria 160-240 part
Nanometer Radix Glycyrrhizae 80-120 part nanometer Pericarpium Citri Reticulatae 80-120 part nano pinellia 160-240 part
3, nanometer Traditional Chinese medicine formulation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
200 parts of 200 parts of nano Porias of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Codonopsis
200 parts of 100 parts of nano pinellias of 100 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Glycyrrhizae
4, according to claim 1 or 2 or 3 described nanometer Traditional Chinese medicine formulation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer Traditional Chinese medicine formulation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100340 CN1362185A (en) | 2001-01-02 | 2001-01-02 | Nano six-mild-ingredient medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100340 CN1362185A (en) | 2001-01-02 | 2001-01-02 | Nano six-mild-ingredient medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362185A true CN1362185A (en) | 2002-08-07 |
Family
ID=4651509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100340 Pending CN1362185A (en) | 2001-01-02 | 2001-01-02 | Nano six-mild-ingredient medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362185A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108079274A (en) * | 2018-02-10 | 2018-05-29 | 郑小眼 | It is a kind of to treat AIDS Digestive Chinese medicine composition |
-
2001
- 2001-01-02 CN CN 01100340 patent/CN1362185A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108079274A (en) * | 2018-02-10 | 2018-05-29 | 郑小眼 | It is a kind of to treat AIDS Digestive Chinese medicine composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1362173A (en) | Nano medicine prepared with six mild drugs and Aucklandiae and Amomi and its preparation | |
| CN1363287A (en) | Nano Wuling medicine and its preparing process | |
| CN1362185A (en) | Nano six-mild-ingredient medicine and its preparation | |
| CN1362183A (en) | Nano Lycii-chrysanthemia-rhemanniae medicine and its preparation | |
| CN1364543A (en) | Nano apricot kernel and perilla antitussive medicine and its preparing method | |
| CN1366966A (en) | Nano pinellia preparation medicine and preparation method | |
| CN1366895A (en) | Nano supplement both qi and blood preparation medicine and preparation method thereof | |
| CN1362248A (en) | Nano stomach-calming medicine of Aucklandiae and Amomi and its preparation | |
| CN1362180A (en) | Nano spleen and stomach invigorating and vital energy benefiting medicine and its preparation | |
| CN1362238A (en) | Nano analgesic Rhizome corydalis medicine and its preparation | |
| CN1366898A (en) | Nano jizhi preparation medicine and preparation method thereof | |
| CN1368274A (en) | Nano medicine 'Zhibao Lingzhi' and its preparing process | |
| CN1362090A (en) | Nano energy-stagnation stomachache treating medicine and its preparation | |
| CN1362232A (en) | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation | |
| CN1365675A (en) | Nano medicine 'Fuzilizhong' and its preparing process | |
| CN1365713A (en) | Nano medicine for treating ulcer and its preparing process | |
| CN1362179A (en) | Nano eight-ingredient medicine and its preparation | |
| CN1364602A (en) | Nano powerful tonic medicine and its preparing method | |
| CN1362182A (en) | Nano spleen-invigorating medicine and its preparation | |
| CN1362240A (en) | Nano medicine powder for treating cold limbs caused by Yang exhaustion and its preparation | |
| CN1362233A (en) | Nano medicine for strengthening body's resistance and treating dyspnenic cough and its preparation | |
| CN1365795A (en) | Nano medicine for treating infantile diarrhea and its preparing process | |
| CN1362157A (en) | Nano Sanjiuweitai medicine and its preparation | |
| CN1368290A (en) | Nano medicine 'Xiaoer Shengxue' and its preparing process | |
| CN1364514A (en) | Nano eight ingredient motherwort medicine and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |