CN1360929A - Nanometer nasosinusitis treating medicine and its prepn - Google Patents
Nanometer nasosinusitis treating medicine and its prepn Download PDFInfo
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- CN1360929A CN1360929A CN 00136925 CN00136925A CN1360929A CN 1360929 A CN1360929 A CN 1360929A CN 00136925 CN00136925 CN 00136925 CN 00136925 A CN00136925 A CN 00136925A CN 1360929 A CN1360929 A CN 1360929A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 239000000463 material Substances 0.000 claims abstract description 21
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 10
- 241000125175 Angelica Species 0.000 claims description 9
- 241001061264 Astragalus Species 0.000 claims description 9
- 241000202726 Bupleurum Species 0.000 claims description 9
- 241000903946 Clematidis Species 0.000 claims description 9
- 241000628997 Flos Species 0.000 claims description 9
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- 239000009670 cang er zi wan Substances 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241001071795 Gentiana Species 0.000 claims description 5
- 235000014435 Mentha Nutrition 0.000 claims description 5
- 241001072983 Mentha Species 0.000 claims description 5
- 241000207929 Scutellaria Species 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 241000218378 Magnolia Species 0.000 abstract 1
- 244000246386 Mentha pulegium Species 0.000 abstract 1
- 235000016257 Mentha pulegium Nutrition 0.000 abstract 1
- 235000004357 Mentha x piperita Nutrition 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 240000003582 Platycodon grandiflorus Species 0.000 abstract 1
- 241000951473 Schizonepeta Species 0.000 abstract 1
- 235000001050 hortel pimenta Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 8
- 201000009890 sinusitis Diseases 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 206010039083 rhinitis Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 201000009151 chronic rhinitis Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The nano nasosinusitis treating medicine is prepared with nano magnolia flower, nano fineleaf schizonepeta, nano peppermint, nano balloonflower, nano Radix Bupleuri and other nine kinds of nano Chinese medicinal materials in certain proportion as material. It has grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to the sharp key of a kind of stuffy nose relieving, cure mainly the nanometer nasosinusitis treating medicine of sinusitis, the invention still further relates to the method for this medication preparation.
Bidouyan mixture, bidouyan koufuye is a kind of classical Chinese patent medicine, mainly contains the sharp key effect of stuffy nose relieving, obstructed, the yellow dense tears of stream of being used to have a stuffy nose, acute and chronic rhinitis, nasal sinusitis.But traditional bidouyan mixture, bidouyan koufuye disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer nasosinusitis treating medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer nasosinusitis treating medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Flos Magnoliae 100-180 part nanometer Herba Schizonepetae 100-180 part nanometer Herba Menthae 100-180 part
Nanometer Radix Platycodonis 100-180 part nano bupleurum 80-160 part nanometer Fructus Xanthii 80-160 part
Nano angelica root 80-160 part nanometer Rhizoma Chuanxiong 80-160 part nanometer Radix Scutellariae 80-160 part
Nanometer Fructus Gardeniae 80-150 part nano Poria 140-220 part nanometer Caulis Clematidis Armandii 80-160 part
Nano astragalus 260-340 part nanometer Radix Gentianae 20-60 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Flos Magnoliae 120-160 part nanometer Herba Schizonepetae 120-160 part nanometer Herba Menthae 120-160 part
Nanometer Radix Platycodonis 120-160 part nano bupleurum 100-140 part nanometer Fructus Xanthii 100-140 part
Nano angelica root 100-140 part nanometer Rhizoma Chuanxiong 100-140 part nanometer Radix Scutellariae 100-130 part
Nanometer Fructus Gardeniae 100-130 part nano Poria 160-200 part nanometer Caulis Clematidis Armandii 100-140 part
Nano astragalus 280-320 part nanometer Radix Gentianae 25-55 part
The best important proportioning of medicine of the present invention is:
148 parts of 148 parts of nanometer Herba Menthaes of 148 parts of nanometer Herba Schizonepetae of nanometer Flos Magnoliae
126 parts of 126 parts of nanometer Fructus Xanthii of 148 parts of nano bupleurums of nanometer Radix Platycodonis
112 parts of 126 parts of nanometer Radix Scutellariaes of 126 parts of nanometer Rhizoma Chuanxiongs of nano angelica root
126 parts of 186 parts of nanometer Caulis Clematidis Armandiis of 112 parts of nano Porias of nanometer Fructus Gardeniae
34 parts of 304 parts of nanometer Radix Gentianaes of nano astragalus
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material--the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05Mpa under the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05Mpa under the pressure,, get sinusitis preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common sinusitis preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer nasosinusitis treating medicine is identical.
Another important feature of the present invention is, traditional sinusitis disintegrate is slow, absorption is incomplete, bioavailability is not high, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nanometer nasosinusitis treating medicine etc. is had no precedent in the past.
Treatment of conditions such as that pharmaceutical preparation of the present invention can be used for having a stuffy nose is obstructed, the yellow dense tears of stream, acute and chronic rhinitis, nasal sinusitis, clinical efficacy significantly is better than traditional guarantor's Fukang granule for women.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
148 parts of 148 parts of nanometer Herba Menthaes of 148 parts of nanometer Herba Schizonepetae of nanometer Flos Magnoliae
126 parts of 126 parts of nanometer Fructus Xanthii of 148 parts of nano bupleurums of nanometer Radix Platycodonis
112 parts of 126 parts of nanometer Radix Scutellariaes of 126 parts of nanometer Rhizoma Chuanxiongs of nano angelica root
126 parts of 186 parts of nanometer Caulis Clematidis Armandiis of 112 parts of nano Porias of nanometer Fructus Gardeniae
34 parts of 304 parts of nanometer Radix Gentianaes of nano astragalus
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
148 parts of 148 parts of nanometer Herba Menthaes of 148 parts of nanometer Herba Schizonepetae of nanometer Flos Magnoliae
126 parts of 126 parts of nanometer Fructus Xanthii of 148 parts of nano bupleurums of nanometer Radix Platycodonis
112 parts of 126 parts of nanometer Radix Scutellariaes of 126 parts of nanometer Rhizoma Chuanxiongs of nano angelica root
126 parts of 186 parts of nanometer Caulis Clematidis Armandiis of 112 parts of nano Porias of nanometer Fructus Gardeniae
34 parts of 304 parts of nanometer Radix Gentianaes of nano astragalus
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nanometer nasosinusitis powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
148 parts of 148 parts of nanometer Herba Menthaes of 148 parts of nanometer Herba Schizonepetae of nanometer Flos Magnoliae
126 parts of 126 parts of nanometer Fructus Xanthii of 148 parts of nano bupleurums of nanometer Radix Platycodonis
112 parts of 126 parts of nanometer Radix Scutellariaes of 126 parts of nanometer Rhizoma Chuanxiongs of nano angelica root
126 parts of 186 parts of nanometer Caulis Clematidis Armandiis of 112 parts of nano Porias of nanometer Fructus Gardeniae
34 parts of 304 parts of nanometer Radix Gentianaes of nano astragalus
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer nasosinusitis membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, and paste the medicine position: abdominal part, back, chest, cervical region and thigh, shank, upper arm etc. are located.
Claims (6)
1, a kind of nanometer nasosinusitis treating medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Flos Magnoliae 100-180 part nanometer Herba Schizonepetae 100-180 part nanometer Herba Menthae 100-180 part
Nanometer Radix Platycodonis 100-180 part nano bupleurum 80-160 part nanometer Fructus Xanthii 80-160 part
Nano angelica root 80-160 part nanometer Rhizoma Chuanxiong 80-160 part nanometer Radix Scutellariae 80-160 part
Nanometer Fructus Gardeniae 80-150 part nano Poria 140-220 part nanometer Caulis Clematidis Armandii 80-160 part
Nano astragalus 260-340 part nanometer Radix Gentianae 20-60 part
And adopt following method to make:
Select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer nasosinusitis treating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Flos Magnoliae 120-160 part nanometer Herba Schizonepetae 120-160 part nanometer Herba Menthae 120-160 part
Nanometer Radix Platycodonis 120-160 part nano bupleurum 100-140 part nanometer Fructus Xanthii 100-140 part
Nano angelica root 100-140 part nanometer Rhizoma Chuanxiong 100-140 part nanometer Radix Scutellariae 100-130 part
Nanometer Fructus Gardeniae 100-130 part nano Poria 160-200 part nanometer Caulis Clematidis Armandii 100-140 part
Nano astragalus 280-320 part nanometer Radix Gentianae 25-55 part
3, nanometer nasosinusitis treating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
148 parts of 148 parts of nanometer Herba Menthaes of 148 parts of nanometer Herba Schizonepetae of nanometer Flos Magnoliae
126 parts of 126 parts of nanometer Fructus Xanthii of 148 parts of nano bupleurums of nanometer Radix Platycodonis
112 parts of 126 parts of nanometer Radix Scutellariaes of 126 parts of nanometer Rhizoma Chuanxiongs of nano angelica root
126 parts of 186 parts of nanometer Caulis Clematidis Armandiis of 112 parts of nano Porias of nanometer Fructus Gardeniae
34 parts of 304 parts of nanometer Radix Gentianaes of nano astragalus
4, according to claim 1 or 2 or 3 described nanometer nasosinusitis pharmaceutical preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer nasosinusitis treating medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136925 CN1360929A (en) | 2000-12-29 | 2000-12-29 | Nanometer nasosinusitis treating medicine and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136925 CN1360929A (en) | 2000-12-29 | 2000-12-29 | Nanometer nasosinusitis treating medicine and its prepn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1360929A true CN1360929A (en) | 2002-07-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00136925 Pending CN1360929A (en) | 2000-12-29 | 2000-12-29 | Nanometer nasosinusitis treating medicine and its prepn |
Country Status (1)
| Country | Link |
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| CN (1) | CN1360929A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450500C (en) * | 2002-12-31 | 2009-01-14 | 北京东方绿原科技发展有限公司 | Medicinal composition for treating and preventing nasal sinusitis and preparing method |
| CN104984042A (en) * | 2015-07-23 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Traditional Chinese medicine preparation for treating chronic/acute rhinitis and nasosinusitis and preparation method thereof |
-
2000
- 2000-12-29 CN CN 00136925 patent/CN1360929A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450500C (en) * | 2002-12-31 | 2009-01-14 | 北京东方绿原科技发展有限公司 | Medicinal composition for treating and preventing nasal sinusitis and preparing method |
| CN104984042A (en) * | 2015-07-23 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Traditional Chinese medicine preparation for treating chronic/acute rhinitis and nasosinusitis and preparation method thereof |
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