CN1362160A - Nano Heavn king tonic medicine for mental discomfort and its preparation - Google Patents
Nano Heavn king tonic medicine for mental discomfort and its preparation Download PDFInfo
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- CN1362160A CN1362160A CN 01100315 CN01100315A CN1362160A CN 1362160 A CN1362160 A CN 1362160A CN 01100315 CN01100315 CN 01100315 CN 01100315 A CN01100315 A CN 01100315A CN 1362160 A CN1362160 A CN 1362160A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 230000003340 mental effect Effects 0.000 title 1
- 230000001256 tonic effect Effects 0.000 title 1
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 241000756943 Codonopsis Species 0.000 claims abstract description 10
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 10
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 210000000582 semen Anatomy 0.000 claims description 18
- 230000003014 reinforcing effect Effects 0.000 claims description 14
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 235000005412 red sage Nutrition 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 241000208966 Polygala Species 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000209495 Acorus Species 0.000 abstract 1
- 241000544270 Angelica acutiloba Species 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 239000001670 anatto Substances 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 229940126678 chinese medicines Drugs 0.000 description 1
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- 230000036543 hypotension Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
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- 239000002547 new drug Substances 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
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Abstract
The present invention discloses a nano Tianwang-Bixin preparation medicine. It is made up by using 16 Chinese meddicinal materials of nano codonopsis, nano tangkuei, nano salvia, nano acorus, nano poria and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of YIN nourishing, nourish blood, heart tonifying and tranquilizing, cure mainly neurasthenic nanometer king's reinforcing the heart preparation medicine, the invention still further relates to the method for this medication preparation.
King's heart-invigoration pill is a kind of classical Chinese patent medicine, mainly contains effects such as anti-myocardial infarction, raise immunity, calmness, convulsion, arrhythmia, is used for insufficiency of heart-YIN, palpitation and amnesia, insomnia and dreamful sleep, is hard and dry etc.But traditional king's heart-invigoration pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully nanometer king's reinforcing the heart preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer king reinforcing the heart preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Codonopsis 10-40 part nano Chinese angelica 20-80 part nano red sage 10-40 part
Nanometer Rhizoma Acori Graminei 10-40 part nano Poria 10-40 part nanometer Fructus Schisandrae Chinensis 20-80 part
Nanometer 20-80 Radix Ophiopogonis part nanometer Radix Asparagi 20-80 part nanometer Radix Rehmanniae 120-280 part
Nanometer Radix Scrophulariae 10-40 part nanometer Radix Platycodonis 10-40 part nanometer Radix Polygalae 10-40 part
Nanometer Radix Glycyrrhizae 10-40 part nm acid Semen Ziziphi Spinosae 20-80 part nanometer Cinnabaris 6-15 part
Nanometer Semen Platycladi 20-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Codonopsis 20-30 part nano Chinese angelica 40-60 part nano red sage 20-30 part
Nanometer Rhizoma Acori Graminei 20-30 part nano Poria 20-30 part nanometer Fructus Schisandrae Chinensis 40-60 part
Nanometer 40-60 Radix Ophiopogonis part nanometer Radix Asparagi 40-60 part nanometer Radix Rehmanniae 60-240 part
Nanometer Radix Scrophulariae 20-30 part nanometer Radix Platycodonis 20-30 part nanometer Radix Polygalae 20-30 part
Nanometer Radix Glycyrrhizae 20-30 part nm acid Semen Ziziphi Spinosae 40-60 part nanometer Cinnabaris 8-12 part
Nanometer Semen Platycladi 40-60 part
The optimum weight proportioning of medicine of the present invention is:
25 parts of 50 parts of nano red sages of 25 parts of nano Chinese angelicas of nanometer Radix Codonopsis
50 parts of 25 parts of nanometer Fructus Schisandrae Chinensis of 25 parts of nano Porias of nanometer Rhizoma Acori Graminei
200 parts of 50 parts of nanometer Radix Rehmanniae of nanometer 50 parts of nanometer Radix Asparagis Radix Ophiopogonis
25 parts of 25 parts of nanometer Radix Polygalaes of 25 parts of nanometer Radix Platycodoniss of nanometer Radix Scrophulariae
10 parts in 50 parts of nanometer Cinnabaris of 25 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Glycyrrhizae
50 parts of nanometer Semen Platycladi
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since nano material special construction---the material grains size is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, effluxvelocity 330-990 meter per second, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, effluxvelocity 330-990 meter per second, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get king's reinforcing the heart preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer king reinforcing the heart preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common king's heart-invigoration pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine of nanometer king's reinforcing the heart preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as hypotension, neurasthenia, insomnia, psychosis, arrhythmia, and clinical efficacy significantly is better than traditional king's heart-invigoration pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
25 parts of 50 parts of nano red sages of 25 parts of nano Chinese angelicas of nanometer Radix Codonopsis
50 parts of 25 parts of nanometer Fructus Schisandrae Chinensis of 25 parts of nano Porias of nanometer Rhizoma Acori Graminei
200 parts of 50 parts of nanometer Radix Rehmanniae of nanometer 50 parts of nanometer Radix Asparagis Radix Ophiopogonis
25 parts of 25 parts of nanometer Radix Polygalaes of 25 parts of nanometer Radix Platycodoniss of nanometer Radix Scrophulariae
10 parts in 50 parts of nanometer Cinnabaris of 25 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Glycyrrhizae
50 parts of nanometer Semen Platycladi
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and is every with 1-4 time.
Embodiment 2:
Prepare nano raw material by preceding method:
25 parts of 50 parts of nano red sages of 25 parts of nano Chinese angelicas of nanometer Radix Codonopsis
50 parts of 25 parts of nanometer Fructus Schisandrae Chinensis of 25 parts of nano Porias of nanometer Rhizoma Acori Graminei
200 parts of 50 parts of nanometer Radix Rehmanniae of nanometer 50 parts of nanometer Radix Asparagis Radix Ophiopogonis
25 parts of 25 parts of nanometer Radix Polygalaes of 25 parts of nanometer Radix Platycodoniss of nanometer Radix Scrophulariae
10 parts in 50 parts of nanometer Cinnabaris of 25 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Glycyrrhizae
50 parts of nanometer Semen Platycladi
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make nanometer king reinforcing the heart powder needle injection, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3
Prepare nano raw material by preceding method:
25 parts of 50 parts of nano red sages of 25 parts of nano Chinese angelicas of nanometer Radix Codonopsis
50 parts of 25 parts of nanometer Fructus Schisandrae Chinensis of 25 parts of nano Porias of nanometer Rhizoma Acori Graminei
200 parts of 50 parts of nanometer Radix Rehmanniae of nanometer 50 parts of nanometer Radix Asparagis Radix Ophiopogonis
25 parts of 25 parts of nanometer Radix Polygalaes of 25 parts of nanometer Radix Platycodoniss of nanometer Radix Scrophulariae
10 parts in 50 parts of nanometer Cinnabaris of 25 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Glycyrrhizae
50 parts of nanometer Semen Platycladi
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make nanometer king reinforcing the heart membrane, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nanometer king's reinforcing the heart preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Codonopsis 10-40 part nano Chinese angelica 20-80 part nano red sage 10-40 part
Nanometer Rhizoma Acori Graminei 10-40 part nano Poria 10-40 part nanometer Fructus Schisandrae Chinensis 20-80 part
Nanometer 20-80 Radix Ophiopogonis part nanometer Radix Asparagi 20-80 part nanometer Radix Rehmanniae 120-280 part
Nanometer Radix Scrophulariae 10-40 part nanometer Radix Platycodonis 10-40 part nanometer Radix Polygalae 10-40 part
Nanometer Radix Glycyrrhizae 10-40 part nm acid Semen Ziziphi Spinosae 20-80 part nanometer Cinnabaris 6-15 part
Nanometer Semen Platycladi 20-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer king's reinforcing the heart preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Codonopsis 20-30 part nano Chinese angelica 40-60 part nano red sage 20-30 part
Nanometer Rhizoma Acori Graminei 20-30 part nano Poria 20-30 part nanometer Fructus Schisandrae Chinensis 40-60 part
Nanometer 40-60 Radix Ophiopogonis part nanometer Radix Asparagi 40-60 part nanometer Radix Rehmanniae 160-240 part
Nanometer Radix Scrophulariae 20-30 part nanometer Radix Platycodonis 20-30 part nanometer Radix Polygalae 20-30 part
Nanometer Radix Glycyrrhizae 20-30 part nm acid Semen Ziziphi Spinosae 40-60 part nanometer Cinnabaris 8-12 part
Nanometer Semen Platycladi 40-60 part
3, nanometer king's reinforcing the heart preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
25 parts of 50 parts of nano red sages of 25 parts of nano Chinese angelicas of nanometer Radix Codonopsis
50 parts of 25 parts of nanometer Fructus Schisandrae Chinensis of 25 parts of nano Porias of nanometer Rhizoma Acori Graminei
200 parts of 50 parts of nanometer Radix Rehmanniae of nanometer 50 parts of nanometer Radix Asparagis Radix Ophiopogonis
25 parts of 25 parts of nanometer Radix Polygalaes of 25 parts of nanometer Radix Platycodoniss of nanometer Radix Scrophulariae
10 parts in 50 parts of nanometer Cinnabaris of 25 parts of nm acid Semen Ziziphi Spinosaes of nanometer Radix Glycyrrhizae
50 parts of nanometer Semen Platycladi
4, according to claim 1 or 2 or 3 described nanometer king's reinforcing the heart preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer king's reinforcing the heart preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is the 330-990 meter per second, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100315 CN1362160A (en) | 2001-01-02 | 2001-01-02 | Nano Heavn king tonic medicine for mental discomfort and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100315 CN1362160A (en) | 2001-01-02 | 2001-01-02 | Nano Heavn king tonic medicine for mental discomfort and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362160A true CN1362160A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100315 Pending CN1362160A (en) | 2001-01-02 | 2001-01-02 | Nano Heavn king tonic medicine for mental discomfort and its preparation |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721608B (en) * | 2009-12-11 | 2011-09-21 | 涂用贤 | Chinese herbal medicine pill used for treating heart diseases |
| CN102319352A (en) * | 2011-09-26 | 2012-01-18 | 李建奎 | Chinese medicinal formula for treating heart disease |
| CN102784308A (en) * | 2012-07-24 | 2012-11-21 | 马千里 | Chinese medicine composition for treating neurasthenia |
| CN102861222A (en) * | 2012-09-07 | 2013-01-09 | 李承平 | Spina date seed heart-nourishing tablet |
| CN115227757A (en) * | 2021-08-05 | 2022-10-25 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of antihypertensive drugs |
-
2001
- 2001-01-02 CN CN 01100315 patent/CN1362160A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721608B (en) * | 2009-12-11 | 2011-09-21 | 涂用贤 | Chinese herbal medicine pill used for treating heart diseases |
| CN102319352A (en) * | 2011-09-26 | 2012-01-18 | 李建奎 | Chinese medicinal formula for treating heart disease |
| CN102784308A (en) * | 2012-07-24 | 2012-11-21 | 马千里 | Chinese medicine composition for treating neurasthenia |
| CN102861222A (en) * | 2012-09-07 | 2013-01-09 | 李承平 | Spina date seed heart-nourishing tablet |
| CN115227757A (en) * | 2021-08-05 | 2022-10-25 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of antihypertensive drugs |
| CN115227757B (en) * | 2021-08-05 | 2023-10-24 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of antihypertensive drugs |
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