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MX2015007921A - Compuestos heterociclicos novedosos como inhibidores de bromodominio. - Google Patents

Compuestos heterociclicos novedosos como inhibidores de bromodominio.

Info

Publication number
MX2015007921A
MX2015007921A MX2015007921A MX2015007921A MX2015007921A MX 2015007921 A MX2015007921 A MX 2015007921A MX 2015007921 A MX2015007921 A MX 2015007921A MX 2015007921 A MX2015007921 A MX 2015007921A MX 2015007921 A MX2015007921 A MX 2015007921A
Authority
MX
Mexico
Prior art keywords
heterocyclic compounds
novel heterocyclic
bromodomain inhibitors
compounds
bromodomain
Prior art date
Application number
MX2015007921A
Other languages
English (en)
Inventor
He Zhao
Shuang Liu
Bryan Cordell Duffy
John Frederick Quinn
May Xiaowu Jiang
Ruifang Wang
Gregory Scott Martin
Bruce Francis Molino
Peter Ronald Young
Original Assignee
Zenith Epigenetics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenith Epigenetics Corp filed Critical Zenith Epigenetics Corp
Publication of MX2015007921A publication Critical patent/MX2015007921A/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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Abstract

La presente descripción se refiere a compuestos, que son útiles para la inhibición de la función de la proteína BET mediante la unión a bromodominios, y su uso en la terapia. (ver Fórmula).
MX2015007921A 2012-12-21 2013-12-19 Compuestos heterociclicos novedosos como inhibidores de bromodominio. MX2015007921A (es)

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