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SV2002000321A - Una nueva forma cristalina del acido n-[4-[2-(2- amino-4,7-dihidro-4-oxo-3h-pirrolo[2,3-d]pirimidin -5-il)etil]benzoil]-l-glutamico y procedimiento para su preparacion ref. x-11969 - Google Patents

Una nueva forma cristalina del acido n-[4-[2-(2- amino-4,7-dihidro-4-oxo-3h-pirrolo[2,3-d]pirimidin -5-il)etil]benzoil]-l-glutamico y procedimiento para su preparacion ref. x-11969

Info

Publication number
SV2002000321A
SV2002000321A SV2001000321A SV2001000321A SV2002000321A SV 2002000321 A SV2002000321 A SV 2002000321A SV 2001000321 A SV2001000321 A SV 2001000321A SV 2001000321 A SV2001000321 A SV 2001000321A SV 2002000321 A SV2002000321 A SV 2002000321A
Authority
SV
El Salvador
Prior art keywords
pirrolo
benzoil
glutamic
amino
acid
Prior art date
Application number
SV2001000321A
Other languages
English (en)
Inventor
Erik Christopher Chelius
Susan Marie Reutzel-Edens
Den Berghe Sharon Van
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22679017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SV2002000321(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SV2002000321A publication Critical patent/SV2002000321A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION SE REFIERE AL CAMPO DE LA QUIMICA FARMACEUTICA Y ORGANICA Y PROPORCIONA UN PROCEDIMIENTO MEJORADO PARA PREPARAR LA NUEVA SAL CRISTALINA HEPTAHIDRATO DEL ANTIFOLATO MULTIDIRIGIDO ACIDO N-[4-[2-(2-AMINO-4,7-DIHIDRO-4-OXO-3H-PIRROLO[2,3-D]PIRIMIDIN-5-IL)ETIL]BENZOIL]-L-GLUTAMICO.
SV2001000321A 2000-02-25 2001-02-23 Una nueva forma cristalina del acido n-[4-[2-(2- amino-4,7-dihidro-4-oxo-3h-pirrolo[2,3-d]pirimidin -5-il)etil]benzoil]-l-glutamico y procedimiento para su preparacion ref. x-11969 SV2002000321A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18496400P 2000-02-25 2000-02-25

Publications (1)

Publication Number Publication Date
SV2002000321A true SV2002000321A (es) 2002-07-16

Family

ID=22679017

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2001000321A SV2002000321A (es) 2000-02-25 2001-02-23 Una nueva forma cristalina del acido n-[4-[2-(2- amino-4,7-dihidro-4-oxo-3h-pirrolo[2,3-d]pirimidin -5-il)etil]benzoil]-l-glutamico y procedimiento para su preparacion ref. x-11969

Country Status (35)

Country Link
US (1) US7138521B2 (es)
EP (1) EP1259513B1 (es)
JP (1) JP4846158B2 (es)
KR (1) KR100744917B1 (es)
CN (1) CN1183135C (es)
AR (1) AR029471A1 (es)
AT (1) ATE249462T1 (es)
AU (1) AU777047B2 (es)
BR (1) BR0108604A (es)
CA (1) CA2400155C (es)
CO (1) CO5261585A1 (es)
CZ (1) CZ303772B6 (es)
DE (1) DE60100750T2 (es)
DK (1) DK1259513T3 (es)
DZ (1) DZ3283A1 (es)
EA (1) EA004684B1 (es)
EG (1) EG24073A (es)
ES (1) ES2206403T3 (es)
HR (1) HRP20020701B1 (es)
HU (1) HU229704B1 (es)
IL (2) IL150480A0 (es)
MX (1) MXPA02008242A (es)
MY (1) MY124784A (es)
NO (1) NO323422B1 (es)
NZ (1) NZ519796A (es)
PE (1) PE20011082A1 (es)
PL (1) PL208061B1 (es)
PT (1) PT1259513E (es)
SI (1) SI1259513T1 (es)
SK (1) SK287375B6 (es)
SV (1) SV2002000321A (es)
TW (1) TWI237024B (es)
UA (1) UA72791C2 (es)
WO (1) WO2001062760A2 (es)
ZA (1) ZA200205265B (es)

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CN100364994C (zh) * 2004-11-25 2008-01-30 重庆医药工业研究院有限责任公司 培美曲塞二钠的一种新晶型及其制备方法
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KR101101443B1 (ko) 2006-08-14 2012-01-03 시코르, 인크. 페메트렉세드의 중간체의 제조 방법
ATE490257T1 (de) * 2006-08-14 2010-12-15 Sicor Inc Kristalline formen von pemetrexed-disäure und herstellungsverfahren dafür
US20100113392A1 (en) * 2006-11-03 2010-05-06 Badros Ashraf Z Methods of using saha and bortezomib for treating multiple myeloma
BRPI0807939A2 (pt) * 2007-04-03 2014-07-01 Reddys Lab Ltd Dr Formas sólidas de pemetrexed
CN101417998B (zh) * 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
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WO2010030598A2 (en) * 2008-09-11 2010-03-18 Dr. Reddy's Laboratories Limited Pharmaceutical formulations comprising pemetrexed
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CN102050825B (zh) * 2009-11-05 2014-12-17 上海创诺制药有限公司 制备培美曲塞二钠2.5水结晶的方法
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KR101069128B1 (ko) * 2011-03-10 2011-09-30 건일제약 주식회사 페메트렉시드 또는 그의 염을 포함하는 항산화제-비함유 주사용 용액 형태의 약학적 제제의 제조방법
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
ES2639639T3 (es) 2011-03-25 2017-10-27 Scinopharm Taiwan, Ltd. Proceso para la producción de pemetrexed disódico
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
WO2014060959A1 (en) * 2012-10-17 2014-04-24 Shilpa Medicare Limited Crystalline pemetrexed dipotassium process
WO2014122460A2 (en) 2013-02-06 2014-08-14 Cipla House Pemetrexed complexes and pharmaceutical compositions containing pemetrexed complexes
EP3308770A1 (en) 2013-04-12 2018-04-18 Actavis Group PTC EHF Pemetrexed formulation
KR101485243B1 (ko) 2013-05-08 2015-01-21 씨제이헬스케어 주식회사 안정화된 페메트렉시드 제제
JP6094388B2 (ja) * 2013-06-07 2017-03-15 ニプロ株式会社 ペメトレキセドを含む注射用組成物
EP3008064B1 (en) 2013-06-14 2017-11-22 Synthon B.V. Stable pemetrexed arginine salt and compositions comprising it
US9688682B2 (en) 2013-07-16 2017-06-27 Dr. Reddy's Laboratories Limited Crystalline forms of pemetrexed tromethamine salts
WO2015050230A1 (ja) 2013-10-03 2015-04-09 富士フイルム株式会社 注射液製剤及びその製造方法
NZ630292A (en) * 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
NZ630299A (en) 2014-06-30 2014-11-28 Shilpa Medicare Ltd Pemetrexed dipotassium formulations
WO2016068796A1 (en) 2014-10-30 2016-05-06 Scinopharm Taiwan, Ltd. Crystalline forms of pemetrexed diacid and manufacturing processes therefor
CN105566328B (zh) * 2014-11-06 2018-04-24 博瑞生物医药（苏州）股份有限公司 培美曲塞二酸多晶型的制备方法
CN109906071A (zh) * 2017-10-10 2019-06-18 太阳制药工业公司 培美曲塞的静脉输注剂型
JP7490239B2 (ja) 2018-02-07 2024-05-27 エル．イー．エー．エフ． ホールディングス グループ エルエルシー ガンマポリグルタミン酸化ペメトレキセドおよびその使用
JP7491572B2 (ja) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化ペメトレキセドおよびその使用
WO2025244944A1 (en) * 2024-05-20 2025-11-27 Opna Bio SA Crystal forms of an agent

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KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US5416211A (en) 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
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Also Published As

Publication number Publication date
CN1183135C (zh) 2005-01-05
WO2001062760A2 (en) 2001-08-30
NO20023974L (no) 2002-08-21
CN1406238A (zh) 2003-03-26
ES2206403T3 (es) 2004-05-16
DK1259513T3 (da) 2004-01-12
HRP20020701A2 (en) 2003-12-31
ATE249462T1 (de) 2003-09-15
DE60100750D1 (de) 2003-10-16
WO2001062760A3 (en) 2001-12-06
SK11862002A3 (sk) 2003-01-09
PL356423A1 (en) 2004-06-28
AU3445101A (en) 2001-09-03
KR100744917B1 (ko) 2007-08-01
HUP0204232A2 (hu) 2003-04-28
CO5261585A1 (es) 2003-03-31
IL150480A (en) 2007-12-03
BR0108604A (pt) 2002-11-19
HUP0204232A3 (en) 2006-01-30
AU777047B2 (en) 2004-09-30
EP1259513A2 (en) 2002-11-27
HRP20020701B1 (en) 2011-02-28
MXPA02008242A (es) 2002-11-29
EA200200905A1 (ru) 2003-02-27
TWI237024B (en) 2005-08-01
DZ3283A1 (fr) 2001-08-30
JP4846158B2 (ja) 2011-12-28
NO323422B1 (no) 2007-04-30
CZ303772B6 (cs) 2013-05-02
DE60100750T2 (de) 2004-07-29
HU229704B1 (en) 2014-05-28
EA004684B1 (ru) 2004-06-24
US7138521B2 (en) 2006-11-21
PT1259513E (pt) 2004-02-27
PE20011082A1 (es) 2001-10-22
AR029471A1 (es) 2003-07-02
US20030216416A1 (en) 2003-11-20
MY124784A (en) 2006-07-31
HK1051856A1 (en) 2003-08-22
CA2400155C (en) 2009-09-15
KR20020075449A (ko) 2002-10-04
SK287375B6 (sk) 2010-08-09
ZA200205265B (en) 2003-11-11
SI1259513T1 (en) 2003-12-31
EG24073A (en) 2008-05-11
UA72791C2 (uk) 2005-04-15
EP1259513B1 (en) 2003-09-10
NO20023974D0 (no) 2002-08-21
CZ20022875A3 (cs) 2003-02-12
IL150480A0 (en) 2002-12-01
CA2400155A1 (en) 2001-08-30
JP2003530321A (ja) 2003-10-14
PL208061B1 (pl) 2011-03-31
NZ519796A (en) 2003-01-31

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