[go: up one dir, main page]

NO20023974D0 - Ny krystallinsk form av N-[4-[2-(2-amino-4,7-dihydro-4-okso- 3H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre ogfremgangsmåte for fremstilling derav - Google Patents

Ny krystallinsk form av N-[4-[2-(2-amino-4,7-dihydro-4-okso- 3H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre ogfremgangsmåte for fremstilling derav

Info

Publication number
NO20023974D0
NO20023974D0 NO20023974A NO20023974A NO20023974D0 NO 20023974 D0 NO20023974 D0 NO 20023974D0 NO 20023974 A NO20023974 A NO 20023974A NO 20023974 A NO20023974 A NO 20023974A NO 20023974 D0 NO20023974 D0 NO 20023974D0
Authority
NO
Norway
Prior art keywords
pyrrolo
pyrimidin
dihydro
benzoyl
oxo
Prior art date
Application number
NO20023974A
Other languages
English (en)
Other versions
NO20023974L (no
NO323422B1 (no
Inventor
Erik Christopher Chelius
Susan Marie Reutzel-Edens
Sharon Van Den Berghe Snorek
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22679017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20023974(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20023974L publication Critical patent/NO20023974L/no
Publication of NO20023974D0 publication Critical patent/NO20023974D0/no
Publication of NO323422B1 publication Critical patent/NO323422B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
NO20023974A 2000-02-25 2002-08-21 Ny krystallinsk form av N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre og fremgangsmate for fremstilling derav NO323422B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18496400P 2000-02-25 2000-02-25
PCT/US2001/001229 WO2001062760A2 (en) 2000-02-25 2001-02-12 A NOVEL CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR

Publications (3)

Publication Number Publication Date
NO20023974L NO20023974L (no) 2002-08-21
NO20023974D0 true NO20023974D0 (no) 2002-08-21
NO323422B1 NO323422B1 (no) 2007-04-30

Family

ID=22679017

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023974A NO323422B1 (no) 2000-02-25 2002-08-21 Ny krystallinsk form av N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre og fremgangsmate for fremstilling derav

Country Status (35)

Country Link
US (1) US7138521B2 (no)
EP (1) EP1259513B1 (no)
JP (1) JP4846158B2 (no)
KR (1) KR100744917B1 (no)
CN (1) CN1183135C (no)
AR (1) AR029471A1 (no)
AT (1) ATE249462T1 (no)
AU (1) AU777047B2 (no)
BR (1) BR0108604A (no)
CA (1) CA2400155C (no)
CO (1) CO5261585A1 (no)
CZ (1) CZ303772B6 (no)
DE (1) DE60100750T2 (no)
DK (1) DK1259513T3 (no)
DZ (1) DZ3283A1 (no)
EA (1) EA004684B1 (no)
EG (1) EG24073A (no)
ES (1) ES2206403T3 (no)
HR (1) HRP20020701B1 (no)
HU (1) HU229704B1 (no)
IL (2) IL150480A0 (no)
MX (1) MXPA02008242A (no)
MY (1) MY124784A (no)
NO (1) NO323422B1 (no)
NZ (1) NZ519796A (no)
PE (1) PE20011082A1 (no)
PL (1) PL208061B1 (no)
PT (1) PT1259513E (no)
SI (1) SI1259513T1 (no)
SK (1) SK287375B6 (no)
SV (1) SV2002000321A (no)
TW (1) TWI237024B (no)
UA (1) UA72791C2 (no)
WO (1) WO2001062760A2 (no)
ZA (1) ZA200205265B (no)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100364993C (zh) * 2003-05-30 2008-01-30 江苏恒瑞医药股份有限公司 培美曲噻盐及其制备方法
CN100364994C (zh) * 2004-11-25 2008-01-30 重庆医药工业研究院有限责任公司 培美曲塞二钠的一种新晶型及其制备方法
AU2006311820A1 (en) * 2005-11-04 2007-05-18 Merck Sharp & Dohme Corp. Methods of using SAHA and erlotinib for treating cancer
AU2006311808A1 (en) * 2005-11-04 2007-05-18 Merck Sharp & Dohme Corp. Methods of using SAHA and bortezomib for treating cancer
EP1957497B1 (en) 2006-08-14 2015-09-30 Sicor, Inc. Processes for preparing intermediates of pemetrexed
EP2305681A1 (en) * 2006-08-14 2011-04-06 Sicor, Inc. Crystalline form of pemetrexed diacid and process for the preparation thereof
EP1934226A2 (en) 2006-08-14 2008-06-25 Sicor, Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
WO2008021411A2 (en) * 2006-08-14 2008-02-21 Sicor Inc. Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid
AU2007317921A1 (en) * 2006-11-03 2008-05-15 University Of Maryland, Baltimore Methods of using SAHA and Bortezomib for treating multiple myeloma
KR20100014854A (ko) 2007-04-03 2010-02-11 닥터 레디스 레보러터리즈 리미티드 페메트렉세드의 고체 형태
CN101417998B (zh) * 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
EP2072518A1 (en) 2007-12-23 2009-06-24 Sun Pharma Advanced Research Company Limited Stable Amorphous Form of Pemextred Disodium
EP2334685A4 (en) * 2008-09-08 2011-10-26 Reddys Lab Ltd Dr AMORPHOUS PEMETREXED DISODIUM
WO2010030598A2 (en) * 2008-09-11 2010-03-18 Dr. Reddy's Laboratories Limited Pharmaceutical formulations comprising pemetrexed
CN101684121B (zh) 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
CN102050825B (zh) * 2009-11-05 2014-12-17 上海创诺制药有限公司 制备培美曲塞二钠2.5水结晶的方法
US9174991B2 (en) 2009-11-24 2015-11-03 Azad Pharmaceutical Ingredients Ag Crystalline form of pemetrexed disodium
CN102372719B (zh) * 2010-08-26 2013-10-30 齐鲁制药有限公司 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
KR101069128B1 (ko) * 2011-03-10 2011-09-30 건일제약 주식회사 페메트렉시드 또는 그의 염을 포함하는 항산화제-비함유 주사용 용액 형태의 약학적 제제의 제조방법
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
EP2688888B1 (en) * 2011-03-25 2017-06-14 Scinopharm Taiwan, Ltd. Process for the production of disodium pemetrexed
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
WO2014060959A1 (en) * 2012-10-17 2014-04-24 Shilpa Medicare Limited Crystalline pemetrexed dipotassium process
ZA201400898B (en) 2013-02-06 2015-12-23 Cipla Ltd Pemetrexed complexes and pharmaceutical compositions containing pemetrexed complexes
US20160051679A1 (en) 2013-04-12 2016-02-25 Actavis Group Ptc Ehf. Pemetrexed Formulation
KR101485243B1 (ko) 2013-05-08 2015-01-21 씨제이헬스케어 주식회사 안정화된 페메트렉시드 제제
JP6094388B2 (ja) * 2013-06-07 2017-03-15 ニプロ株式会社 ペメトレキセドを含む注射用組成物
EP3008064B1 (en) 2013-06-14 2017-11-22 Synthon B.V. Stable pemetrexed arginine salt and compositions comprising it
US9688682B2 (en) 2013-07-16 2017-06-27 Dr. Reddy's Laboratories Limited Crystalline forms of pemetrexed tromethamine salts
PL3040074T3 (pl) 2013-10-03 2019-03-29 Fujifilm Corporation Preparat iniekcyjny i sposób jego wytwarzania
NZ630292A (en) * 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
NZ630299A (en) 2014-06-30 2014-11-28 Shilpa Medicare Ltd Pemetrexed dipotassium formulations
EP3212193A4 (en) * 2014-10-30 2018-08-01 ScinoPharm Taiwan, Ltd. Crystalline forms of pemetrexed diacid and manufacturing processes therefor
CN105566328B (zh) * 2014-11-06 2018-04-24 博瑞生物医药（苏州）股份有限公司 培美曲塞二酸多晶型的制备方法
PL3470045T3 (pl) * 2017-10-10 2021-03-08 Sun Pharmaceutical Industries Ltd Dożylna infuzyjna postać dawkowania dla pemetreksedu
EP3749311A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC PEMETREXED POLYGLUTAMATE GAMMA COMPOSITIONS AND THEIR USES
US11779584B2 (en) 2018-02-07 2023-10-10 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
WO2025244944A1 (en) * 2024-05-20 2025-11-27 Opna Bio SA Crystal forms of an agent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169490C (no) 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US5416211A (en) 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
WO1998008382A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
IL135190A (en) * 1997-09-26 2005-03-20 Lilly Co Eli Processes and intermediates useful to make antifolates
ZA987550B (en) * 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
WO2001014379A2 (en) * 1999-08-23 2001-03-01 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor

Also Published As

Publication number Publication date
EA004684B1 (ru) 2004-06-24
IL150480A0 (en) 2002-12-01
CA2400155C (en) 2009-09-15
JP2003530321A (ja) 2003-10-14
PT1259513E (pt) 2004-02-27
ES2206403T3 (es) 2004-05-16
WO2001062760A3 (en) 2001-12-06
NZ519796A (en) 2003-01-31
IL150480A (en) 2007-12-03
UA72791C2 (uk) 2005-04-15
KR100744917B1 (ko) 2007-08-01
NO20023974L (no) 2002-08-21
PE20011082A1 (es) 2001-10-22
DE60100750T2 (de) 2004-07-29
EA200200905A1 (ru) 2003-02-27
HRP20020701A2 (en) 2003-12-31
MY124784A (en) 2006-07-31
US7138521B2 (en) 2006-11-21
ZA200205265B (en) 2003-11-11
EP1259513B1 (en) 2003-09-10
CZ303772B6 (cs) 2013-05-02
PL356423A1 (en) 2004-06-28
KR20020075449A (ko) 2002-10-04
BR0108604A (pt) 2002-11-19
SI1259513T1 (en) 2003-12-31
SK11862002A3 (sk) 2003-01-09
MXPA02008242A (es) 2002-11-29
HUP0204232A2 (hu) 2003-04-28
AU777047B2 (en) 2004-09-30
EP1259513A2 (en) 2002-11-27
NO323422B1 (no) 2007-04-30
HK1051856A1 (en) 2003-08-22
ATE249462T1 (de) 2003-09-15
AU3445101A (en) 2001-09-03
CZ20022875A3 (cs) 2003-02-12
TWI237024B (en) 2005-08-01
DE60100750D1 (de) 2003-10-16
CN1183135C (zh) 2005-01-05
HUP0204232A3 (en) 2006-01-30
SK287375B6 (sk) 2010-08-09
US20030216416A1 (en) 2003-11-20
AR029471A1 (es) 2003-07-02
EG24073A (en) 2008-05-11
JP4846158B2 (ja) 2011-12-28
DZ3283A1 (fr) 2001-08-30
SV2002000321A (es) 2002-07-16
CO5261585A1 (es) 2003-03-31
CN1406238A (zh) 2003-03-26
HU229704B1 (en) 2014-05-28
DK1259513T3 (da) 2004-01-12
PL208061B1 (pl) 2011-03-31
HRP20020701B1 (en) 2011-02-28
WO2001062760A2 (en) 2001-08-30
CA2400155A1 (en) 2001-08-30

Similar Documents

Publication Publication Date Title
NO20023974D0 (no) Ny krystallinsk form av N-[4-[2-(2-amino-4,7-dihydro-4-okso- 3H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre ogfremgangsmåte for fremstilling derav
AU6890800A (en) A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
NO20013994D0 (no) Fremgangsmate for fremstilling av tert-butyl (E)-(6[2-[4-(4- fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]pyrimidin-5-yl]vinyl](4R,6S)-2,2-dimetyl[1,3]dioksan-4-yl)acetat
CA2379560A1 (en) Purine derivatives inhibitors of tyrosine protein kinase syk
NO2014030I1 (no) (E)-4-[[4-[[4-(2-cyanoetenyl)-2,6-dimetylfenyl]-amino]-2-pyrimidinyl]-amino]-benzonitril("Rilpivirine") samt enhver terapeutisk form derav som er dekket av det aktuelle patentet så som farmasøytisk akseptable salter av Rilpivirie innbefattende hydrokloridsaltet av Rilpivirine, og emtricitabine.
EE05222B1 (et) Triasolo(4,5-d)primidiinihendi kristalne ja amorfne vorm, meetod selle valmistamiseks ning kasutamine
NO324228B1 (no) 4-amino-5-cyano-2-anilino-pyrimidinderivater og deres anvendelse og fremgangsmate for fremstilling, samt farmasoytisk sammensetning
DE50213202D1 (de) Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel
DE602007010894D1 (de) Tellungsverfahren dafür
NO20050524L (no) Fremgangsmater for fremstillingen av 4-[[4-[[4-(2-cyanoetenyl)-2,6-dimetylfenyl]amino]-2-pyrimidinyl]amino]benzonitril
NO20040122L (no) Fremgangsmåte for fremstilling av aminopyrimidinforbindelser samt pyrimidinforbindelser
HUP0402129A3 (en) Crystalline hydrates of nicotinic acid anilide and benzoyl anilide derivatives, preparation thereof, compositions containing the same and processes for their use
CA2423357A1 (en) Fused heterocyclic derivatives as phosphodiesterase inhibitors
DK1073673T3 (da) Hidtil ukendte octahydro-6, 10-dioxo-6H-pyridazino [1,2-a] [1,2] - diazepin-1-carboxylsyre-derivater, fremgangsmåde til deres fremstilling og deres anvendelse til fremstilling af terapeutisk aktive forbindelser
IL157061A (en) Process and intermediates for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl)piperazin -1-yl)-methanone and salts thereof
WO2002072100A3 (en) Pharmaceutical composition containing pde v inhibitors and surfactants
PT1005471E (pt) Pirazolo¬3,4-d|pirimidinas com accao anticonvulsivas e antialergica/antiasmatica
WO2002067866A3 (en) Piperazine derivatives as metalloprotease inhibitors
ITMI990001A0 (it) Mutanti di proteine e plasmidi idonei per la loro sintesi
WO2002022582A3 (en) Solid salt forms of n-[2-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]ethyl]-2-oxo-1-piperidineacetamide
SI1353906T1 (en) Process for the preparation of (3-cyano-1h-indol-7-yl)(4-(4-fluorophenethyl)piperazin-1-yl)-methanone and salts thereof
AU2002230022A1 (en) Salts of pyrimidine derivatives for use against coronary heart disease and atherosclerose

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees