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EA200200905A1 - Новая кристаллическая форма n-[4-[2-(2-амино-4,7-дигидро-4-оксо-3h-пирроло[ 2,3-d]пиримидин-5-ил) этил]бензоил]-l-глутаминовой кислоты и способ ее получения - Google Patents

Новая кристаллическая форма n-[4-[2-(2-амино-4,7-дигидро-4-оксо-3h-пирроло[ 2,3-d]пиримидин-5-ил) этил]бензоил]-l-глутаминовой кислоты и способ ее получения

Info

Publication number
EA200200905A1
EA200200905A1 EA200200905A EA200200905A EA200200905A1 EA 200200905 A1 EA200200905 A1 EA 200200905A1 EA 200200905 A EA200200905 A EA 200200905A EA 200200905 A EA200200905 A EA 200200905A EA 200200905 A1 EA200200905 A1 EA 200200905A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolo
dihydro
oxo
ethyl
amino
Prior art date
Application number
EA200200905A
Other languages
English (en)
Other versions
EA004684B1 (ru
Inventor
Эрик Кристофер Челиус
Сюзн Мари Ройтцель-Эденс
Шэрон Ван ден Берг Снорек
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22679017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200200905(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200200905A1 publication Critical patent/EA200200905A1/ru
Publication of EA004684B1 publication Critical patent/EA004684B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к области фармацевтической и органической химии и предоставляет улучшенный способ получения новой гептагидратной кристаллической соли - многоцелевого антифолата N-[4-[2-(2-амино-4,7-дигидро-4-оксо-3Н-пирроло[2,3-d]пиримидин-5-ил)этил]бензоил]-L-глутаминовой кислоты.Отчет о международном поиске был опубликован 2001.12.06.
EA200200905A 2000-02-25 2001-02-12 НОВАЯ КРИСТАЛЛИЧЕСКАЯ ФОРМА N-[4-[2-(2-АМИНО-4,7-ДИГИДРО-4-ОКСО-3H-ПИРРОЛО[2,3-d]ПИРИМИДИН-5-ИЛ)ЭТИЛ]БЕНЗОИЛ]-L-ГЛУТАМИНОВОЙ КИСЛОТЫ И СПОСОБ ЕЕ ПОЛУЧЕНИЯ EA004684B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18496400P 2000-02-25 2000-02-25
PCT/US2001/001229 WO2001062760A2 (en) 2000-02-25 2001-02-12 A NOVEL CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR

Publications (2)

Publication Number Publication Date
EA200200905A1 true EA200200905A1 (ru) 2003-02-27
EA004684B1 EA004684B1 (ru) 2004-06-24

Family

ID=22679017

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200905A EA004684B1 (ru) 2000-02-25 2001-02-12 НОВАЯ КРИСТАЛЛИЧЕСКАЯ ФОРМА N-[4-[2-(2-АМИНО-4,7-ДИГИДРО-4-ОКСО-3H-ПИРРОЛО[2,3-d]ПИРИМИДИН-5-ИЛ)ЭТИЛ]БЕНЗОИЛ]-L-ГЛУТАМИНОВОЙ КИСЛОТЫ И СПОСОБ ЕЕ ПОЛУЧЕНИЯ

Country Status (35)

Country Link
US (1) US7138521B2 (ru)
EP (1) EP1259513B1 (ru)
JP (1) JP4846158B2 (ru)
KR (1) KR100744917B1 (ru)
CN (1) CN1183135C (ru)
AR (1) AR029471A1 (ru)
AT (1) ATE249462T1 (ru)
AU (1) AU777047B2 (ru)
BR (1) BR0108604A (ru)
CA (1) CA2400155C (ru)
CO (1) CO5261585A1 (ru)
CZ (1) CZ303772B6 (ru)
DE (1) DE60100750T2 (ru)
DK (1) DK1259513T3 (ru)
DZ (1) DZ3283A1 (ru)
EA (1) EA004684B1 (ru)
EG (1) EG24073A (ru)
ES (1) ES2206403T3 (ru)
HR (1) HRP20020701B1 (ru)
HU (1) HU229704B1 (ru)
IL (2) IL150480A0 (ru)
MX (1) MXPA02008242A (ru)
MY (1) MY124784A (ru)
NO (1) NO323422B1 (ru)
NZ (1) NZ519796A (ru)
PE (1) PE20011082A1 (ru)
PL (1) PL208061B1 (ru)
PT (1) PT1259513E (ru)
SI (1) SI1259513T1 (ru)
SK (1) SK287375B6 (ru)
SV (1) SV2002000321A (ru)
TW (1) TWI237024B (ru)
UA (1) UA72791C2 (ru)
WO (1) WO2001062760A2 (ru)
ZA (1) ZA200205265B (ru)

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AU2006311808A1 (en) * 2005-11-04 2007-05-18 Merck Sharp & Dohme Corp. Methods of using SAHA and bortezomib for treating cancer
EP1957497B1 (en) 2006-08-14 2015-09-30 Sicor, Inc. Processes for preparing intermediates of pemetrexed
EP2305681A1 (en) * 2006-08-14 2011-04-06 Sicor, Inc. Crystalline form of pemetrexed diacid and process for the preparation thereof
EP1934226A2 (en) 2006-08-14 2008-06-25 Sicor, Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
WO2008021411A2 (en) * 2006-08-14 2008-02-21 Sicor Inc. Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid
AU2007317921A1 (en) * 2006-11-03 2008-05-15 University Of Maryland, Baltimore Methods of using SAHA and Bortezomib for treating multiple myeloma
KR20100014854A (ko) 2007-04-03 2010-02-11 닥터 레디스 레보러터리즈 리미티드 페메트렉세드의 고체 형태
CN101417998B (zh) * 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
EP2072518A1 (en) 2007-12-23 2009-06-24 Sun Pharma Advanced Research Company Limited Stable Amorphous Form of Pemextred Disodium
EP2334685A4 (en) * 2008-09-08 2011-10-26 Reddys Lab Ltd Dr AMORPHOUS PEMETREXED DISODIUM
WO2010030598A2 (en) * 2008-09-11 2010-03-18 Dr. Reddy's Laboratories Limited Pharmaceutical formulations comprising pemetrexed
CN101684121B (zh) 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
CN102050825B (zh) * 2009-11-05 2014-12-17 上海创诺制药有限公司 制备培美曲塞二钠2.5水结晶的方法
US9174991B2 (en) 2009-11-24 2015-11-03 Azad Pharmaceutical Ingredients Ag Crystalline form of pemetrexed disodium
CN102372719B (zh) * 2010-08-26 2013-10-30 齐鲁制药有限公司 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
KR101069128B1 (ko) * 2011-03-10 2011-09-30 건일제약 주식회사 페메트렉시드 또는 그의 염을 포함하는 항산화제-비함유 주사용 용액 형태의 약학적 제제의 제조방법
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
EP2688888B1 (en) * 2011-03-25 2017-06-14 Scinopharm Taiwan, Ltd. Process for the production of disodium pemetrexed
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
WO2014060959A1 (en) * 2012-10-17 2014-04-24 Shilpa Medicare Limited Crystalline pemetrexed dipotassium process
ZA201400898B (en) 2013-02-06 2015-12-23 Cipla Ltd Pemetrexed complexes and pharmaceutical compositions containing pemetrexed complexes
US20160051679A1 (en) 2013-04-12 2016-02-25 Actavis Group Ptc Ehf. Pemetrexed Formulation
KR101485243B1 (ko) 2013-05-08 2015-01-21 씨제이헬스케어 주식회사 안정화된 페메트렉시드 제제
JP6094388B2 (ja) * 2013-06-07 2017-03-15 ニプロ株式会社 ペメトレキセドを含む注射用組成物
EP3008064B1 (en) 2013-06-14 2017-11-22 Synthon B.V. Stable pemetrexed arginine salt and compositions comprising it
US9688682B2 (en) 2013-07-16 2017-06-27 Dr. Reddy's Laboratories Limited Crystalline forms of pemetrexed tromethamine salts
PL3040074T3 (pl) 2013-10-03 2019-03-29 Fujifilm Corporation Preparat iniekcyjny i sposób jego wytwarzania
NZ630292A (en) * 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
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EP3212193A4 (en) * 2014-10-30 2018-08-01 ScinoPharm Taiwan, Ltd. Crystalline forms of pemetrexed diacid and manufacturing processes therefor
CN105566328B (zh) * 2014-11-06 2018-04-24 博瑞生物医药（苏州）股份有限公司 培美曲塞二酸多晶型的制备方法
PL3470045T3 (pl) * 2017-10-10 2021-03-08 Sun Pharmaceutical Industries Ltd Dożylna infuzyjna postać dawkowania dla pemetreksedu
EP3749311A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC PEMETREXED POLYGLUTAMATE GAMMA COMPOSITIONS AND THEIR USES
US11779584B2 (en) 2018-02-07 2023-10-10 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
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Also Published As

Publication number Publication date
EA004684B1 (ru) 2004-06-24
IL150480A0 (en) 2002-12-01
CA2400155C (en) 2009-09-15
JP2003530321A (ja) 2003-10-14
PT1259513E (pt) 2004-02-27
ES2206403T3 (es) 2004-05-16
WO2001062760A3 (en) 2001-12-06
NZ519796A (en) 2003-01-31
IL150480A (en) 2007-12-03
UA72791C2 (ru) 2005-04-15
KR100744917B1 (ko) 2007-08-01
NO20023974L (no) 2002-08-21
PE20011082A1 (es) 2001-10-22
DE60100750T2 (de) 2004-07-29
HRP20020701A2 (en) 2003-12-31
MY124784A (en) 2006-07-31
US7138521B2 (en) 2006-11-21
ZA200205265B (en) 2003-11-11
EP1259513B1 (en) 2003-09-10
CZ303772B6 (cs) 2013-05-02
PL356423A1 (en) 2004-06-28
KR20020075449A (ko) 2002-10-04
BR0108604A (pt) 2002-11-19
SI1259513T1 (en) 2003-12-31
SK11862002A3 (sk) 2003-01-09
MXPA02008242A (es) 2002-11-29
NO20023974D0 (no) 2002-08-21
HUP0204232A2 (hu) 2003-04-28
AU777047B2 (en) 2004-09-30
EP1259513A2 (en) 2002-11-27
NO323422B1 (no) 2007-04-30
HK1051856A1 (en) 2003-08-22
ATE249462T1 (de) 2003-09-15
AU3445101A (en) 2001-09-03
CZ20022875A3 (cs) 2003-02-12
TWI237024B (en) 2005-08-01
DE60100750D1 (de) 2003-10-16
CN1183135C (zh) 2005-01-05
HUP0204232A3 (en) 2006-01-30
SK287375B6 (sk) 2010-08-09
US20030216416A1 (en) 2003-11-20
AR029471A1 (es) 2003-07-02
EG24073A (en) 2008-05-11
JP4846158B2 (ja) 2011-12-28
DZ3283A1 (fr) 2001-08-30
SV2002000321A (es) 2002-07-16
CO5261585A1 (es) 2003-03-31
CN1406238A (zh) 2003-03-26
HU229704B1 (en) 2014-05-28
DK1259513T3 (da) 2004-01-12
PL208061B1 (pl) 2011-03-31
HRP20020701B1 (en) 2011-02-28
WO2001062760A2 (en) 2001-08-30
CA2400155A1 (en) 2001-08-30

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