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RU2325389C2 - Композиция и производные замещенного азаиндолоксоацетапиперазина, обладающие противовирусной активностью - Google Patents

Композиция и производные замещенного азаиндолоксоацетапиперазина, обладающие противовирусной активностью Download PDF

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RU2325389C2
RU2325389C2 RU2005106350/04A RU2005106350A RU2325389C2 RU 2325389 C2 RU2325389 C2 RU 2325389C2 RU 2005106350/04 A RU2005106350/04 A RU 2005106350/04A RU 2005106350 A RU2005106350 A RU 2005106350A RU 2325389 C2 RU2325389 C2 RU 2325389C2
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antiviral activity
azaindoloxoacetapiperazine
derivatives
substituted
composition
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RU2005106350/04A
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RU2005106350A (ru
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Тао ВАНГ (US)
Тао Ванг
Жонгксинг ЖАНГ (US)
Жонгксинг Жанг
Николас А. МИНВЕЛЛ (US)
Николас А. Минвелл
Джон Ф. КЭДОУ (US)
Джон Ф. Кэдоу
Живей ЙИН (US)
Живей Йин
Киуфен Мэй КСУИ (US)
Киуфен Мэй КСУИ
Алисиа РЕГВЭЙРО-РЕН (US)
Алисиа РЕГВЭЙРО-РЕН
Джон Д. МЭТИСКЕЛЛА (US)
Джон Д. МЭТИСКЕЛЛА
Ясатсага УЕДА (US)
Ясатсага УЕДА
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Бристол-Маерс Сквибб Компани
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings

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Abstract

Изобретение относится к новым соединениям формулы I и II:
Figure 00000001
Figure 00000002
которые проявляют антивирусную активность, что позволяет использовать их в фармацевтических композициях и для изготовления средств для лечения вирусных заболеваний. 5 н.п. ф-лы, 6 табл.

Description

Текст описания приведен в факсимильном виде.
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Claims (5)

1. Соединение формулы I,
Figure 00000070
2. Соединение формулы II,
Figure 00000071
3. Фармацевтическая композиция с антивирусной активностью, содержащая соединение по п.1 или 2 и фармацевтически приемлемый носитель.
4. Применение соединения по п.1 для изготовления средств для лечения вирусных заболеваний.
5. Применение соединения по п.2 для изготовления средств для лечения вирусных заболеваний.
RU2005106350/04A 2002-08-07 2003-08-04 Композиция и производные замещенного азаиндолоксоацетапиперазина, обладающие противовирусной активностью RU2325389C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/214,982 US20030207910A1 (en) 2001-02-02 2002-08-07 Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US10/214,982 2002-08-07

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RU2325389C2 true RU2325389C2 (ru) 2008-05-27

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Cited By (2)

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RU2804033C2 (ru) * 2019-06-19 2023-09-26 Виив Хэлскэар Юкей (Но.5) Лимитед Ингибиторы репликации вируса иммунодефицита человека
US12129255B2 (en) 2019-06-19 2024-10-29 Viiv Healthcare Uk (No. 5) Limited Pyrido [2,3-d]pyrimidine derivatives as inhibitors of human immunodeficiency virus replication

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US20050124623A1 (en) * 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US20050215544A1 (en) * 2004-03-24 2005-09-29 Pin-Fang Lin Methods of treating HIV infection
US7776863B2 (en) * 2004-03-24 2010-08-17 Bristol-Myers Squibb Company Methods of treating HIV infection
UY28945A1 (es) 2004-06-09 2006-01-31 Glaxo Group Ltd Derivados de pirrolopiridina
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
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