SMAP200900065A - Derivati ciclizzati come inibitori di eg-5 - Google Patents

Derivati ciclizzati come inibitori di eg-5

Info

Publication number: SMAP200900065A
Authority: SM; San Marino
Prior art keywords: inhibitors; cyclized derivatives; cyclized; derivatives
Prior art date: 2007-01-05

Application number

SM200900065T

Other languages

English (en)

Other versions

SMP200900065B (it

Inventor

Paul A Barsanti

Weibo Wang

Hong Yang

Rustum Boyce

Eric Martin

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-01-05

Filing date

2009-07-23

Publication date

2009-09-07

2009-07-23 Application filed by Novartis Ag filed Critical Novartis Ag

2009-09-07 Publication of SMAP200900065A publication Critical patent/SMAP200900065A/it

2010-09-10 Publication of SMP200900065B publication Critical patent/SMP200900065B/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

SM200900065T 2007-01-05 2009-07-23 Derivati ciclizzati come inibitori di EG-5. SMP200900065B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US88374007P	2007-01-05	2007-01-05
PCT/US2008/050149 WO2008086122A2 (en)	2007-01-05	2008-01-03	Imidazole derivatives as kinesin spindle protein inhibitors (eg-5)

Publications (2)

Publication Number	Publication Date
SMAP200900065A true SMAP200900065A (it)	2009-09-07
SMP200900065B SMP200900065B (it)	2010-09-10

Family

ID=39577804

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM200900065T SMP200900065B (it)	2007-01-05	2009-07-23	Derivati ciclizzati come inibitori di EG-5.

Country Status (30)

Country	Link
US (3)	US7820646B2 (it)
EP (1)	EP2106399A2 (it)
JP (1)	JP2010515687A (it)
KR (1)	KR20090097210A (it)
CN (1)	CN101622247A (it)
AR (1)	AR064760A1 (it)
AU (1)	AU2008205169B2 (it)
BR (1)	BRPI0806264A2 (it)
CA (1)	CA2674318A1 (it)
CL (1)	CL2008000029A1 (it)
CO (1)	CO6561828A2 (it)
CR (1)	CR10879A (it)
DO (1)	DOP2009000169A (it)
EA (1)	EA200900924A1 (it)
EC (1)	ECSP099485A (it)
GE (1)	GEP20125415B (it)
GT (1)	GT200900192A (it)
HN (1)	HN2009001262A (it)
MA (1)	MA31080B1 (it)
MX (1)	MX2009007260A (it)
NI (1)	NI200900134A (it)
NZ (1)	NZ577727A (it)
PE (1)	PE20081850A1 (it)
SM (1)	SMP200900065B (it)
SV (1)	SV2009003325A (it)
TN (1)	TN2009000287A1 (it)
TW (1)	TW200836722A (it)
UA (1)	UA97821C2 (it)
WO (1)	WO2008086122A2 (it)
ZA (1)	ZA200904175B (it)

Families Citing this family (16)

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US8252832B2 (en) *	2007-12-14	2012-08-28	Novartis Ag	Kinesin inhibitors as cancer therapeutics
EP2558452A2 (en) *	2010-04-15	2013-02-20	Novartis AG	Oxazole and thiazole compounds as ksp inhibitors
MX2012011910A (es)	2010-04-15	2012-11-29	Novartis Ag	Compuestos de triazol como inhibidores de ksp.
EP2390247A1 (en) *	2010-05-26	2011-11-30	Netherlands Organisation for Scientific Research (Advanced Chemical Technologies for Sustainability)	Preparation of caprolactone, caprolactam, 2,5-tetrahydrofuran dimethanol, 1,6-hexanediol or 1,2,6-hexanetriol from 5-hydroxymethyl-2-furfuraldehyde
GB201113538D0 (en)	2011-08-04	2011-09-21	Karobio Ab	Novel estrogen receptor ligands
US9498540B2 (en)	2013-03-15	2016-11-22	Novartis Ag	Cell proliferation inhibitors and conjugates thereof
EP2968591A1 (en) *	2013-03-15	2016-01-20	Novartis AG	Cell proliferation inhibitors and conjugates thereof
AU2014372833B2 (en) *	2013-12-23	2019-08-22	Bayer Pharma Aktiengesellschaft	Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP)
WO2016207089A1 (de) *	2015-06-22	2016-12-29	Bayer Pharma Aktiengesellschaft	Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen
CN105367506B (zh) *	2015-12-08	2021-02-05	华润双鹤药业股份有限公司	手性高哌嗪环的制备方法
CN105330657B (zh) *	2015-12-08	2019-05-21	华润双鹤药业股份有限公司	5-氯-2-[5-(r)-甲基-1,4-二氮杂环庚烷-1-]苯并恶唑的制备方法
US11001636B2 (en)	2016-06-15	2021-05-11	Bayer Pharma Aktiengesellschaft	Specific antibody-drug-conjugates (ADCs) with KSP inhibitors and anti-CD123-antibodies
CA3047522A1 (en)	2016-12-21	2018-06-28	Bayer Pharma Aktiengesellschaft	Specific antibody drug conjugates (adcs) having ksp inhibitors
KR102628678B1 (ko)	2016-12-21	2024-01-25	바이엘 파마 악티엔게젤샤프트	효소적으로 절단가능한 기를 갖는 항체 약물 접합체 (adc)
KR20210033470A (ko)	2018-06-18	2021-03-26	바이엘 악티엔게젤샤프트	효소에 의해 절단 가능한 링커 및 개선된 활성 프로파일을 갖는, cxcr5에 대해 유도된 결합제-약물 접합체
CN119859151A (zh) *	2023-10-19	2025-04-22	北京振东光明药物研究院有限公司	从白土苓中分离得到的生物碱类化合物及其制备方法和应用

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2008
- 2008-01-03 WO PCT/US2008/050149 patent/WO2008086122A2/en not_active Ceased
- 2008-01-03 GE GEAP200811346A patent/GEP20125415B/en unknown
- 2008-01-03 JP JP2009544977A patent/JP2010515687A/ja active Pending
- 2008-01-03 BR BRPI0806264-1A patent/BRPI0806264A2/pt not_active IP Right Cessation
- 2008-01-03 EA EA200900924A patent/EA200900924A1/ru unknown
- 2008-01-03 US US11/969,164 patent/US7820646B2/en not_active Expired - Fee Related
- 2008-01-03 NZ NZ577727A patent/NZ577727A/en not_active IP Right Cessation
- 2008-01-03 AU AU2008205169A patent/AU2008205169B2/en not_active Ceased
- 2008-01-03 CN CN200880007148A patent/CN101622247A/zh active Pending
- 2008-01-03 MX MX2009007260A patent/MX2009007260A/es not_active Application Discontinuation
- 2008-01-03 KR KR1020097016289A patent/KR20090097210A/ko not_active Withdrawn
- 2008-01-03 EP EP08705667A patent/EP2106399A2/en not_active Withdrawn
- 2008-01-03 CA CA002674318A patent/CA2674318A1/en not_active Abandoned
- 2008-01-04 CL CL200800029A patent/CL2008000029A1/es unknown
- 2008-01-04 TW TW097100432A patent/TW200836722A/zh unknown
- 2008-01-04 AR ARP080100042A patent/AR064760A1/es not_active Application Discontinuation
- 2008-01-04 PE PE2008000091A patent/PE20081850A1/es not_active Application Discontinuation
- 2008-03-01 UA UAA200906929A patent/UA97821C2/ru unknown
2009
- 2009-06-15 ZA ZA200904175A patent/ZA200904175B/xx unknown
- 2009-06-19 CR CR10879A patent/CR10879A/es unknown
- 2009-06-30 MA MA32061A patent/MA31080B1/fr unknown
- 2009-07-02 NI NI200900134A patent/NI200900134A/es unknown
- 2009-07-02 DO DO2009000169A patent/DOP2009000169A/es unknown
- 2009-07-02 CO CO09068496A patent/CO6561828A2/es not_active Application Discontinuation
- 2009-07-03 HN HN2009001262A patent/HN2009001262A/es unknown
- 2009-07-03 SV SV2009003325A patent/SV2009003325A/es not_active Application Discontinuation
- 2009-07-03 TN TNP2009000287A patent/TN2009000287A1/fr unknown
- 2009-07-03 EC EC2009009485A patent/ECSP099485A/es unknown
- 2009-07-03 GT GT200900192A patent/GT200900192A/es unknown
- 2009-07-23 SM SM200900065T patent/SMP200900065B/it unknown
2010
- 2010-09-15 US US12/882,473 patent/US20110003791A1/en not_active Abandoned
2012
- 2012-04-03 US US13/438,569 patent/US20120189623A1/en not_active Abandoned

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Publication number	Publication date
EA200900924A1 (ru)	2009-12-30
GEP20125415B (en)	2012-03-12
SMP200900065B (it)	2010-09-10
TW200836722A (en)	2008-09-16
BRPI0806264A2 (pt)	2011-08-30
US20110003791A1 (en)	2011-01-06
MA31080B1 (fr)	2010-01-04
CN101622247A (zh)	2010-01-06
US7820646B2 (en)	2010-10-26
AU2008205169A1 (en)	2008-07-17
AR064760A1 (es)	2009-04-22
MX2009007260A (es)	2009-07-10
NZ577727A (en)	2012-03-30
UA97821C2 (en)	2012-03-26
HN2009001262A (es)	2012-01-09
CR10879A (es)	2009-08-05
PE20081850A1 (es)	2009-02-05
US20080207589A1 (en)	2008-08-28
WO2008086122A2 (en)	2008-07-17
CA2674318A1 (en)	2008-07-17
US20120189623A1 (en)	2012-07-26
EP2106399A2 (en)	2009-10-07
TN2009000287A1 (en)	2010-12-31
ECSP099485A (es)	2009-08-28
NI200900134A (es)	2010-07-05
GT200900192A (es)	2010-06-24
WO2008086122A3 (en)	2008-10-16
CO6561828A2 (es)	2012-11-15
CL2008000029A1 (es)	2008-04-04
DOP2009000169A (es)	2009-08-31
SV2009003325A (es)	2011-08-09
AU2008205169B2 (en)	2012-02-02
KR20090097210A (ko)	2009-09-15
ZA200904175B (en)	2010-04-28
JP2010515687A (ja)	2010-05-13

Publication	Publication Date	Title
SMAP200900065A (it)	2009-09-07	Derivati ciclizzati come inibitori di eg-5
SMAP201000096A (it)	2010-09-10	Derivati tiazolici utilizzati come inibitori di pi3chinasi
SMP200800048B (it)	2009-07-14	Derivati pirimidinici utilizzati come inibitori dip13-chinasi
ATE549340T1 (de)	2012-03-15	Spiroindolinon-derivate als mdm2-p53 inhibitoren
HRP20161562T1 (hr)	2016-12-30	Derivati benzimidazola
HRP20171534T8 (hr)	2018-08-24	Derivati fosfora kao inhibitori kinaza
DK2308877T3 (da)	2014-04-22	Imidazopyridin-2-on-derivater
DK2164844T3 (da)	2012-08-20	Pyrimidinyl-pyridazinonderivater
DK2209786T3 (da)	2013-06-03	Pyrimidinsubstituerede purinderivater
EP2192838A4 (en)	2011-07-27	HETEROCYCLIC NEKROPTOSIS HEMMER
BRPI0811065A2 (pt)	2014-12-02	Indazóis 5-heteroaril substituídos como inibidores de quinase
BRPI0918846A2 (pt)	2019-09-24	inibidores de cinase heterocíclica
EP2266989A4 (en)	2011-10-12	HETEROCYCLIC DERIVATIVES
ATE506358T1 (de)	2011-05-15	2-benzylpyridazinonderivate als met-kinasehemmer
BRPI0809992A2 (pt)	2014-10-14	Derivados de pirrolopirimidina
BRPI0813836A2 (pt)	2015-01-06	Derivados pirazólicos
BRPI0915064A2 (pt)	2015-10-27	derivados de qunoxalinadiona
ATE518837T1 (de)	2011-08-15	Indazolamidderivate
DK2142533T3 (da)	2011-12-12	Imidazolidinonderivater
BRPI0814236A2 (pt)	2015-01-06	Derivados de quinazolinamida
BRPI0913832A2 (pt)	2015-10-20	derivados de pirrolopiridinilpirimidin-2-ilamina
DK2152370T3 (da)	2011-08-15	Aryletherpyridazinonderivater
DK2275414T3 (da)	2015-06-22	Cyclopentylacrylamidderivat
ATE545417T1 (de)	2012-03-15	Pyrazoloä3,4-büpyridin-derivate als phosphodiesterasehemmer
ATE545635T1 (de)	2012-03-15	Substituierte n-oxidpyrazinderivate