BRPI0811065A2 - Indazóis 5-heteroaril substituídos como inibidores de quinase - Google Patents
Indazóis 5-heteroaril substituídos como inibidores de quinaseInfo
- Publication number
- BRPI0811065A2 BRPI0811065A2 BRPI0811065-4A2A BRPI0811065A BRPI0811065A2 BR PI0811065 A2 BRPI0811065 A2 BR PI0811065A2 BR PI0811065 A BRPI0811065 A BR PI0811065A BR PI0811065 A2 BRPI0811065 A2 BR PI0811065A2
- Authority
- BR
- Brazil
- Prior art keywords
- indazoes
- heteroaryl
- replaced
- kinase inhibitors
- kinase
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93396007P | 2007-06-08 | 2007-06-08 | |
| PCT/US2008/065727 WO2008154241A1 (en) | 2007-06-08 | 2008-06-04 | 5-heteroaryl substituted indazoles as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0811065A2 true BRPI0811065A2 (pt) | 2014-12-02 |
Family
ID=39951673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0811065-4A2A BRPI0811065A2 (pt) | 2007-06-08 | 2008-06-04 | Indazóis 5-heteroaril substituídos como inibidores de quinase |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2167491A1 (pt) |
| JP (2) | JP5451602B2 (pt) |
| KR (1) | KR20100032886A (pt) |
| CN (1) | CN101790526A (pt) |
| AU (1) | AU2008262038A1 (pt) |
| BR (1) | BRPI0811065A2 (pt) |
| CA (1) | CA2689117A1 (pt) |
| IL (1) | IL202318A0 (pt) |
| MX (1) | MX2009013213A (pt) |
| RU (1) | RU2487873C2 (pt) |
| SG (1) | SG182187A1 (pt) |
| WO (1) | WO2008154241A1 (pt) |
| ZA (1) | ZA200908624B (pt) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
| DE602007009932D1 (de) | 2006-02-16 | 2010-12-02 | Schering Corp | Pyrrolidin-derivate als erk-hemmer |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| JP2011502958A (ja) * | 2007-06-19 | 2011-01-27 | 武田薬品工業株式会社 | グルコキナーゼ活性化インダゾール化合物 |
| WO2009011871A2 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
| CA2692713A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Heterocyclic modulators of pkb |
| EA201070323A1 (ru) * | 2007-08-30 | 2010-10-29 | Такеда Фармасьютикал Компани Лимитед | Замещенное производное пиразола |
| CN102015693B (zh) | 2008-02-21 | 2014-10-29 | 默沙东公司 | 作为erk抑制剂的化合物 |
| AR071780A1 (es) | 2008-05-15 | 2010-07-14 | Nerviano Medical Sciences Srl | Derivados de carbamoilo de carbonilamino-pirazoles biciclicos como profarmacos |
| US8697685B2 (en) * | 2008-11-20 | 2014-04-15 | Glaxosmithkline Llc | Chemical compounds |
| CN105037355B (zh) | 2009-08-10 | 2017-06-06 | 萨穆梅德有限公司 | Wnt信号传导途径的吲唑抑制剂及其治疗用途 |
| SI3001903T1 (en) | 2009-12-21 | 2018-02-28 | Samumed, Llc | 1h-pyrazolo(3,4-b)pyridines and therapeutic uses thereof |
| UY33213A (es) * | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| KR101233082B1 (ko) | 2010-02-25 | 2013-02-14 | 주식회사 이큐스앤자루 | 신규한 이미다졸피라진 유도체 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스 치료용 약학적 조성물 |
| US9181233B2 (en) | 2010-03-03 | 2015-11-10 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| BR112012026948A2 (pt) * | 2010-04-28 | 2019-09-24 | Daiichi Sankyo Co Ltd | composto, composição farmacêutica, e, métodos para melhorar o metabolismo ósseo, para previnir ou tratar uma doença associada com metabolismo ósseo e para previnir ou tratar osteoporose. |
| WO2011140333A1 (en) | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
| EP2655357B1 (en) * | 2010-12-20 | 2016-06-22 | Merck Serono S.A. | Indazolyl triazole derivatives as irak inhibitors |
| JP5918264B2 (ja) | 2010-12-22 | 2016-05-18 | アッヴィ・インコーポレイテッド | C型肝炎阻害剤およびその使用 |
| US9090592B2 (en) * | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
| CN102675286B (zh) * | 2011-03-07 | 2015-08-19 | 中国科学院上海药物研究所 | 一类吲唑类化合物及其制备方法、用途和药物组合物 |
| JP5906303B2 (ja) * | 2011-04-07 | 2016-04-20 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | Aktキナーゼ阻害剤としてのイミダゾピリダジン類 |
| KR20140071361A (ko) * | 2011-08-12 | 2014-06-11 | 에프. 호프만-라 로슈 아게 | 피라졸로[3,4-c]피리딘 화합물 및 사용 방법 |
| CN103929963A (zh) * | 2011-09-14 | 2014-07-16 | 萨穆梅德有限公司 | 吲唑-3-羧酰胺及其作为WNT/β-CATENIN信号传导通路抑制剂的用途 |
| DK2921492T3 (en) | 2011-12-27 | 2017-12-11 | Bayer Ip Gmbh | HETEROARYLPIPERIDINE AND ¿PIPERAZINE DERIVATIVES |
| GEP20166489B (en) * | 2012-02-21 | 2016-06-10 | Acraf | 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| MY173049A (en) | 2012-05-04 | 2019-12-20 | Samumed Llc | 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| TW201406758A (zh) * | 2012-06-28 | 2014-02-16 | Daiichi Sankyo Co Ltd | 三環性化合物 |
| EP2943198B1 (en) | 2013-01-08 | 2019-07-17 | Samumed, LLC | 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof |
| EP2964221B1 (en) | 2013-03-04 | 2017-12-06 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134776A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134772A1 (en) * | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134774A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| JO3383B1 (ar) * | 2013-03-14 | 2019-03-13 | Lilly Co Eli | مثبطات cdc7 |
| EP3010918B1 (en) * | 2013-06-21 | 2018-08-15 | Zenith Epigenetics Ltd. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| CR20160395A (es) | 2014-02-13 | 2016-12-20 | Incyte Corp | Ciclopropilaminas como inhibidores de lsd1 |
| ES2672797T3 (es) | 2014-02-13 | 2018-06-18 | Incyte Corporation | Ciclopropilaminas como inhibidores de LSD1 |
| MY183499A (en) | 2014-02-13 | 2021-02-22 | Incyte Corp | Cyclopropylamines as lsd1 inhibitors |
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| RU2009149696A (ru) | 2011-07-20 |
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| SG182187A1 (en) | 2012-07-30 |
| CN101790526A (zh) | 2010-07-28 |
| CA2689117A1 (en) | 2008-12-18 |
| EP2167491A1 (en) | 2010-03-31 |
| RU2487873C2 (ru) | 2013-07-20 |
| JP2010529137A (ja) | 2010-08-26 |
| JP2014074057A (ja) | 2014-04-24 |
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| B25A | Requested transfer of rights approved |
Owner name: ABBOTT GMBH AND CO. KG (DE) , ABBVIE INC. (US) |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |