BRPI0915064A2 - derivados de qunoxalinadiona - Google Patents

derivados de qunoxalinadiona

Info

Publication number: BRPI0915064A2
Authority: BR; Brazil
Prior art keywords: qunoxalinadione; derivatives; qunoxalinadione derivatives
Prior art date: 2008-06-16

Application number

BRPI0915064A

Other languages

English (en)

Inventor

Daniel Cravo

Franck Leprife

Sophie Hallakou-Bozec

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-16

Filing date

2009-05-19

Publication date

2015-10-27

2009-05-19 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2015-10-27 Publication of BRPI0915064A2 publication Critical patent/BRPI0915064A2/pt

2019-10-08 Publication of BRPI0915064B1 publication Critical patent/BRPI0915064B1/pt

2021-05-25 Publication of BRPI0915064B8 publication Critical patent/BRPI0915064B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BRPI0915064A 2008-06-16 2009-05-19 derivados de quinoxalinadiona, seus usos, e medicamentos BRPI0915064B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08290564.7		2008-06-16
EP08290564		2008-06-16
PCT/EP2009/003538 WO2009152909A1 (en)	2008-06-16	2009-05-19	Quinoxalinedione derivatives

Publications (3)

Publication Number	Publication Date
BRPI0915064A2 true BRPI0915064A2 (pt)	2015-10-27
BRPI0915064B1 BRPI0915064B1 (pt)	2019-10-08
BRPI0915064B8 BRPI0915064B8 (pt)	2021-05-25

Family

ID=40823394

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0915064A BRPI0915064B8 (pt)	2008-06-16	2009-05-19	derivados de quinoxalinadiona, seus usos, e medicamentos

Country Status (24)

Country	Link
US (2)	US8329698B2 (pt)
EP (1)	EP2285786B1 (pt)
JP (1)	JP5596676B2 (pt)
KR (1)	KR101641391B1 (pt)
CN (1)	CN102066342B (pt)
AR (1)	AR072148A1 (pt)
AU (1)	AU2009259754B2 (pt)
BR (1)	BRPI0915064B8 (pt)
CA (1)	CA2728018C (pt)
CO (1)	CO6321252A2 (pt)
CY (1)	CY1114737T1 (pt)
DK (1)	DK2285786T3 (pt)
EA (1)	EA020236B1 (pt)
EC (1)	ECSP11010760A (pt)
ES (1)	ES2436195T3 (pt)
HR (1)	HRP20131069T1 (pt)
IL (1)	IL209421A (pt)
MX (1)	MX2010013577A (pt)
MY (1)	MY155695A (pt)
NZ (1)	NZ590503A (pt)
PL (1)	PL2285786T3 (pt)
PT (1)	PT2285786E (pt)
SI (1)	SI2285786T1 (pt)
WO (1)	WO2009152909A1 (pt)

Families Citing this family (24)

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US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8889730B2 (en)	2012-04-10	2014-11-18	Pfizer Inc.	Indole and indazole compounds that activate AMPK
MX371331B (es)	2012-04-24	2020-01-27	Vertex Pharma	Inhibidores de la proteina cinasa dependiente de acido desoxirribonucleico(adn-pk).
SI3527563T1 (sl)	2013-03-12	2022-01-31	Vertex Pharmaceuticals Incorporated	Inhibitorji DNA-PK
CA2905242C (en)	2013-03-15	2016-11-29	Pfizer Inc.	Indole compounds that activate ampk
CN103435561B (zh) *	2013-08-19	2016-08-10	上海交通大学	一种新型d-氨基酸氧化酶抑制剂及其制备和应用
DK3424920T3 (da)	2013-10-17	2020-06-08	Vertex Pharma	Co-krystaller af (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinolin-4-carboxamid og deuterede derivater deraf som dna-pk-inhibitorer
JP2019529475A (ja)	2016-09-27	2019-10-17	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	Ｄｎａ損傷剤とｄｎａ−ｐｋ阻害剤との組合せ物を使用する、がんを処置するための方法
EP3941496A4 (en) *	2019-03-18	2022-11-23	University of Washington	METHODS OF PROMOTING CELLULAR MATURATION WITH AMPK ACTIVATORS
CN110642798B (zh) *	2019-11-10	2020-07-24	湖南科技学院	一种n-取代-1,4-二氢-2,3-喹喔啉二酮化合物的绿色合成方法
US11618751B1 (en)	2022-03-25	2023-04-04	Ventus Therapeutics U.S., Inc.	Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
KR20230012597A (ko)	2020-05-19	2023-01-26	칼리오페, 인크.	Ampk 활성화제
AU2021297323A1 (en)	2020-06-26	2023-02-16	Kallyope, Inc.	AMPK activators
EP4221700A1 (en)	2020-09-30	2023-08-09	Bioverativ Therapeutics Inc.	Ampk activators and methods of use thereof
US11767320B2 (en)	2020-10-02	2023-09-26	Incyte Corporation	Bicyclic dione compounds as inhibitors of KRAS
EP4249489A4 (en) *	2020-11-26	2023-10-18	Lg Chem, Ltd.	HETEROCYCLIC COMPOUND AS DIACYLGLYCEROL KINASE INHIBITOR AND USE THEREOF
US11319319B1 (en)	2021-04-07	2022-05-03	Ventus Therapeutics U.S., Inc.	Compounds for inhibiting NLRP3 and uses thereof
CA3238252A1 (en)	2021-11-19	2023-05-25	Amit Choudhary	Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof
US12331048B2 (en)	2022-10-31	2025-06-17	Ventus Therapeutics U.S., Inc.	Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
US5631373A (en)	1993-11-05	1997-05-20	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon	Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
EP0963372A1 (en)	1997-02-18	1999-12-15	American Home Products Corporation	5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists
AU2002314101A1 (en)	2001-05-25	2002-12-09	Boehringer Ingelheim Pharma Gmbh &Co. Kg	Combination of a dopamine d2-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways
MXPA06007715A (es)	2004-01-06	2007-01-26	Johnson & Johnson	Derivados de (3-oxo-3,4-dihidro-quinoxalin-2-il-amino)-benzamida y compuesto relacionado, como inhibidores de glucogeno fosforilasa para el tratamiento de la diabetes y obesidad.
MY139645A (en) *	2004-02-11	2009-10-30	Amgen Inc	Vanilloid receptor ligands and their use in treatments
EP2018167A4 (en) *	2006-05-15	2010-07-14	Irm Llc	COMPOSITIONS AND METHODS AS INHIBITORS OF FGF RECEPTOR KINASES
FR2903695B1 (fr) *	2006-07-13	2008-10-24	Merck Sante Soc Par Actions Si	Utilisation de derives d'imidazole activateurs de l'ampk, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

2009
- 2009-05-19 HR HRP20131069AT patent/HRP20131069T1/hr unknown
- 2009-05-19 US US12/997,641 patent/US8329698B2/en not_active Expired - Fee Related
- 2009-05-19 ES ES09765489T patent/ES2436195T3/es active Active
- 2009-05-19 DK DK09765489.1T patent/DK2285786T3/da active
- 2009-05-19 JP JP2011513895A patent/JP5596676B2/ja not_active Expired - Fee Related
- 2009-05-19 EP EP09765489.1A patent/EP2285786B1/en active Active
- 2009-05-19 KR KR1020117000992A patent/KR101641391B1/ko not_active Expired - Fee Related
- 2009-05-19 CN CN2009801227397A patent/CN102066342B/zh not_active Expired - Fee Related
- 2009-05-19 PT PT97654891T patent/PT2285786E/pt unknown
- 2009-05-19 EA EA201100007A patent/EA020236B1/ru not_active IP Right Cessation
- 2009-05-19 PL PL09765489T patent/PL2285786T3/pl unknown
- 2009-05-19 AU AU2009259754A patent/AU2009259754B2/en not_active Ceased
- 2009-05-19 BR BRPI0915064A patent/BRPI0915064B8/pt not_active IP Right Cessation
- 2009-05-19 NZ NZ590503A patent/NZ590503A/xx not_active IP Right Cessation
- 2009-05-19 WO PCT/EP2009/003538 patent/WO2009152909A1/en not_active Ceased
- 2009-05-19 CA CA2728018A patent/CA2728018C/en active Active
- 2009-05-19 MX MX2010013577A patent/MX2010013577A/es active IP Right Grant
- 2009-05-19 MY MYPI2010005917A patent/MY155695A/en unknown
- 2009-05-19 SI SI200930812T patent/SI2285786T1/sl unknown
- 2009-06-16 AR ARP090102166A patent/AR072148A1/es active IP Right Grant
2010
- 2010-11-18 IL IL209421A patent/IL209421A/en active IP Right Grant
- 2010-12-14 CO CO10156748A patent/CO6321252A2/es active IP Right Grant
2011
- 2011-01-14 EC EC2011010760A patent/ECSP11010760A/es unknown
2012
- 2012-08-24 US US13/593,722 patent/US8674097B2/en active Active
2013
- 2013-12-27 CY CY20131101166T patent/CY1114737T1/el unknown

Also Published As

Publication number	Publication date
ECSP11010760A (es)	2011-02-28
HK1157784A1 (en)	2012-07-06
US8674097B2 (en)	2014-03-18
EA201100007A1 (ru)	2011-08-30
BRPI0915064B8 (pt)	2021-05-25
KR20110017455A (ko)	2011-02-21
IL209421A (en)	2015-06-30
CO6321252A2 (es)	2011-09-20
PT2285786E (pt)	2014-01-07
MX2010013577A (es)	2010-12-21
US20120322806A1 (en)	2012-12-20
EA020236B1 (ru)	2014-09-30
US8329698B2 (en)	2012-12-11
EP2285786B1 (en)	2013-10-09
IL209421A0 (en)	2011-01-31
EP2285786A1 (en)	2011-02-23
CA2728018A1 (en)	2009-12-23
BRPI0915064B1 (pt)	2019-10-08
US20110130404A1 (en)	2011-06-02
CA2728018C (en)	2016-10-11
ES2436195T3 (es)	2013-12-27
CN102066342A (zh)	2011-05-18
AR072148A1 (es)	2010-08-11
SI2285786T1 (sl)	2014-02-28
KR101641391B1 (ko)	2016-07-20
NZ590503A (en)	2012-08-31
AU2009259754A1 (en)	2009-12-23
JP2011524384A (ja)	2011-09-01
JP5596676B2 (ja)	2014-09-24
CY1114737T1 (el)	2016-12-14
AU2009259754B2 (en)	2014-10-02
PL2285786T3 (pl)	2014-01-31
DK2285786T3 (da)	2013-11-04
MY155695A (en)	2015-11-13
WO2009152909A1 (en)	2009-12-23
HRP20131069T1 (hr)	2013-12-20
CN102066342B (zh)	2013-09-04

Publication	Publication Date	Title
DK2308877T3 (da)	2014-04-22	Imidazopyridin-2-on-derivater
BRPI0915064A2 (pt)	2015-10-27	derivados de qunoxalinadiona
EP2376493A4 (en)	2012-05-30	DIHYDROPYRIMIDOPYRIMIDINDERIVAT
EP2380877A4 (en)	2012-06-27	PYRIDINE-3-CARBONSÄUREAMIDDERIVAT
BRPI0813707A2 (pt)	2014-12-30	Derivados de pirimidinil-piridazinona
BRPI0820112A2 (pt)	2015-05-05	Derivados de isoxazol-piridina
BRPI0809992A2 (pt)	2014-10-14	Derivados de pirrolopirimidina
BRPI0913832A2 (pt)	2015-10-20	derivados de pirrolopiridinilpirimidin-2-ilamina
BRPI0820113A2 (pt)	2015-05-05	Derivados de isoxazolo-piridazina
BRPI0812155A2 (pt)	2019-09-24	derivados de espiroindolinona
BRPI1013246A2 (pt)	2016-04-05	derivados de benzofuralina
BR112012002828A2 (pt)	2015-10-13	derivados de 5-fluorpirimidinona
BRPI0817935A2 (pt)	2015-04-07	Derivados de biarila
BRPI0921327A2 (pt)	2015-08-25	Combinação de herbicida-protetor
DK2209786T3 (da)	2013-06-03	Pyrimidinsubstituerede purinderivater
DK2340021T3 (da)	2012-12-10	Substituerede pyrrolidin-2-carboxamider
BRPI0814236A2 (pt)	2015-01-06	Derivados de quinazolinamida
BRPI0813836A2 (pt)	2015-01-06	Derivados pirazólicos
BRPI0812518A2 (pt)	2015-03-31	Derivados de indazolamida
EP2336132A4 (en)	2012-03-21	MORPHOLINPURINDERIVAT
BRPI0820649A2 (pt)	2015-06-16	Derivados de isoxazalo-pirazina
BRPI1013844A2 (pt)	2016-04-12	derivados de piridina-isoxazol
DK2275414T3 (da)	2015-06-22	Cyclopentylacrylamidderivat
DK2152370T3 (da)	2011-08-15	Aryletherpyridazinonderivater
BRPI0913234A2 (pt)	2016-01-19	derivados de tiazolilpiperidina

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-02-12	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2019-05-07	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2019-08-20	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-10-08	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/10/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/10/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/05/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2025-03-18	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 16A ANUIDADE.
2025-07-15	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2828 DE 18-03-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.